Entry |
|
Name |
Valine, leucine and isoleucine degradation - Homo sapiens (human) |
Class |
Metabolism; Amino acid metabolism
|
Pathway map |
hsa00280 | Valine, leucine and isoleucine degradation |
|
Module |
|
Network |
|
Element |
N00832 | Branched-chain amino acids degradation 1 |
N00842 | Propanoyl-CoA metabolism |
N01619 | Branched-chain amino acids degradation 2 |
|
Other DBs |
|
Organism |
Homo sapiens (human) [GN: hsa]
|
Gene |
593 | BCKDHA; branched chain keto acid dehydrogenase E1 subunit alpha [KO:K00166] [EC:1.2.4.4] |
594 | BCKDHB; branched chain keto acid dehydrogenase E1 subunit beta [KO:K00167] [EC:1.2.4.4] |
36 | ACADSB; acyl-CoA dehydrogenase short/branched chain [KO:K09478] [EC:1.3.8.5] |
27034 | ACAD8; acyl-CoA dehydrogenase family member 8 [KO:K11538] [EC:1.3.99.-] |
3032 | HADHB; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [KO:K07509] [EC:2.3.1.16] |
|
Compound |
C00141 | 3-Methyl-2-oxobutanoic acid |
C00233 | 4-Methyl-2-oxopentanoate |
C00349 | 2-Methyl-3-oxopropanoate |
C00356 | (S)-3-Hydroxy-3-methylglutaryl-CoA |
C00671 | (S)-3-Methyl-2-oxopentanoic acid |
C01205 | (R)-3-Amino-2-methylpropanoate |
C03344 | 2-Methylacetoacetyl-CoA |
C03345 | 2-Methylbut-2-enoyl-CoA |
C03460 | 2-Methylprop-2-enoyl-CoA |
C04405 | (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA |
C05996 | Branched chain fatty acid |
C05998 | 3-Hydroxyisovaleryl-CoA |
C06000 | (S)-3-Hydroxyisobutyryl-CoA |
C06001 | (S)-3-Hydroxyisobutyrate |
C06002 | (S)-Methylmalonate semialdehyde |
C15972 | Enzyme N6-(lipoyl)lysine |
C15973 | Enzyme N6-(dihydrolipoyl)lysine |
C15974 | 3-Methyl-1-hydroxybutyl-ThPP |
C15975 | [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine |
C15976 | 2-Methyl-1-hydroxypropyl-ThPP |
C15977 | [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine |
C15978 | 2-Methyl-1-hydroxybutyl-ThPP |
C15979 | [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine |
C15980 | (S)-2-Methylbutanoyl-CoA |
|
Related pathway |
hsa00290 | Valine, leucine and isoleucine biosynthesis |
hsa00900 | Terpenoid backbone biosynthesis |
|
KO pathway |
|