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KEGG   PATHWAY: hsa00310
Entry
hsa00310                    Pathway                                
Name
Lysine degradation - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
Pathway map
hsa00310  Lysine degradation
hsa00310

Module
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:hsa00310]
Network
  Element
N01685  Lysine degradation 1
N01686  Lysine degradation 2
N01687  Lysine degradation 3
Drug
D11444  Tazemetostat (USAN/INN)
D11485  Tazemetostat hydrobromide (JAN/USAN)
D11551  Valemetostat (INN)
D11662  Valemetostat tosilate (JAN)
D12602  Tulmimetostat (USAN/INN)
D12845  Mevrometostat (USAN)
Other DBs
GO: 0006554
Organism
Homo sapiens (human) [GN:hsa]
Gene
10157  AASS; aminoadipate-semialdehyde synthase [KO:K14157] [EC:1.5.1.8 1.5.1.9]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
51166  AADAT; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.7 2.6.1.39]
55526  DHTKD1; dehydrogenase E1 and transketolase domain containing 1 [KO:K15791] [EC:1.2.4.-]
1743  DLST; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
2639  GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
3030  HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]
1962  EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
1892  ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
3033  HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
123688  HYKK; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
85007  PHYKPL; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
51268  PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
79823  CAMKMT; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
4297  KMT2A; lysine methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
8085  KMT2D; lysine methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
58508  KMT2C; lysine methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
9757  KMT2B; lysine methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
55904  KMT2E; lysine methyltransferase 2E (inactive) [KO:K09189] [EC:2.1.1.354]
23067  SETD1B; SET domain containing 1B, histone lysine methyltransferase [KO:K11422] [EC:2.1.1.354]
9739  SETD1A; SET domain containing 1A, histone lysine methyltransferase [KO:K11422] [EC:2.1.1.354]
80854  SETD7; SET domain containing 7, histone lysine methyltransferase [KO:K11431] [EC:2.1.1.364]
56979  PRDM9; PR/SET domain 9 [KO:K20796] [EC:2.1.1.354]
11105  PRDM7; PR/SET domain 7 [KO:K20796] [EC:2.1.1.354]
55870  ASH1L; ASH1 like histone lysine methyltransferase [KO:K06101] [EC:2.1.1.354]
56950  SMYD2; SET and MYND domain containing 2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
64754  SMYD3; SET and MYND domain containing 3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
150572  SMYD1; SET and MYND domain containing 1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
6839  SUV39H1; SUV39H1 histone lysine methyltransferase [KO:K11419] [EC:2.1.1.355]
79723  SUV39H2; SUV39H2 histone lysine methyltransferase [KO:K11419] [EC:2.1.1.355]
10919  EHMT2; euchromatic histone lysine methyltransferase 2 [KO:K11420] [EC:2.1.1.355]
79813  EHMT1; euchromatic histone lysine methyltransferase 1 [KO:K11420] [EC:2.1.1.355]
9869  SETDB1; SET domain bifurcated histone lysine methyltransferase 1 [KO:K11421] [EC:2.1.1.366]
83852  SETDB2; SET domain bifurcated histone lysine methyltransferase 2 [KO:K18494] [EC:2.1.1.355]
7799  PRDM2; PR/SET domain 2 [KO:K11432] [EC:2.1.1.355]
2145  EZH1; enhancer of zeste 1 polycomb repressive complex 2 subunit [KO:K17451] [EC:2.1.1.356]
2146  EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit [KO:K11430] [EC:2.1.1.356]
6419  SETMAR; SET domain and mariner transposase fusion gene [KO:K11433] [EC:2.1.1.357]
64324  NSD1; nuclear receptor binding SET domain protein 1 [KO:K15588] [EC:2.1.1.357]
7468  NSD2; nuclear receptor binding SET domain protein 2 [KO:K11424] [EC:2.1.1.357]
54904  NSD3; nuclear receptor binding SET domain protein 3 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
29072  SETD2; SET domain containing 2, histone lysine methyltransferase [KO:K11423] [EC:2.1.1.359]
84444  DOT1L; DOT1 like histone lysine methyltransferase [KO:K11427] [EC:2.1.1.360]
387893  KMT5A; lysine methyltransferase 5A [KO:K11428] [EC:2.1.1.361]
93166  PRDM6; PR/SET domain 6 [KO:K20795] [EC:2.1.1.361]
84787  KMT5C; lysine methyltransferase 5C [KO:K11429] [EC:2.1.1.362]
51111  KMT5B; lysine methyltransferase 5B [KO:K11429] [EC:2.1.1.362]
2122  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
63976  PRDM16; PR/SET domain 16 [KO:K22410] [EC:2.1.1.367]
55217  TMLHE; trimethyllysine hydroxylase, epsilon [KO:K00474] [EC:1.14.11.8]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
8424  BBOX1; gamma-butyrobetaine hydroxylase 1 [KO:K00471] [EC:1.14.11.1]
5351  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
5352  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [KO:K13645] [EC:1.14.11.4]
8985  PLOD3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
79709  COLGALT1; collagen beta(1-O)galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
23127  COLGALT2; collagen beta(1-O)galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00780  Biotin metabolism
KO pathway
ko00310   

  All links  
Network (3)   
   KEGG NETWORK (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (63)   
   KEGG GENES (63)   
All databases (67)   

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