KEGG   PATHWAY: hsa00350
Entry
hsa00350                    Pathway                                

Name
Tyrosine metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
Pathway map
hsa00350  Tyrosine metabolism
hsa00350

Module
hsa_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:hsa00350]
hsa_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:hsa00350]
hsa_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:hsa00350]
Network
nt06016  Phenylalanine and tyrosine metabolism
nt06322  TRH-TSH-TH signaling
nt06422  Dopamine metabolism
nt06463  Parkinson disease
  Element
N00708  Tyrosine degradation
N00803  Iodide organification/coupling reactions
N01036  L-DOPA generation
N01038  DOPAL generation
Drug
D00152  Phloroglucinol (JAN)
D00505  Phenelzine sulfate (USP)
D00762  Metyrosine (USP)
D00826  Tranylcypromine sulfate (USP)
D01259  Flopropione (JP18/INN)
D01888  Safrazine hydrochloride (JAN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02563  Befloxatone (INN)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D03248  Clorgiline (INN)
D03409  Caroxazone (USAN/INN)
D05177  Nitisinone (JAN/USAN/INN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D08085  Iproniazid phosphate
D08349  Phenelzine (BAN)
D08369  Polyphloroglucinol phosphate
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08625  Tranylcypromine (INN)
Other DBs
GO: 0006570
Organism
Homo sapiens (human) [GN:hsa]
Gene
2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
6898  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
3242  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
3081  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
2954  GSTZ1; glutathione S-transferase zeta 1 [KO:K01800] [EC:5.2.1.2]
2184  FAH; fumarylacetoacetate hydrolase [KO:K01555] [EC:3.7.1.2]
7299  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
7054  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
1638  DCT; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
7306  TYRP1; tyrosinase related protein 1 [KO:K00506] [EC:1.14.18.-]
1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
1621  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
5409  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
1312  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
220074  LRTOMT; leucine rich transmembrane and O-methyltransferase domain containing [KO:K00545] [EC:2.1.1.6]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
8639  AOC3; amine oxidase copper containing 3 [KO:K00276] [EC:1.4.3.21]
314  AOC2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]
221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
7173  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
81889  FAHD1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
4282  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00360  Phenylalanine metabolism
hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00620  Pyruvate metabolism
hsa00650  Butanoate metabolism
KO pathway
ko00350   

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