KEGG   PATHWAY: hsa00350
Entry
hsa00350                    Pathway                                
Name
Tyrosine metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
Pathway map
hsa00350  Tyrosine metabolism
hsa00350

Module
hsa_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:hsa00350]
hsa_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:hsa00350]
hsa_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:hsa00350]
Network
nt06016  Phenylalanine and tyrosine metabolism
nt06028  Dopamine and serotonin metabolism
nt06322  TRH-TSH-TH signaling
nt06463  Parkinson disease
nt06544  Neuroactive ligand signaling
  Element
N00708  Tyrosine degradation
N00803  Iodide organification/coupling reactions
N01530  Dopamine metabolism
N01550  Adrenaline metabolism
N01552  Eumelanin biosynthesis
N01918  Dopamine metabolism in astrocyte
N01919  Dopamine/Adrenaline metabolism in presynaptic neuron
Drug
D00152  Phloroglucinol (JAN)
D00505  Phenelzine sulfate (USP)
D00762  Metyrosine (USP)
D00826  Tranylcypromine sulfate (USP)
D01259  Flopropione (JP18/INN)
D01888  Safrazine hydrochloride (JAN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02563  Befloxatone (INN)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D03248  Clorgiline (INN)
D03409  Caroxazone (USAN/INN)
D05177  Nitisinone (JAN/USAN/INN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D08085  Iproniazid phosphate
D08349  Phenelzine (BAN)
D08369  Polyphloroglucinol phosphate
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08625  Tranylcypromine (INN)
D12407  Eladocagene exuparvovec (USAN/INN)
Other DBs
GO: 0006570
Organism
Homo sapiens (human) [GN:hsa]
Gene
120356740  TOMT; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
1312  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
1621  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
1638  DCT; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
2184  FAH; fumarylacetoacetate hydrolase [KO:K01555] [EC:3.7.1.2]
220074  LRTOMT; leucine rich transmembrane and O-methyltransferase domain containing [KO:K00545] [EC:2.1.1.6]
221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
2954  GSTZ1; glutathione S-transferase zeta 1 [KO:K01800] [EC:5.2.1.2]
3081  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
314  AOC2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
3242  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4282  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
5409  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
6898  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
7054  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
7173  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
7299  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
7306  TYRP1; tyrosinase related protein 1 [KO:K00506] [EC:1.14.18.-]
81889  FAHD1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
8639  AOC3; amine oxidase copper containing 3 [KO:K00276] [EC:1.4.3.21]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
C23042  Atromentin
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00360  Phenylalanine metabolism
hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00620  Pyruvate metabolism
hsa00650  Butanoate metabolism
KO pathway
ko00350   

  All links  
No link information was found.
KEGG   PATHWAY: hsa00350
Entry
hsa00350                    Pathway                                
Name
Tyrosine metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
Pathway map
hsa00350  Tyrosine metabolism
hsa00350

Module
hsa_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:hsa00350]
hsa_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:hsa00350]
hsa_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:hsa00350]
Network
nt06016  Phenylalanine and tyrosine metabolism
nt06028  Dopamine and serotonin metabolism
nt06322  TRH-TSH-TH signaling
nt06463  Parkinson disease
nt06544  Neuroactive ligand signaling
  Element
N00708  Tyrosine degradation
N00803  Iodide organification/coupling reactions
N01530  Dopamine metabolism
N01550  Adrenaline metabolism
N01552  Eumelanin biosynthesis
N01918  Dopamine metabolism in astrocyte
N01919  Dopamine/Adrenaline metabolism in presynaptic neuron
Drug
D00152  Phloroglucinol (JAN)
D00505  Phenelzine sulfate (USP)
D00762  Metyrosine (USP)
D00826  Tranylcypromine sulfate (USP)
D01259  Flopropione (JP18/INN)
D01888  Safrazine hydrochloride (JAN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02563  Befloxatone (INN)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D03248  Clorgiline (INN)
D03409  Caroxazone (USAN/INN)
D05177  Nitisinone (JAN/USAN/INN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D08085  Iproniazid phosphate
D08349  Phenelzine (BAN)
D08369  Polyphloroglucinol phosphate
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08625  Tranylcypromine (INN)
D12407  Eladocagene exuparvovec (USAN/INN)
Other DBs
GO: 0006570
Organism
Homo sapiens (human) [GN:hsa]
Gene
120356740  TOMT; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
1312  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
1621  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
1638  DCT; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
2184  FAH; fumarylacetoacetate hydrolase [KO:K01555] [EC:3.7.1.2]
220074  LRTOMT; leucine rich transmembrane and O-methyltransferase domain containing [KO:K00545] [EC:2.1.1.6]
221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
2954  GSTZ1; glutathione S-transferase zeta 1 [KO:K01800] [EC:5.2.1.2]
3081  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
314  AOC2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
3242  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4282  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
5409  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
6898  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
7054  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
7173  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
7299  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
7306  TYRP1; tyrosinase related protein 1 [KO:K00506] [EC:1.14.18.-]
81889  FAHD1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
8639  AOC3; amine oxidase copper containing 3 [KO:K00276] [EC:1.4.3.21]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
C23042  Atromentin
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00360  Phenylalanine metabolism
hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00620  Pyruvate metabolism
hsa00650  Butanoate metabolism
KO pathway
ko00350   

  All links  
No link information was found.
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