KEGG   PATHWAY: hsa00561Help
Entry
hsa00561                    Pathway                                

Name
Glycerolipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
hsa00561  Glycerolipid metabolism
hsa00561

Ortholog table
Module
hsa_M00089  Triacylglycerol biosynthesis [PATH:hsa00561]
hsa_M00098  Acylglycerol degradation [PATH:hsa00561]
Disease
H00154  Hyperlipoproteinemia, type I
H00552  Chromosome Xp21 deletion syndrome
H01117  Chronic recurrent multifocal osteomyelitis
H01290  Acute recurrent myoglobinuria
H01333  Nonalcoholic fatty liver disease
H02013  Glycerol kinase deficiency
Drug
D02047  Dextran sulfate sodium (JAN)
D03343  Dextran sulfate sodium sulfur 5 (JP17)
D03747  Ibrolipim (USAN/INN)
D04268  Elastase ES
D05255  Omega-3-acid ethyl esters (USAN)
D09208  Cetilistat (JAN/USAN/INN)
D10657  Pradigastat sodium (USAN)
D10664  Pradigastat (USAN)
Other DBs
BSID: 82986
GO: 0045017 0046486 0046503
Organism
Homo sapiens (human) [GN:hsa]
Gene
132158  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
231  AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]
57016  AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
10327  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
26007  TKFC; triokinase and FMN cyclase [KO:K00863] [EC:4.6.1.15 2.7.1.29 2.7.1.28]
2712  GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
2710  GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
57678  GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
150763  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
137964  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
84803  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
10554  AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
10555  AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
56894  AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
56895  AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
55326  AGPAT5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
253558  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.51 2.3.1.-]
154141  MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
129642  MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
8611  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
8613  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
8612  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
23175  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64900  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
9663  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
84513  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.1.3.4 3.1.3.81]
196051  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.1.3.4 3.1.3.81]
8525  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
8527  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
9162  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
1606  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
8526  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
1607  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
160851  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
1608  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
1609  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
139189  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
8694  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.76 2.3.1.75 2.3.1.20]
84649  DGAT2; diacylglycerol O-acyltransferase 2 [KO:K11160] [EC:2.3.1.75 2.3.1.20]
346606  MOGAT3; monoacylglycerol O-acyltransferase 3 [KO:K14456] [EC:2.3.1.22 2.3.1.20]
1056  CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
57104  PNPLA2; patatin like phospholipase domain containing 2 [KO:K16816] [EC:3.1.1.3]
80339  PNPLA3; patatin like phospholipase domain containing 3 [KO:K13534] [EC:2.3.1.- 3.1.1.3]
5406  PNLIP; pancreatic lipase [KO:K14073] [EC:3.1.1.3]
5407  PNLIPRP1; pancreatic lipase related protein 1 [KO:K14074] [EC:3.1.1.3]
5408  PNLIPRP2; pancreatic lipase related protein 2 (gene/pseudogene) [KO:K14075] [EC:3.1.1.3]
119548  PNLIPRP3; pancreatic lipase related protein 3 [KO:K14076] [EC:3.1.1.3]
3990  LIPC; lipase C, hepatic type [KO:K22283] [EC:3.1.1.3]
8513  LIPF; lipase F, gastric type [KO:K14452] [EC:3.1.1.3]
9388  LIPG; lipase G, endothelial type [KO:K22284] [EC:3.1.1.3]
4023  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
55750  AGK; acylglycerol kinase [KO:K09881] [EC:2.7.1.94]
11343  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
116255  MOGAT1; monoacylglycerol O-acyltransferase 1 [KO:K14458] [EC:2.3.1.22]
80168  MOGAT2; monoacylglycerol O-acyltransferase 2 [KO:K14457] [EC:2.3.1.22]
2717  GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
Compound
C00029  UDP-glucose
C00040  Acyl-CoA
C00093  sn-Glycerol 3-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00116  Glycerol
C00162  Fatty acid
C00184  Glycerone
C00197  3-Phospho-D-glycerate
C00258  D-Glycerate
C00416  Phosphatidate
C00422  Triacylglycerol
C00577  D-Glyceraldehyde
C00631  2-Phospho-D-glycerate
C00641  1,2-Diacyl-sn-glycerol
C00681  1-Acyl-sn-glycerol 3-phosphate
C00969  3-Hydroxypropanal
C01885  1-Acylglycerol
C02457  Propane-1,3-diol
C03692  1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
C04046  3-D-Glucosyl-1,2-diacylglycerol
C04315  2-Acyl-3-O-(beta-D-galactosyl)-sn-glycerol
C04872  1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
C05401  3-beta-D-Galactosyl-sn-glycerol
C06037  Digalactosyl-diacylglycerol
C06038  Acyl1-monogalactosyl-diacylglycerol
C06040  Diglucosyldiacylglycerol
C06041  Glycerophosphoglycoglycerolipid
C06042  Lipoteichoic acid
C06364  1,2-Diacyl-3-alpha-D-glucosyl-sn-glycerol
C06365  alpha-Kojibiosyldiacylglycerol
C11521  UDP-6-sulfoquinovose
C13508  Sulfoquinovosyldiacylglycerol
C20897  Glycerophosphoglycoglycerolipid
C20898  Lipoteichoic acid
C20991  1,2-Diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
Reference
PMID:8662716
  Authors
Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L.
  Title
Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway.
  Journal
J Biol Chem 271:13875-81 (1996)
DOI:10.1074/jbc.271.23.13875
Reference
PMID:8995384
  Authors
Karlsson OP, Dahlqvist A, Vikstrom S, Wieslander A.
  Title
Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii.
  Journal
J Biol Chem 272:929-36 (1997)
DOI:10.1074/jbc.272.2.929
Reference
  Authors
Berg S, Edman M, Li L, Wikstrom M, Wieslander A.
  Title
Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea.
  Journal
J Biol Chem 276:22056-63 (2001)
DOI:10.1074/jbc.M102576200
KO pathway
ko00561   

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