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KEGG   PATHWAY: hsa00562
Entry
hsa00562                    Pathway                                
Name
Inositol phosphate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsa00562  Inositol phosphate metabolism
hsa00562

Module
hsa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:hsa00562]
hsa_M00131  Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:hsa00562]
hsa_M00132  Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:hsa00562]
Drug
D11158  Leniolisib (USAN/INN)
D11159  Leniolisib phosphate (JAN/USAN)
D11319  Fimepinostat (USAN/INN)
D11322  Umbralisib (USAN/INN)
D11323  Umbralisib tosylate (USAN)
Other DBs
GO: 0006020
Organism
Homo sapiens (human) [GN:hsa]
Gene
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
4534  MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
8776  MTMR1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
8898  MTMR2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
8897  MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
9110  MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
55613  MTMR8; myotubularin related protein 8 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
9107  MTMR6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
9108  MTMR7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
64419  MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
5297  PI4KA; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
5298  PI4KB; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
55361  PI4K2A; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
55300  PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
22908  SACM1L; SAC1 like phosphatidylinositide phosphatase [KO:K21797] [EC:3.1.3.-]
22876  INPP5F; inositol polyphosphate-5-phosphatase F [KO:K21798] [EC:3.1.3.-]
23396  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
8394  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
138429  PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase like 1 [KO:K13712] [EC:2.7.1.68]
4952  OCRL; OCRL inositol polyphosphate-5-phosphatase [KO:K01099] [EC:3.1.3.36]
3633  INPP5B; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
56623  INPP5E; inositol polyphosphate-5-phosphatase E [KO:K20278] [EC:3.1.3.36]
8867  SYNJ1; synaptojanin 1 [KO:K20279] [EC:3.1.3.36]
8871  SYNJ2; synaptojanin 2 [KO:K20279] [EC:3.1.3.36]
23236  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
5333  PLCD1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
113026  PLCD3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
84812  PLCD4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
51196  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
5335  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
89869  PLCZ1; phospholipase C zeta 1 [KO:K05861] [EC:3.1.4.11]
23007  PLCH1; phospholipase C eta 1 [KO:K19006] [EC:3.1.4.11]
9651  PLCH2; phospholipase C eta 2 [KO:K19006] [EC:3.1.4.11]
3707  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
9562  MINPP1; multiple inositol-polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]
3632  INPP5A; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
51763  INPP5K; inositol polyphosphate-5-phosphatase K [KO:K24222] [EC:3.1.3.56]
27124  INPP5J; inositol polyphosphate-5-phosphatase J [KO:K24222] [EC:3.1.3.56]
3628  INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
3613  IMPA2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
3612  IMPA1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
3705  ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
253430  IPMK; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
64768  IPPK; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
3631  INPP4A; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
8821  INPP4B; inositol polyphosphate-4-phosphatase type II B [KO:K01109] [EC:3.1.3.66]
51477  ISYNA1; inositol-3-phosphate synthase 1 [KO:K01858] [EC:5.5.1.4]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
5728  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
3635  INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
3636  INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
5288  PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5286  PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287  PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
200576  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
9896  FIG4; FIG4 phosphoinositide 5-phosphatase [KO:K22913] [EC:3.1.3.-]
79837  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
5305  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
8396  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
10423  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
55586  MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
4329  ALDH6A1; aldehyde dehydrogenase 6 family member A1 [KO:K00140] [EC:1.2.1.18 1.2.1.27]
7167  TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]
Compound
C00024  Acetyl-CoA
C00092  D-Glucose 6-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00137  myo-Inositol
C00191  D-Glucuronate
C00222  3-Oxopropanoate
C00558  D-Tagaturonate
C00641  1,2-Diacyl-sn-glycerol
C00691  2,4,6/3,5-Pentahydroxycyclohexanone
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C03659  D-Bornesitol
C03660  L-Bornesitol
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04287  3D-3,5/4-Trihydroxycyclohexane-1,2-dione
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04520  1D-myo-Inositol 3,4,5,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04563  D-myo-Inositol 1,2,4,5,6-pentakisphosphate
C04579  Inositol 1,2,3,5,6-pentakisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06153  scyllo-Inositol
C06892  2-Deoxy-5-keto-D-gluconic acid
C06893  2-Deoxy-5-keto-D-gluconic acid 6-phosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C16737  5-Deoxy-D-glucuronate
C19794  CDP-1L-myo-inositol
C19799  Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate
C19891  1D-chiro-Inositol
C20251  1-Keto-D-chiro-inositol
C21643  3-Dehydro-scyllo-inosose
C21644  5-Dehydro-L-gluconate
Reference
PMID:14993306
  Authors
Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y
  Title
The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase.
  Journal
Microbiology 150:571-80 (2004)
DOI:10.1099/mic.0.26768-0
Reference
PMID:18310071
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y.
  Title
myo-Inositol catabolism in Bacillus subtilis.
  Journal
J Biol Chem 283:10415-24 (2008)
DOI:10.1074/jbc.M708043200
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00040  Pentose and glucuronate interconversions
hsa00564  Glycerophospholipid metabolism
KO pathway
ko00562   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (73)   
   KEGG GENES (73)   
All databases (74)   

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