KEGG   PATHWAY: hsa00564Help
Entry
hsa00564                    Pathway                                

Name
Glycerophospholipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
hsa00564  Glycerophospholipid metabolism
hsa00564

Ortholog table
Module
hsa_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:hsa00564]
hsa_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:hsa00564]
hsa_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:hsa00564]
Disease
H00158  Lecithin:cholesterol acyltransferase deficiency
H00207  Rhizomelic chondrodysplasia punctata
H00654  Barth syndrome
H00770  Congenital myasthenic syndrome
H01117  Chronic recurrent multifocal osteomyelitis
H01290  Acute recurrent myoglobinuria
H01821  Spondylometaphyseal dysplasia with cone-rod dystrophy
H01832  Lenz-Majewski syndrome
H01898  PNPLA6-related disorders
H02137  Laurence-Moon syndrome
H02140  Boucher-Neuhauser syndrome
Drug
D00469  Pralidoxime chloride (USP)
D00487  Pyridostigmine bromide (JP17/USP/INN)
D00670  Donepezil hydrochloride (JP17/USAN)
D00995  Neostigmine bromide (JAN/USP/INN)
D00998  Neostigmine methylsulfate (JP17/USP)
D01001  Ambenonium chloride (JP17/INN)
D01228  Distigmine bromide (JP17/INN)
D01572  Pralidoxime iodide (JAN/USAN)
D02068  Tacrine hydrochloride (USP)
D02173  Galantamine hydrobromide (JAN/USAN)
D02558  Rivastigmine tartrate
D02565  Dimetacrine (INN)
D03822  Rivastigmine (JAN/USAN/INN)
D04292  Galantamine (USAN/INN)
D05590  Pralidoxime mesylate (USAN)
D07869  Donepezil (INN)
D08261  Neostigmine (BAN)
D08555  Tacrine (INN)
D09750  Ipidacrine hydrochloride hydrate (JAN)
Other DBs
BSID: 82989
GO: 0006650 0046474 0046475
Organism
Homo sapiens (human) [GN:hsa]
Gene
23171  GPD1L; glycerol-3-phosphate dehydrogenase 1 like [KO:K00006] [EC:1.1.1.8]
2819  GPD1; glycerol-3-phosphate dehydrogenase 1 [KO:K00006] [EC:1.1.1.8]
2820  GPD2; glycerol-3-phosphate dehydrogenase 2 [KO:K00111] [EC:1.1.5.3]
57678  GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
150763  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
137964  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
84803  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
10554  AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
10555  AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
56894  AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
56895  AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
55326  AGPAT5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
253558  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.51 2.3.1.-]
154141  MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
129642  MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
8443  GNPAT; glyceronephosphate O-acyltransferase [KO:K00649] [EC:2.3.1.42]
56985  ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.53 3.6.1.16 3.6.1.13]
8611  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
8613  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
8612  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
23175  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64900  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
9663  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
84513  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.1.3.4 3.1.3.81]
196051  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.1.3.4 3.1.3.81]
8525  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
8527  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
9162  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
1606  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
8526  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
1607  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
160851  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
1608  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
1609  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
139189  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
56994  CHPT1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
10390  CEPT1; choline/ethanolamine phosphotransferase 1 [KO:K13644] [EC:2.7.8.2 2.7.8.1]
5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
23646  PLD3; phospholipase D family member 3 [KO:K16860] [EC:3.1.4.4]
122618  PLD4; phospholipase D family member 4 [KO:K16860] [EC:3.1.4.4]
3931  LCAT; lecithin-cholesterol acyltransferase [KO:K00650] [EC:2.3.1.43]
8399  PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
26279  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
30814  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
50487  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
64600  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
81579  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
84647  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
5319  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
5322  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
5320  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
391013  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
123745  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
5321  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
100137049  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
8605  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
283748  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
255189  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
8398  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
151056  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.5 3.1.1.4]
11145  PLA2G16; phospholipase A2 group XVI [KO:K16817] [EC:3.1.1.4 3.1.1.32]
54947  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.67 2.3.1.23]
79888  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.67 2.3.1.23]
254531  LPCAT4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.- 2.3.1.23]
10162  LPCAT3; lysophosphatidylcholine acyltransferase 3 [KO:K13515] [EC:2.3.1.- 2.3.1.23]
10434  LYPLA1; lysophospholipase I [KO:K06128] [EC:3.1.1.5]
23659  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
11313  LYPLA2; lysophospholipase II [KO:K06130] [EC:3.1.1.5]
10908  PNPLA6; patatin like phospholipase domain containing 6 [KO:K14676] [EC:3.1.1.5]
375775  PNPLA7; patatin like phospholipase domain containing 7 [KO:K14676] [EC:3.1.1.5]
56261  GPCPD1; glycerophosphocholine phosphodiesterase 1 [KO:K18695] [EC:3.1.4.2]
1103  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
43  ACHE; acetylcholinesterase (Cartwright blood group) [KO:K01049] [EC:3.1.1.7]
1119  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.82 2.7.1.32]
1120  CHKB; choline kinase beta [KO:K14156] [EC:2.7.1.82 2.7.1.32]
162466  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
9468  PCYT1B; phosphate cytidylyltransferase 1, choline, beta [KO:K00968] [EC:2.7.7.15]
5130  PCYT1A; phosphate cytidylyltransferase 1, choline, alpha [KO:K00968] [EC:2.7.7.15]
85465  SELENOI; selenoprotein I [KO:K00993] [EC:2.7.8.1]
55500  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
55224  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
5833  PCYT2; phosphate cytidylyltransferase 2, ethanolamine [KO:K00967] [EC:2.7.7.14]
64850  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
10400  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.71 2.1.1.17]
1040  CDS1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
8760  CDS2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
9791  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
81490  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
23761  PISD; phosphatidylserine decarboxylase [KO:K01613] [EC:4.1.1.65]
9489  PGS1; phosphatidylglycerophosphate synthase 1 [KO:K00995] [EC:2.7.8.5]
54675  CRLS1; cardiolipin synthase 1 [KO:K08744] [EC:2.7.8.41]
6901  TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
9926  LPGAT1; lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
10423  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
79143  MBOAT7; membrane bound O-acyltransferase domain containing 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
KO pathway
ko00564   

DBGET integrated database retrieval system