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KEGG   PATHWAY: hsa00603
Entry
hsa00603                    Pathway                                
Name
Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
hsa00603  Glycosphingolipid biosynthesis - globo and isoglobo series
hsa00603

Module
hsa_M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer [PATH:hsa00603]
Network
  Element
N01654  Forssman blood group antigen biosynthesis
N01679  Pk and P antigens biosynthesis
N01680  NOR antigen biosynthesis
N01682  Blood group A antigen type 4 (Globo-A) biosynthesis
N01690  Blood group H antigen type 4 (Globo-H) biosynthesis
N01697  P/PX2 negative, Pk positive
N01698  P1/Pk/P/NOR all negative (P null)
N01703  Blood group B antigen type 4 (Globo-B) biosynthesis
N01709  Hydrolysis of globoside
Other DBs
GO: 0001576 1990387
Organism
Homo sapiens (human) [GN:hsa]
Gene
127550  A3GALT2; alpha 1,3-galactosyltransferase 2 [KO:K20736] [EC:2.4.1.87]
8706  B3GALNT1; beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group) [KO:K00719] [EC:2.4.1.79]
26301  GBGT1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) [KO:K00722] [EC:2.4.1.88]
53947  A4GALT; alpha 1,4-galactosyltransferase (P1PK blood group) [KO:K01988] [EC:2.4.1.228]
2717  GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
10317  B3GALT5; beta-1,3-galactosyltransferase 5 [KO:K03877] [EC:2.4.1.-]
3073  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
3074  HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
4668  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
2523  FUT1; fucosyltransferase 1 (H blood group) [KO:K00718] [EC:2.4.1.69]
2524  FUT2; fucosyltransferase 2 (H blood group) [KO:K00718] [EC:2.4.1.69]
28  ABO; ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase [KO:K00709] [EC:2.4.1.40 2.4.1.37]
6482  ST3GAL1; ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.3.2 2.4.3.4]
6483  ST3GAL2; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.3.2 2.4.3.4]
6489  ST8SIA1; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [KO:K03371] [EC:2.4.3.8]
10690  FUT9; fucosyltransferase 9 [KO:K03663] [EC:2.4.1.152]
Compound
G00092  Lactosylceramide
G00093  Globotriaosylceramide
G00094  Globoside
G00095  Forssman antigen
G00096  IV3GalNAcb-Gb4Cer
G00097  Galactosylgloboside
G00098  Monosialylgalactosylgloboside
G00099  Globo-H
G00100  V3(NeuAc)2-Gb5Cer
G00101   
G00102   
G00103   
G00104   
G00105  GalGb3Cer
G00106   
G00107   
G00181  Disialosylglobopentaosylceramide
G00392  iGb4-Cer
G00403  iGb3-Cer
G00474  Globo-A
G02977   
G11492  IV4-alpha-Gal-Gb4Cer
G13080  NORint
G13081  NOR2 antigen
G13341  Globo-B
Reference
PMID:12716912
  Authors
Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T.
  Title
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  Journal
J Biol Chem 278:26474-9 (2003)
DOI:10.1074/jbc.M213223200
Reference
PMID:10837462
  Authors
Zhou D, Henion TR, Jungalwala FB, Berger EG, Hennet T.
  Title
The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase.
  Journal
J Biol Chem 275:22631-4 (2000)
DOI:10.1074/jbc.C000263200
Reference
PMID:10748143
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
DOI:10.1074/jbc.M909620199
Reference
PMID:10854428
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU.
  Title
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipidsynthesis, predicts a family of alpha 1, 4-glycosyltransferases conservedin plants, insects, and mammals.
  Journal
J Biol Chem 275:25315-21 (2000)
DOI:10.1074/jbc.M002630200
Reference
PMID:10854427
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU
  Title
Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.
  Journal
J Biol Chem 275:25308-14 (2000)
DOI:10.1074/jbc.M002629200
Related
pathway
hsa00600  Sphingolipid metabolism
KO pathway
ko00603   

  All links  
Network (9)   
   KEGG NETWORK (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG GENES (16)   
All databases (26)   

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