KEGG   PATHWAY: hsa00620
Entry
hsa00620                    Pathway                                

Name
Pyruvate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsa00620  Pyruvate metabolism
hsa00620

Module
hsa_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00620]
Disease
H00072  Pyruvate dehydrogenase complex deficiency
H00073  Pyruvate carboxylase deficiency
H01096  Pyruvate kinase deficiency
H01946  Glycogen storage disease type XI
H01997  Pyruvate dehydrogenase E1-alpha deficiency
H01998  Pyruvate dehydrogenase E1-beta deficiency
H01999  Pyruvate dehydrogenase E2 deficiency
H02000  Dihydrolipoamide dehydrogenase deficiency
Drug
D00123  Cyanamide (JP17)
D00131  Disulfiram (JP17/USP/INN)
D11408  Mitapivat sulfate (USAN)
Other DBs
GO: 0006090
Organism
Homo sapiens (human) [GN:hsa]
Gene
84532  ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902  ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]
5161  PDHA2; pyruvate dehydrogenase E1 subunit alpha 2 [KO:K00161] [EC:1.2.4.1]
5160  PDHA1; pyruvate dehydrogenase E1 subunit alpha 1 [KO:K00161] [EC:1.2.4.1]
5162  PDHB; pyruvate dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]
1737  DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
5315  PKM; pyruvate kinase M1/2 [KO:K00873] [EC:2.7.1.40]
5313  PKLR; pyruvate kinase L/R [KO:K12406] [EC:2.7.1.40]
31  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
32  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
98  ACYP2; acylphosphatase 2 [KO:K01512] [EC:3.6.1.7]
97  ACYP1; acylphosphatase 1 [KO:K01512] [EC:3.6.1.7]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
134526  ACOT12; acyl-CoA thioesterase 12 [KO:K01067] [EC:3.1.2.1]
160287  LDHAL6A; lactate dehydrogenase A like 6A [KO:K00016] [EC:1.1.1.27]
92483  LDHAL6B; lactate dehydrogenase A like 6B [KO:K00016] [EC:1.1.1.27]
3939  LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
3945  LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
3948  LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
197257  LDHD; lactate dehydrogenase D [KO:K00102] [EC:1.1.2.4]
2739  GLO1; glyoxalase I [KO:K01759] [EC:4.4.1.5]
3029  HAGH; hydroxyacylglutathione hydrolase [KO:K01069] [EC:3.1.2.6]
9380  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
4200  ME2; malic enzyme 2 [KO:K00027] [EC:1.1.1.38]
10873  ME3; malic enzyme 3 [KO:K00029] [EC:1.1.1.40]
4199  ME1; malic enzyme 1 [KO:K00029] [EC:1.1.1.40]
5091  PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
4190  MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
4191  MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
2271  FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
5105  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
5106  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00033  Acetate
C00036  Oxaloacetate
C00042  Succinate
C00058  Formate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00122  Fumarate
C00149  (S)-Malate
C00186  (S)-Lactate
C00227  Acetyl phosphate
C00256  (R)-Lactate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00546  Methylglyoxal
C00937  (R)-Lactaldehyde
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488  (R)-2-Ethylmalate
C02504  alpha-Isopropylmalate
C03248  Acetylenedicarboxylate
C03451  (R)-S-Lactoylglutathione
C03981  2-Hydroxyethylenedicarboxylate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993  Acetyl adenylate
C05994  2-Propylmalate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00061  Fatty acid biosynthesis
hsa00072  Synthesis and degradation of ketone bodies
hsa00260  Glycine, serine and threonine metabolism
hsa00290  Valine, leucine and isoleucine biosynthesis
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00640  Propanoate metabolism
hsa00650  Butanoate metabolism
hsa00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00620   

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