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KEGG   PATHWAY: hsa00670
Entry
hsa00670                    Pathway                                
Name
One carbon pool by folate - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00670  One carbon pool by folate
hsa00670

Module
hsa_M00141  C1-unit interconversion, eukaryotes [PATH:hsa00670]
Network
  Element
N01629  Remethylation, THF to 5-MTHF
N01630  Remethylation, Hcy to Met
N01725  Tetrahydrofolate biosynthesis
N01726  Folate cycle
N01728  Histidine degradation 2
Drug
D00142  Methotrexate (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01064  Raltitrexed (JAN/USAN/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D02115  Methotrexate sodium
D03828  Pemetrexed disodium (USAN)
D03942  Edatrexate (USAN/INN)
D04197  Floxuridine (USP/INN)
D04766  Lometrexol sodium (USAN)
D04964  Metesind glucuronate (USAN)
D05500  Piritrexim isethionate (USAN)
D05589  Pralatrexate (JAN/USAN/INN)
D05999  Talotrexin ammonium (USAN)
D06238  Trimetrexate (USAN/INN)
D06239  Trimetrexate glucuronate (USAN)
D06503  Pemetrexed sodium hydrate (JAN)
D07472  Pemetrexed (INN)
D07974  Fluorouracil sodium salt
D10596  Pemetrexed sodium hemipentahydrate (JAN)
D10803  Plevitrexed (INN)
D11352  Pemetrexed tromethamine (USAN)
D11447  Arfolitixorin (USAN/INN)
D12388  Fosifloxuridine nafalbenamide
D12528  Arfolitixorin sulfate (JAN)
Other DBs
GO: 0035999
Organism
Homo sapiens (human) [GN:hsa]
Gene
1719  DHFR; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
200895  DHFR2; dihydrofolate reductase 2 [KO:K00287] [EC:1.5.1.3]
25902  MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [KO:K13402] [EC:6.3.4.3]
4522  MTHFD1; methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [KO:K00288] [EC:1.5.1.5 3.5.4.9 6.3.4.3]
10797  MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [KO:K13403] [EC:1.5.1.15 3.5.4.9]
441024  MTHFD2L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like [KO:K13403] [EC:1.5.1.15 3.5.4.9]
6472  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
6470  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
2618  GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
471  ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
10841  FTCD; formimidoyltransferase cyclodeaminase [KO:K13990] [EC:2.1.2.5 4.3.1.4]
123263  MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
275  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
4548  MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
7298  TYMS; thymidylate synthetase [KO:K00560] [EC:2.1.1.45]
10840  ALDH1L1; aldehyde dehydrogenase 1 family member L1 [KO:K00289] [EC:1.5.1.6]
160428  ALDH1L2; aldehyde dehydrogenase 1 family member L2 [KO:K00289] [EC:1.5.1.6]
4524  MTHFR; methylenetetrahydrofolate reductase [KO:K25004] [EC:1.5.1.53]
10588  MTHFS; methenyltetrahydrofolate synthetase [KO:K01934] [EC:6.3.3.2]
100528021  ST20-MTHFS; ST20-MTHFS readthrough [KO:K01934] [EC:6.3.3.2]
Compound
C00101  Tetrahydrofolate
C00143  5,10-Methylenetetrahydrofolate
C00234  10-Formyltetrahydrofolate
C00415  Dihydrofolate
C00440  5-Methyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00504  Folate
C00664  5-Formiminotetrahydrofolate
C03479  Folinic acid
Related
pathway
hsa00790  Folate biosynthesis
KO pathway
ko00670   

  All links  
Network (5)   
   KEGG NETWORK (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (26)   

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