KEGG   PATHWAY: hsa00750
Entry
hsa00750                    Pathway                                
Name
Vitamin B6 metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00750  Vitamin B6 metabolism
hsa00750

Other DBs
GO: 0042816
Organism
Homo sapiens (human) [GN:hsa]
Gene
55163  PNPO; pyridoxamine 5'-phosphate oxidase [KO:K00275] [EC:1.4.3.5]
8566  PDXK; pyridoxal kinase [KO:K00868] [EC:2.7.1.35]
57026  PDXP; pyridoxal phosphatase [KO:K07758] [EC:3.1.3.74]
493911  PHOSPHO2; phosphatase, orphan 2 [KO:K13248] [EC:3.1.3.74]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
29968  PSAT1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
Compound
C00018  Pyridoxal phosphate
C00064  L-Glutamine
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00232  Succinate semialdehyde
C00250  Pyridoxal
C00266  Glycolaldehyde
C00279  D-Erythrose 4-phosphate
C00314  Pyridoxine
C00534  Pyridoxamine
C00627  Pyridoxine phosphate
C00647  Pyridoxamine phosphate
C00847  4-Pyridoxate
C00971  4-Pyridoxolactone
C01215  2-(Acetamidomethylene)succinate
C01270  3-Hydroxy-2-methylpyridine-5-carboxylate
C03393  4-Phospho-D-erythronate
C04106  2-(Hydroxymethyl)-4-oxobutanoate
C04604  3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
C04690  2-(Hydroxymethyl)-3-(acetamidomethylene)succinate
C04773  3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate
C06050  2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
C06051  Isopyridoxal
C06052  5-Pyridoxolactone
C06054  2-Oxo-3-hydroxy-4-phosphobutanoate
C06055  O-Phospho-4-hydroxy-L-threonine
C06056  4-Hydroxy-L-threonine
C07335  2-Amino-3-oxo-4-phosphonooxybutyrate
C11638  3-Amino-2-oxopropyl phosphate
Reference
PMID:10753941
  Authors
Tazoe M, Ichikawa K, Hoshino T.
  Title
Biosynthesis of vitamin B(6) in rhizobium.
  Journal
J Biol Chem 275:11300-5 (2000)
DOI:10.1074/jbc.275.15.11300
Reference
PMID:9696782
  Authors
Yang Y, Zhao G, Man TK, Winkler ME.
  Title
Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.
  Journal
J Bacteriol 180:4294-9 (1998)
DOI:10.1128/JB.180.16.4294-4299.1998
Reference
PMID:12269807
  Authors
Yeh JI, Du S, Pohl E, Cane DE.
  Title
Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.
  Journal
Biochemistry 41:11649-57 (2002)
DOI:10.1021/bi026292t
Reference
PMID:10225425
  Authors
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.
  Title
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
  Journal
FEBS Lett 449:45-8 (1999)
DOI:10.1016/S0014-5793(99)00393-2
Reference
PMID:16157873
  Authors
Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB.
  Title
Vitamin B6 biosynthesis in higher plants.
  Journal
Proc Natl Acad Sci U S A 102:13687-92 (2005)
DOI:10.1073/pnas.0506228102
Reference
PMID:22276911
  Authors
Nagase T, Mugo AN, Chu HN, Yoshikane Y, Ohnishi K, Yagi T
  Title
The mll6786 gene encodes a repressor protein controlling the degradation pathway for vitamin B6 in Mesorhizobium loti.
  Journal
FEMS Microbiol Lett 329:116-22 (2012)
DOI:10.1111/j.1574-6968.2012.02510.x
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00030  Pentose phosphate pathway
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00650  Butanoate metabolism
hsa00730  Thiamine metabolism
KO pathway
ko00750   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG GENES (6)   
All databases (7)   

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