KEGG   PATHWAY: hsa00760
Entry
hsa00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00760  Nicotinate and nicotinamide metabolism
hsa00760

Module
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:hsa00760]
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
N01724  NAD+ phosphorylation
Drug
D04245  Forodesine hydrochloride (JAN/USAN)
D05396  Peldesine (USAN)
D06596  Forodesine (USAN/INN)
D09678  Teglarinad chloride (USAN/INN)
D10431  Ulodesine (USAN/INN)
D10432  Ulodesine succinate (USAN)
D12373  Quemliclustat (USAN/INN)
D12401  Uliledlimab (USAN/INN)
D13109  Forvisirvat (USAN)
D13146  Mavrostobart (USAN/INN)
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Homo sapiens (human) [GN:hsa]
Gene
100526794  NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]
10135  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
133686  NADK2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]
22933  SIRT2; sirtuin 2 [KO:K11412] [EC:2.3.1.286]
22978  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
23057  NMNAT2; nicotinamide nucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
23098  SARM1; sterile alpha and TIR motif containing 1 [KO:K27536]
23408  SIRT5; sirtuin 5 [KO:K11415] [EC:2.3.1.286]
23409  SIRT4; sirtuin 4 [KO:K11414] [EC:2.3.1.286 2.3.1.313]
23410  SIRT3; sirtuin 3 [KO:K11413] [EC:2.3.1.286]
23411  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
23475  QPRT; quinolinate phosphoribosyltransferase [KO:K00767] [EC:2.4.2.19]
23530  NNT; nicotinamide nucleotide transhydrogenase [KO:K00323] [EC:7.1.1.1]
25961  NUDT13; nudix hydrolase 13 [KO:K03426] [EC:3.6.1.22]
27231  NMRK2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
284958  NT5DC4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
30833  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
349565  NMNAT3; nicotinamide nucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
4837  NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
4860  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
4907  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
51547  SIRT7; sirtuin 7 [KO:K11417] [EC:2.3.1.286]
51548  SIRT6; sirtuin 6 [KO:K11416] [EC:2.3.1.286]
5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
54981  NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
55191  NADSYN1; NAD synthetase 1 [KO:K01950] [EC:6.3.5.1]
554235  ASPDH; aspartate dehydrogenase domain containing [KO:K06989] [EC:1.4.1.21]
56953  NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
64802  NMNAT1; nicotinamide nucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
65220  NADK; NAD kinase [KO:K00858] [EC:2.7.1.23]
683  BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
83594  NUDT12; nudix hydrolase 12 [KO:K03426] [EC:3.6.1.22]
84618  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
93034  NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
93100  NAPRT; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
952  CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00380  Tryptophan metabolism
hsa00620  Pyruvate metabolism
KO pathway
ko00760   

  All links  
No link information was found.
KEGG   PATHWAY: hsa00760
Entry
hsa00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00760  Nicotinate and nicotinamide metabolism
hsa00760

Module
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:hsa00760]
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
N01724  NAD+ phosphorylation
Drug
D04245  Forodesine hydrochloride (JAN/USAN)
D05396  Peldesine (USAN)
D06596  Forodesine (USAN/INN)
D09678  Teglarinad chloride (USAN/INN)
D10431  Ulodesine (USAN/INN)
D10432  Ulodesine succinate (USAN)
D12373  Quemliclustat (USAN/INN)
D12401  Uliledlimab (USAN/INN)
D13109  Forvisirvat (USAN)
D13146  Mavrostobart (USAN/INN)
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Homo sapiens (human) [GN:hsa]
Gene
100526794  NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]
10135  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
133686  NADK2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]
22933  SIRT2; sirtuin 2 [KO:K11412] [EC:2.3.1.286]
22978  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
23057  NMNAT2; nicotinamide nucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
23098  SARM1; sterile alpha and TIR motif containing 1 [KO:K27536]
23408  SIRT5; sirtuin 5 [KO:K11415] [EC:2.3.1.286]
23409  SIRT4; sirtuin 4 [KO:K11414] [EC:2.3.1.286 2.3.1.313]
23410  SIRT3; sirtuin 3 [KO:K11413] [EC:2.3.1.286]
23411  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
23475  QPRT; quinolinate phosphoribosyltransferase [KO:K00767] [EC:2.4.2.19]
23530  NNT; nicotinamide nucleotide transhydrogenase [KO:K00323] [EC:7.1.1.1]
25961  NUDT13; nudix hydrolase 13 [KO:K03426] [EC:3.6.1.22]
27231  NMRK2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
284958  NT5DC4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
30833  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
349565  NMNAT3; nicotinamide nucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
4837  NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
4860  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
4907  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
51547  SIRT7; sirtuin 7 [KO:K11417] [EC:2.3.1.286]
51548  SIRT6; sirtuin 6 [KO:K11416] [EC:2.3.1.286]
5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
54981  NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
55191  NADSYN1; NAD synthetase 1 [KO:K01950] [EC:6.3.5.1]
554235  ASPDH; aspartate dehydrogenase domain containing [KO:K06989] [EC:1.4.1.21]
56953  NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
64802  NMNAT1; nicotinamide nucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
65220  NADK; NAD kinase [KO:K00858] [EC:2.7.1.23]
683  BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
83594  NUDT12; nudix hydrolase 12 [KO:K03426] [EC:3.6.1.22]
84618  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
93034  NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
93100  NAPRT; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
952  CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00380  Tryptophan metabolism
hsa00620  Pyruvate metabolism
KO pathway
ko00760   

  All links  
No link information was found.
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