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KEGG   PATHWAY: hsa00970
Entry
hsa00970                    Pathway                                
Name
Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
Class
Genetic Information Processing; Translation
Pathway map
hsa00970  Aminoacyl-tRNA biosynthesis
hsa00970

Drug
D12612  Efzofitimod (INN)
D12794  Bersiporocin (USAN/INN)
D12795  Bersiporocin hydrochloride (USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
4553  TRNA; tRNA-Ala [KO:K14218]
4573  TRNR; tRNA-Arg [KO:K14219]
4570  TRNN; tRNA-Asn [KO:K14220]
4555  TRND; tRNA-Asp [KO:K14221]
4511  TRNC; tRNA-Cys [KO:K14222]
4572  TRNQ; tRNA-Gln [KO:K14223]
4556  TRNE; tRNA-Glu [KO:K14224]
4563  TRNG; tRNA-Gly [KO:K14225]
4564  TRNH; tRNA-His [KO:K14226]
4565  TRNI; tRNA-Ile [KO:K14227]
4568  TRNL2; tRNA-Leu [KO:K14228]
4567  TRNL1; tRNA-Leu [KO:K14228]
4566  TRNK; tRNA-Lys [KO:K14229]
4569  TRNM; tRNA-Met [KO:K14230]
4558  TRNF; tRNA-Phe [KO:K14231]
4571  TRNP; tRNA-Pro [KO:K14232]
4575  TRNS2; tRNA-Ser [KO:K14233]
4574  TRNS1; tRNA-Ser [KO:K14233]
4576  TRNT; tRNA-Thr [KO:K14234]
4578  TRNW; tRNA-Trp [KO:K14235]
4579  TRNY; tRNA-Tyr [KO:K14236]
4577  TRNV; tRNA-Val [KO:K14237]
124454  EARS2; glutamyl-tRNA synthetase 2, mitochondrial [KO:K01885] [EC:6.1.1.17]
2058  EPRS1; glutamyl-prolyl-tRNA synthetase 1 [KO:K14163] [EC:6.1.1.17 6.1.1.15]
55278  QRSL1; glutaminyl-tRNA amidotransferase subunit QRSL1 [KO:K02433] [EC:6.3.5.6 6.3.5.7]
5188  GATB; glutamyl-tRNA amidotransferase subunit B [KO:K02434] [EC:6.3.5.6 6.3.5.7]
283459  GATC; glutamyl-tRNA amidotransferase subunit C [KO:K02435] [EC:6.3.5.6 6.3.5.7]
5859  QARS1; glutaminyl-tRNA synthetase 1 [KO:K01886] [EC:6.1.1.18]
57505  AARS2; alanyl-tRNA synthetase 2, mitochondrial [KO:K01872] [EC:6.1.1.7]
16  AARS1; alanyl-tRNA synthetase 1 [KO:K01872] [EC:6.1.1.7]
1615  DARS1; aspartyl-tRNA synthetase 1 [KO:K22503] [EC:6.1.1.12]
55157  DARS2; aspartyl-tRNA synthetase 2, mitochondrial [KO:K01876] [EC:6.1.1.12]
79731  NARS2; asparaginyl-tRNA synthetase 2, mitochondrial [KO:K01893] [EC:6.1.1.22]
4677  NARS1; asparaginyl-tRNA synthetase 1 [KO:K01893] [EC:6.1.1.22]
2617  GARS1; glycyl-tRNA synthetase 1 [KO:K01880] [EC:6.1.1.14]
80222  TARS2; threonyl-tRNA synthetase 2, mitochondrial [KO:K01868] [EC:6.1.1.3]
6897  TARS1; threonyl-tRNA synthetase 1 [KO:K01868] [EC:6.1.1.3]
123283  TARS3; threonyl-tRNA synthetase 3 [KO:K01868] [EC:6.1.1.3]
54938  SARS2; seryl-tRNA synthetase 2, mitochondrial [KO:K01875] [EC:6.1.1.11]
6301  SARS1; seryl-tRNA synthetase 1 [KO:K01875] [EC:6.1.1.11]
118672  PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
51091  SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
833  CARS1; cysteinyl-tRNA synthetase 1 [KO:K01883] [EC:6.1.1.16]
79587  CARS2; cysteinyl-tRNA synthetase 2, mitochondrial [KO:K01883] [EC:6.1.1.16]
4141  MARS1; methionyl-tRNA synthetase 1 [KO:K01874] [EC:6.1.1.10]
92935  MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
123263  MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
57176  VARS2; valyl-tRNA synthetase 2, mitochondrial [KO:K01873] [EC:6.1.1.9]
7407  VARS1; valyl-tRNA synthetase 1 [KO:K01873] [EC:6.1.1.9]
51520  LARS1; leucyl-tRNA synthetase 1 [KO:K01869] [EC:6.1.1.4]
23395  LARS2; leucyl-tRNA synthetase 2, mitochondrial [KO:K01869] [EC:6.1.1.4]
3376  IARS1; isoleucyl-tRNA synthetase 1 [KO:K01870] [EC:6.1.1.5]
55699  IARS2; isoleucyl-tRNA synthetase 2, mitochondrial [KO:K01870] [EC:6.1.1.5]
3735  KARS1; lysyl-tRNA synthetase 1 [KO:K04567] [EC:6.1.1.6]
57038  RARS2; arginyl-tRNA synthetase 2, mitochondrial [KO:K01887] [EC:6.1.1.19]
5917  RARS1; arginyl-tRNA synthetase 1 [KO:K01887] [EC:6.1.1.19]
25973  PARS2; prolyl-tRNA synthetase 2, mitochondrial [KO:K01881] [EC:6.1.1.15]
3035  HARS1; histidyl-tRNA synthetase 1 [KO:K01892] [EC:6.1.1.21]
23438  HARS2; histidyl-tRNA synthetase 2, mitochondrial [KO:K01892] [EC:6.1.1.21]
2193  FARSA; phenylalanyl-tRNA synthetase subunit alpha [KO:K01889] [EC:6.1.1.20]
10667  FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial [KO:K01889] [EC:6.1.1.20]
10056  FARSB; phenylalanyl-tRNA synthetase subunit beta [KO:K01890] [EC:6.1.1.20]
8565  YARS1; tyrosyl-tRNA synthetase 1 [KO:K01866] [EC:6.1.1.1]
51067  YARS2; tyrosyl-tRNA synthetase 2 [KO:K01866] [EC:6.1.1.1]
10352  WARS2; tryptophanyl tRNA synthetase 2, mitochondrial [KO:K01867] [EC:6.1.1.2]
7453  WARS1; tryptophanyl-tRNA synthetase 1 [KO:K01867] [EC:6.1.1.2]
Compound
C00025  L-Glutamate
C00037  Glycine
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00073  L-Methionine
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00123  L-Leucine
C00135  L-Histidine
C00148  L-Proline
C00152  L-Asparagine
C00183  L-Valine
C00188  L-Threonine
C00234  10-Formyltetrahydrofolate
C00407  L-Isoleucine
C00886  L-Alanyl-tRNA
C01005  O-Phospho-L-serine
C01931  L-Lysyl-tRNA
C02047  L-Leucyl-tRNA
C02163  L-Arginyl-tRNA(Arg)
C02282  Glutaminyl-tRNA
C02412  Glycyl-tRNA(Gly)
C02430  L-Methionyl-tRNA
C02553  L-Seryl-tRNA(Ser)
C02554  L-Valyl-tRNA(Val)
C02702  L-Prolyl-tRNA(Pro)
C02839  L-Tyrosyl-tRNA(Tyr)
C02984  L-Aspartyl-tRNA(Asp)
C02987  L-Glutamyl-tRNA(Glu)
C02988  L-Histidyl-tRNA(His)
C02992  L-Threonyl-tRNA(Thr)
C03125  L-Cysteinyl-tRNA(Cys)
C03127  L-Isoleucyl-tRNA(Ile)
C03294  N-Formylmethionyl-tRNA
C03402  L-Asparaginyl-tRNA(Asn)
C03511  L-Phenylalanyl-tRNA(Phe)
C03512  L-Tryptophanyl-tRNA(Trp)
C06112  L-Glutamyl-tRNA(Gln)
C06113  L-Aspartyl-tRNA(Asn)
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16138  L-Pyrrolysine
C16638  O-Phosphoseryl-tRNA(Sec)
C17022  O-Phosphoseryl-tRNA(Cys)
C17027  L-Pyrrolysyl-tRNA(Pyl)
Reference
PMID:18252769
  Authors
Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Soll D
  Title
From one amino acid to another: tRNA-dependent amino acid biosynthesis.
  Journal
Nucleic Acids Res 36:1813-25 (2008)
DOI:10.1093/nar/gkn015
Reference
PMID:15314242
  Authors
Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D
  Title
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
  Journal
Proc Natl Acad Sci U S A 101:12450-4 (2004)
DOI:10.1073/pnas.0405362101
Related
pathway
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa00290  Valine, leucine and isoleucine biosynthesis
hsa00330  Arginine and proline metabolism
hsa00340  Histidine metabolism
hsa00380  Tryptophan metabolism
hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
ko00970   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (66)   
   KEGG GENES (66)   
All databases (67)   

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