KEGG   PATHWAY: hsa03440Help
Entry
hsa03440                    Pathway                                

Name
Homologous recombination - Homo sapiens (human)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
hsa03440  Homologous recombination
hsa03440

Ortholog table
Module
hsa_M00288  RPA complex [PATH:hsa03440]
hsa_M00291  MRN complex [PATH:hsa03440]
hsa_M00295  BRCA1-associated genome surveillance complex (BASC) [PATH:hsa03440]
Disease
H00064  Ataxia telangiectasia
H00094  Immunodeficiency associated with DNA repair defects
H00296  Defects in RecQ helicases
H01287  Congenital mirror movements
H01344  Nijmegen syndrome
H01346  Bloom syndrome
H02014  Ataxia-telangiectasia-like syndrome
Other DBs
BSID: 83046
GO: 0000724
Organism
Homo sapiens (human) [GN:hsa]
Gene
6742  SSBP1; single stranded DNA binding protein 1 [KO:K03111]
10111  RAD50; RAD50 double strand break repair protein [KO:K10866] [EC:3.6.-.-]
4361  MRE11; MRE11 homolog, double strand break repair nuclease [KO:K10865]
4683  NBN; nibrin [KO:K10867]
472  ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
672  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
580  BARD1; BRCA1 associated RING domain 1 [KO:K10683]
5932  RBBP8; RB binding protein 8, endonuclease [KO:K20773] [EC:3.1.-.-]
83990  BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
11073  TOPBP1; DNA topoisomerase II binding protein 1 [KO:K10728]
84142  ABRAXAS1; abraxas 1, BRCA1 A complex subunit [KO:K20774]
51720  UIMC1; ubiquitin interaction motif containing 1 [KO:K20775]
29086  BABAM1; BRISC and BRCA1 A complex member 1 [KO:K20776]
9577  BABAM2; BRISC and BRCA1 A complex member 2 [KO:K12173]
79184  BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO:K11864] [EC:3.4.19.-]
79728  PALB2; partner and localizer of BRCA2 [KO:K10897]
675  BRCA2; BRCA2, DNA repair associated [KO:K08775]
7979  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
50511  SYCP3; synaptonemal complex protein 3 [KO:K19528]
6117  RPA1; replication protein A1 [KO:K07466]
6118  RPA2; replication protein A2 [KO:K10739]
6119  RPA3; replication protein A3 [KO:K10740]
29935  RPA4; replication protein A4 [KO:K10741]
5888  RAD51; RAD51 recombinase [KO:K04482]
5893  RAD52; RAD52 homolog, DNA repair protein [KO:K10873]
5890  RAD51B; RAD51 paralog B [KO:K10869]
5889  RAD51C; RAD51 paralog C [KO:K10870]
5892  RAD51D; RAD51 paralog D [KO:K10871]
7516  XRCC2; X-ray repair cross complementing 2 [KO:K10879]
7517  XRCC3; X-ray repair cross complementing 3 [KO:K10880]
8438  RAD54L; RAD54 like [KO:K10875] [EC:3.6.4.-]
25788  RAD54B; RAD54 homolog B [KO:K10877] [EC:3.6.4.-]
5424  POLD1; DNA polymerase delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
5425  POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
10714  POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
57804  POLD4; DNA polymerase delta 4, accessory subunit [KO:K03505]
641  BLM; Bloom syndrome RecQ like helicase [KO:K10901] [EC:3.6.4.12]
7156  TOP3A; DNA topoisomerase III alpha [KO:K03165] [EC:5.99.1.2]
8940  TOP3B; DNA topoisomerase III beta [KO:K03165] [EC:5.99.1.2]
80198  MUS81; MUS81 structure-specific endonuclease subunit [KO:K08991] [EC:3.1.22.-]
146956  EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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