Entry |
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Name |
VEGF signaling pathway - Homo sapiens (human)
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Description |
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
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Class |
Environmental Information Processing; Signal transduction
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Pathway map |

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Drug |
D05029 | Midostaurin (JAN/USAN/INN) |
D05386 | Pegaptanib sodium (JAN/USAN) |
D06272 | Sorafenib tosylate (USAN) |
D06402 | Sunitinib malate (JAN/USAN) |
D06407 | Vandetanib (JAN/USAN/INN) |
D08544 | Toceranib phosphate (USAN) |
D08874 | Bevasiranib sodium (USAN) |
D08878 | Brivanib alaninate (JAN/USAN/INN) |
D08883 | Cediranib maleate (JAN/USAN) |
D08947 | Motesanib diphosphate (USAN) |
D09603 | Dilmapimod tosylate (USAN) |
D09665 | Saracatinib difumarate (USAN) |
D09920 | Lenvatinib mesylate (USAN) |
D09945 | Pegdinetanib (USAN/INN) |
D10095 | Cabozantinib s-malate (USAN) |
D10137 | Regorafenib hydrate (JAN) |
D10190 | Tivozanib hydrochloride (USAN) |
D10396 | Nintedanib esylate (USAN) |
D10465 | Golvatinib tartrate (USAN) |
D10486 | Pimasertib hydrochloride (USAN) |
D11083 | Brolucizumab (USAN/INN) |
D11126 | Navicixizumab (USAN/INN) |
D11289 | Rivoceranib mesylate (USAN) |
D11517 | Abicipar pegol (USAN/INN) |
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Other DBs |
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Organism |
Homo sapiens (human) [GN: hsa]
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Gene |
7422 | VEGFA; vascular endothelial growth factor A [KO:K05448] |
3265 | HRAS; HRas proto-oncogene, GTPase [KO:K02833] |
3845 | KRAS; KRAS proto-oncogene, GTPase [KO:K07827] |
4893 | NRAS; NRAS proto-oncogene, GTPase [KO:K07828] |
5534 | PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268] |
5535 | PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268] |
4773 | NFATC2; nuclear factor of activated T cells 2 [KO:K17332] |
998 | CDC42; cell division cycle 42 [KO:K04393] |
3315 | HSPB1; heat shock protein family B (small) member 1 [KO:K04455] |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] |
5295 | PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] |
5296 | PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] |
8503 | PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] |
572 | BAD; BCL2 associated agonist of cell death [KO:K02158] |
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Compound |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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Reference |
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Authors |
Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. |
Title |
VEGF-receptor signal transduction. |
Journal |
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Reference |
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Authors |
Matsumoto T, Claesson-Welsh L. |
Title |
VEGF receptor signal transduction. |
Journal |
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Reference |
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Authors |
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. |
Title |
Vascular endothelial growth factor and angiogenesis. |
Journal |
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Reference |
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Authors |
Takahashi H, Shibuya M. |
Title |
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. |
Journal |
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Reference |
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Authors |
Zachary I. |
Title |
VEGF signalling: integration and multi-tasking in endothelial cell biology. |
Journal |
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Reference |
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Authors |
Munoz-Chapuli R, Quesada AR, Angel Medina M. |
Title |
Angiogenesis and signal transduction in endothelial cells. |
Journal |
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Reference |
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Authors |
Lamalice L, Houle F, Jourdan G, Huot J. |
Title |
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. |
Journal |
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Reference |
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Authors |
Shu X, Wu W, Mosteller RD, Broek D. |
Title |
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. |
Journal |
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Related pathway |
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KO pathway |
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