KEGG   PATHWAY: hsa04512Help
Entry
hsa04512                    Pathway                                

Name
ECM-receptor interaction - Homo sapiens (human)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
hsa04512  ECM-receptor interaction
hsa04512

Ortholog table
Disease
H00219  Hemophilia
H00224  Bernard-Soulier syndrome
H00226  Glanzmann thrombasthenia
H00520  Type II collagenopathies
H00576  Pierson syndrome
H00579  Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
H00581  Alport syndrome
H00582  Benign familial hematuria
H00586  Epidermolysis bullosa, junctional
H00770  Congenital myasthenic syndrome
H00802  Ehlers-Danlos syndrome
H00805  Vitreoretinal degeneration
H00813  Laryngo onycho cutaneous syndrome
H00839  Porencephaly
H00877  Brain small vessel disease with hemorrhage
H01260  Glomerulopathy with fibronectin deposits
H01338  Myosclerosis
H01340  Bethlem myopathy
H01341  Collagen VI myopathy
H01526  Legg-Calve-Perthes Disease
H01777  Schwartz-Jampel syndrome
H01778  Ullrich disease
H01958  Merosin-deficient congenital muscular dystrophy
H02066  Achondrogenesis type II
H02070  Kniest dysplasia
H02071  Czech dysplasia
H02072  Stickler syndrome
H02241  Ehlers-Danlos syndrome cardiac valvular type
H02243  Ehlers-Danlos syndrome arthrochalasia type
Drug
D00709  Levetiracetam (JAN/USAN/INN)
D01914  Piracetam (JAN/USAN/INN)
D03497  Cilengitide (USAN/INN)
D04660  Lamifiban hydrochloride (USAN)
D05817  Seletracetam (USAN/INN)
D06319  Volociximab (USAN)
D06590  Firategrast (USAN)
D06886  Natalizumab (INN)
D08083  Vedolizumab (USAN)
D08879  Brivaracetam (USAN/INN)
D09342  Etaracizumab (USAN/INN)
D09631  Intetumumab (USAN/INN)
D09903  Fluciclatide F 18 (USAN/INN)
D09929  Maraciclatide (USAN/INN)
D10028  Valategrast hydrochloride (USAN)
Other DBs
GO: 0005201
Organism
Homo sapiens (human) [GN:hsa]
Gene
1277  COL1A1; collagen type I alpha 1 chain [KO:K06236]
1278  COL1A2; collagen type I alpha 2 chain [KO:K06236]
1280  COL2A1; collagen type II alpha 1 chain [KO:K19719]
1284  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
1286  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
1288  COL4A6; collagen type IV alpha 6 chain [KO:K06237]
1282  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
1287  COL4A5; collagen type IV alpha 5 chain [KO:K06237]
1285  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
1291  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
1292  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
1293  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
131873  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
256076  COL6A5; collagen type VI alpha 5 chain [KO:K06238]
1297  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
1298  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
1299  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
284217  LAMA1; laminin subunit alpha 1 [KO:K05637]
3908  LAMA2; laminin subunit alpha 2 [KO:K05637]
3909  LAMA3; laminin subunit alpha 3 [KO:K06240]
3911  LAMA5; laminin subunit alpha 5 [KO:K06240]
3910  LAMA4; laminin subunit alpha 4 [KO:K06241]
3912  LAMB1; laminin subunit beta 1 [KO:K05636]
3913  LAMB2; laminin subunit beta 2 [KO:K06243]
3914  LAMB3; laminin subunit beta 3 [KO:K06244]
22798  LAMB4; laminin subunit beta 4 [KO:K06245]
3915  LAMC1; laminin subunit gamma 1 [KO:K05635]
3918  LAMC2; laminin subunit gamma 2 [KO:K06246]
10319  LAMC3; laminin subunit gamma 3 [KO:K06247]
1101  CHAD; chondroadherin [KO:K06248]
5649  RELN; reelin [KO:K06249] [EC:3.4.21.-]
7057  THBS1; thrombospondin 1 [KO:K16857]
1311  COMP; cartilage oligomeric matrix protein [KO:K04659]
7058  THBS2; thrombospondin 2 [KO:K04659]
7059  THBS3; thrombospondin 3 [KO:K04659]
7060  THBS4; thrombospondin 4 [KO:K04659]
2335  FN1; fibronectin 1 [KO:K05717]
6696  SPP1; secreted phosphoprotein 1 [KO:K06250]
7448  VTN; vitronectin [KO:K06251]
3371  TNC; tenascin C [KO:K06252]
63923  TNN; tenascin N [KO:K06252]
7143  TNR; tenascin R [KO:K06252]
7148  TNXB; tenascin XB [KO:K06252]
255743  NPNT; nephronectin [KO:K06824]
80144  FRAS1; Fraser extracellular matrix complex subunit 1 [KO:K23379]
341640  FREM2; FRAS1 related extracellular matrix 2 [KO:K23380]
158326  FREM1; FRAS1 related extracellular matrix 1 [KO:K23380]
1834  DSPP; dentin sialophosphoprotein [KO:K23573]
7450  VWF; von Willebrand factor [KO:K03900]
3381  IBSP; integrin binding sialoprotein [KO:K06253]
1758  DMP1; dentin matrix acidic phosphoprotein 1 [KO:K23328]
375790  AGRN; agrin [KO:K06254]
3339  HSPG2; heparan sulfate proteoglycan 2 [KO:K06255]
3672  ITGA1; integrin subunit alpha 1 [KO:K06480]
3673  ITGA2; integrin subunit alpha 2 [KO:K06481]
3674  ITGA2B; integrin subunit alpha 2b [KO:K06476]
3675  ITGA3; integrin subunit alpha 3 [KO:K06482]
3676  ITGA4; integrin subunit alpha 4 [KO:K06483]
3678  ITGA5; integrin subunit alpha 5 [KO:K06484]
3655  ITGA6; integrin subunit alpha 6 [KO:K06485]
3679  ITGA7; integrin subunit alpha 7 [KO:K06583]
8516  ITGA8; integrin subunit alpha 8 [KO:K06584]
3680  ITGA9; integrin subunit alpha 9 [KO:K06585]
8515  ITGA10; integrin subunit alpha 10 [KO:K06586]
22801  ITGA11; integrin subunit alpha 11 [KO:K06587]
3685  ITGAV; integrin subunit alpha V [KO:K06487]
3688  ITGB1; integrin subunit beta 1 [KO:K05719]
3690  ITGB3; integrin subunit beta 3 [KO:K06493]
3691  ITGB4; integrin subunit beta 4 [KO:K06525]
3693  ITGB5; integrin subunit beta 5 [KO:K06588]
3694  ITGB6; integrin subunit beta 6 [KO:K06589]
3695  ITGB7; integrin subunit beta 7 [KO:K06590]
3696  ITGB8; integrin subunit beta 8 [KO:K06591]
960  CD44; CD44 molecule (Indian blood group) [KO:K06256]
6382  SDC1; syndecan 1 [KO:K06257]
6385  SDC4; syndecan 4 [KO:K16338]
22987  SV2C; synaptic vesicle glycoprotein 2C [KO:K06258]
9899  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
9900  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
948  CD36; CD36 molecule [KO:K06259]
2814  GP5; glycoprotein V platelet [KO:K06260]
2811  GP1BA; glycoprotein Ib platelet subunit alpha [KO:K06261]
2812  GP1BB; glycoprotein Ib platelet subunit beta [KO:K06262]
2815  GP9; glycoprotein IX platelet [KO:K06263]
51206  GP6; glycoprotein VI platelet [KO:K06264]
1605  DAG1; dystroglycan 1 [KO:K06265]
961  CD47; CD47 molecule [KO:K06266]
3161  HMMR; hyaluronan mediated motility receptor [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
KO pathway
ko04512   

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