KEGG   PATHWAY: hsa04514Help
Entry
hsa04514                    Pathway                                

Name
Cell adhesion molecules (CAMs) - Homo sapiens (human)
Description
Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
hsa04514  Cell adhesion molecules (CAMs)
hsa04514

Ortholog table
Disease
H00586  Epidermolysis bullosa, junctional
H00639  Ectodermal dysplasia, ectrodactyly, and macular dystrophy
H00742  Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome
H00756  Pitt-Hopkins syndrome
H00785  Congenital hypotrichosis with juvenile macular dystrophy
H00805  Vitreoretinal degeneration
H00840  Band-like calcification with simplified gyration and polymicrogyria
H01034  L1 syndrome
H01155  Roussy-Levy syndrome
H01210  Hypomagnesemia
H01677  Congenital hydrocephalus
H01882  Asperger syndrome
H02073  Wagner syndrome
H02111  Autism
Drug
D02800  Alefacept (USAN/INN)
D02811  Alicaforsen sodium (USAN)
D02967  Apolizumab (USAN/INN)
D03066  Bectumomab (USAN/INN)
D03114  Bimosiamose disodium (USAN)
D03203  Abatacept (USAN/INN)
D03222  Belatacept (USAN/INN)
D03420  Cedelizumab (USAN/INN)
D03497  Cilengitide (USAN/INN)
D03959  Efalizumab (USAN/INN)
D04000  Enlimomab (USAN/INN)
D04036  Epratuzumab (USAN/INN)
D04045  Erlizumab (USAN/INN)
D04295  Galiximab (USAN/INN)
D05610  Priliximab (USAN/INN)
D05777  Ruplizumab (USAN/INN)
D05847  Siplizumab (USAN/INN)
D06071  Teneliximab (USAN/INN)
D06590  Firategrast (USAN)
D06657  Tremelimumab (USAN/INN)
D08083  Vedolizumab (USAN)
D08933  Inotuzumab ozogamicin (USAN/INN)
D09575  Ibalizumab (USAN/INN)
D09631  Intetumumab (USAN/INN)
D09927  Lorvotuzumab mertansine (USAN/INN)
D09929  Maraciclatide (USAN/INN)
D09932  Moxetumomab pasudotox (USAN/INN)
D10028  Valategrast hydrochloride (USAN)
D10374  Lifitegrast (USAN/INN)
D10392  Lifitegrast sodium (USAN)
D10773  Atezolizumab (USAN/INN)
D10808  Durvalumab (USAN/INN)
Other DBs
BSID: 83069
GO: 0050839
Organism
Homo sapiens (human) [GN:hsa]
Gene
965  CD58; CD58 molecule [KO:K06492]
914  CD2; CD2 molecule [KO:K06449]
941  CD80; CD80 molecule [KO:K05412]
29126  CD274; CD274 molecule [KO:K06745]
940  CD28; CD28 molecule [KO:K06470]
942  CD86; CD86 molecule [KO:K05413]
1493  CTLA4; cytotoxic T-lymphocyte associated protein 4 [KO:K06538]
23308  ICOSLG; inducible T cell costimulator ligand [KO:K06710]
102723996  ICOS ligand [KO:K06710]
29851  ICOS; inducible T cell costimulator [KO:K06713]
3108  HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
920  CD4; CD4 molecule [KO:K06454]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
925  CD8A; CD8a molecule [KO:K06458]
926  CD8B; CD8b molecule [KO:K06459]
80380  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
80381  CD276; CD276 molecule [KO:K06746]
79679  VTCN1; V-set domain containing T cell activation inhibitor 1 [KO:K06747]
5133  PDCD1; programmed cell death 1 [KO:K06744]
958  CD40; CD40 molecule [KO:K03160]
959  CD40LG; CD40 ligand [KO:K03161]
214  ALCAM; activated leukocyte cell adhesion molecule [KO:K06547]
923  CD6; CD6 molecule [KO:K06456]
5817  PVR; poliovirus receptor [KO:K06539]
10666  CD226; CD226 molecule [KO:K06567]
5819  NECTIN2; nectin cell adhesion molecule 2 [KO:K06531]
201633  TIGIT; T cell immunoreceptor with Ig and ITIM domains [KO:K16350]
3683  ITGAL; integrin subunit alpha L [KO:K05718]
3689  ITGB2; integrin subunit beta 2 [KO:K06464]
3383  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
3384  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
3385  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
933  CD22; CD22 molecule [KO:K06467]
5788  PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
6614  SIGLEC1; sialic acid binding Ig like lectin 1 [KO:K06548]
6693  SPN; sialophorin [KO:K06477]
25945  NECTIN3; nectin cell adhesion molecule 3 [KO:K06592]
1364  CLDN4; claudin 4 [KO:K06087]
1365  CLDN3; claudin 3 [KO:K06087]
1366  CLDN7; claudin 7 [KO:K06087]
149461  CLDN19; claudin 19 [KO:K06087]
10686  CLDN16; claudin 16 [KO:K06087]
23562  CLDN14; claudin 14 [KO:K06087]
24146  CLDN15; claudin 15 [KO:K06087]
26285  CLDN17; claudin 17 [KO:K06087]
49861  CLDN20; claudin 20 [KO:K06087]
5010  CLDN11; claudin 11 [KO:K06087]
51208  CLDN18; claudin 18 [KO:K06087]
53842  CLDN22; claudin 22 [KO:K06087]
7122  CLDN5; claudin 5 [KO:K06087]
9071  CLDN10; claudin 10 [KO:K06087]
9073  CLDN8; claudin 8 [KO:K06087]
9074  CLDN6; claudin 6 [KO:K06087]
9075  CLDN2; claudin 2 [KO:K06087]
9076  CLDN1; claudin 1 [KO:K06087]
9080  CLDN9; claudin 9 [KO:K06087]
137075  CLDN23; claudin 23 [KO:K06087]
644672  CLDN25; claudin 25 [KO:K06087]
100132463  CLDN24; claudin 24 [KO:K06087]
100506658  OCLN; occludin [KO:K06088]
50848  F11R; F11 receptor [KO:K06089]
58494  JAM2; junctional adhesion molecule 2 [KO:K06735]
83700  JAM3; junctional adhesion molecule 3 [KO:K06785]
90952  ESAM; endothelial cell adhesion molecule [KO:K06787]
1003  CDH5; cadherin 5 [KO:K06533]
5175  PECAM1; platelet and endothelial cell adhesion molecule 1 [KO:K06471]
4267  CD99; CD99 molecule (Xg blood group) [KO:K06520]
3684  ITGAM; integrin subunit alpha M [KO:K06461]
6404  SELPLG; selectin P ligand [KO:K06544]
6403  SELP; selectin P [KO:K06496]
3676  ITGA4; integrin subunit alpha 4 [KO:K06483]
3688  ITGB1; integrin subunit beta 1 [KO:K05719]
3680  ITGA9; integrin subunit alpha 9 [KO:K06585]
7412  VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
3695  ITGB7; integrin subunit beta 7 [KO:K06590]
8174  MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
6402  SELL; selectin L [KO:K06495]
947  CD34; CD34 molecule [KO:K06474]
2734  GLG1; golgi glycoprotein 1 [KO:K06816]
6401  SELE; selectin E [KO:K06494]
5818  NECTIN1; nectin cell adhesion molecule 1 [KO:K06081]
1000  CDH2; cadherin 2 [KO:K06736]
4684  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
4685  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
3897  L1CAM; L1 cell adhesion molecule [KO:K06550]
23705  CADM1; cell adhesion molecule 1 [KO:K06781]
257194  NEGR1; neuronal growth regulator 1 [KO:K06775]
22854  NTNG1; netrin G1 [KO:K07522]
57689  LRRC4C; leucine rich repeat containing 4C [KO:K07523]
84628  NTNG2; netrin G2 [KO:K16359]
64101  LRRC4; leucine rich repeat containing 4 [KO:K16351]
5792  PTPRF; protein tyrosine phosphatase, receptor type F [KO:K05695] [EC:3.1.3.48]
94030  LRRC4B; leucine rich repeat containing 4B [KO:K16360]
6382  SDC1; syndecan 1 [KO:K06257]
6383  SDC2; syndecan 2 [KO:K16336]
9672  SDC3; syndecan 3 [KO:K16337]
6385  SDC4; syndecan 4 [KO:K16338]
3685  ITGAV; integrin subunit alpha V [KO:K06487]
3696  ITGB8; integrin subunit beta 8 [KO:K06591]
8516  ITGA8; integrin subunit alpha 8 [KO:K06584]
9378  NRXN1; neurexin 1 [KO:K07377]
9379  NRXN2; neurexin 2 [KO:K07377]
9369  NRXN3; neurexin 3 [KO:K07377]
22871  NLGN1; neuroligin 1 [KO:K07378]
57555  NLGN2; neuroligin 2 [KO:K07378]
54413  NLGN3; neuroligin 3 [KO:K07378]
57502  NLGN4X; neuroligin 4 X-linked [KO:K07378]
22829  NLGN4Y; neuroligin 4 Y-linked [KO:K07378]
57863  CADM3; cell adhesion molecule 3 [KO:K06780]
4897  NRCAM; neuronal cell adhesion molecule [KO:K06756]
1272  CNTN1; contactin 1 [KO:K06759]
5797  PTPRM; protein tyrosine phosphatase, receptor type M [KO:K05693] [EC:3.1.3.48]
6900  CNTN2; contactin 2 [KO:K06760]
23114  NFASC; neurofascin [KO:K06757]
8506  CNTNAP1; contactin associated protein 1 [KO:K07379]
26047  CNTNAP2; contactin associated protein like 2 [KO:K07380]
4359  MPZ; myelin protein zero [KO:K06770]
9019  MPZL1; myelin protein zero like 1 [KO:K06770]
4099  MAG; myelin associated glycoprotein [KO:K06771]
999  CDH1; cadherin 1 [KO:K05689]
1462  VCAN; versican [KO:K06793]
3655  ITGA6; integrin subunit alpha 6 [KO:K06485]
1001  CDH3; cadherin 3 [KO:K06796]
1002  CDH4; cadherin 4 [KO:K06797]
1013  CDH15; cadherin 15 [KO:K06809]
4756  NEO1; neogenin 1 [KO:K06766]
Reference
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
KO pathway
ko04514   

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