KEGG   PATHWAY: hsa04612Help
Entry
hsa04612                    Pathway                                

Name
Antigen processing and presentation - Homo sapiens (human)
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
hsa04612  Antigen processing and presentation
hsa04612

Ortholog table
Network
nt06129  MHC presentation (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06229  MHC presentation
  Element
N00363  Antigen processing and presentation by MHC class I molecules
N00590  Antigen processing and presentation by MHC class II molecules
Disease
H00344  Leprosy
H00425  Lysosomal cysteine protease deficiencies
H00932  Tropical calcific pancreatitis
H00984  Bare lymphocyte syndrome type1
H00985  Bare lymphocyte syndrome type2
H01132  Aplastic anemia
H01227  Inflammatory bowel disease (IBD)
H01303  Hypercatabolic hypoproteinemia
H01674  Ankylosing spondylitis
Drug
D00742  Etanercept (USAN/INN)
D02597  Adalimumab (USAN/INN)
D02598  Infliximab (USAN/INN)
D02967  Apolizumab (USAN/INN)
D03441  Certolizumab pegol (USAN/INN)
D04318  Glatiramer acetate (JAN/USAN)
D05610  Priliximab (USAN/INN)
D07436  Afelimomab (INN)
D11376  Petesicatib (USAN)
Other DBs
GO: 0019885 0019886 0042591
Organism
Homo sapiens (human) [GN:hsa]
Gene
3458  IFNG; interferon gamma [KO:K04687]
7124  TNF; tumor necrosis factor [KO:K03156]
5720  PSME1; proteasome activator subunit 1 [KO:K06696]
5721  PSME2; proteasome activator subunit 2 [KO:K06697]
10197  PSME3; proteasome activator subunit 3 [KO:K06698]
3312  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
3303  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
3306  HSPA2; heat shock protein family A (Hsp70) member 2 [KO:K03283]
3305  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
3304  HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
3310  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
3308  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
3320  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
3326  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
821  CANX; calnexin [KO:K08054]
567  B2M; beta-2-microglobulin [KO:K08055]
2923  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
811  CALR; calreticulin [KO:K08057]
6892  TAPBP; TAP binding protein [KO:K08058]
6890  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653]
6891  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654]
925  CD8A; CD8a molecule [KO:K06458]
926  CD8B; CD8b molecule [KO:K06459]
3812  KIR3DL2; killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 [KO:K07980]
3811  KIR3DL1; killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 [KO:K07980]
115653  KIR3DL3; killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 [KO:K07980]
3803  KIR2DL2; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 [KO:K07981]
3802  KIR2DL1; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 [KO:K07981]
3804  KIR2DL3; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 [KO:K07981]
3805  KIR2DL4; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 [KO:K07981]
57292  KIR2DL5A; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A [KO:K07981]
3821  KLRC1; killer cell lectin like receptor C1 [KO:K06541]
3822  KLRC2; killer cell lectin like receptor C2 [KO:K06541]
3823  KLRC3; killer cell lectin like receptor C3 [KO:K06541]
8302  KLRC4; killer cell lectin like receptor C4 [KO:K06541]
3824  KLRD1; killer cell lectin like receptor D1 [KO:K06516]
3806  KIR2DS1; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 [KO:K07982]
3808  KIR2DS3; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 [KO:K07982]
3809  KIR2DS4; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 [KO:K07982]
3810  KIR2DS5; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 [KO:K07982]
100132285  KIR2DS2; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 [KO:K07982]
10437  IFI30; IFI30 lysosomal thiol reductase [KO:K08059]
5641  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
1508  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
3108  HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
972  CD74; CD74 molecule [KO:K06505]
1514  CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
1520  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
920  CD4; CD4 molecule [KO:K06454]
4261  CIITA; class II major histocompatibility complex transactivator [KO:K08060] [EC:2.7.11.1]
5993  RFX5; regulatory factor X5 [KO:K08061]
8625  RFXANK; regulatory factor X associated ankyrin containing protein [KO:K08062]
5994  RFXAP; regulatory factor X associated protein [KO:K08063]
1385  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
4800  NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
4801  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
4802  NFYC; nuclear transcription factor Y subunit gamma [KO:K08066]
3309  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490]
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
KO pathway
ko04612   

DBGET integrated database retrieval system