Entry
Name
Serotonergic synapse - Homo sapiens (human)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Drug
D00197 Reserpine (JP18/USP/INN)
D00228 Amoxapine (JP18/USP/INN)
D00270 Chlorpromazine (USP/INN)
D00283 Clozapine (JAN/USP/INN)
D00394 Trimipramine (USAN/INN)
D00415 Zolmitriptan (JAN/USP/INN)
D00426 Risperidone (JP18/USP/INN)
D00451 Sumatriptan (JAN/USP/INN)
D00454 Olanzapine (JAN/USP/INN)
D00456 Ondansetron (JAN/USP/INN)
D00458 Quetiapine fumarate (JP18/USP)
D00484 Protriptyline hydrochloride (USP)
D00505 Phenelzine sulfate (USP)
D00563 Mirtazapine (JAN/USP/INN)
D00674 Naratriptan hydrochloride (JAN/USP)
D00675 Rizatriptan benzoate (JAN/USP)
D00676 Sumatriptan succinate (JAN/USP)
D00677 Granisetron hydrochloride (JAN/USP)
D00678 Ondansetron hydrochloride hydrate (JAN/USP)
D00681 Methysergide maleate (USP)
D00702 Buspirone hydrochloride (USP)
D00725 Dolasetron mesylate (USP)
D00785 Selegiline hydrochloride (JAN/USP)
D00789 Chlorpromazine hydrochloride (JP18/USP)
D00794 Loxapine succinate (USP)
D00795 Mesoridazine besylate (USP)
D00809 Amitriptyline hydrochloride (JP18/USP)
D00811 Clomipramine hydrochloride (JP18/USP)
D00812 Desipramine hydrochloride (JAN/USP)
D00814 Doxepin hydrochloride (USP)
D00815 Imipramine hydrochloride (JP18/USP)
D00816 Nortriptyline hydrochloride (JP18/USP/INN)
D00819 Nefazodone hydrochloride (USP)
D00820 Trazodone hydrochloride (JAN/USP)
D00821 Venlafaxine hydrochloride (JAN/USP)
D00822 Citalopram hydrobromide (USP)
D00823 Fluoxetine hydrochloride (JAN/USP)
D00824 Fluvoxamine maleate (JP18/USP)
D00825 Sertraline hydrochloride (JAN/USP)
D00826 Tranylcypromine sulfate (USP)
D01097 Lazabemide hydrochloride (JAN/USAN)
D01107 Milnacipran hydrochloride (JAN/USAN)
D01164 Aripiprazole (JP18/USP/INN)
D01179 Duloxetine hydrochloride (JAN/USP)
D01285 Lofepramine hydrochloride (JAN/USAN)
D01358 Mianserin hydrochloride (JAN/USAN)
D01477 Opipramol hydrochloride (JAN/USAN)
D01537 Xaliproden hydrochloride (JAN)
D01546 Dothiepin hydrochloride (USAN)
D01613 Azasetron hydrochloride (JAN)
D01624 Sarpogrelate hydrochloride (JP18)
D01653 Benserazide hydrochloride (JP18)
D01838 Fabesetron hydrochloride (JAN)
D01888 Safrazine hydrochloride (JAN)
D01939 Ziprasidone hydrochloride (USP)
D01973 Eletriptan hydrobromide (JAN/USAN)
D01992 Tandospirone citrate (JAN/USAN)
D01994 Mosapride citrate hydrate (JP18)
D02016 Ramosetron hydrochloride (JAN)
D02041 Tropisetron hydrochloride (JAN)
D02100 Ziprasidone mesylate (USAN)
D02170 Indeloxazine hydrochloride (JAN/USAN)
D02182 Cocaine hydrochloride (JP18/USP)
D02211 Dihydroergotamine mesylate (USP)
D02234 Cyproheptadine hydrochloride (JP18/USP)
D02242 Methamphetamine hydrochloride (JP18/USP)
D02260 Paroxetine hydrochloride hemihydrate (USP)
D02290 Flurbiprofen sodium (USP)
D02357 Methysergide (USAN/INN)
D02408 Trimipramine maleate (JAN/USP)
D02562 Rasagiline mesylate (USAN)
D02564 Pargyline hydrochloride (USAN)
D02567 Escitalopram oxalate (JAN/USP)
D02569 Sunepitron hydrochloride (USAN)
D02570 Desvenlafaxine succinate (USAN)
D02571 Sibutramine hydrochloride (USP)
D02632 Indisetron hydrochloride (JAN)
D02671 Mesoridazine (USAN/INN)
D02680 Pipotiazine palmitate (USAN)
D02688 Tiospirone hydrochloride (USAN)
D02730 Tegaserod maleate (USAN)
D02767 Adatanserin hydrochloride (USAN)
D02825 Almotriptan malate (USP)
D02826 Alniditan dihydrochloride (USAN)
D02829 Alosetron hydrochloride (USAN)
D02836 Altanserin tartrate (USAN)
D02995 Asenapine maleate (JAN/USAN)
D03005 Atiprosin maleate (USAN)
D03014 Avitriptan fumarate (USAN)
D03060 Batanopride hydrochloride (USAN)
D03239 Ladostigil tartrate (USAN)
D03274 Chlorpromazine hibenzate (JAN)
D03491 Cidoxepin hydrochloride (USAN)
D03496 Cilansetron hydrochloride (USAN)
D03649 Dapoxetine hydrochloride (USAN)
D03662 Dazopride fumarate (USAN)
D03713 Dexfenfluramine hydrochloride (USAN)
D03721 Dexmethylphenidate hydrochloride (USAN)
D03733 Mofegiline hydrochloride (USAN)
D03740 Dextroamphetamine (USAN)
D03982 Elzasonan citrate (USAN)
D03983 Elzasonan hydrochloride (USAN)
D04034 Chlorpromazine phenolphthalinate (JAN)
D04055 Esmirtazapine maleate (USAN)
D04092 Etryptamine acetate (USAN)
D04148 Fenfluramine hydrochloride (JAN/USAN)
D04264 Frovatriptan succinate (USAN)
D04294 Galdansetron hydrochloride (USAN)
D04314 Gepirone hydrochloride (USAN)
D04370 Granisetron (JAN/USAN/INN)
D04533 Indorenate hydrochloride (USAN)
D04611 Ipsapirone hydrochloride (USAN)
D04683 Lecozotan hydrochloride (USAN)
D04788 Lubazodone hydrochloride (USAN)
D04820 Lurasidone hydrochloride (JAN/USAN)
D04821 Lurosetron mesylate (USAN)
D05015 Metrenperone (USAN/INN)
D05033 Milacemide hydrochloride (USAN)
D05040 Minaprine hydrochloride (USAN)
D05050 Mirisetron maleate (USAN)
D05339 Paliperidone (JAN/USP/INN)
D05340 Paliperidone palmitate (JAN/USAN)
D05343 Palonosetron hydrochloride (JAN/USP)
D05374 Paroxetine hydrochloride (USP)
D05375 Paroxetine mesylate (USAN)
D05395 Pelanserin hydrochloride (USAN)
D05459 Phentermine hydrochloride (USP)
D05471 Piboserod hydrochloride (USAN)
D05685 Quipazine maleate (USAN)
D05740 Rizatriptan sulfate (USAN)
D05804 Sarizotan hydrochloride (USAN)
D05829 Sergolexole maleate (USAN)
D05941 Sulamserod hydrochloride (USAN)
D06253 Tropanserin hydrochloride (USAN)
D06353 Zacopride hydrochloride (USAN)
D06354 Zalospirone hydrochloride (USAN)
D06358 Zatosetron maleate (USAN)
D06567 Bifeprunox mesylate (USAN)
D06613 Lorcaserin hydrochloride (USAN)
D06623 Olanzapine pamoate (USAN)
D06633 Pruvanserin hydrochloride (USAN)
D06660 Vabicaserin hydrochloride (USAN)
D07097 Isometheptene mucate (USP)
D07449 Amitriptylinoxide (INN)
D07515 Benzfetamine hydrochloride
D07705 Citalopram hydrochloride
D07806 Dexmethylphenidate (INN)
D07837 Dihydroergotamine (INN)
D07838 Dihydroergotamine tartrate
D08071 Imipramine pamoate (USP)
D08072 Imipraminoxide hydrochloride
D08393 Pirlindole hydrochloride
D08575 Tetrabenazine (JAN/INN)
D08969 Pimavanserin tartrate (USAN)
D09205 Prucalopride (USAN/INN)
D09359 Naluzotan hydrochloride (USAN)
D09366 Pardoprunox hydrochloride (USAN)
D09645 Nelotanserin (USAN/INN)
D09694 Velusetrag hydrochloride (USAN)
D09699 Vilazodone hydrochloride (USAN)
D09749 Itasetron hydrochloride hydrate (JAN)
D09819 Chlorpromazine tannate (JAN)
D09876 Cariprazine hydrochloride (JAN/USAN)
D09934 Naronapride dihydrochloride (USAN)
D09974 Telotristat ethyl (USAN)
D09975 Telotristat etiprate (USAN)
D10006 Eplivanserin (USAN/INN)
D10072 Levomilnacipran (USAN/INN)
D10089 Amitifadine hydrochloride (USAN)
D10100 Cerlapirdine hydrochloride (USAN)
D10133 Levomilnacipran hydrochloride (USAN)
D10152 Prucalopride succinate (USAN)
D10171 Tedatioxetine hydrobromide (USAN)
D10185 Vortioxetine hydrobromide (JAN/USAN)
D10191 Safinamide mesylate (USAN)
D10309 Brexpiprazole (JAN/USAN/INN)
D10355 Aripiprazole cavoxil (USAN)
D10364 Aripiprazole lauroxil (USAN)
D10424 Lasmiditan succinate (JAN/USAN)
D10516 Aripiprazole hydrate (JAN)
D10697 Centanafadine (USAN/INN)
D10698 Centanafadine hydrochloride (USAN)
D10701 Deutetrabenazine (USAN/INN)
D10747 Idalopirdine hydrochloride (JAN)
D10999 Valbenazine tosylate (USAN)
D11056 Mirtazapine hydrate (JAN)
D11169 Lumateperone (USAN/INN)
D11170 Lumateperone tosylate (USAN)
D11172 Midomafetamine (USAN/INN)
D11221 Relenopride hydrochloride (USAN)
D11224 Sembragiline (USAN/INN)
D11318 Rodatristat ethyl (USAN)
D11566 Lorcaserin hydrochloride hemihydrate
D11617 Eletriptan hydrobromide monohydrate
D11619 Desvenlafaxine succinate anhydrous
D11622 Amphetamine aspartate monohydrate
D11688 Ampreloxetine (USAN/INN)
D11689 Ampreloxetine hydrochloride (USAN)
D11940 Toludesvenlafaxine (USAN/INN)
D11941 Toludesvenlafaxine hydrochloride (USAN)
D12403 Venlafaxine besylate monohydrate
D12475 Ulotaront hydrochloride (JAN/USAN)
D12510 Utreloxastat (JAN/USAN/INN)
D12544 Vortioxetine hemihydrobromide (USAN)
D12937 Midomafetamine hydrochloride (USAN)
D13036 Bexicaserin hydrochloride (USAN)
Other DBs
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
6570 SLC18A1; solute carrier family 18 member A1 [KO:K08155 ]
6571 SLC18A2; solute carrier family 18 member A2 [KO:K08155 ]
775 CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850 ]
776 CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851 ]
778 CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853 ]
779 CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857 ]
3356 HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157 ]
3357 HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157 ]
3358 HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157 ]
3708 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
3709 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
3710 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
1564 CYP2D7; cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) [KO:K17712 ] [EC:1.14.14.1 ]
1565 CYP2D6; cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) [KO:K17712 ] [EC:1.14.14.1 ]
242 ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021 ] [EC:1.13.11.-]
3359 HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819 ]
9177 HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819 ]
3360 HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160 ]
3362 HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162 ]
3363 HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163 ]
3781 KCNN2; potassium calcium-activated channel subfamily N member 2 [KO:K04943 ]
3751 KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892 ]
2560 GABRB1; gamma-aminobutyric acid type A receptor subunit beta1 [KO:K05181 ]
2561 GABRB2; gamma-aminobutyric acid type A receptor subunit beta2 [KO:K05181 ]
2562 GABRB3; gamma-aminobutyric acid type A receptor subunit beta3 [KO:K05181 ]
10411 RAPGEF3; Rap guanine nucleotide exchange factor 3 [KO:K08014 ]
351 APP; amyloid beta precursor protein [KO:K04520 ]
3350 HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153 ]
3351 HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153 ]
3352 HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153 ]
3354 HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153 ]
3355 HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153 ]
3361 HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161 ]
2770 GNAI1; G protein subunit alpha i1 [KO:K04630 ]
2771 GNAI2; G protein subunit alpha i2 [KO:K04630 ]
2773 GNAI3; G protein subunit alpha i3 [KO:K04630 ]
2775 GNAO1; G protein subunit alpha o1 [KO:K04534 ]
2790 GNG10; G protein subunit gamma 10 [KO:K04545 ]
2791 GNG11; G protein subunit gamma 11 [KO:K04546 ]
2792 GNGT1; G protein subunit gamma transducin 1 [KO:K04548 ]
2793 GNGT2; G protein subunit gamma transducin 2 [KO:K04549 ]
3265 HRAS; HRas proto-oncogene, GTPase [KO:K02833 ]
3845 KRAS; KRAS proto-oncogene, GTPase [KO:K07827 ]
4893 NRAS; NRAS proto-oncogene, GTPase [KO:K07828 ]
773 CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344 ]
774 CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849 ]
3760 KCNJ3; potassium inwardly rectifying channel subfamily J member 3 [KO:K04997 ]
3763 KCNJ6; potassium inwardly rectifying channel subfamily J member 6 [KO:K05000 ]
3765 KCNJ9; potassium inwardly rectifying channel subfamily J member 9 [KO:K05002 ]
3762 KCNJ5; potassium inwardly rectifying channel subfamily J member 5 [KO:K04999 ]
7220 TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964 ]
6532 SLC6A4; solute carrier family 6 member 4 [KO:K05037 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05964 11-Dehydro-thromboxane B2
Reference
Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
Journal
Reference
Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
Journal
Reference
Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
Journal
Reference
Authors
Noda M, Higashida H, Aoki S, Wada K
Title
Multiple signal transduction pathways mediated by 5-HT receptors.
Journal
Reference
Authors
Daubert EA, Condron BG
Title
Serotonin: a regulator of neuronal morphology and circuitry.
Journal
Reference
Authors
Chameau P, van Hooft JA
Title
Serotonin 5-HT(3) receptors in the central nervous system.
Journal
Reference
Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
Journal
Reference
Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
Title
Epoxyeicosanoid signaling in CNS function and disease.
Journal
Reference
Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
Journal
Reference
Authors
Albert PR, Tiberi M
Title
Receptor signaling and structure: insights from serotonin-1 receptors.
Journal
Reference
Authors
Durham PL, Russo AF
Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
Journal
Reference
Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
Journal
Reference
Authors
Lezoualc'h F, Robert SJ
Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
Journal
Reference
Authors
Durham PL, Russo AF
Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
Journal
Reference
Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
Journal
Reference
Authors
Nestler EJ, Hyman SE, Malenka RC.
Title
Molecular neuropharmacology: A foundation for clinical neuroscience
Journal
The McGraw-Hill Companies, Inc. (2001)
Related pathway
KO pathway