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KEGG   PATHWAY: hsa04810
Entry
hsa04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Homo sapiens (human)
Class
Cellular Processes; Cell motility
Pathway map
hsa04810  Regulation of actin cytoskeleton
hsa04810

Network
nt06124  Chemokine signaling (viruses)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06167  Human cytomegalovirus (HCMV)
nt06464  Amyotrophic lateral sclerosis
  Element
N00405  CXCR4-GNA12/13-Rho signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01097  LPA-GNA12/13-RhoA signaling pathway
N01161  Actin polymerization
Drug
D01175  Carpronium chloride (JAN/INN)
D01840  Fasudil hydrochloride (JAN)
D03065  Becaplermin (USAN/INN)
D03115  Fasudil hydrochloride hydrate (JAN)
D03497  Cilengitide (USAN/INN)
D03722  Efegatran sulfate (USAN)
D03728  Napsagatran (USAN)
D04492  Icatibant acetate (JAN/USAN)
D05338  Palifermin (USAN/INN)
D05716  Repifermin (USAN/INN)
D06319  Volociximab (USAN)
D07941  Fasudil (INN)
D09342  Etaracizumab (USAN/INN)
D09752  Carpronium chloride hydrate (JAN)
D10028  Valategrast hydrochloride (USAN)
D10374  Lifitegrast (USAN/INN)
D10392  Lifitegrast sodium (USAN)
D10463  Ripasudil hydrochloride hydrate (JAN)
Other DBs
GO: 0030036
Organism
Homo sapiens (human) [GN:hsa]
Gene
1902  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
9170  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
2846  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
57121  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
6387  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
7852  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
2147  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
2149  F2R; coagulation factor II thrombin receptor [KO:K03914]
3630  INS; insulin [KO:K04526]
1950  EGF; epidermal growth factor [KO:K04357]
2246  FGF1; fibroblast growth factor 1 [KO:K18496]
2247  FGF2; fibroblast growth factor 2 [KO:K18497]
2248  FGF3; fibroblast growth factor 3 [KO:K04358]
2249  FGF4; fibroblast growth factor 4 [KO:K04358]
8822  FGF17; fibroblast growth factor 17 [KO:K04358]
2251  FGF6; fibroblast growth factor 6 [KO:K04358]
2252  FGF7; fibroblast growth factor 7 [KO:K04358]
2253  FGF8; fibroblast growth factor 8 [KO:K04358]
2254  FGF9; fibroblast growth factor 9 [KO:K04358]
2255  FGF10; fibroblast growth factor 10 [KO:K04358]
8823  FGF16; fibroblast growth factor 16 [KO:K04358]
2250  FGF5; fibroblast growth factor 5 [KO:K04358]
8817  FGF18; fibroblast growth factor 18 [KO:K04358]
26281  FGF20; fibroblast growth factor 20 [KO:K04358]
27006  FGF22; fibroblast growth factor 22 [KO:K04358]
9965  FGF19; fibroblast growth factor 19 [KO:K22603]
26291  FGF21; fibroblast growth factor 21 [KO:K22429]
8074  FGF23; fibroblast growth factor 23 [KO:K22428]
5154  PDGFA; platelet derived growth factor subunit A [KO:K04359]
5155  PDGFB; platelet derived growth factor subunit B [KO:K17386]
56034  PDGFC; platelet derived growth factor C [KO:K05450]
80310  PDGFD; platelet derived growth factor D [KO:K05450]
3645  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2260  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
2263  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2261  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2264  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
5156  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
5159  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
2335  FN1; fibronectin 1 [KO:K05717]
3672  ITGA1; integrin subunit alpha 1 [KO:K06480]
3673  ITGA2; integrin subunit alpha 2 [KO:K06481]
3674  ITGA2B; integrin subunit alpha 2b [KO:K06476]
3675  ITGA3; integrin subunit alpha 3 [KO:K06482]
3676  ITGA4; integrin subunit alpha 4 [KO:K06483]
3678  ITGA5; integrin subunit alpha 5 [KO:K06484]
3655  ITGA6; integrin subunit alpha 6 [KO:K06485]
3679  ITGA7; integrin subunit alpha 7 [KO:K06583]
8516  ITGA8; integrin subunit alpha 8 [KO:K06584]
3680  ITGA9; integrin subunit alpha 9 [KO:K06585]
8515  ITGA10; integrin subunit alpha 10 [KO:K06586]
22801  ITGA11; integrin subunit alpha 11 [KO:K06587]
3685  ITGAV; integrin subunit alpha V [KO:K06487]
3683  ITGAL; integrin subunit alpha L [KO:K05718]
3684  ITGAM; integrin subunit alpha M [KO:K06461]
3687  ITGAX; integrin subunit alpha X [KO:K06462]
3681  ITGAD; integrin subunit alpha D [KO:K06594]
3682  ITGAE; integrin subunit alpha E [KO:K06524]
3688  ITGB1; integrin subunit beta 1 [KO:K05719]
3689  ITGB2; integrin subunit beta 2 [KO:K06464]
3690  ITGB3; integrin subunit beta 3 [KO:K06493]
3691  ITGB4; integrin subunit beta 4 [KO:K06525]
3693  ITGB5; integrin subunit beta 5 [KO:K06588]
3694  ITGB6; integrin subunit beta 6 [KO:K06589]
3695  ITGB7; integrin subunit beta 7 [KO:K06590]
3696  ITGB8; integrin subunit beta 8 [KO:K06591]
3827  KNG1; kininogen 1 [KO:K03898]
623  BDKRB1; bradykinin receptor B1 [KO:K03915]
624  BDKRB2; bradykinin receptor B2 [KO:K03916]
1128  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
1129  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
1131  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
1132  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
1133  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
727  C5; complement C5 [KO:K03994]
729  C6; complement C6 [KO:K03995]
730  C7; complement C7 [KO:K03996]
731  C8A; complement C8 alpha chain [KO:K03997]
732  C8B; complement C8 beta chain [KO:K03998]
733  C8G; complement C8 gamma chain [KO:K03999]
735  C9; complement C9 [KO:K04000]
2768  GNA12; G protein subunit alpha 12 [KO:K04346]
10672  GNA13; G protein subunit alpha 13 [KO:K04639]
55970  GNG12; G protein subunit gamma 12 [KO:K04347]
2245  FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
89846  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
5747  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
9564  BCAR1; BCAR1 scaffold protein, Cas family member [KO:K05726]
1398  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
1399  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
1793  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
6237  RRAS; RAS related [KO:K07829]
22800  RRAS2; RAS related 2 [KO:K07830]
22808  MRAS; muscle RAS oncogene homolog [KO:K07831]
9459  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
10451  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
7409  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
7410  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
7074  TIAM1; TIAM Rac1 associated GEF 1 [KO:K05731]
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
4342  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
28984  RGCC; regulator of cell cycle [KO:K26108]
9138  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
2909  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
387  RHOA; ras homolog family member A [KO:K04513]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
5880  RAC2; Rac family small GTPase 2 [KO:K07860]
5881  RAC3; Rac family small GTPase 3 [KO:K07861]
998  CDC42; cell division cycle 42 [KO:K04393]
5058  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
5062  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
5063  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
10298  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
57144  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
56924  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
106821730  BUB1B-PAK6; BUB1B-PAK6 readthrough [KO:K05735] [EC:2.7.11.1]
8874  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
28964  GIT1; GIT ArfGAP 1 [KO:K05737]
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
4638  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
85366  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
91807  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
340156  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
4659  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
4660  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
54776  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
4633  MYL2; myosin light chain 2 [KO:K10351]
4636  MYL5; myosin light chain 5 [KO:K12753]
58498  MYL7; myosin light chain 7 [KO:K12754]
10398  MYL9; myosin light chain 9 [KO:K12755]
93408  MYL10; myosin light chain 10 [KO:K12756]
103910  MYL12B; myosin light chain 12B [KO:K12757]
10627  MYL12A; myosin light chain 12A [KO:K12757]
29895  MYL11; myosin light chain 11 [KO:K12758]
4627  MYH9; myosin heavy chain 9 [KO:K10352]
4628  MYH10; myosin heavy chain 10 [KO:K10352]
4629  MYH11; myosin heavy chain 11 [KO:K10352]
79784  MYH14; myosin heavy chain 14 [KO:K10352]
1729  DIAPH1; diaphanous related formin 1 [KO:K05740]
1730  DIAPH2; diaphanous related formin 2 [KO:K05741]
6548  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
23396  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
8394  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
79837  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
5305  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
8396  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
200576  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
3984  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
3985  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
81624  DIAPH3; diaphanous related formin 3 [KO:K05745]
10458  BAIAP2; BAR/IMD domain containing adaptor protein 2 [KO:K05627]
55740  ENAH; ENAH actin regulator [KO:K05746]
8976  WASL; WASP like actin nucleation promoting factor [KO:K23612]
10163  WASF2; WASP family member 2 [KO:K05748]
23191  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
26999  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
10787  NCKAP1; NCK associated protein 1 [KO:K05750]
3071  NCKAP1L; NCK associated protein 1 like [KO:K05750]
10152  ABI2; abl interactor 2 [KO:K05751]
55845  BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex [KO:K05752]
8936  WASF1; WASP family member 1 [KO:K05753]
10097  ACTR2; actin related protein 2 [KO:K17260]
57180  ACTR3B; actin related protein 3B [KO:K18584]
653857  ACTR3C; actin related protein 3C [KO:K18584]
10096  ACTR3; actin related protein 3 [KO:K18584]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
71  ACTG1; actin gamma 1 [KO:K05692]
60  ACTB; actin beta [KO:K05692]
345456  PFN3; profilin 3 [KO:K05759]
5216  PFN1; profilin 1 [KO:K05759]
5217  PFN2; profilin 2 [KO:K05759]
375189  PFN4; profilin family member 4 [KO:K05759]
5829  PXN; paxillin [KO:K05760]
7430  EZR; ezrin [KO:K08007]
5962  RDX; radixin [KO:K05762]
4478  MSN; moesin [KO:K05763]
7114  TMSB4X; thymosin beta 4 X-linked [KO:K05764]
9087  TMSB4Y; thymosin beta 4 Y-linked [KO:K05764]
1072  CFL1; cofilin 1 [KO:K05765]
1073  CFL2; cofilin 2 [KO:K05765]
54434  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
54961  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
85464  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
7414  VCL; vinculin [KO:K05700]
8826  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
10788  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
128239  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
2934  GSN; gelsolin [KO:K05768]
85477  SCIN; scinderin [KO:K05768]
87  ACTN1; actinin alpha 1 [KO:K05699]
81  ACTN4; actinin alpha 4 [KO:K05699]
324  APC; APC regulator of WNT signaling pathway [KO:K02085]
10297  APC2; APC regulator of WNT signaling pathway 2 [KO:K02085]
50649  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
221178  SPATA13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hsa04010  MAPK signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
KO pathway
ko04810   

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Network (4)   
   KEGG NETWORK (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (229)   
   KEGG GENES (229)   
All databases (234)   

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