Entry |
|
Name |
Progesterone-mediated oocyte maturation - Homo sapiens (human)
|
Description |
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
|
Class |
Organismal Systems; Endocrine system
|
Pathway map |
hsa04914 | Progesterone-mediated oocyte maturation |

|
Disease |
H01274 | Growth delay due to insulin-like growth factor I resistance |
|
Drug |
D00066 | Progesterone (JP17/USP/INN) |
D00585 | Mifepristone (JAN/USAN/INN) |
D00949 | Hydroxyprogesterone caproate (JAN/USP/INN) |
D00950 | Levonorgestrel (JAN/USP/INN) |
D00951 | Medroxyprogesterone acetate (JP17/USP) |
D00952 | Megestrol acetate (USP) |
D00953 | Norethindrone acetate (USP) |
D00954 | Norgestrel (JP17/USP/INN) |
D01159 | Gestonorone caproate (JAN/USAN) |
D01217 | Dydrogesterone (JP17/USP/INN) |
D01294 | Ethynodiol diacetate (JAN/USP) |
D01299 | Chlormadinone acetate (JP17/USAN) |
D01374 | Allylestrenol (JAN/INN) |
D03799 | Dienogest (JAN/USAN/INN) |
D03917 | Drospirenone (JAN/USP/INN) |
D04104 | Etonogestrel (USAN/INN) |
D04885 | Medrogestone (USAN/INN) |
D05003 | Methynodiol diacetate (USAN) |
D05205 | Norelgestromin (USP/INN) |
D05308 | Oxogestone phenpropionate (USAN) |
D05679 | Quingestanol acetate (USAN) |
D05680 | Quingestrone (USAN/INN) |
D06235 | Trimegestone (USAN/INN) |
D08052 | Hydroxyprogesterone (INN) |
D08053 | Hydroxyprogesterone 17alfa-acetate |
D08166 | Medroxyprogesterone (INN) |
D08281 | Nomegestrol acetate (USAN) |
D08285 | Norethisterone enantate |
D09687 | Ulipristal acetate (JAN/USAN) |
D09972 | Telapristone acetate (USAN) |
D10986 | Segesterone acetate (USAN) |
D11181 | Vilaprisan (JAN/USAN/INN) |
|
Other DBs |
|
Organism |
Homo sapiens (human) [GN: hsa]
|
Gene |
5295 | PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] |
5296 | PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] |
8503 | PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] |
2770 | GNAI1; G protein subunit alpha i1 [KO:K04630] |
2773 | GNAI3; G protein subunit alpha i3 [KO:K04630] |
2771 | GNAI2; G protein subunit alpha i2 [KO:K04630] |
64506 | CPEB1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602] |
132864 | CPEB2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602] |
22849 | CPEB3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602] |
80315 | CPEB4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602] |
245711 | SPDYA; speedy/RINGO cell cycle regulator family member A [KO:K08694] |
387778 | SPDYC; speedy/RINGO cell cycle regulator family member C [KO:K08694] |
100310812 | SPDYE2B; speedy/RINGO cell cycle regulator family member E2B [KO:K08694] |
100505767 | SPDYE18; speedy/RINGO cell cycle regulator family member E18 [KO:K08694] |
100996746 | SPDYE11; speedy/RINGO cell cycle regulator family member E11 [KO:K08694] |
102723555 | SPDYE16; speedy/RINGO cell cycle regulator family member E16 [KO:K08694] |
102723849 | SPDYE17; speedy/RINGO cell cycle regulator family member E17 [KO:K08694] |
285955 | SPDYE1; speedy/RINGO cell cycle regulator family member E1 [KO:K08694] |
388333 | SPDYE4; speedy/RINGO cell cycle regulator family member E4 [KO:K08694] |
441272 | SPDYE3; speedy/RINGO cell cycle regulator family member E3 [KO:K08694] |
441273 | SPDYE2; speedy/RINGO cell cycle regulator family member E2 [KO:K08694] |
442590 | SPDYE5; speedy/RINGO cell cycle regulator family member E5 [KO:K08694] |
729597 | SPDYE6; speedy/RINGO cell cycle regulator family member E6 [KO:K08694] |
105180391 | SPDYE15; speedy/RINGO cell cycle regulator family member E15 [KO:K08694] |
3320 | HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079] |
3326 | HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079] |
9088 | PKMYT1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:2.7.11.1] |
3479 | IGF1; insulin like growth factor 1 [KO:K05459] |
3845 | KRAS; KRAS proto-oncogene, GTPase [KO:K07827] |
8379 | MAD1L1; mitotic arrest deficient 1 like 1 [KO:K06679] |
4085 | MAD2L1; mitotic arrest deficient 2 like 1 [KO:K02537] |
10459 | MAD2L2; mitotic arrest deficient 2 like 2 [KO:K13728] |
51343 | FZR1; fizzy and cell division cycle 20 related 1 [KO:K03364] |
64682 | ANAPC1; anaphase promoting complex subunit 1 [KO:K03348] |
29882 | ANAPC2; anaphase promoting complex subunit 2 [KO:K03349] |
996 | CDC27; cell division cycle 27 [KO:K03350] |
29945 | ANAPC4; anaphase promoting complex subunit 4 [KO:K03351] |
51433 | ANAPC5; anaphase promoting complex subunit 5 [KO:K03352] |
51434 | ANAPC7; anaphase promoting complex subunit 7 [KO:K03354] |
10393 | ANAPC10; anaphase promoting complex subunit 10 [KO:K03357] |
51529 | ANAPC11; anaphase promoting complex subunit 11 [KO:K03358] |
25847 | ANAPC13; anaphase promoting complex subunit 13 [KO:K12456] |
|
Compound |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
C11554 | 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate |
|
Reference |
|
Authors |
Schmitt A, Nebreda AR. |
Title |
Signalling pathways in oocyte meiotic maturation. |
Journal |
J Cell Sci 115:2457-9 (2002) |
Reference |
|
Authors |
Cato AC, Nestl A, Mink S. |
Title |
Rapid actions of steroid receptors in cellular signaling pathways. |
Journal |
|
Reference |
|
Authors |
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ. |
Title |
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes. |
Journal |
|
Reference |
|
Authors |
Nebreda AR, Ferby I. |
Title |
Regulation of the meiotic cell cycle in oocytes. |
Journal |
|
Reference |
|
Authors |
Ferrell JE Jr. |
Title |
Xenopus oocyte maturation: new lessons from a good egg. |
Journal |
|
Reference |
|
Authors |
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA. |
Title |
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes. |
Journal |
|
Reference |
|
Authors |
Duckworth BC, Weaver JS, Ruderman JV. |
Title |
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. |
Journal |
|
Reference |
|
Authors |
Abrieu A, Doree M, Fisher D. |
Title |
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes. |
Journal |
J Cell Sci 114:257-67 (2001) |
Related pathway |
|
KO pathway |
|