KEGG   PATHWAY: hsa05132Help
Entry
hsa05132                    Pathway                                

Name
Salmonella infection - Homo sapiens (human)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious diseases: Bacterial
BRITE hierarchy
Pathway map
hsa05132  Salmonella infection
hsa05132

Ortholog table
Disease
H00111  Typhoid fever
Organism
Homo sapiens (human) [GN:hsa]
Gene
929  CD14; CD14 molecule [KO:K04391]
7099  TLR4; toll like receptor 4 [KO:K10160]
3929  LBP; lipopolysaccharide binding protein [KO:K05399]
4615  MYD88; MYD88, innate immune signal transduction adaptor [KO:K04729]
7100  TLR5; toll like receptor 5 [KO:K10168]
58484  NLRC4; NLR family CARD domain containing 4 [KO:K12805]
29108  PYCARD; PYD and CARD domain containing [KO:K12799]
834  CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
998  CDC42; cell division cycle 42 [KO:K04393]
391  RHOG; ras homolog family member G [KO:K07863]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
3606  IL18; interleukin 18 [KO:K05482]
3553  IL1B; interleukin 1 beta [KO:K04519]
3552  IL1A; interleukin 1 alpha [KO:K04383]
3569  IL6; interleukin 6 [KO:K05405]
3576  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
6348  CCL3; C-C motif chemokine ligand 3 [KO:K05408]
6349  CCL3L1; C-C motif chemokine ligand 3 like 1 [KO:K05408]
414062  CCL3L3; C-C motif chemokine ligand 3 like 3 [KO:K05408]
6351  CCL4; C-C motif chemokine ligand 4 [KO:K12964]
9560  CCL4L2; C-C motif chemokine ligand 4 like 2 [KO:K12964]
388372  CCL4L1; C-C motif chemokine ligand 4 like 1 [KO:K12964]
2919  CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505]
2920  CXCL2; C-X-C motif chemokine ligand 2 [KO:K05505]
2921  CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505]
1437  CSF2; colony stimulating factor 2 [KO:K05427]
8936  WASF1; WAS protein family member 1 [KO:K05753]
10163  WASF2; WAS protein family member 2 [KO:K05748]
7454  WAS; Wiskott-Aldrich syndrome [KO:K05747]
8976  WASL; Wiskott-Aldrich syndrome like [KO:K05747]
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
7082  TJP1; tight junction protein 1 [KO:K05701]
60  ACTB; actin beta [KO:K05692]
71  ACTG1; actin gamma 1 [KO:K05692]
5585  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
29941  PKN3; protein kinase N3 [KO:K06071] [EC:2.7.11.13]
5586  PKN2; protein kinase N2 [KO:K06071] [EC:2.7.11.13]
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
23207  PLEKHM2; pleckstrin homology and RUN domain containing M2 [KO:K15348]
147700  KLC3; kinesin light chain 3 [KO:K10407]
3831  KLC1; kinesin light chain 1 [KO:K10407]
64837  KLC2; kinesin light chain 2 [KO:K10407]
89953  KLC4; kinesin light chain 4 [KO:K10407]
7879  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
338382  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
83547  RILP; Rab interacting lysosomal protein [KO:K13883]
1778  DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
79659  DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
1780  DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
1781  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
1783  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
51143  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
345456  PFN3; profilin 3 [KO:K05759]
5216  PFN1; profilin 1 [KO:K05759]
5217  PFN2; profilin 2 [KO:K05759]
375189  PFN4; profilin family member 4 [KO:K05759]
2316  FLNA; filamin A [KO:K04437]
2318  FLNC; filamin C [KO:K04437]
2317  FLNB; filamin B [KO:K04437]
3458  IFNG; interferon gamma [KO:K04687]
3459  IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460  IFNGR2; interferon gamma receptor 2 [KO:K05133]
4843  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
4627  MYH9; myosin heavy chain 9 [KO:K10352]
4628  MYH10; myosin heavy chain 10 [KO:K10352]
79784  MYH14; myosin heavy chain 14 [KO:K10352]
Compound
C00062  L-Arginine
C00338  Lipopolysaccharide
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Reference
  Authors
Trebichavsky I, Splichal I, Splichalova A
  Title
Innate immune response in the gut against Salmonella - review.
  Journal
Folia Microbiol (Praha) 55:295-300 (2010)
DOI:10.1007/s12223-010-0044-3
Reference
  Authors
Talbot S, Totemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE
  Title
Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
  Journal
Immunology 128:472-83 (2009)
DOI:10.1111/j.1365-2567.2009.03146.x
Reference
  Authors
Ibarra JA, Steele-Mortimer O
  Title
Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
  Journal
Cell Microbiol 11:1579-86 (2009)
DOI:10.1111/j.1462-5822.2009.01368.x
Reference
  Authors
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL
  Title
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
  Journal
J Immunol 167:1882-5 (2001)
DOI:10.4049/jimmunol.167.4.1882
Reference
  Authors
Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS
  Title
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
  Journal
Am J Pathol 169:1686-700 (2006)
DOI:10.2353/ajpath.2006.060345
Reference
  Authors
Miao EA, Andersen-Nissen E, Warren SE, Aderem A
  Title
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
  Journal
Semin Immunopathol 29:275-88 (2007)
DOI:10.1007/s00281-007-0078-z
Reference
  Authors
Bueno SM, Riedel CA, Carreno LJ, Kalergis AM
  Title
Virulence mechanisms displayed by Salmonella to impair dendritic cell function.
  Journal
Curr Med Chem 17:1156-66 (2010)
DOI:10.2174/092986710790827825
Reference
  Authors
Haraga A, Ohlson MB, Miller SI
  Title
Salmonellae interplay with host cells.
  Journal
Nat Rev Microbiol 6:53-66 (2008)
DOI:10.1038/nrmicro1788
Reference
  Authors
Kimbrough TG, Miller SI
  Title
Assembly of the type III secretion needle complex of Salmonella typhimurium.
  Journal
Microbes Infect 4:75-82 (2002)
DOI:10.1016/S1286-4579(01)01512-X
Reference
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
  Authors
Bulgin R, Raymond B, Garnett JA, Frankel G, Crepin VF, Berger CN, Arbeloa A
  Title
Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.
  Journal
Infect Immun 78:1417-25 (2010)
DOI:10.1128/IAI.01250-09
Reference
  Authors
Bakowski MA, Braun V, Brumell JH
  Title
Salmonella-containing vacuoles: directing traffic and nesting to grow.
  Journal
Traffic 9:2022-31 (2008)
DOI:10.1111/j.1600-0854.2008.00827.x
Reference
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
  Authors
Nikolaus T, Deiwick J, Rappl C, Freeman JA, Schroder W, Miller SI, Hensel M
  Title
SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon.
  Journal
J Bacteriol 183:6036-45 (2001)
DOI:10.1128/JB.183.20.6036-6045.2001
Reference
  Authors
Eckmann L, Kagnoff MF
  Title
Cytokines in host defense against Salmonella.
  Journal
Microbes Infect 3:1191-200 (2001)
DOI:10.1016/S1286-4579(01)01479-4
Reference
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Reference
  Authors
Du F, Galan JE
  Title
Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA.
  Journal
PLoS Pathog 5:e1000595 (2009)
DOI:10.1371/journal.ppat.1000595
Reference
  Authors
Jones RM, Wu H, Wentworth C, Luo L, Collier-Hyams L, Neish AS
  Title
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade.
  Journal
Cell Host Microbe 3:233-44 (2008)
DOI:10.1016/j.chom.2008.02.016
Reference
  Authors
Haraga A, Miller SI
  Title
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.
  Journal
Cell Microbiol 8:837-46 (2006)
DOI:10.1111/j.1462-5822.2005.00670.x
Reference
  Authors
Abrahams GL, Muller P, Hensel M
  Title
Functional dissection of SseF, a type III effector protein involved in positioning the salmonella-containing vacuole.
  Journal
Traffic 7:950-65 (2006)
DOI:10.1111/j.1600-0854.2006.00454.x
Reference
  Authors
Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S
  Title
The Salmonella effector protein PipB2 is a linker for kinesin-1.
  Journal
Proc Natl Acad Sci U S A 103:13497-502 (2006)
DOI:10.1073/pnas.0605443103
Reference
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
  Authors
Prior K, Hautefort I, Hinton JC, Richardson DJ, Rowley G
  Title
All stressed out. Salmonella pathogenesis and reactive nitrogen species.
  Journal
Adv Microb Physiol 56:1-28 (2009)
DOI:10.1016/S0065-2911(09)05601-X
KO pathway
ko05132   

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