KEGG   PATHWAY: hsa05160Help
Entry
hsa05160                    Pathway                                

Name
Hepatitis C - Homo sapiens (human)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious diseases: Viral
BRITE hierarchy
Pathway map
hsa05160  Hepatitis C
hsa05160

Ortholog table
Network
N00269  HCV Core to host-cell-protein activation
N00270  HCV Core to host-cell-protein inhibition
N00271  HCV NS3 to host-cell-protein inhibition
N00272  HCV NS5A to host-cell-protein activation
N00273  HCV NS5A to host-cell-protein inhibition
N00274  HCV NS5A binding to host-cell-protein
Disease
H00048  Hepatocellular carcinoma
H00413  Hepatitis C
Drug
D02745  Interferon alfa-2b (USAN)
D02747  Peginterferon alfa-2a (USAN/INN)
D02748  Peginterferon alfa-2b (INN)
D03304  Interferon beta (JAN)
D03305  Interferon alfa (NAMALWA) (JP17)
Organism
Homo sapiens (human) [GN:hsa]
Gene
3949  LDLR; low density lipoprotein receptor [KO:K12473]
949  SCARB1; scavenger receptor class B member 1 [KO:K13885]
975  CD81; CD81 molecule [KO:K06508]
1364  CLDN4; claudin 4 [KO:K06087]
1365  CLDN3; claudin 3 [KO:K06087]
1366  CLDN7; claudin 7 [KO:K06087]
149461  CLDN19; claudin 19 [KO:K06087]
10686  CLDN16; claudin 16 [KO:K06087]
23562  CLDN14; claudin 14 [KO:K06087]
24146  CLDN15; claudin 15 [KO:K06087]
26285  CLDN17; claudin 17 [KO:K06087]
49861  CLDN20; claudin 20 [KO:K06087]
5010  CLDN11; claudin 11 [KO:K06087]
51208  CLDN18; claudin 18 [KO:K06087]
53842  CLDN22; claudin 22 [KO:K06087]
7122  CLDN5; claudin 5 [KO:K06087]
9071  CLDN10; claudin 10 [KO:K06087]
9073  CLDN8; claudin 8 [KO:K06087]
9074  CLDN6; claudin 6 [KO:K06087]
9075  CLDN2; claudin 2 [KO:K06087]
9076  CLDN1; claudin 1 [KO:K06087]
9080  CLDN9; claudin 9 [KO:K06087]
137075  CLDN23; claudin 23 [KO:K06087]
644672  CLDN25; claudin 25 [KO:K06087]
100132463  CLDN24; claudin 24 [KO:K06087]
100506658  OCLN; occludin [KO:K06088]
4938  OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
4939  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
4940  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
6041  RNASEL; ribonuclease L [KO:K01165]
23586  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:3.6.3.14]
57506  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
7187  TRAF3; TNF receptor associated factor 3 [KO:K03174]
29110  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
3661  IRF3; interferon regulatory factor 3 [KO:K05411]
3665  IRF7; interferon regulatory factor 7 [KO:K09447]
3456  IFNB1; interferon beta 1 [KO:K05415]
7098  TLR3; toll like receptor 3 [KO:K05401]
148022  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
8737  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
1147  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
4792  NFKBIA; NFKB inhibitor alpha [KO:K04734]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
3659  IRF1; interferon regulatory factor 1 [KO:K09444]
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
3576  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
6774  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
3434  IFIT1; interferon induced protein with tetratricopeptide repeats 1 [KO:K14217]
439996  IFIT1B; interferon induced protein with tetratricopeptide repeats 1B [KO:K14217]
3646  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
3439  IFNA1; interferon alpha 1 [KO:K05414]
3440  IFNA2; interferon alpha 2 [KO:K05414]
3441  IFNA4; interferon alpha 4 [KO:K05414]
3442  IFNA5; interferon alpha 5 [KO:K05414]
3443  IFNA6; interferon alpha 6 [KO:K05414]
3444  IFNA7; interferon alpha 7 [KO:K05414]
3445  IFNA8; interferon alpha 8 [KO:K05414]
3446  IFNA10; interferon alpha 10 [KO:K05414]
3447  IFNA13; interferon alpha 13 [KO:K05414]
3448  IFNA14; interferon alpha 14 [KO:K05414]
3449  IFNA16; interferon alpha 16 [KO:K05414]
3451  IFNA17; interferon alpha 17 [KO:K05414]
3452  IFNA21; interferon alpha 21 [KO:K05414]
3454  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
3455  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
3716  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
7297  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6772  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
6773  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
10379  IRF9; interferon regulatory factor 9 [KO:K04693]
9021  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
5519  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
5518  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
5520  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
5521  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
5522  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
55844  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
5515  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
5516  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
8554  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706]
1950  EGF; epidermal growth factor [KO:K04357]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2885  GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5170  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
2932  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
572  BAD; BCL2 associated agonist of cell death [KO:K02158]
7157  TP53; tumor protein p53 [KO:K04451]
1026  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
7124  TNF; tumor necrosis factor [KO:K03156]
7132  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
7186  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
8717  TRADD; TNFRSF1A associated via death domain [KO:K03171]
10197  PSME3; proteasome activator subunit 3 [KO:K06698]
6256  RXRA; retinoid X receptor alpha [KO:K08524]
5465  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
10062  NR1H3; nuclear receptor subfamily 1 group H member 3 [KO:K08536]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Polyak SJ
  Title
Hepatitis C virus--cell interactions and their role in pathogenesis.
  Journal
Clin Liver Dis 7:67-88 (2003)
DOI:10.1016/S1089-3261(02)00075-2
Reference
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
  Authors
Giannini C, Brechot C
  Title
Hepatitis C virus biology.
  Journal
Cell Death Differ 10 Suppl 1:S27-38 (2003)
DOI:10.1038/sj.cdd.4401121
Reference
  Authors
Tang H, Grise H
  Title
Cellular and molecular biology of HCV infection and hepatitis.
  Journal
Clin Sci (Lond) 117:49-65 (2009)
DOI:10.1042/CS20080631
Reference
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
  Authors
Georgel P, Schuster C, Zeisel MB, Stoll-Keller F, Berg T, Bahram S, Baumert TF
  Title
Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies.
  Journal
Trends Mol Med 16:277-86 (2010)
DOI:10.1016/j.molmed.2010.04.003
Reference
  Authors
Freundt EC, Lenardo MJ
  Title
Interfering with interferons: Hepatitis C virus counters innate immunity.
  Journal
Proc Natl Acad Sci U S A 102:17539-40 (2005)
DOI:10.1073/pnas.0509221102
Reference
  Authors
Ishii S, Koziel MJ
  Title
Immune responses during acute and chronic infection with hepatitis C virus.
  Journal
Clin Immunol 128:133-47 (2008)
DOI:10.1016/j.clim.2008.03.525
Reference
  Authors
Asselah T, Bieche I, Sabbagh A, Bedossa P, Moreau R, Valla D, Vidaud M, Marcellin P
  Title
Gene expression and hepatitis C virus infection.
  Journal
Gut 58:846-58 (2009)
DOI:10.1136/gut.2008.166348
Reference
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
  Authors
Han JQ, Barton DJ
  Title
Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.
  Journal
RNA 8:512-25 (2002)
DOI:10.1017/S1355838202020617
Reference
  Authors
Negro F, Sanyal AJ
  Title
Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data.
  Journal
Liver Int 29 Suppl 2:26-37 (2009)
DOI:10.1111/j.1478-3231.2008.01950.x
Reference
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
  Authors
Tan SL (ed).
  Title
Hepatitis C Viruses Genomes and Molecular Biology
  Journal
Horizon Bioscience (2006)
KO pathway
ko05160   

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