KEGG   PATHWAY: hsa05162Help
hsa05162                    Pathway                                

Measles - Homo sapiens (human)
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation.
Human Diseases; Infectious diseases: Viral
BRITE hierarchy
Pathway map
hsa05162  Measles

Ortholog table
H00394  Measles
D03305  Interferon alfa (NAMALWA) (JP17)
Homo sapiens (human) [GN:hsa]
4478  MSN; moesin [KO:K05763]
10332  CLEC4M; C-type lectin domain family 4 member M [KO:K06563]
30835  CD209; CD209 molecule [KO:K06563]
6869  TACR1; tachykinin receptor 1 [KO:K04222]
4179  CD46; CD46 molecule [KO:K04007]
6504  SLAMF1; signaling lymphocytic activation molecule family member 1 [KO:K06536]
4068  SH2D1A; SH2 domain containing 1A [KO:K07990]
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:]
1796  DOK1; docking protein 1 [KO:K14752]
5588  PRKCQ; protein kinase C theta [KO:K18052] [EC:]
3596  IL13; interleukin 13 [KO:K05435]
3565  IL4; interleukin 4 [KO:K05430]
915  CD3D; CD3d molecule [KO:K06450]
916  CD3E; CD3e molecule [KO:K06451]
917  CD3G; CD3g molecule [KO:K06452]
940  CD28; CD28 molecule [KO:K06470]
3558  IL2; interleukin 2 [KO:K05429]
3559  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3560  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
868  CBLB; Cbl proto-oncogene B [KO:K22517] [EC:]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
2932  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:]
3716  JAK1; Janus kinase 1 [KO:K11217] [EC:]
3718  JAK3; Janus kinase 3 [KO:K11218] [EC:]
6774  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
6776  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
6777  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
23586  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:]
64135  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:]
57506  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:]
29110  TBK1; TANK binding kinase 1 [KO:K05410] [EC:]
3661  IRF3; interferon regulatory factor 3 [KO:K05411]
51284  TLR7; toll like receptor 7 [KO:K05404]
54106  TLR9; toll like receptor 9 [KO:K10161]
4615  MYD88; MYD88, innate immune signal transduction adaptor [KO:K04729]
3654  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:]
51135  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:]
3665  IRF7; interferon regulatory factor 7 [KO:K09447]
1147  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:]
7097  TLR2; toll like receptor 2 [KO:K10159]
7099  TLR4; toll like receptor 4 [KO:K10160]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:]
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:]
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [KO:K04404]
4793  NFKBIB; NFKB inhibitor beta [KO:K02581]
4792  NFKBIA; NFKB inhibitor alpha [KO:K04734]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
1457  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:]
1459  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:]
283106  CSNK2A3; casein kinase 2 alpha 3 [KO:K03097] [EC:]
1460  CSNK2B; casein kinase 2 beta [KO:K03115]
7128  TNFAIP3; TNF alpha induced protein 3 [KO:K11859] [EC:]
3439  IFNA1; interferon alpha 1 [KO:K05414]
3440  IFNA2; interferon alpha 2 [KO:K05414]
3441  IFNA4; interferon alpha 4 [KO:K05414]
3442  IFNA5; interferon alpha 5 [KO:K05414]
3443  IFNA6; interferon alpha 6 [KO:K05414]
3444  IFNA7; interferon alpha 7 [KO:K05414]
3445  IFNA8; interferon alpha 8 [KO:K05414]
3446  IFNA10; interferon alpha 10 [KO:K05414]
3447  IFNA13; interferon alpha 13 [KO:K05414]
3448  IFNA14; interferon alpha 14 [KO:K05414]
3449  IFNA16; interferon alpha 16 [KO:K05414]
3451  IFNA17; interferon alpha 17 [KO:K05414]
3452  IFNA21; interferon alpha 21 [KO:K05414]
3456  IFNB1; interferon beta 1 [KO:K05415]
3552  IL1A; interleukin 1 alpha [KO:K04383]
3553  IL1B; interleukin 1 beta [KO:K04519]
3569  IL6; interleukin 6 [KO:K05405]
3592  IL12A; interleukin 12A [KO:K05406]
3593  IL12B; interleukin 12B [KO:K05425]
102723407  IGH; immunoglobulin heavy variable 4-38-2-like [KO:K06856]
2213  FCGR2B; Fc fragment of IgG receptor IIb [KO:K12560]
3454  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
3455  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
10399  RACK1; receptor for activated C kinase 1 [KO:K14753]
7297  TYK2; tyrosine kinase 2 [KO:K11219] [EC:]
6772  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
6773  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
10379  IRF9; interferon regulatory factor 9 [KO:K04693]
3458  IFNG; interferon gamma [KO:K04687]
3459  IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460  IFNGR2; interferon gamma receptor 2 [KO:K05133]
3717  JAK2; Janus kinase 2 [KO:K04447] [EC:]
4938  OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:]
4939  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:]
4940  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:]
103  ADAR; adenosine deaminase, RNA specific [KO:K12968] [EC:]
4599  MX1; MX dynamin like GTPase 1 [KO:K14754]
595  CCND1; cyclin D1 [KO:K04503]
894  CCND2; cyclin D2 [KO:K10151]
896  CCND3; cyclin D3 [KO:K10152]
898  CCNE1; cyclin E1 [KO:K06626]
9134  CCNE2; cyclin E2 [KO:K06626]
1019  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:]
1021  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:]
1017  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:]
1027  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
9367  RAB9A; RAB9A, member RAS oncogene family [KO:K07899]
51209  RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
3312  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
3303  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
3306  HSPA2; heat shock protein family A (Hsp70) member 2 [KO:K03283]
3305  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
3304  HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
3310  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
8667  EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:]
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:]
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:]
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:]
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
25898  RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:]
7157  TP53; tumor protein p53 [KO:K04451]
7161  TP73; tumor protein p73 [KO:K10148]
27113  BBC3; BCL2 binding component 3 [KO:K10132]
356  FASLG; Fas ligand [KO:K04389]
355  FAS; Fas cell surface death receptor [KO:K04390]
8743  TNFSF10; TNF superfamily member 10 [KO:K04721]
8797  TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722]
8795  TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722]
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Schneider-Schaulies S, Schneider-Schaulies J
Measles virus-induced immunosuppression.
Curr Top Microbiol Immunol 330:243-69 (2009)
Navaratnarajah CK, Leonard VH, Cattaneo R
Measles virus glycoprotein complex assembly, receptor attachment, and cell entry.
Curr Top Microbiol Immunol 329:59-76 (2009)
Hahm B
Hostile communication of measles virus with host innate immunity and dendritic cells.
Curr Top Microbiol Immunol 330:271-87 (2009)
Naniche D
Human immunology of measles virus infection.
Curr Top Microbiol Immunol 330:151-71 (2009)
Gerlier D, Valentin H
Measles virus interaction with host cells and impact on innate immunity.
Curr Top Microbiol Immunol 329:163-91 (2009)
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
Virology 306:135-46 (2003)
Yanagi Y, Takeda M, Ohno S
Measles virus: cellular receptors, tropism and pathogenesis.
J Gen Virol 87:2767-79 (2006)
Kerdiles YM, Sellin CI, Druelle J, Horvat B
Immunosuppression caused by measles virus: role of viral proteins.
Rev Med Virol 16:49-63 (2006)
Schneider-Schaulies S, Dittmer U
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
J Gen Virol 87:1423-38 (2006)
Avota E, Gassert E, Schneider-Schaulies S
Measles virus-induced immunosuppression: from effectors to mechanisms.
Med Microbiol Immunol 199:227-37 (2010)
Schneider-Schaulies J, ter Meulen V, Schneider-Schaulies S
Measles virus interactions with cellular receptors: consequences for viral pathogenesis.
J Neurovirol 7:391-9 (2001)
Griffin DE
Measles virus-induced suppression of immune responses.
Immunol Rev 236:176-89 (2010)
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
Nat Med 7:725-31 (2001)
Pfaller CK, Conzelmann KK
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
J Virol 82:12365-73 (2008)
Yokota S, Okabayashi T, Yokosawa N, Fujii N
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
FASEB J 22:74-83 (2008)
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
FEBS Lett 545:177-82 (2003)
Gotoh B, Komatsu T, Takeuchi K, Yokoo J
Paramyxovirus strategies for evading the interferon response.
Rev Med Virol 12:337-57 (2002)
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
J Virol 77:7635-44 (2003)
Shaffer JA, Bellini WJ, Rota PA
The C protein of measles virus inhibits the type I interferon response.
Virology 315:389-97 (2003)
KO pathway

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