KEGG   PATHWAY: hsa05168Help
Entry
hsa05168                    Pathway                                

Name
Herpes simplex infection - Homo sapiens (human)
Description
Herpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishment of latent infection in neuronal ganglia. HSV is the main cause of herpes infections that lead to the formation of characteristic blistering lesion. HSV express multiple viral accessory proteins that interfere with host immune responses and are indispensable for viral replication. Among these proteins, the immediate early (IE) gene ICP0, ICP4, and ICP27 are essential for regulation of HSV gene expression in productive infection. On the other hand, ORF P and ORF O gene are transcribed during latency and blocks the expression of the IE genes, thus maintaining latent infection.
Class
Human Diseases; Infectious diseases: Viral
BRITE hierarchy
Pathway map
hsa05168  Herpes simplex infection
hsa05168

Ortholog table
Module
hsa_M00381  SCF-SKP2 complex [PATH:hsa05168]
Disease
H00365  Herpes simplex infection
Organism
Homo sapiens (human) [GN:hsa]
Gene
4049  LTA; lymphotoxin alpha [KO:K05468]
8740  TNFSF14; TNF superfamily member 14 [KO:K05477]
8764  TNFRSF14; TNF receptor superfamily member 14 [KO:K05152]
7185  TRAF1; TNF receptor associated factor 1 [KO:K03172]
7186  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
7187  TRAF3; TNF receptor associated factor 3 [KO:K03174]
7188  TRAF5; TNF receptor associated factor 5 [KO:K09849]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
1147  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
4792  NFKBIA; NFKB inhibitor alpha [KO:K04734]
4793  NFKBIB; NFKB inhibitor beta [KO:K02581]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
5818  NECTIN1; nectin cell adhesion molecule 1 [KO:K06081]
5819  NECTIN2; nectin cell adhesion molecule 2 [KO:K06531]
29992  PILRA; paired immunoglobin like type 2 receptor alpha [KO:K15411]
5781  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
7097  TLR2; toll like receptor 2 [KO:K10159]
4615  MYD88; MYD88, innate immune signal transduction adaptor [KO:K04729]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [KO:K04404]
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
54106  TLR9; toll like receptor 9 [KO:K10161]
7098  TLR3; toll like receptor 3 [KO:K05401]
148022  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
3661  IRF3; interferon regulatory factor 3 [KO:K05411]
3665  IRF7; interferon regulatory factor 7 [KO:K09447]
23586  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:3.6.4.13]
64135  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
57506  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
29110  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
6347  CCL2; C-C motif chemokine ligand 2 [KO:K14624]
6352  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
7124  TNF; tumor necrosis factor [KO:K03156]
3553  IL1B; interleukin 1 beta [KO:K04519]
3569  IL6; interleukin 6 [KO:K05405]
3592  IL12A; interleukin 12A [KO:K05406]
3593  IL12B; interleukin 12B [KO:K05425]
3600  IL15; interleukin 15 [KO:K05433]
3439  IFNA1; interferon alpha 1 [KO:K05414]
3440  IFNA2; interferon alpha 2 [KO:K05414]
3441  IFNA4; interferon alpha 4 [KO:K05414]
3442  IFNA5; interferon alpha 5 [KO:K05414]
3443  IFNA6; interferon alpha 6 [KO:K05414]
3444  IFNA7; interferon alpha 7 [KO:K05414]
3445  IFNA8; interferon alpha 8 [KO:K05414]
3446  IFNA10; interferon alpha 10 [KO:K05414]
3447  IFNA13; interferon alpha 13 [KO:K05414]
3448  IFNA14; interferon alpha 14 [KO:K05414]
3449  IFNA16; interferon alpha 16 [KO:K05414]
3451  IFNA17; interferon alpha 17 [KO:K05414]
3452  IFNA21; interferon alpha 21 [KO:K05414]
3434  IFIT1; interferon induced protein with tetratricopeptide repeats 1 [KO:K14217]
439996  IFIT1B; interferon induced protein with tetratricopeptide repeats 1B [KO:K14217]
7874  USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
4938  OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
4939  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
4940  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
6041  RNASEL; ribonuclease L [KO:K01165]
718  C3; complement C3 [KO:K03990]
727  C5; complement C5 [KO:K03994]
5199  CFP; complement factor properdin [KO:K15412]
6500  SKP1; S-phase kinase associated protein 1 [KO:K03094]
54926  UBE2R2; ubiquitin conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
997  CDC34; cell division cycle 34 [KO:K02207] [EC:2.3.2.23]
8454  CUL1; cullin 1 [KO:K03347]
6502  SKP2; S-phase kinase associated protein 2 [KO:K03875]
1936  EEF1D; eukaryotic translation elongation factor 1 delta [KO:K15410]
29997  NOP53; NOP53 ribosome biogenesis factor [KO:K14840]
10445  MCRS1; microspherule protein 1 [KO:K11674]
5430  POLR2A; RNA polymerase II subunit A [KO:K03006] [EC:2.7.7.6]
6732  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
6426  SRSF1; serine and arginine rich splicing factor 1 [KO:K12890]
6427  SRSF2; serine and arginine rich splicing factor 2 [KO:K12891]
10929  SRSF8; serine and arginine rich splicing factor 8 [KO:K12891]
6428  SRSF3; serine and arginine rich splicing factor 3 [KO:K12892]
6429  SRSF4; serine and arginine rich splicing factor 4 [KO:K12893]
6430  SRSF5; serine and arginine rich splicing factor 5 [KO:K12893]
6431  SRSF6; serine and arginine rich splicing factor 6 [KO:K12893]
6432  SRSF7; serine and arginine rich splicing factor 7 [KO:K12896]
8683  SRSF9; serine and arginine rich splicing factor 9 [KO:K21123]
5371  PML; promyelocytic leukemia [KO:K10054]
6672  SP100; SP100 nuclear antigen [KO:K15413]
1387  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
7157  TP53; tumor protein p53 [KO:K04451]
1616  DAXX; death domain associated protein [KO:K02308]
983  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
1017  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
1457  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
1459  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
283106  CSNK2A3; casein kinase 2 alpha 3 [KO:K03097] [EC:2.7.11.1]
1460  CSNK2B; casein kinase 2 beta [KO:K03115]
29915  HCFC2; host cell factor C2 [KO:K14966]
3054  HCFC1; host cell factor C1 [KO:K14966]
387332  TBPL2; TATA-box binding protein like 2 [KO:K03120]
9519  TBPL1; TATA-box binding protein like 1 [KO:K03120]
6908  TBP; TATA-box binding protein [KO:K03120]
51616  TAF9B; TATA-box binding protein associated factor 9b [KO:K03133]
6878  TAF6; TATA-box binding protein associated factor 6 [KO:K03131]
10629  TAF6L; TATA-box binding protein associated factor 6 like [KO:K03131]
27097  TAF5L; TATA-box binding protein associated factor 5 like [KO:K03130]
6877  TAF5; TATA-box binding protein associated factor 5 [KO:K03130]
6875  TAF4B; TATA-box binding protein associated factor 4b [KO:K03129]
6874  TAF4; TATA-box binding protein associated factor 4 [KO:K03129]
83860  TAF3; TATA-box binding protein associated factor 3 [KO:K14650]
6884  TAF13; TATA-box binding protein associated factor 13 [KO:K03127]
6881  TAF10; TATA-box binding protein associated factor 10 [KO:K03134]
112950  MED8; mediator complex subunit 8 [KO:K15129]
9569  GTF2IRD1; GTF2I repeat domain containing 1 [KO:K03121]
2969  GTF2I; general transcription factor IIi [KO:K03121]
3150  HMGN1; high mobility group nucleosome binding domain 1 [KO:K11299]
10189  ALYREF; Aly/REF export factor [KO:K12881]
10482  NXF1; nuclear RNA export factor 1 [KO:K14284]
56001  NXF2; nuclear RNA export factor 2 [KO:K14284]
728343  NXF2B; nuclear RNA export factor 2B [KO:K14284]
55998  NXF5; nuclear RNA export factor 5 [KO:K14284]
56000  NXF3; nuclear RNA export factor 3 [KO:K14284]
708  C1QBP; complement C1q binding protein [KO:K15414]
3190  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
3108  HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
972  CD74; CD74 molecule [KO:K06505]
6890  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653]
6891  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3456  IFNB1; interferon beta 1 [KO:K05415]
3454  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
3455  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
3716  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
7297  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6772  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
6773  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
10379  IRF9; interferon regulatory factor 9 [KO:K04693]
9021  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
3458  IFNG; interferon gamma [KO:K04687]
3459  IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460  IFNGR2; interferon gamma receptor 2 [KO:K05133]
3717  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
356  FASLG; Fas ligand [KO:K04389]
355  FAS; Fas cell surface death receptor [KO:K04390]
7132  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
8772  FADD; Fas associated via death domain [KO:K02373]
841  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
836  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
54205  CYCS; cytochrome c, somatic [KO:K08738]
406  ARNTL; aryl hydrocarbon receptor nuclear translocator like [KO:K02296]
9575  CLOCK; clock circadian regulator [KO:K02223] [EC:2.3.1.48]
5187  PER1; period circadian regulator 1 [KO:K21944]
8864  PER2; period circadian regulator 2 [KO:K02633]
8863  PER3; period circadian regulator 3 [KO:K21945]
25833  POU2F3; POU class 2 homeobox 3 [KO:K09364]
Reference
  Authors
Kobelt D, Lechmann M, Steinkasserer A
  Title
The interaction between dendritic cells and herpes simplex virus-1.
  Journal
Curr Top Microbiol Immunol 276:145-61 (2003)
DOI:10.1007/978-3-662-06508-2_7
Reference
  Authors
Leib DA
  Title
Counteraction of interferon-induced antiviral responses by herpes simplex viruses.
  Journal
Curr Top Microbiol Immunol 269:171-85 (2002)
DOI:10.1007/978-3-642-59421-2_11
Reference
  Authors
Martinez-Martin N, Viejo-Borbolla A
  Title
Toll-like receptor-mediated recognition of herpes simplex virus.
  Journal
Front Biosci (Schol Ed) 2:718-29 (2010)
DOI:10.2741/96
Reference
  Authors
Roizman B
  Title
HSV gene functions: what have we learned that could be generally applicable to its near and distant cousins?
  Journal
Acta Virol 43:75-80 (1999)
Reference
  Authors
Bauer D, Tampe R
  Title
Herpes viral proteins blocking the transporter associated with antigen processing TAP--from genes to function and structure.
  Journal
Curr Top Microbiol Immunol 269:87-99 (2002)
DOI:10.1007/978-3-642-59421-2_6
Reference
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
  Authors
Reits E, Griekspoor A, Neefjes J
  Title
Herpes viral proteins manipulating the peptide transporter TAP.
  Journal
Curr Top Microbiol Immunol 269:75-83 (2002)
DOI:10.1007/978-3-642-59421-2_5
Reference
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
  Authors
Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR
  Title
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.
  Journal
Nature 454:780-3 (2008)
DOI:10.1038/nature07103
Reference
  Authors
Ellermann-Eriksen S
  Title
Macrophages and cytokines in the early defence against herpes simplex virus.
  Journal
Virol J 2:59 (2005)
DOI:10.1186/1743-422X-2-59
Reference
  Authors
Novak N, Peng WM
  Title
Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells.
  Journal
Clin Exp Immunol 142:405-10 (2005)
DOI:10.1111/j.1365-2249.2005.02927.x
Reference
  Authors
Koelle DM, Corey L
  Title
Recent progress in herpes simplex virus immunobiology and vaccine research.
  Journal
Clin Microbiol Rev 16:96-113 (2003)
DOI:10.1128/CMR.16.1.96-113.2003
Reference
  Authors
Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL
  Title
The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes.
  Journal
J Virol 78:1675-84 (2004)
DOI:10.1128/JVI.78.4.1675-1684.2004
Reference
  Authors
Hagglund R, Roizman B
  Title
Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1.
  Journal
J Virol 78:2169-78 (2004)
DOI:10.1128/JVI.78.5.2169-2178.2004
Reference
  Authors
Everett RD
  Title
ICP0, a regulator of herpes simplex virus during lytic and latent infection.
  Journal
Reference
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
  Authors
Paladino P, Mossman KL
  Title
Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response.
  Journal
J Interferon Cytokine Res 29:599-607 (2009)
DOI:10.1089/jir.2009.0074
Reference
  Authors
Bryant HE, Matthews DA, Wadd S, Scott JE, Kean J, Graham S, Russell WC, Clements JB
  Title
Interaction between herpes simplex virus type 1 IE63 protein and cellular protein p32.
  Journal
J Virol 74:11322-8 (2000)
DOI:10.1128/JVI.74.23.11322-11328.2000
Reference
  Authors
Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD
  Title
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.
  Journal
Trends Cell Biol 10:429-39 (2000)
DOI:10.1016/S0962-8924(00)01834-1
Reference
  Authors
Long MC, Leong V, Schaffer PA, Spencer CA, Rice SA
  Title
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II.
  Journal
J Virol 73:5593-604 (1999)
Reference
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:9499021
  Authors
Kawaguchi Y, Van Sant C, Roizman B
  Title
Eukaryotic elongation factor 1delta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1.
  Journal
J Virol 72:1731-6 (1998)
Reference
  Authors
Bruni R, Fineschi B, Ogle WO, Roizman B
  Title
A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection.
  Journal
J Virol 73:3810-7 (1999)
Reference
  Authors
Johnson KE, Knipe DM
  Title
Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.
  Journal
Virology 396:21-9 (2010)
DOI:10.1016/j.virol.2009.09.021
Reference
  Authors
Chee AV, Roizman B
  Title
Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.
  Journal
J Virol 78:4185-96 (2004)
DOI:10.1128/JVI.78.8.4185-4196.2004
Reference
  Authors
Rasmussen SB, Sorensen LN, Malmgaard L, Ank N, Baines JD, Chen ZJ, Paludan SR
  Title
Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems.
  Journal
J Virol 81:13315-24 (2007)
DOI:10.1128/JVI.01167-07
Reference
  Authors
Dufour F, Sasseville AM, Chabaud S, Massie B, Siegel RM, Langelier Y
  Title
The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFalpha- and FasL-induced apoptosis by interacting with caspase-8.
  Journal
Apoptosis 16:256-71 (2011)
DOI:10.1007/s10495-010-0560-2
Reference
PMID:9621021
  Authors
Schang LM, Phillips J, Schaffer PA
  Title
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.
  Journal
J Virol 72:5626-37 (1998)
Reference
  Authors
Medici MA, Sciortino MT, Perri D, Amici C, Avitabile E, Ciotti M, Balestrieri E, De Smaele E, Franzoso G, Mastino A
  Title
Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB.
  Journal
J Biol Chem 278:36059-67 (2003)
DOI:10.1074/jbc.M306198200
Reference
  Authors
Nguyen ML, Blaho JA
  Title
Apoptosis during herpes simplex virus infection.
  Journal
Adv Virus Res 69:67-97 (2007)
DOI:10.1016/S0065-3527(06)69002-7
KO pathway
ko05168   

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