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KEGG   PATHWAY: hsa05204
Entry
hsa05204                    Pathway                                
Name
Chemical carcinogenesis - DNA adducts - Homo sapiens (human)
Description
It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Mutations cause an undefined number of cell changes, translated into aberrant protein expression and in changes in cell cycle control.
Class
Human Diseases; Cancer: overview
Pathway map
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05204

Network
  Element
N01369  4-ABP to DNA adducts
N01370  PhIP to DNA adducts
N01371  PhIP to DNA adducts
N01372  IQ to DNA adducts
N01373  MeIQx to DNA adducts
N01374  BaP to DNA adducts
N01375  DMBA to DNA adducts
N01376  Melphalan to DNA adducts/cross-links
N01377  Thiotepa to DNA adducts/cross-links
N01378  AFB1 to DNA adducts
N01379  NNK to DNA adducts
N01380  NNK to DNA adducts
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
N01383  NDMA to DNA adducts
N01384  EO to DNA adducts
N01385  VC to DNA adducts
N01386  DCE to DNA adducts
N01387  SM to DNA adducts/cross-links
Organism
Homo sapiens (human) [GN:hsa]
Gene
10  NAT2; N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
9  NAT1; N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
6799  SULT1A2; sulfotransferase family 1A member 2 [KO:K01014] [EC:2.8.2.1]
6817  SULT1A1; sulfotransferase family 1A member 1 [KO:K01014] [EC:2.8.2.1]
6818  SULT1A3; sulfotransferase family 1A member 3 [KO:K01014] [EC:2.8.2.1]
445329  SULT1A4; sulfotransferase family 1A member 4 [KO:K01014] [EC:2.8.2.1]
124907837  sulfotransferase 1A3 [KO:K01014] [EC:2.8.2.1]
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1 [KO:K07410] [EC:1.14.14.1]
1558  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
1559  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
1562  CYP2C18; cytochrome P450 family 2 subfamily C member 18 [KO:K17720] [EC:1.14.14.1]
1557  CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17721] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
2052  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
221357  GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
2939  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
2941  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
119391  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
2948  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
2952  GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
2947  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
4257  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
4259  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
2944  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
2949  GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
4258  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
2938  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
2946  GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
2940  GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
9446  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
653689  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
25774  GSTT4; glutathione S-transferase theta 4 [KO:K00799] [EC:2.5.1.18]
2950  GSTP1; glutathione S-transferase pi 1 [KO:K23790] [EC:2.5.1.18]
373156  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
27306  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
6822  SULT2A1; sulfotransferase family 2A member 1 [KO:K11822] [EC:2.8.2.14]
1577  CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
1551  CYP3A7; cytochrome P450 family 3 subfamily A member 7 [KO:K17691] [EC:1.14.14.1]
100861540  CYP3A7-CYP3A51P; CYP3A7-CYP3A51P readthrough [KO:K17691] [EC:1.14.14.1]
64816  CYP3A43; cytochrome P450 family 3 subfamily A member 43 [KO:K17692] [EC:1.14.14.1]
5743  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.14.-]
1549  CYP2A7; cytochrome P450 family 2 subfamily A member 7 [KO:K17683] [EC:1.14.14.-]
1553  CYP2A13; cytochrome P450 family 2 subfamily A member 13 [KO:K17685] [EC:1.14.14.1]
1646  AKR1C2; aldo-keto reductase family 1 member C2 [KO:K00089] [EC:1.1.1.213 1.1.1.357]
3290  HSD11B1; hydroxysteroid 11-beta dehydrogenase 1 [KO:K15680] [EC:1.1.1.146]
374875  HSD11B1L; hydroxysteroid 11-beta dehydrogenase 1 like [KO:K15680] [EC:1.1.1.146]
873  CBR1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
10941  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
Compound
C00027  Hydrogen peroxide
C03012  Naphthalene-1,2-diol
C03621  N-Acetoxy-4-aminobiphenyl
C03622  N-Hydroxy-4-aminobiphenyl
C06268  Chromium
C06547  Ethylene
C06548  Ethylene oxide
C06752  1,2-Dichloroethane
C06754  Chloroacetaldehyde
C06793  Vinyl chloride
C06800  Aflatoxin B1
C07122  Melphalan
C07535  Benzo[a]pyrene
C07641  Thiotepa
C10998  4-Aminobiphenyl
C14556  9-Hydroxybenzo[a]pyrene
C14704  N-Nitrosodimethylamine
C14783  1,2-Naphthoquinone
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14874  Glutathione episulfonium ion
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C19164  Sulfur mustard
C19180  2-Amino-3-methylimidazo[4,5-f]quinoline
C19255  MeIQx
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19525  Sudan I
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19586  Aflatoxin B1-exo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C20280  1-Phenylazo-2,6-dihydroxynaphthalene
C20281  1-(4-Hydroxyphenylazo)-2-naphthol
C20282  1-(4-Hydroxyphenylazo)-naphthalene-2,6-diol
C20283  1-(3,4-Dihydroxyphenylazo)-2-naphthol
C20284  Benzenediazonium
C20285  4-Acetylaminobiphenyl
C20286  2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C20287  2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C20288  N-Sulfonyloxy-PhIP
C20289  N-Hydroxy-IQ
C20290  N-Acetoxy-IQ
C20291  N-Hydroxy-MeIQx
C20293  N-Acetoxy-MeIQx
C20301  alpha-Hydroxy-NDMA
C20302  Methyldiazonium ion
C20303  Chloroethylene oxide
C20304  S-(2-Chloroethyl)glutathione
C20305  1,2-Dichloroethanol
C20306  Methyldiazohydroxide
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Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, Nakamura J, Starr TB
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Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment.
  Journal
Toxicol Sci 120 Suppl 1:S130-45 (2011)
DOI:10.1093/toxsci/kfq371
Reference
PMID:10753215
  Authors
Yang Y, Nair J, Barbin A, Bartsch H
  Title
Immunohistochemical detection of 1,N(6)-ethenodeoxyadenosine, a promutagenic DNA adduct, in liver of rats exposed to vinyl chloride or an iron overload.
  Journal
Carcinogenesis 21:777-81 (2000)
DOI:10.1093/carcin/21.4.777
Reference
PMID:15582261
  Authors
Bartsch H, Nair J
  Title
Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis.
  Journal
Cancer Detect Prev 28:385-91 (2004)
DOI:10.1016/j.cdp.2004.07.004
Reference
PMID:16084004
  Authors
Kehe K, Szinicz L
  Title
Medical aspects of sulphur mustard poisoning.
  Journal
Toxicology 214:198-209 (2005)
DOI:10.1016/j.tox.2005.06.014
Reference
PMID:17292678
  Authors
Matijasevic Z, Volkert MR
  Title
Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide.
  Journal
DNA Repair (Amst) 6:733-41 (2007)
DOI:10.1016/j.dnarep.2006.12.014
Related
pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05215  Prostate cancer
hsa05219  Bladder cancer
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
KO pathway
ko05204   

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Network (19)   
   KEGG NETWORK (19)   
Genome (1)   
   KEGG GENOME (1)   
Gene (71)   
   KEGG GENES (71)   
All databases (91)   

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