KEGG   PATHWAY: hsa05310Help
Entry
hsa05310                    Pathway                                

Name
Asthma - Homo sapiens (human)
Description
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
Class
Human Diseases; Immune disease
BRITE hierarchy
Pathway map
hsa05310  Asthma
hsa05310

Ortholog table
Disease
H00079  Asthma
H01094  Eosinophil peroxidase deficiency
Drug
D05251  Omalizumab (USAN/INN)
D09633  Lebrikizumab (USAN/INN)
D09897  Enokizumab (USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
3108  HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
3565  IL4; interleukin 4 [KO:K05430]
959  CD40LG; CD40 ligand [KO:K03161]
958  CD40; CD40 molecule [KO:K03160]
102723407  IGH; immunoglobulin heavy variable 4-38-2-like [KO:K06856]
2205  FCER1A; Fc fragment of IgE receptor Ia [KO:K08089]
2206  MS4A2; membrane spanning 4-domains A2 [KO:K08090]
2207  FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
3578  IL9; interleukin 9 [KO:K05432]
3586  IL10; interleukin 10 [KO:K05443]
3596  IL13; interleukin 13 [KO:K05435]
3567  IL5; interleukin 5 [KO:K05428]
6356  CCL11; C-C motif chemokine ligand 11 [KO:K16597]
7124  TNF; tumor necrosis factor [KO:K03156]
3562  IL3; interleukin 3 [KO:K04736]
5553  PRG2; proteoglycan 2, pro eosinophil major basic protein [KO:K10786]
6037  RNASE3; ribonuclease A family member 3 [KO:K10787] [EC:3.1.27.-]
8288  EPX; eosinophil peroxidase [KO:K10788] [EC:1.11.1.7]
Compound
C00388  Histamine
C00696  Prostaglandin D2
C02166  Leukotriene C4
C04598  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
C05951  Leukotriene D4
Reference
  Authors
Busse WW, Lemanske RF Jr.
  Title
Asthma.
  Journal
N Engl J Med 344:350-62 (2001)
DOI:10.1056/NEJM200102013440507
Reference
  Authors
Renauld JC.
  Title
New insights into the role of cytokines in asthma.
  Journal
J Clin Pathol 54:577-89 (2001)
DOI:10.1136/jcp.54.8.577
Reference
  Authors
Romagnani S.
  Title
The role of lymphocytes in allergic disease.
  Journal
J Allergy Clin Immunol 105:399-408 (2000)
DOI:10.1067/mai.2000.104575
Reference
  Authors
Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC.
  Title
Immunologic principles of allergic disease.
  Journal
J Dtsch Dermatol Ges 5:1015-28 (2007)
DOI:10.1111/j.1610-0387.2007.06538.x
Reference
  Authors
Conroy DM, Williams TJ.
  Title
Eotaxin and the attraction of eosinophils to the asthmatic lung.
  Journal
Respir Res 2:150-6 (2001)
DOI:10.1186/rr52
Reference
  Authors
Effros RM, Nagaraj H.
  Title
Asthma: new developments concerning immune mechanisms, diagnosis and treatment.
  Journal
Curr Opin Pulm Med 13:37-43 (2007)
DOI:10.1097/MCP.0b013e3280108757
Reference
  Authors
Barnes PJ.
  Title
Immunology of asthma and chronic obstructive pulmonary disease.
  Journal
Nat Rev Immunol 8:183-92 (2008)
DOI:10.1038/nri2254
Reference
  Authors
Holgate ST, Polosa R.
  Title
Treatment strategies for allergy and asthma.
  Journal
Nat Rev Immunol 8:218-30 (2008)
DOI:10.1038/nri2262
Reference
  Authors
Valenta R.
  Title
The future of antigen-specific immunotherapy of allergy.
  Journal
Nat Rev Immunol 2:446-53 (2002)
DOI:10.1038/nri824
Reference
  Authors
Trivedi SG, Lloyd CM.
  Title
Eosinophils in the pathogenesis of allergic airways disease.
  Journal
Cell Mol Life Sci 64:1269-89 (2007)
DOI:10.1007/s00018-007-6527-y
Reference
  Authors
Heinecke JW.
  Title
Eosinophil-dependent bromination in the pathogenesis of asthma.
  Journal
J Clin Invest 105:1331-2 (2000)
DOI:10.1172/JCI10072
KO pathway
ko05310   

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