KEGG   Homo sapiens (human): 10019
Entry
10019             CDS       T01001                                 
Symbol
SH2B3, IDDM20, LNK
Name
(RefSeq) SH2B adaptor protein 3
  KO
K12459  SH2B adaptor protein 1/3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04722  Neurotrophin signaling pathway
Disease
H00236  Congenital polycythemia
H00408  Type 1 diabetes mellitus
H01605  Myelofibrosis
H01612  Essential thrombocythemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    10019 (SH2B3)
SSDB
Motif
Pfam: Phe_ZIP SH2 PH
Other DBs
NCBI-GeneID: 10019
NCBI-ProteinID: NP_005466
OMIM: 605093
HGNC: 29605
Ensembl: ENSG00000111252
UniProt: Q9UQQ2 Q59H48
Position
12:111404730..111451623
AA seq 575 aa
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
NT seq 1728 nt   +upstreamnt  +downstreamnt
atgaacgggcctgccctgcagccctcctcgccctcttccgcgccctcagcctccccggcg
gcggccccgcggggctggagcgagttctgtgagttgcacgccgtagcggcggcccgggag
ctggcccgccagtactggctgttcgcccgggagcatccgcagcacgcgccgctgcgcgcc
gagctggtgtcgctgcagttcaccgacctcttccagcgctacttctgccgcgaggtgcgc
gacggacgggcgccgggccgcgactaccgggacacaggccgtgggcccccagccaaggcc
gaggcgtccccggagccaggccccggccccgccgcccctggcctgcccaaggcccgcagc
tctgaggagctggccccgccgcggccgcccgggccctgctccttccagcactttcgccgc
agcctccgccacatcttccgccgccgctcggccggggagctgccagcggcccacaccgct
gccgcccccgggacccccggagaggctgctgagacccccgcccggcctggcctggccaag
aagttcctgccctggagcctggcccgggagccgccacccgaggcgctgaaggaggcggtg
ctgcgctacagcctggccgacgaggcctccatggacagcggggcacgctggcagcgcggg
aggctggcgctgcgccgggccccgggccccgatggccccgaccgcgtgctggagctcttc
gacccacccaagagttcaaggcccaagctacaagcagcttgctccagcatccaggaggtc
cggtggtgcacacggcttgagatgcctgacaacctttacacctttgtgctgaaggtgaag
gaccggacagacatcatctttgaggtgggagacgagcagcagctgaattcatggatggct
gagctctcggagtgcacaggccgagggctggagagcacagaagcagagatgcatattccc
tcagccctagagcctagcacgtccagctccccaaggggcagcacagattcccttaaccaa
ggtgcttctcctggggggctgctggacccggcctgccagaagacggaccatttcctgtcc
tgctacccctggttccacggccccatctccagagtgaaagcagctcagctggttcagctg
cagggccctgatgctcatggagtgttcctggtgcggcagagcgagacgcggcgtggggaa
tacgtgctcactttcaactttcaggggatagccaagcacctgcgcctgtcgctgacagag
cggggccagtgccgtgtgcagcacctccactttccctcggtcgtggacatgctccaccac
ttccagcgctcgcccatcccactcgagtgcggcgccgcctgtgatgtccggctctccagc
tacgtggtagtcgtctcccaaccaccaggttcctgcaacacggtcctcttccctttctcc
cttcctcactgggattcagagtcccttcctcactggggttcagagttgggccttccccac
cttagttcttctggctgtccccgggggctcagcccagagggtctcccagggcgatcctca
ccccccgagcagatcttccacctggtgccttcgcccgaagaactggccaacagcctgcag
cacctggagcatgagcctgtgaatcgagcccgggactcggactacgaaatggactcatcc
tcccggagccacctgcgggccatagacaatcagtacacacctctctga

  All links  
Disease (4)   
   OMIM (4)   
Gene (26)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (23)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (36)   
   RefSeq(nuc) (20)   
   GenBank (8)   
   EMBL (8)   
Protein domain (3)   
   Pfam (3)   
All databases (92)   

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