KEGG   Homo sapiens (human): 10021
Entry
10021             CDS       T01001                                 
Symbol
HCN4, BRGDA8, EIG18, SSS2
Name
(RefSeq) hyperpolarization activated cyclic nucleotide gated potassium channel 4
  KO
K04957  hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04742  Taste transduction
Disease
H00728  Brugada syndrome
H00729  Sick sinus syndrome
H00808  Idiopathic generalized epilepsies
Drug target
Ivabradine (DG00246): D07165 D08095<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    10021 (HCN4)
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    10021 (HCN4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    10021 (HCN4)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Cyclic nucleotide-gated channel (HCN)
   10021 (HCN4)
SSDB
Motif
Pfam: Ion_trans Ion_trans_N cNMP_binding Ion_trans_2
Other DBs
NCBI-GeneID: 10021
NCBI-ProteinID: NP_005468
OMIM: 605206
HGNC: 16882
Ensembl: ENSG00000138622
UniProt: Q9Y3Q4
Structure
Position
15:complement(73319859..73368958)
AA seq 1203 aa
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSA
AAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHG
HLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCE
QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAV
EREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNV
VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE
TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN
LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIG
YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF
HKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD
PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE
ICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSI
LLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQA
PLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA
SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVA
ATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLP
PPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT
PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT
QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR
PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP
SNL
NT seq 3612 nt   +upstreamnt  +downstreamnt
atggacaagctgccgccgtccatgcgcaagcggctctacagcctcccgcagcaggtgggg
gccaaggcgtggatcatggacgaggaagaggacgccgaggaggagggggccgggggccgc
caagaccccagccgcaggagcatccggctgcggccactgccctcgccctccccctcggcg
gccgcgggtggcacggagtcccggagctcggccctcggggcagcggacagcgaagggccg
gcccgcggcgcgggcaagtccagcacgaacggcgactgcaggcgcttccgcgggagcctg
gcctcgctgggcagccggggcggcggcagcggcggcacggggagcggcagcagtcacgga
cacctgcatgactccgcggaggagcggcggctcatcgccgagggcgacgcgtcccccggc
gaggacaggacgcccccaggcctggcggccgagcccgagcgccccggcgcctcggcgcag
cccgcagcctcgccgccgccgccccagcagccaccgcagccggcctccgcctcctgcgag
cagccctcggtggacaccgctatcaaagtggagggaggcgcggctgccggcgaccagatc
ctcccggaggccgaggtgcgcctgggccaggccggcttcatgcagcgccagttcggggcc
atgctccaacccggggtcaacaaattctccctaaggatgttcggcagccagaaagccgtg
gagcgcgaacaggagagggtcaagtcggccggattttggattatccacccctacagtgac
ttcagattttactgggacctgaccatgctgctgctgatggtgggaaacctgattatcatt
cctgtgggcatcaccttcttcaaggatgagaacaccacaccctggattgtcttcaatgtg
gtgtcagacacattcttcctcatcgacttggtcctcaacttccgcacagggatcgtggtg
gaggacaacacagagatcatcctggacccgcagcggattaaaatgaagtacctgaaaagc
tggttcatggtagatttcatttcctccatccccgtggactacatcttcctcattgtggag
acacgcatcgactcggaggtctacaagactgcccgggccctgcgcattgtccgcttcacg
aagatcctcagcctcttacgcctgttacgcctctcccgcctcattcgatatattcaccag
tgggaagagatcttccacatgacctacgacctggccagcgccgtggtgcgcatcgtgaac
ctcatcggcatgatgctcctgctctgccactgggacggctgcctgcagttcctggtaccc
atgctacaggacttccctgacgactgctgggtgtccatcaacaacatggtgaacaactcc
tgggggaagcagtactcctacgcgctcttcaaggccatgagccacatgctgtgcatcggc
tacgggcggcaggcgcccgtgggcatgtccgacgtctggctcaccatgctcagcatgatc
gtgggtgccacctgctacgccatgttcattggccacgccactgccctcatccagtccctg
gactcctcccggcgccagtaccaggaaaagtacaagcaggtggagcagtacatgtccttt
cacaagctcccgcccgacacccggcagcgcatccacgactactacgagcaccgctaccag
ggcaagatgttcgacgaggagagcatcctgggcgagctaagcgagcccctgcgggaggag
atcatcaactttaactgtcggaagctggtggcctccatgccactgtttgccaatgcggac
cccaacttcgtgacgtccatgctgaccaagctgcgtttcgaggtcttccagcctggggac
tacatcatccgggaaggcaccattggcaagaagatgtacttcatccagcatggcgtggtc
agcgtgctcaccaagggcaacaaggagaccaagctggccgacggctcctactttggagag
atctgcctgctgacccggggccggcgcacagccagcgtgagggccgacacctactgccgc
ctctactcgctgagcgtggacaacttcaatgaggtgctggaggagtaccccatgatgcga
agggccttcgagaccgtggcgctggaccgcctggaccgcattggcaagaagaactccatc
ctcctccacaaagtccagcacgacctcaactccggcgtcttcaactaccaggagaatgag
atcatccagcagattgtgcagcatgaccgggagatggcccactgcgcgcaccgcgtccag
gctgctgcctctgccaccccaacccccacgcccgtcatctggaccccgctgatccaggca
ccactgcaggctgccgctgccaccacttctgtggccatagccctcacccaccaccctcgc
ctgcctgctgccatcttccgccctcccccaggatctgggctgggcaacctcggtgccggg
cagacgccaaggcacctgaaacggctgcagtccctgatcccttctgcgctgggctccgcc
tcgcccgccagcagcccgtcccaggtggacacaccgtcttcatcctccttccacatccaa
cagctggctggattctctgcccccgctggactgagcccactcctgccctcatccagctcc
tccccaccccccggggcctgtggctccccctcggctcccacaccatcagctggcgtagcc
gccaccaccatagccgggtttggccacttccacaaggcgctgggtggctccctgtcctcc
tccgactctcccctgctcaccccgctgcagccaggcgcccgctccccgcaggctgcccag
ccatctcccgcgccacccggggcccggggaggcctgggactcccggagcacttcctgcca
cccccaccctcatccagatccccgtcatctagccccgggcagctgggccagcctcccggg
gagttgtccctaggtctggccactggcccactgagcacgccagagacacccccacggcag
cctgagccgccgtcccttgtggcaggggcctctgggggggcttcccctgtaggctttact
ccccgaggaggtctcagcccccctggccacagcccaggccccccaagaaccttcccgagt
gccccgccccgggcctctggctcccacggatccttgctcctgccacctgcatccagcccc
ccaccaccccaggtcccccagcgccggggcacacccccgctcacccccggccgcctcacc
caggacctcaagctcatctccgcgtctcagccagccctgcctcaggacggggcgcagact
ctccgcagagcctccccgcactcctcaggggagtccatggctgccttcccgctcttcccc
agggctgggggtggcagcgggggcagtgggagcagcgggggcctcggtccccctgggagg
ccctatggtgccatccccggccagcacgtcactctgcctcggaagacatcctcaggttct
ttgccaccccctctgtctttgtttggggcaagagccacctcttctggggggccccctctg
actgctggaccccagagggaacctggggccaggcctgagccagtgcgctccaaactgcca
tccaatctatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG ORTHOLOGY (1)   
   RefGene (41)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (13)   
   RefSeq(nuc) (3)   
   GenBank (5)   
   EMBL (5)   
3D Structure (8)   
   PDB (8)   
Protein domain (4)   
   Pfam (4)   
All databases (91)   

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