KEGG   Homo sapiens (human): 10025
Entry
10025             CDS       T01001                                 
Symbol
MED16, DRIP92, GGNS, THRAP5, TRAP95
Name
(RefSeq) mediator of RNA polymerase II transcription subunit 16
  KO
K15159  mediator of RNA polymerase II transcription subunit 16
Organism
hsa  Homo sapiens (human)
Pathway
hsa04919  Thyroid hormone signaling pathway
Disease
H02961  Guillouet-Gordon syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    10025 (MED16)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    10025 (MED16)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Mediator complex
    Tail
     10025 (MED16)
SSDB
Motif
Pfam: Med16_bridge Med16_N Med16_C WD40 Beta-prop_IFT140_1st Beta-prop_WDR3_1st ANAPC4_WD40 Beta-prop_IFT122_1st Beta-prop_WDR35_TULP_N Beta-prop_THOC3 WD40_WDHD1_1st WD40_Prp19 Beta-prop_WDR5 WD40_CDC20-Fz Beta-prop_HPS5 Beta-prop_Aladin Beta-prop_EML Beta-prop_EML_2 ASA1 CDC45
Other DBs
NCBI-GeneID: 10025
NCBI-ProteinID: NP_005472
OMIM: 604062
HGNC: 17556
Ensembl: ENSP00000325612.1
UniProt: Q9Y2X0
Structure
Position
19:complement(867963..893187)
AA seq 877 aa
MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTR
MIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWES
SVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWI
AVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQ
FYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASS
QTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLP
ISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK
RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEY
CMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCT
VTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLK
TEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMV
VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLL
PSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKID
HLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVT
SRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
NT seq 2634 nt   +upstreamnt  +downstreamnt
atgtgtgatttgcggcggccagcggcaggtgggatgatggacttggcctacgtctgtgag
tgggagaaatggtccaagagcacccactgcccatcggtgcccctggcctgcgcctggtcc
tgccgaaatctcatcgccttcaccatggacctgcgcagcgatgaccaggacctgacccgc
atgatccacatcctggacacggagcacccctgggacctgcactcgatcccctcagagcac
cacgaggccatcacctgcctggagtgggaccagtcaggctcccggctcctgtcagcagat
gccgacgggcagatcaagtgctggagcatggcggaccacctggctaatagctgggagagc
tcagtgggcagcctagtggagggggaccccattgtggccctgtcctggctgcacaatggt
gtgaaactggccctgcacgtggagaagtcgggcgcctccagcttcggggagaagttctcc
cgagtcaagttctcaccgtcgctcacgctgttcggcggcaagcccatggagggctggatc
gcggtgacggtcagcggcctggtcaccgtgtccctgctgaagcccagcgggcaggtgctg
acgtccaccgagagcctgtgccggctgcgcggccgcgtggccctggccgacatcgccttc
accggcggcggcaacatcgtggtggccacggcggacggcagcagcgcgtcgcccgtgcag
ttctacaaggtgtgcgtgagcgtggtgagcgagaagtgccgtatcgacacggagatcctg
ccctccctgttcatgcgctgcaccaccgacctcaaccgcaaggacaagtttcccgccatc
acccacctcaagttcctggcccgggacatgtcggagcaggtgcttttgtgcgcgtccagc
cagaccagcagcatcgtggagtgctggtccctgcgcaaggagggactccccgtgaacaac
atcttccagcagatctcccccgtggttggcgacaaacagcccacaattctcaaatggcgg
atcctatcggccaccaacgatctggaccgtgtgtcggccgtggcgctgcccaagctgccc
atctcgctcaccaacaccgacctcaaggtggccagcgacacacagttctaccctggcctc
gggctggccctggccttccacgacggcagcgtccacatcgtgcaccggctctcactgcag
accatggccgtcttctacagctccgcggccccgaggcctgtggatgagccggccatgaag
cgcccccgcaccgcgggccccgccgtccacttaaaggctatgcagctatcgtggacgtca
ctggccctggtggggattgacagccacgggaagctgagcgtgctccgcctctcaccttcc
atgggccacccgctggaggtggggctggcgctgcggcacctgctcttcctgctggagtac
tgcatggtgaccggctacgactggtgggacatcctgctgcacgtgcagcccagtatggta
cagagcctggtggagaagctgcacgaggagtacacgcgccagaccgctgccctgcagcag
gtcctctccacccggatcctggccatgaaggcctcgctctgcaagctgtcgccctgcacg
gtgacccgcgtgtgcgactaccacaccaagctcttcctcatcgccatcagctccaccctg
aagtcgctgctgcgcccccactttctcaacacgcctgacaagagccccggcgaccggctg
accgagatctgcaccaagatcaccgacgtcgacattgacaaggtcatgatcaacctcaag
acggaggaatttgtgctggacatgaacacactgcaggcgctgcagcagctcttgcagtgg
gtgggcgacttcgtgctgtacctgctggccagcctacccaaccagggttccctgctgagg
ccgggccacagctttctgcgggacggcacctcgctgggcatgcttcgggaattgatggtg
gtcatccgcatctggggccttctgaagcccagctgcctgcccgtgtatacggccacctcg
gatacccaggacagcatgtccctgctcttccgcctgctcaccaagctctggatctgctgt
cgcgatgagggcccagcgagcgagccggacgaggcgctggtggatgaatgctgcctgctg
cccagccagctgcttatccccagcctggactggctgccagccagcgacggcctggttagc
cgcctgcagcccaagcagccccttcgtctgcagtttggccgggcgcccacgctgcctggc
agtgctgccaccctgcagctcgacggcctcgccagggccccaggccagcccaagatcgac
cacctgcggaggctgcaccttggcgcttgccccacggaggaatgcaaggcctgcaccagg
tgcggctgtgtcaccatgctcaagtcgcccaacagaaccacggcggtgaagcagtgggag
cagcgctggatcaagaactgcctggctgttgaaggccgtgggccggacgcctgcgtgacc
agcagagcttctgaggaagcccctgcctttgtccagctgggcccgcagtccacacaccac
tctcccaggacccccagatccctggaccatctgcatccagaggaccgtccgtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (21)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (129)   
   RefSeq(nuc) (5)   
   GenBank (62)   
   EMBL (62)   
3D Structure (10)   
   PDB (10)   
Protein domain (20)   
   Pfam (20)   
All databases (189)   

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