KEGG   Homo sapiens (human): 10039Help
Entry
10039             CDS       T01001                                 

Gene name
PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
Definition
(RefSeq) poly(ADP-ribose) polymerase family member 3
  KO
K10798  poly [ADP-ribose] polymerase [EC:2.4.2.30]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa04210  Apoptosis
hsa04217  Necroptosis
Drug target
Olaparib: D09730
Pamiparib: D11426
Rucaparib (DG01864): D10079 D10157 D10982
Veliparib: D09692
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    10039 (PARP3)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    10039 (PARP3)
   04217 Necroptosis
    10039 (PARP3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    10039 (PARP3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    10039 (PARP3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    10039 (PARP3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.30  NAD+ ADP-ribosyltransferase
     10039 (PARP3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other telomere regulation proteins
    Others
     10039 (PARP3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centriole proteins
    10039 (PARP3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     10039 (PARP3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PARP PARP_reg WGR
Motif
Other DBs
NCBI-GeneID: 10039
NCBI-ProteinID: NP_005476
OMIM: 607726
HGNC: 273
Ensembl: ENSG00000041880
Vega: OTTHUMG00000156931
Pharos: Q9Y6F1(Tclin)
UniProt: Q9Y6F1 A0A024R2X5
Structure
PDB: 

Position
3p21.2
AA seq 533 aa AA seqDB search
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
NT seq 1602 nt NT seq  +upstreamnt  +downstreamnt
atggctccaaagccgaagccctgggtacagactgagggccctgagaagaagaagggccgg
caggcaggaagggaggaggaccccttccgctccaccgctgaggccctcaaggccataccc
gcagagaagcgcataatccgcgtggatccaacatgtccactcagcagcaaccccgggacc
caggtgtatgaggactacaactgcaccctgaaccagaccaacatcgagaacaacaacaac
aagttctacatcatccagctgctccaagacagcaaccgcttcttcacctgctggaaccgc
tggggccgtgtgggagaggtcggccagtcaaagatcaaccacttcacaaggctagaagat
gcaaagaaggactttgagaagaaatttcgggaaaagaccaagaacaactgggcagagcgg
gaccactttgtgtctcacccgggcaagtacacacttatcgaagtacaggcagaggatgag
gcccaggaagctgtggtgaaggtggacagaggcccagtgaggactgtgactaagcgggtg
cagccctgctccctggacccagccacgcagaagctcatcactaacatcttcagcaaggag
atgttcaagaacaccatggccctcatggacctggatgtgaagaagatgcccctgggaaag
ctgagcaagcaacagattgcacggggtttcgaggccttggaggcgctggaggaggccctg
aaaggccccacggatggtggccaaagcctggaggagctgtcctcacacttttacaccgtc
atcccgcacaacttcggccacagccagcccccgcccatcaattcccctgagcttctgcag
gccaagaaggacatgctgctggtgctggcggacatcgagctggcccaggccctgcaggca
gtctctgagcaggagaagacggtggaggaggtgccacaccccctggaccgagactaccag
cttctcaagtgccagctgcagctgctagactctggagcacctgagtacaaggtgatacag
acctacttagaacagactggcagcaaccacaggtgccctacacttcaacacatctggaaa
gtaaaccaagaaggggaggaagacagattccaggcccactccaaactgggtaatcggaag
ctgctgtggcatggcaccaacatggccgtggtggccgccatcctcactagtgggctccgc
atcatgccacattctggtgggcgtgttggcaagggcatctactttgcctcagagaacagc
aagtcagctggatatgttattggcatgaagtgtggggcccaccatgtcggctacatgttc
ctgggtgaggtggccctgggcagagagcaccatatcaacacggacaaccccagcttgaag
agcccacctcctggcttcgacagtgtcattgcccgaggccacaccgagcctgatccgacc
caggacactgagttggagctggatggccagcaagtggtggtgccccagggccagcctgtg
ccctgcccagagttcagcagctccacattctcccagagcgagtacctcatctaccaggag
agccagtgtcgcctgcgctacctgctggaggtccacctctga

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