KEGG   Homo sapiens (human): 10062
Entry
10062             CDS       T01001                                 
Symbol
NR1H3, LXR-a, LXRA, RLD-1
Name
(RefSeq) nuclear receptor subfamily 1 group H member 3
  KO
K08536  liver X receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04148  Efferocytosis
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06535  Efferocytosis
  Element
N00530  HCV core to RXRA/LXRA-mediated transcription
N01781  Activation of LXRs by oxysterols
Drug target
Abequolixron (DG03218): D12298 D12299
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    10062 (NR1H3)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    10062 (NR1H3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    10062 (NR1H3)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    10062 (NR1H3)
   04931 Insulin resistance
    10062 (NR1H3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    10062 (NR1H3)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    10062 (NR1H3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    10062 (NR1H3)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1H. Liver X receptor like receptor
   10062 (NR1H3)
SSDB
Motif
Pfam: Hormone_recep zf-C4
Other DBs
NCBI-GeneID: 10062
NCBI-ProteinID: NP_005684
OMIM: 602423
HGNC: 7966
Ensembl: ENSG00000025434
UniProt: Q13133 B4DXU5 F1D8N1
Structure
Position
11:47248300..47269033
AA seq 447 aa
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
NT seq 1344 nt   +upstreamnt  +downstreamnt
atgtccttgtggctgggggcccctgtgcctgacattcctcctgactctgcggtggagctg
tggaagccaggcgcacaggatgcaagcagccaggcccagggaggcagcagctgcatcctc
agagaggaagccaggatgccccactctgctgggggtactgcaggggtggggctggaggct
gcagagcccacagccctgctcaccagggcagagcccccttcagaacccacagagatccgt
ccacaaaagcggaaaaaggggccagcccccaaaatgctggggaacgagctatgcagcgtg
tgtggggacaaggcctcgggcttccactacaatgttctgagctgcgagggctgcaaggga
ttcttccgccgcagcgtcatcaagggagcgcactacatctgccacagtggcggccactgc
cccatggacacctacatgcgtcgcaagtgccaggagtgtcggcttcgcaaatgccgtcag
gctggcatgcgggaggagtgtgtcctgtcagaagaacagatccgcctgaagaaactgaag
cggcaagaggaggaacaggctcatgccacatccttgccccccagggcttcctcacccccc
caaatcctgccccagctcagcccggaacaactgggcatgatcgagaagctcgtcgctgcc
cagcaacagtgtaaccggcgctccttttctgaccggcttcgagtcacgccttggcccatg
gcaccagatccccatagccgggaggcccgtcagcagcgctttgcccacttcactgagctg
gccatcgtctctgtgcaggagatagttgactttgctaaacagctacccggcttcctgcag
ctcagccgggaggaccagattgccctgctgaagacctctgcgatcgaggtgatgcttctg
gagacatctcggaggtacaaccctgggagtgagagtatcaccttcctcaaggatttcagt
tataaccgggaagactttgccaaagcagggctgcaagtggaattcatcaaccccatcttc
gagttctccagggccatgaatgagctgcaactcaatgatgccgagtttgccttgctcatt
gctatcagcatcttctctgcagaccggcccaacgtgcaggaccagctccaggtagagagg
ctgcagcacacatatgtggaagccctgcatgcctacgtctccatccaccatccccatgac
cgactgatgttcccacggatgctaatgaaactggtgagcctccggaccctgagcagcgtc
cactcagagcaagtgtttgcactgcgtctgcaggacaaaaagctcccaccgctgctctct
gagatctgggatgtgcacgaatga

  All links  
Disease (1)   
   OMIM (1)   
Gene (14)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (44)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (40)   
DNA sequence (80)   
   RefSeq(nuc) (40)   
   GenBank (20)   
   EMBL (20)   
3D Structure (7)   
   PDB (7)   
Protein domain (2)   
   Pfam (2)   
All databases (148)   

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