KEGG   Homo sapiens (human): 10062
Entry
10062             CDS       T01001                                 
Symbol
NR1H3, LXR-a, LXRA, RLD-1
Name
(RefSeq) nuclear receptor subfamily 1 group H member 3
  KO
K08536  liver X receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04148  Efferocytosis
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06535  Efferocytosis
  Element
N00530  HCV core to RXRA/LXRA-mediated transcription
N01781  Activation of LXRs by oxysterols
Drug target
Abequolixron (DG03218): D12298 D12299
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    10062 (NR1H3)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    10062 (NR1H3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    10062 (NR1H3)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    10062 (NR1H3)
   04931 Insulin resistance
    10062 (NR1H3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    10062 (NR1H3)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    10062 (NR1H3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    10062 (NR1H3)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1H. Liver X receptor like receptor
   10062 (NR1H3)
SSDB
Motif
Pfam: Hormone_recep zf-C4
Other DBs
NCBI-GeneID: 10062
NCBI-ProteinID: NP_005684
OMIM: 602423
HGNC: 7966
Ensembl: ENSG00000025434
UniProt: Q13133 B4DXU5 F1D8N1
Structure
Position
11:47248300..47269033
AA seq 447 aa
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
NT seq 1344 nt   +upstreamnt  +downstreamnt
atgtccttgtggctgggggcccctgtgcctgacattcctcctgactctgcggtggagctg
tggaagccaggcgcacaggatgcaagcagccaggcccagggaggcagcagctgcatcctc
agagaggaagccaggatgccccactctgctgggggtactgcaggggtggggctggaggct
gcagagcccacagccctgctcaccagggcagagcccccttcagaacccacagagatccgt
ccacaaaagcggaaaaaggggccagcccccaaaatgctggggaacgagctatgcagcgtg
tgtggggacaaggcctcgggcttccactacaatgttctgagctgcgagggctgcaaggga
ttcttccgccgcagcgtcatcaagggagcgcactacatctgccacagtggcggccactgc
cccatggacacctacatgcgtcgcaagtgccaggagtgtcggcttcgcaaatgccgtcag
gctggcatgcgggaggagtgtgtcctgtcagaagaacagatccgcctgaagaaactgaag
cggcaagaggaggaacaggctcatgccacatccttgccccccagggcttcctcacccccc
caaatcctgccccagctcagcccggaacaactgggcatgatcgagaagctcgtcgctgcc
cagcaacagtgtaaccggcgctccttttctgaccggcttcgagtcacgccttggcccatg
gcaccagatccccatagccgggaggcccgtcagcagcgctttgcccacttcactgagctg
gccatcgtctctgtgcaggagatagttgactttgctaaacagctacccggcttcctgcag
ctcagccgggaggaccagattgccctgctgaagacctctgcgatcgaggtgatgcttctg
gagacatctcggaggtacaaccctgggagtgagagtatcaccttcctcaaggatttcagt
tataaccgggaagactttgccaaagcagggctgcaagtggaattcatcaaccccatcttc
gagttctccagggccatgaatgagctgcaactcaatgatgccgagtttgccttgctcatt
gctatcagcatcttctctgcagaccggcccaacgtgcaggaccagctccaggtagagagg
ctgcagcacacatatgtggaagccctgcatgcctacgtctccatccaccatccccatgac
cgactgatgttcccacggatgctaatgaaactggtgagcctccggaccctgagcagcgtc
cactcagagcaagtgtttgcactgcgtctgcaggacaaaaagctcccaccgctgctctct
gagatctgggatgtgcacgaatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (5)   
   KEGG NETWORK (5)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (42)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (38)   
DNA sequence (78)   
   RefSeq(nuc) (38)   
   GenBank (20)   
   EMBL (20)   
3D Structure (7)   
   PDB (7)   
Protein domain (2)   
   Pfam (2)   
All databases (161)   

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