KEGG   Homo sapiens (human): 10109
Entry
10109             CDS       T01001                                 
Symbol
ARPC2, ARC34, PNAS-139, PRO2446, p34-Arc
Name
(RefSeq) actin related protein 2/3 complex subunit 2
  KO
K05758  actin related protein 2/3 complex, subunit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
hsa04530  Tight junction
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05100  Bacterial invasion of epithelial cells
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
Network
nt06135  Cytoskeletal regulation (viruses and bacteria)
  Element
N01066  ARNO-ARF-ACTB_G signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01078  EGF-EGFR-Actin signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01287  Tight junction-Actin signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    10109 (ARPC2)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    10109 (ARPC2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10109 (ARPC2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    10109 (ARPC2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10109 (ARPC2)
   05132 Salmonella infection
    10109 (ARPC2)
   05131 Shigellosis
    10109 (ARPC2)
   05135 Yersinia infection
    10109 (ARPC2)
   05100 Bacterial invasion of epithelial cells
    10109 (ARPC2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10109 (ARPC2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10109 (ARPC2)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Arp2/3 complex
    10109 (ARPC2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Arp2/3 complex
     10109 (ARPC2)
SSDB
Motif
Pfam: P34-Arc ARPC4
Other DBs
NCBI-GeneID: 10109
NCBI-ProteinID: NP_005722
OMIM: 604224
HGNC: 705
Ensembl: ENSG00000163466
Pharos: O15144(Tbio)
UniProt: O15144 Q53R19
Structure
Position
2:218217189..218254348
AA seq 300 aa
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSIS
LKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNC
FASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKV
FMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNT
INLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
NT seq 903 nt   +upstreamnt  +downstreamnt
atgatcctgctggaggtgaacaaccgcatcatcgaggagacgctcgcgctcaagttcgag
aacgcggccgccggaaacaaaccggaagcagtagaagtaacatttgcagatttcgatggg
gtcctctatcatatttcaaatcctaatggagacaaaacaaaagtgatggtcagtatttct
ttgaaattctacaaggaacttcaggcacatggtgctgatgagttattaaagagggtgtac
gggagtttcttggtaaatccagaatcaggatacaatgtctctttgctatatgaccttgaa
aatcttccggcatccaaggattccattgtgcatcaagctggcatgttgaagcgaaattgt
tttgcctctgtctttgaaaaatacttccaattccaagaagagggcaaggaaggagagaac
agggcagttatccattatagggatgatgagaccatgtatgttgagtctaaaaaggacaga
gtcacagtagtcttcagcacagtgtttaaggatgacgacgatgtggtcattggaaaggtg
ttcatgcaggagttcaaagaaggacgcagagccagccacacagccccacaggtcctcttt
agccacagggaacctcctctggagctgaaagacacagacgccgctgtgggtgacaacatt
ggctacattacctttgtgctgttccctcgtcacaccaatgccagtgctcgagacaacacc
atcaacctgatccacacgttccgggactacctgcactaccacatcaagtgctctaaggcc
tatattcacacacgtatgcgggcgaaaacgtctgacttcctcaaggtgctgaaccgcgca
cgcccagatgccgagaaaaaagaaatgaaaacaatcacggggaagacgttttcatcccgc
taa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Network (11)   
   KEGG NETWORK (11)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
   PHAROS (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (28)   
   RefSeq(nuc) (4)   
   GenBank (12)   
   EMBL (12)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (88)   

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