KEGG   Homo sapiens (human): 10135
Entry
10135             CDS       T01001                                 
Symbol
NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Name
(RefSeq) nicotinamide phosphoribosyltransferase
  KO
K03462  nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa04621  NOD-like receptor signaling pathway
Drug target
Teglarinad chloride: D09678
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    10135 (NAMPT)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    10135 (NAMPT)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    10135 (NAMPT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.12  nicotinamide phosphoribosyltransferase
     10135 (NAMPT)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  Neuropeptides (Unclassified)
   10135 (NAMPT)
SSDB
Motif
Pfam: NAPRTase NAMPT_N NAPRTase_C
Other DBs
NCBI-GeneID: 10135
NCBI-ProteinID: NP_005737
OMIM: 608764
HGNC: 30092
Ensembl: ENSG00000105835
UniProt: P43490
Structure
Position
7:complement(106248298..106285888)
AA seq 491 aa
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
NT seq 1476 nt   +upstreamnt  +downstreamnt
atgaatcctgcggcagaagccgagttcaacatcctcctggccaccgactcctacaaggtt
actcactataaacaatatccacccaacacaagcaaagtttattcctactttgaatgccgt
gaaaagaagacagaaaactccaaattaaggaaggtgaaatatgaggaaacagtattttat
gggttgcagtacattcttaataagtacttaaaaggtaaagtagtaaccaaagagaaaatc
caggaagccaaagatgtctacaaagaacatttccaagatgatgtctttaatgaaaaggga
tggaactacattcttgagaagtatgatgggcatcttccaatagaaataaaagctgttcct
gagggctttgtcattcccagaggaaatgttctcttcacggtggaaaacacagatccagag
tgttactggcttacaaattggattgagactattcttgttcagtcctggtatccaatcaca
gtggccacaaattctagagagcagaagaaaatattggccaaatatttgttagaaacttct
ggtaacttagatggtctggaatacaagttacatgattttggctacagaggagtctcttcc
caagagactgctggcataggagcatctgctcacttggttaacttcaaaggaacagataca
gtagcaggacttgctctaattaaaaaatattatggaacgaaagatcctgttccaggctat
tctgttccagcagcagaacacagtaccataacagcttgggggaaagaccatgaaaaagat
gcttttgaacatattgtaacacagttttcatcagtgcctgtatctgtggtcagcgatagc
tatgacatttataatgcgtgtgagaaaatatggggtgaagatctaagacatttaatagta
tcaagaagtacacaggcaccactaataatcagacctgattctggaaaccctcttgacact
gtgttaaaggttttggagattttaggtaagaagtttcctgttactgagaactcaaagggt
tacaagttgctgccaccttatcttagagttattcaaggggatggagtagatattaatacc
ttacaagagattgtagaaggcatgaaacaaaaaatgtggagtattgaaaatattgccttc
ggttctggtggaggtttgctacagaagttgacaagagatctcttgaattgttccttcaag
tgtagctatgttgtaactaatggccttgggattaacgtcttcaaggacccagttgctgat
cccaacaaaaggtccaaaaagggccgattatctttacataggacgccagcagggaatttt
gttacactggaggaaggaaaaggagaccttgaggaatatggtcaggatcttctccatact
gtcttcaagaatggcaaggtgacaaaaagctattcatttgatgaaataagaaaaaatgca
cagctgaatattgaactggaagcagcacatcattag

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