KEGG   Homo sapiens (human): 10135Help
Entry
10135             CDS       T01001                                 

Gene name
NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Definition
(RefSeq) nicotinamide phosphoribosyltransferase
  KO
K03462  nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa04621  NOD-like receptor signaling pathway
Drug target
Teglarinad chloride: D09678
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    10135 (NAMPT)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    10135 (NAMPT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.12  nicotinamide phosphoribosyltransferase
     10135 (NAMPT)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: NAPRTase DUF5598
Motif
Other DBs
NCBI-GeneID: 10135
NCBI-ProteinID: NP_005737
OMIM: 608764
HGNC: 30092
Ensembl: ENSG00000105835
Vega: OTTHUMG00000140388
Pharos: P43490(Tchem)
UniProt: P43490 A0A024R718
Structure
PDB: 

Position
7q22.3
AA seq 491 aa AA seqDB search
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
NT seq 1476 nt NT seq  +upstreamnt  +downstreamnt
atgaatcctgcggcagaagccgagttcaacatcctcctggccaccgactcctacaaggtt
actcactataaacaatatccacccaacacaagcaaagtttattcctactttgaatgccgt
gaaaagaagacagaaaactccaaattaaggaaggtgaaatatgaggaaacagtattttat
gggttgcagtacattcttaataagtacttaaaaggtaaagtagtaaccaaagagaaaatc
caggaagccaaagatgtctacaaagaacatttccaagatgatgtctttaatgaaaaggga
tggaactacattcttgagaagtatgatgggcatcttccaatagaaataaaagctgttcct
gagggctttgtcattcccagaggaaatgttctcttcacggtggaaaacacagatccagag
tgttactggcttacaaattggattgagactattcttgttcagtcctggtatccaatcaca
gtggccacaaattctagagagcagaagaaaatattggccaaatatttgttagaaacttct
ggtaacttagatggtctggaatacaagttacatgattttggctacagaggagtctcttcc
caagagactgctggcataggagcatctgctcacttggttaacttcaaaggaacagataca
gtagcaggacttgctctaattaaaaaatattatggaacgaaagatcctgttccaggctat
tctgttccagcagcagaacacagtaccataacagcttgggggaaagaccatgaaaaagat
gcttttgaacatattgtaacacagttttcatcagtgcctgtatctgtggtcagcgatagc
tatgacatttataatgcgtgtgagaaaatatggggtgaagatctaagacatttaatagta
tcaagaagtacacaggcaccactaataatcagacctgattctggaaaccctcttgacact
gtgttaaaggttttggagattttaggtaagaagtttcctgttactgagaactcaaagggt
tacaagttgctgccaccttatcttagagttattcaaggggatggagtagatattaatacc
ttacaagagattgtagaaggcatgaaacaaaaaatgtggagtattgaaaatattgccttc
ggttctggtggaggtttgctacagaagttgacaagagatctcttgaattgttccttcaag
tgtagctatgttgtaactaatggccttgggattaacgtcttcaaggacccagttgctgat
cccaacaaaaggtccaaaaagggccgattatctttacataggacgccagcagggaatttt
gttacactggaggaaggaaaaggagaccttgaggaatatggtcaggatcttctccatact
gtcttcaagaatggcaaggtgacaaaaagctattcatttgatgaaataagaaaaaatgca
cagctgaatattgaactggaagcagcacatcattag

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