KEGG T01001: 1017

Homo sapiens (human): 1017

Entry

1017              CDS       T01001

Symbol

CDK2, CDKN2, p33(CDK2)

Name

(RefSeq) cyclin dependent kinase 2

K02206

cyclin-dependent kinase 2 [EC:2.7.11.22]

Organism

hsa Homo sapiens (human)

Pathway

hsa04068

FoxO signaling pathway

hsa04110

Cell cycle

hsa04114

Oocyte meiosis

hsa04115

p53 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04218

Cellular senescence

hsa04914

Progesterone-mediated oocyte maturation

hsa04934

Cushing syndrome

hsa05160

Hepatitis C

hsa05161

Hepatitis B

hsa05162

Measles

hsa05165

Human papillomavirus infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05203

Viral carcinogenesis

hsa05215

Prostate cancer

hsa05222

Small cell lung cancer

hsa05226

Gastric cancer

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06360  Cushing syndrome
nt06509  DNA replication

Element

N00091

p27-Cell cycle G1/S

N00092

Amplified MYC to p27-cell cycle G1/S

N00093

Loss of CDKN1B to p27-cell cycle G1/S

N00254

CDKN1B-reduced expression to p27-cell cycle G1/S

N00255

Amplified CCNE to cell cycle G1/S

N00264

EBV EBNA3C to p27-Cell cycle G1/S

N00316

Mutation-inactivated CDKN1B to p27-cell cycle G1/S

N00360

HPV E7 to p27-cell cycle G1/S

N00482

EBV EBNA3C to p27-Cell cycle G1/S

N00497

HTLV-1 Tax to p21-cell cycle G1/S

N00498

HTLV-1 Tax to p21-cell cycle G1/S

N00536

MDM2-p21-Cell cycle G1/S

N00537

HBV HBx to cell cycle G1/S

N01468

DNA replication licensing

Drug target

Alvocidib (DG02041):

D02880 D09868

Dinaciclib:

D09604

Tagtociclib:

D12601

Zotiraciclib (DG03058):

D11599 D11600

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    1017 (CDK2)
   04151 PI3K-Akt signaling pathway
    1017 (CDK2)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1017 (CDK2)
   04114 Oocyte meiosis
    1017 (CDK2)
   04115 p53 signaling pathway
    1017 (CDK2)
   04218 Cellular senescence
    1017 (CDK2)
09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    1017 (CDK2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1017 (CDK2)
   05203 Viral carcinogenesis
    1017 (CDK2)
  09162 Cancer: specific types
   05226 Gastric cancer
    1017 (CDK2)
   05215 Prostate cancer
    1017 (CDK2)
   05222 Small cell lung cancer
    1017 (CDK2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1017 (CDK2)
   05161 Hepatitis B
    1017 (CDK2)
   05160 Hepatitis C
    1017 (CDK2)
   05162 Measles
    1017 (CDK2)
   05169 Epstein-Barr virus infection
    1017 (CDK2)
   05165 Human papillomavirus infection
    1017 (CDK2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1017 (CDK2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1017 (CDK2)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    1017 (CDK2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1017 (CDK2)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1017 (CDK2)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CMGC group
  CDK family
   1017 (CDK2)
DNA replication proteins [BR:hsa03032]
Eukaryotic type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    1017 (CDK2)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    1017 (CDK2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Kinase-like

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

12:55966830..55972789

AA seq 298 aa
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

NT seq 897 nt +upstreamnt +downstreamnt
atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa
gccagaaacaagttgacgggagaggtggtggcgcttaagaaaatccgcctggacactgag
actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat
cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt
gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct
cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct
catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc
atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc
catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat
tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg
gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg
accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc
cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg
agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc
ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga

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