KEGG   Homo sapiens (human): 1017
Entry
1017              CDS       T01001                                 
Symbol
CDK2, CDKN2, p33(CDK2)
Name
(RefSeq) cyclin dependent kinase 2
  KO
K02206  cyclin-dependent kinase 2 [EC:2.7.11.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04914  Progesterone-mediated oocyte maturation
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05215  Prostate cancer
hsa05222  Small cell lung cancer
hsa05226  Gastric cancer
Network
nt06130  Cell cycle (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06230  Cell cycle
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06360  Cushing syndrome
  Element
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00093  Loss of CDKN1B to p27-cell cycle G1/S
N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  Amplified CCNE to cell cycle G1/S
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00316  Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00482  EBV EBNA3C to p27-Cell cycle G1/S
N00497  HTLV-1 Tax to p21-cell cycle G1/S
N00498  HTLV-1 Tax to p21-cell cycle G1/S
N00536  MDM2-p21-Cell cycle G1/S
N00537  HBV HBx to cell cycle G1/S
Drug target
Alvocidib (DG02041): D02880 D09868
Dinaciclib: D09604
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    1017 (CDK2)
   04151 PI3K-Akt signaling pathway
    1017 (CDK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1017 (CDK2)
   04114 Oocyte meiosis
    1017 (CDK2)
   04115 p53 signaling pathway
    1017 (CDK2)
   04218 Cellular senescence
    1017 (CDK2)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    1017 (CDK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1017 (CDK2)
   05203 Viral carcinogenesis
    1017 (CDK2)
  09162 Cancer: specific types
   05226 Gastric cancer
    1017 (CDK2)
   05215 Prostate cancer
    1017 (CDK2)
   05222 Small cell lung cancer
    1017 (CDK2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1017 (CDK2)
   05161 Hepatitis B
    1017 (CDK2)
   05160 Hepatitis C
    1017 (CDK2)
   05162 Measles
    1017 (CDK2)
   05169 Epstein-Barr virus infection
    1017 (CDK2)
   05165 Human papillomavirus infection
    1017 (CDK2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1017 (CDK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1017 (CDK2)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    1017 (CDK2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1017 (CDK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1017 (CDK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1017 (CDK2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    1017 (CDK2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    1017 (CDK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase APH Kinase-like
Other DBs
NCBI-GeneID: 1017
NCBI-ProteinID: NP_001789
OMIM: 116953
HGNC: 1771
Ensembl: ENSG00000123374
Vega: OTTHUMG00000170575
Pharos: P24941(Tchem)
UniProt: P24941 A0A024RB77
Structure
Position
12:55966830..55972789
AA seq 298 aa
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
NT seq 897 nt   +upstreamnt  +downstreamnt
atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa
gccagaaacaagttgacgggagaggtggtggcgcttaagaaaatccgcctggacactgag
actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat
cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt
gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct
cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct
catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc
atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc
catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat
tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg
gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg
accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc
cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg
agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc
ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga

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