KEGG   Homo sapiens (human): 10203Help
Entry
10203             CDS       T01001                                 

Gene name
CALCRL, CGRPR, CRLR
Definition
(RefSeq) calcitonin receptor like receptor
  KO
K04577  calcitonin receptor-like
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Drug target
Atogepant: D11313
Davalintide (DG01352): D09600 D09601
Erenumab: D10928
Rimegepant (DG01845): D10662 D10663
Telcagepant (DG01353): D09391 D09392
Ubrogepant: D10673
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    10203 (CALCRL)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    10203 (CALCRL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    10203 (CALCRL)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Calcium-regulating peptide
   Calcitonin
    10203 (CALCRL)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_2 HRM DUF4034
Motif
Other DBs
NCBI-GeneID: 10203
NCBI-ProteinID: NP_001258680
OMIM: 114190
HGNC: 16709
Ensembl: ENSG00000064989
Vega: OTTHUMG00000132636
Pharos: Q16602(Tchem)
UniProt: Q16602
Structure
PDB: 

Position
2q32.1
AA seq 461 aa AA seqDB search
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
NT seq 1386 nt NT seq  +upstreamnt  +downstreamnt
atggagaaaaagtgtaccctgtattttctggttctcttgcctttttttatgattcttgtt
acagcagaattagaagagagtcctgaggactcaattcagttgggagttactagaaataaa
atcatgacagctcaatatgaatgttaccaaaagattatgcaagaccccattcaacaagca
gaaggcgtttactgcaacagaacctgggatggatggctctgctggaacgatgttgcagca
ggaactgaatcaatgcagctctgccctgattactttcaggactttgatccatcagaaaaa
gttacaaagatctgtgaccaagatggaaactggtttagacatccagcaagcaacagaaca
tggacaaattatacccagtgtaatgttaacacccacgagaaagtgaagactgcactaaat
ttgttttacctgaccataattggacacggattgtctattgcatcactgcttatctcgctt
ggcatattcttttatttcaagagcctaagttgccaaaggattaccttacacaaaaatctg
ttcttctcatttgtttgtaactctgttgtaacaatcattcacctcactgcagtggccaac
aaccaggccttagtagccacaaatcctgttagttgcaaagtgtcccagttcattcatctt
tacctgatgggctgtaattacttttggatgctctgtgaaggcatttacctacacacactc
attgtggtggccgtgtttgcagagaagcaacatttaatgtggtattattttcttggctgg
ggatttccactgattcctgcttgtatacatgccattgctagaagcttatattacaatgac
aattgctggatcagttctgatacccatctcctctacattatccatggcccaatttgtgct
gctttactggtgaatctttttttcttgttaaatattgtacgcgttctcatcaccaagtta
aaagttacacaccaagcggaatccaatctgtacatgaaagctgtgagagctactcttatc
ttggtgccattgcttggcattgaatttgtgctgattccatggcgacctgaaggaaagatt
gcagaggaggtatatgactacatcatgcacatccttatgcacttccagggtcttttggtc
tctaccattttctgcttctttaatggagaggttcaagcaattctgagaagaaactggaat
caatacaaaatccaatttggaaacagcttttccaactcagaagctcttcgtagtgcgtct
tacacagtgtcaacaatcagtgatggtccaggttatagtcatgactgtcctagtgaacac
ttaaatggaaaaagcatccatgatattgaaaatgttctcttaaaaccagaaaatttatat
aattga

KEGG   Homo sapiens (human): 10266Help
Entry
10266             CDS       T01001                                 

Gene name
RAMP2
Definition
(RefSeq) receptor activity modifying protein 2
  KO
K08448  receptor activity modifying protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    10266 (RAMP2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    10266 (RAMP2)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Others
   Receptor activity modifying protein
    10266 (RAMP2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RAMP
Motif
Other DBs
NCBI-GeneID: 10266
NCBI-ProteinID: NP_005845
OMIM: 605154
HGNC: 9844
Ensembl: ENSG00000131477
Vega: OTTHUMG00000180648
Pharos: O60895(Tchem)
UniProt: O60895 A0A024R1Z2
Structure
PDB: 

Position
17q21.2
AA seq 175 aa AA seqDB search
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKN
YETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERII
FETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA
NT seq 528 nt NT seq  +upstreamnt  +downstreamnt
atggcctcgctccgggtggagcgcgccggcggcccgcgtctccctaggacccgagtcggg
cggccggcagcgctccgcctcctcctcctgctgggcgctgtcctgaatccccacgaggcc
ctggctcagcctcttcccaccacaggcacaccagggtcagaaggggggacggtgaagaac
tatgagacagctgtccaattttgctggaatcattataaggatcaaatggatcctatcgaa
aaggattggtgcgactgggccatgattagcaggccttatagcaccctgcgagattgcctg
gagcactttgcagagttgtttgacctgggcttccccaatcccttggcagagaggatcatc
tttgagactcaccagatccactttgccaactgctccctggtgcagcccaccttctctgac
cccccagaggatgtactcctggccatgatcatagcccccatctgcctcatccccttcctc
atcactcttgtagtatggaggagtaaagacagtgaggcccaggcctag

KEGG   Homo sapiens (human): 10267Help
Entry
10267             CDS       T01001                                 

Gene name
RAMP1
Definition
(RefSeq) receptor activity modifying protein 1
  KO
K08447  receptor activity modifying protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    10267 (RAMP1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    10267 (RAMP1)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Others
   Receptor activity modifying protein
    10267 (RAMP1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RAMP
Motif
Other DBs
NCBI-GeneID: 10267
NCBI-ProteinID: NP_005846
OMIM: 605153
HGNC: 9843
Ensembl: ENSG00000132329
Vega: OTTHUMG00000133337
Pharos: O60894(Tclin)
UniProt: O60894
Structure
PDB: 

Position
2q37.3
AA seq 148 aa AA seqDB search
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
NT seq 447 nt NT seq  +upstreamnt  +downstreamnt
atggcccgggccctgtgccgcctcccgcggcgcggcctctggctgctcctggcccatcac
ctcttcatgaccactgcctgccaggaggctaactacggtgccctcctccgggagctctgc
ctcacccagttccaggtagacatggaggccgtcggggagacgctgtggtgtgactggggc
aggaccatcaggagctacagggagctggccgactgcacctggcacatggcggagaagctg
ggctgcttctggcccaatgcagaggtggacaggttcttcctggcagtgcatggccgctac
ttcaggagctgccccatctcaggcagggccgtgcgggacccgcccggcagcatcctctac
cccttcatcgtggtccccatcacggtgaccctgctggtgacggcactggtggtctggcag
agcaagcgcactgagggcattgtgtag

KEGG   Homo sapiens (human): 10268Help
Entry
10268             CDS       T01001                                 

Gene name
RAMP3
Definition
(RefSeq) receptor activity modifying protein 3
  KO
K08449  receptor activity modifying protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    10268 (RAMP3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    10268 (RAMP3)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Others
   Receptor activity modifying protein
    10268 (RAMP3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RAMP
Motif
Other DBs
NCBI-GeneID: 10268
NCBI-ProteinID: NP_005847
OMIM: 605155
HGNC: 9845
Ensembl: ENSG00000122679
Vega: OTTHUMG00000023729
Pharos: O60896(Tclin)
UniProt: O60896 A4D2L1
Position
7p13
AA seq 148 aa AA seqDB search
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLS
EFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLI
PLIVIPVVLTVAMAGLVVWRSKRTDTLL
NT seq 447 nt NT seq  +upstreamnt  +downstreamnt
atggagactggagcgctgcggcgcccgcaacttctcccgttgctgctgctgctctgcggt
gggtgtcccagagcaggcggctgcaacgagacaggcatgttggagaggctgcccctgtgt
gggaaggctttcgcagacatgatgggcaaggtggacgtctggaagtggtgcaacctgtcc
gagttcatcgtgtactatgagagtttcaccaactgcaccgagatggaggccaatgtcgtg
ggctgctactggcccaaccccctggcccagggcttcatcaccggcatccacaggcagttc
ttctccaactgcaccgtggacagggtccacttggaggaccccccagacgaggttctcatc
ccgctgatcgttatacccgtcgttctgactgtcgccatggctggcctggtggtgtggcgc
agcaaacgcaccgacacgctgctgtga

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