KEGG   Homo sapiens (human): 1025
Entry
1025              CDS       T01001                                 
Symbol
CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK
Name
(RefSeq) cyclin dependent kinase 9
  KO
K02211  cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
  Element
N00119  MLL-AF4 fusion to transcriptional activation
Drug target
Dinaciclib: D09604
Enitociclib: D12525
Istisociclib: D12868
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    1025 (CDK9)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    1025 (CDK9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1025 (CDK9)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    1025 (CDK9)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1025 (CDK9)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     1025 (CDK9)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1025 (CDK9)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     1025 (CDK9)
    Brd4/P-TEFb complex
     1025 (CDK9)
    7SK RNP complex
     1025 (CDK9)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Haspin_kinase ABC1
Other DBs
NCBI-GeneID: 1025
NCBI-ProteinID: NP_001252
OMIM: 603251
HGNC: 1780
Ensembl: ENSG00000136807
UniProt: P50750
Structure
Position
9:127786034..127790792
AA seq 372 aa
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
NT seq 1119 nt   +upstreamnt  +downstreamnt
atggcaaagcagtacgactcggtggagtgccctttttgtgatgaagtttccaaatacgag
aagctcgccaagatcggccaaggcaccttcggggaggtgttcaaggccaggcaccgcaag
accggccagaaggtggctctgaagaaggtgctgatggaaaacgagaaggaggggttcccc
attacagccttgcgggagatcaagatccttcagcttctaaaacacgagaatgtggtcaac
ttgattgagatttgtcgaaccaaagcttccccctataaccgctgcaagggtagtatatac
ctggtgttcgacttctgcgagcatgaccttgctgggctgttgagcaatgttttggtcaag
ttcacgctgtctgagatcaagagggtgatgcagatgctgcttaacggcctctactacatc
cacagaaacaagatcctgcatagggacatgaaggctgctaatgtgcttatcactcgtgat
ggggtcctgaagctggcagactttgggctggcccgggccttcagcctggccaagaacagc
cagcccaaccgctacaccaaccgtgtggtgacactctggtaccggcccccggagctgttg
ctcggggagcgggactacggcccccccattgacctgtggggtgctgggtgcatcatggca
gagatgtggacccgcagccccatcatgcagggcaacacggagcagcaccaactcgccctc
atcagtcagctctgcggctccatcacccctgaggtgtggccaaacgtggacaactatgag
ctgtacgaaaagctggagctggtcaagggccagaagcggaaggtgaaggacaggctgaag
gcctatgtgcgtgacccatacgcactggacctcatcgacaagctgctggtgctggaccct
gcccagcgcatcgacagcgatgacgccctcaaccacgacttcttctggtccgaccccatg
ccctccgacctcaagggcatgctctccacccacctgacgtccatgttcgagtacttggca
ccaccgcgccggaagggcagccagatcacccagcagtccaccaaccagagtcgcaatccc
gccaccaccaaccagacggagtttgagcgcgtcttctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (14)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (28)   
   PDB (28)   
Protein domain (4)   
   Pfam (4)   
All databases (71)   

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