KEGG   Homo sapiens (human): 10298
Entry
10298             CDS       T01001                                 
Symbol
PAK4
Name
(RefSeq) p21 (RAC1) activated kinase 4
  KO
K05734  p21-activated kinase 4 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04360  Axon guidance
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04660  T cell receptor signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05170  Human immunodeficiency virus 1 infection
hsa05206  MicroRNAs in cancer
hsa05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    10298 (PAK4)
   04014 Ras signaling pathway
    10298 (PAK4)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    10298 (PAK4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    10298 (PAK4)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10298 (PAK4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    10298 (PAK4)
  09158 Development and regeneration
   04360 Axon guidance
    10298 (PAK4)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    10298 (PAK4)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    10298 (PAK4)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    10298 (PAK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    10298 (PAK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     10298 (PAK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE20 family
   10298 (PAK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PBD Kinase-like ABC1 Pkinase_fungal hnRNP_Q_AcD RIO1 KIND
Other DBs
NCBI-GeneID: 10298
NCBI-ProteinID: NP_001014831
OMIM: 605451
HGNC: 16059
Ensembl: ENSG00000130669
UniProt: O96013
Structure
Position
19:39125786..39182816
AA seq 591 aa
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
NT seq 1776 nt   +upstreamnt  +downstreamnt
atgtttgggaagaggaagaagcgggtggagatctccgcgccgtccaacttcgagcaccgc
gtgcacacgggcttcgaccagcacgagcagaagttcacggggctgccccgccagtggcag
agcctgatcgaggagtcggctcgccggcccaagcccctcgtcgaccccgcctgcatcacc
tccatccagcccggggcccccaagaccatcgtgcggggcagcaaaggtgccaaagatggg
gccctcacgctgctgctggacgagtttgagaacatgtcggtgacacgctccaactccctg
cggagagacagcccgccgccgcccgcccgtgcccgccaggaaaatgggatgccagaggag
ccggccaccacggccagagggggcccagggaaggcaggcagccgaggccggttcgccggt
cacagcgaggcgggtggcggcagtggtgacaggcgacgggcggggccagagaagaggccc
aagtcttccagggagggctcagggggtccccaggagtcctcccgggacaaacgccccctc
tccgggcctgatgtcggcaccccccagcctgctggtctggccagtggggcgaaactggca
gctggccggccctttaacacctacccgagggctgacacggaccacccatcccggggtgcc
cagggggagcctcatgacgtggcccctaacgggccatcagcggggggcctggccatcccc
cagtcctcctcctcctcctcccggcctcccacccgagcccgaggtgcccccagccctgga
gtgctgggaccccacgcctcagagccccagctggcccctccagcctgcacccccgccgcc
cctgctgttcctgggccccctggcccccgctcaccacagcgggagccacagcgagtatcc
catgagcagttccgggctgccctgcagctggtggtggacccaggcgacccccgctcctac
ctggacaacttcatcaagattggcgagggctccacgggcatcgtgtgcatcgccaccgtg
cgcagctcgggcaagctggtggccgtcaagaagatggacctgcgcaagcagcagaggcgc
gagctgctcttcaacgaggtggtaatcatgagggactaccagcacgagaatgtggtggag
atgtacaacagctacctggtgggggacgagctctgggtggtcatggagttcctggaagga
ggcgccctcaccgacatcgtcacccacaccaggatgaacgaggagcagatcgcggccgtg
tgccttgcagtgctgcaggccctgtcggtgctccacgcccagggcgtcatccaccgggac
atcaagagcgactcgatcctgctgacccatgatggcagggtgaagctgtcagactttggg
ttctgcgcccaggtgagcaaggaagtgccccgaaggaagtcgctggtcggcacgccctac
tggatggccccagagctcatctcccgccttccctacgggccagaggtagacatctggtcg
ctggggataatggtgattgagatggtggacggagagcccccctacttcaacgagccaccc
ctcaaagccatgaagatgattcgggacaacctgccaccccgactgaagaacctgcacaag
gtgtcgccatccctgaagggcttcctggaccgcctgctggtgcgagaccctgcccagcgg
gccacggcagccgagctgctgaagcacccattcctggccaaggcagggccgcctgccagc
atcgtgcccctcatgcgccagaaccgcaccagatga

  All links  
Disease (1)   
   OMIM (1)   
Gene (29)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (30)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (71)   
   RefSeq(nuc) (29)   
   GenBank (21)   
   EMBL (21)   
3D Structure (47)   
   PDB (47)   
Protein domain (9)   
   Pfam (9)   
All databases (187)   

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