Entry |
|
Symbol |
TUBA1B, K-ALPHA-1
|
Name |
(RefSeq) tubulin alpha 1b
|
KO |
|
Organism |
|
Pathway |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05130 | Pathogenic Escherichia coli infection |
|
Network |
|
Element |
N00976 | Retrograde axonal transport |
N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
N00978 | Anterograde axonal transport |
N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
N01285 | Microtubule-RHOA signaling pathway |
N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
N01295 | Rab7-regulated microtubule minus-end directed transport |
N01297 | Arl8-regulated microtubule plus-end directed transport |
N01298 | Salmonella SifA to microtubule plus-end directed transport |
N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
N01403 | Zn to anterograde axonal transport |
N01414 | Iron to anterograde axonal transport |
N01535 | Kinetochore microtubule attachment |
N01547 | Kinetochore fiber organization |
N01549 | Branching microtubule nucleation |
N01553 | Promotion of microtubule growth |
N01561 | Microtubule depolymerization |
N01562 | Microtubule depolymerization at the minus ends |
N01832 | NTN1-MAP1B axon guidance signaling |
N01833 | DRAXIN-MAP1B axon guidance signaling |
N01834 | SEMA3A-MAP1B axon guidance signaling |
N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
N01836 | Microtubule plus end regulation network |
N01837 | Regulation of neurite extension, NAV1-TRIO |
N01838 | Regulation of synaptic plasticity, p140Cap |
N01839 | Severing of microtubule, SPAST/KATN |
N01840 | Severing of microtubule, KIF2A |
N01841 | Anterograde axonal transport, Kinesin-2 |
N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
N01843 | Anterograde dendrite transport, Kinesin-4 |
N01844 | Anterograde dendrite transport, Kinesin-6 |
N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
N01846 | Retrograde axonal/dendrite transport, Dynein |
N01847 | Regulation of dynein-mediated retrograde transport |
N01857 | SEMA3A-DCX axon guidance signaling |
N01858 | EFNB1-MAPT axon guidance signaling |
N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
10376 (TUBA1B)
09142 Cell motility
04814 Motor proteins
10376 (TUBA1B)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
10376 (TUBA1B)
09164 Neurodegenerative disease
05010 Alzheimer disease
10376 (TUBA1B)
05012 Parkinson disease
10376 (TUBA1B)
05014 Amyotrophic lateral sclerosis
10376 (TUBA1B)
05016 Huntington disease
10376 (TUBA1B)
05020 Prion disease
10376 (TUBA1B)
05022 Pathways of neurodegeneration - multiple diseases
10376 (TUBA1B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:hsa03019]
10376 (TUBA1B)
03036 Chromosome and associated proteins [BR:hsa03036]
10376 (TUBA1B)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
10376 (TUBA1B)
04147 Exosome [BR:hsa04147]
10376 (TUBA1B)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
P-body specific factors
10376 (TUBA1B)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
10376 (TUBA1B)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
10376 (TUBA1B)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
10376 (TUBA1B)
Exosomal proteins of other body fluids (saliva and urine)
10376 (TUBA1B)
Exosomal proteins of colorectal cancer cells
10376 (TUBA1B)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
12:complement(49127782..49131395)
|
AA seq |
451 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY |
NT seq |
1356 nt +upstreamnt +downstreamnt
atgcgtgagtgcatctccatccacgttggccaggctggtgtccagattggcaatgcctgc
tgggagctctactgcctggaacacggcatccagcccgatggccagatgccaagtgacaag
accattgggggaggagatgactccttcaacaccttcttcagtgagacgggcgctggcaag
cacgtgccccgggctgtgtttgtagacttggaacccacagtcattgatgaagttcgcact
ggcacctaccgccagctcttccaccctgagcagctcatcacaggcaaggaagatgctgcc
aataactatgcccgagggcactacaccattggcaaggagatcattgaccttgtgttggac
cgaattcgcaagctggctgaccagtgcaccggtcttcagggcttcttggttttccacagc
tttggtgggggaactggttctgggttcacctccctgctcatggaacgtctctcagttgat
tatggcaagaagtccaagctggagttctccatttacccagcaccccaggtttccacagct
gtagttgagccctacaactccatcctcaccacccacaccaccctggagcactctgattgt
gccttcatggtagacaatgaggccatctatgacatctgtcgtagaaacctcgatatcgag
cgcccaacctacactaaccttaaccgccttattagccagattgtgtcctccatcactgct
tccctgagatttgatggagccctgaatgttgacctgacagaattccagaccaacctggtg
ccctacccccgcatccacttccctctggccacatatgcccctgtcatctctgctgagaaa
gcctaccatgaacagctttctgtagcagagatcaccaatgcttgctttgagccagccaac
cagatggtgaaatgtgaccctcgccatggtaaatacatggcttgctgcctgttgtaccgt
ggtgacgtggttcccaaagatgtcaatgctgccattgccaccatcaaaaccaagcgcagc
atccagtttgtggattggtgccccactggcttcaaggttggcatcaactaccagcctccc
actgtggtgcctggtggagacctggccaaggtacagagagctgtgtgcatgctgagcaac
accacagccattgctgaggcctgggctcgcctggaccacaagtttgacctgatgtatgcc
aagcgtgcctttgttcactggtacgtgggtgaggggatggaggaaggcgagttttcagag
gcccgtgaagatatggctgcccttgagaaggattatgaggaggttggtgtggattctgtt
gaaggagagggtgaggaagaaggagaggaatactaa |