KEGG   Homo sapiens (human): 10419
Entry
10419             CDS       T01001                                 
Symbol
PRMT5, HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs
Name
(RefSeq) protein arginine methyltransferase 5
  KO
K02516  type II protein arginine methyltransferase [EC:2.1.1.320]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    10419 (PRMT5)
   03036 Chromosome and associated proteins [BR:hsa03036]
    10419 (PRMT5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.320  type II protein arginine methyltransferase
     10419 (PRMT5)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    10419 (PRMT5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    PRMTs (protein arginine metyltransferases)
     10419 (PRMT5)
SSDB
Motif
Pfam: PRMT5_TIM PRMT5 PRMT5_C Met_10 MTS IF-2B
Other DBs
NCBI-GeneID: 10419
NCBI-ProteinID: NP_006100
OMIM: 604045
HGNC: 10894
Ensembl: ENSG00000100462
UniProt: O14744
Structure
Position
14:complement(22920529..22929376)
AA seq 637 aa
MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
NT seq 1914 nt   +upstreamnt  +downstreamnt
atggcggcgatggcggtcgggggtgctggtgggagccgcgtgtccagcgggagggacctg
aattgcgtccccgaaatagctgacacactaggggctgtggccaagcaggggtttgatttc
ctctgcatgcctgtcttccatccgcgtttcaagagggagttcattcaggaacctgctaag
aatcggcccggtccccagacacgatcagacctactgctgtcaggaagggactggaatacg
ctaattgtgggaaagctttctccatggattcgtccagactcaaaagtggagaagattcgc
aggaactccgaggcggccatgttacaggagctgaattttggtgcatatttgggtcttcca
gctttcctgctgccccttaatcaggaagataacaccaacctggccagagttttgaccaac
cacatccacactggccatcactcttccatgttctggatgcgggtacccttggtggcacca
gaggacctgagagatgatataattgagaatgcaccaactacacacacagaggagtacagt
ggggaggagaaaacgtggatgtggtggcacaacttccggactttgtgtgactatagtaag
aggattgcagtggctcttgaaattggggctgacctcccatctaatcatgtcattgatcgc
tggcttggggagcccatcaaagcagccattctccccactagcattttcctgaccaataag
aagggatttcctgttctttctaagatgcaccagaggctcatcttccggctcctcaagttg
gaggtgcagttcatcatcacaggcaccaaccaccactcagagaaggagttctgctcctac
ctccaatacctggaatacttaagccagaaccgtcctccacctaatgcctatgaactcttt
gccaagggctatgaagactatctgcagtccccgcttcagccactgatggacaatctggaa
tctcagacatatgaagtgtttgaaaaggaccccatcaaatactctcagtaccagcaggcc
atctataaatgtctgctagaccgagtaccagaagaggagaaggataccaatgtccaggta
ctgatggtgctgggagcaggacggggacccctggtgaacgcttccctgcgggcagccaag
caggccgaccggcggataaagctgtatgctgtggagaaaaacccaaatgccgtggtgacg
ctagagaactggcagtttgaagaatggggaagccaagtgaccgtagtctcatcagacatg
agggaatgggtggctccagagaaagcagacatcattgtcagtgagcttctgggctcattt
gctgacaatgaattgtcgcctgagtgcctggatggagcccagcacttcctaaaagatgat
ggtgtgagcatccccggggagtacacttcctttctggctcccatctcttcctccaagctg
tacaatgaggtccgagcctgtagggagaaggaccgtgaccctgaggcccagtttgagatg
ccttatgtggtacggctgcacaacttccaccagctctctgcaccccagccctgtttcacc
ttcagccatcccaacagagatcctatgattgacaacaaccgctattgcaccttggaattt
cctgtggaggtgaacacagtactacatggctttgccggctactttgagactgtgctttat
caggacatcactctgagtatccgtccagagactcactctcctgggatgttctcatggttt
cccatcctcttccctattaagcagcccataacggtacgtgaaggccaaaccatctgtgtg
cgtttctggcgatgcagcaattccaagaaggtgtggtatgagtgggctgtgacagcacca
gtctgttctgctattcataaccccacaggccgctcatataccattggcctctag

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Ontology (4)   
   KEGG BRITE (4)   
Disease (1)   
   OMIM (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (44)   
   RefSeq(nuc) (12)   
   GenBank (16)   
   EMBL (16)   
3D Structure (54)   
   PDB (54)   
Protein domain (6)   
   Pfam (6)   
All databases (149)   

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