KEGG   Homo sapiens (human): 10654Help
Entry
10654             CDS       T01001                                 

Gene name
PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1
Definition
(RefSeq) phosphomevalonate kinase
  KO
K13273  phosphomevalonate kinase [EC:2.7.4.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
hsa04146  Peroxisome
Module
hsa_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Disease
H01933  Porokeratosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    10654 (PMVK)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    10654 (PMVK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.4  Phosphotransferases with a phosphate group as acceptor
    2.7.4.2  phosphomevalonate kinase
     10654 (PMVK)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: P-mevalo_kinase
Motif
Other DBs
NCBI-GeneID: 10654
NCBI-ProteinID: NP_006547
OMIM: 607622
HGNC: 9141
Ensembl: ENSG00000163344
Vega: OTTHUMG00000037415
Pharos: Q15126(Tbio)
UniProt: Q15126 Q6FGV9
Structure
PDB: 

Position
1q21.3
AA seq 192 aa AA seqDB search
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQ
RLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFRE
AYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQ
LENLIEFIRSRL
NT seq 579 nt NT seq  +upstreamnt  +downstreamnt
atggccccgctgggaggcgccccgcggctggtactgctgttcagcggcaagaggaaatcc
gggaaggacttcgtgaccgaggcgctgcagagcagacttggagctgatgtctgtgctgtc
ctccggctctctggtccactcaaggaacagtatgctcaggagcatggcttgaacttccag
agactcctggacaccagcacctacaaggaggcctttcggaaggacatgatccgctgggga
gaggagaaacgccaggctgacccaggcttcttttgcaggaagattgtggagggcatctcc
cagcccatctggctggtgagtgacacacggagagtgtctgacatccagtggtttcgggag
gcctatggggccgtgacgcagacggtccgcgttgtagcgttggagcagagccgacagcag
cggggctgggtgttcacgccaggggtggacgatgctgagtcagaatgtggcctggacaac
ttcggggactttgactgggtcatcgagaaccatggagttgaacagcgcctggaggagcag
ttggagaacctgatagaatttatccgctccagactttag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (30)   
   RefSeq(nuc) (4)   
   GenBank (13)   
   EMBL (13)   
Protein domain (1)   
   Pfam (1)   
All databases (68)   

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