KEGG   Homo sapiens (human): 1066
Entry
1066              CDS       T01001                                 
Symbol
CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
Name
(RefSeq) carboxylesterase 1
  KO
K01044  carboxylesterase 1 [EC:3.1.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00983  Drug metabolism - other enzymes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    1066 (CES1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.1  carboxylesterase
     1066 (CES1)
SSDB
Motif
Pfam: COesterase Abhydrolase_3 BD-FAE Say1_Mug180 Peptidase_S9 Esterase Abhydrolase_6
Other DBs
NCBI-GeneID: 1066
NCBI-ProteinID: NP_001020365
OMIM: 114835
HGNC: 1863
Ensembl: ENSG00000198848
UniProt: P23141
Structure
Position
16:complement(55802851..55833096)
AA seq 567 aa
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
NT seq 1704 nt   +upstreamnt  +downstreamnt
atgtggctccgtgcctttatcctggccactctctctgcttccgcggcttgggggcatccg
tcctcgccacctgtggtggacaccgtgcatggcaaagtgctggggaagttcgtcagctta
gaaggatttgcacagcctgtggccattttcctgggaatcccttttgccaagccgcctctt
ggacccctgaggtttactccaccgcagcctgcagaaccatggagctttgtgaagaatgcc
acctcgtaccctcctatgtgcacccaagatcccaaggcggggcagttactctcagagcta
tttacaaaccgaaaggagaacattcctctcaagctttctgaagactgtctttacctcaat
atttacactcctgctgacttgaccaagaaaaacaggctgccggtgatggtgtggatccac
ggaggggggctgatggtgggtgcggcatcaacctatgatgggctggcccttgctgcccat
gaaaacgtggtggtggtgaccattcaatatcgcctgggcatctggggattcttcagcaca
ggggatgaacacagccgggggaactggggtcacctggaccaggtggctgccctgcgctgg
gtccaggacaacattgccagctttggagggaacccaggctctgtgaccatctttggagag
tcagcgggaggagaaagtgtctctgttcttgttttgtctccattggccaagaacctcttc
caccgggccatttctgagagtggcgtggccctcacttctgttctggtgaagaaaggtgat
gtcaagcccttggctgagcaaattgctatcactgctgggtgcaaaaccaccacctctgct
gtcatggttcactgcctgcgacagaagacggaagaggagctcttggagacgacattgaaa
atgaaattcttatctctggacttacagggagaccccagagagagtcaaccccttctgggc
actgtgattgatgggatgctgctgctgaaaacacctgaagagcttcaagctgaaaggaat
ttccacactgtcccctacatggtcggaattaacaagcaggagtttggctggttgattcca
atgcagttgatgagctatccactctccgaagggcaactggaccagaagacagccatgtca
ctcctgtggaagtcctatccccttgtttgcattgctaaggaactgattccagaagccact
gagaaatacttaggaggaacagacgacactgtcaaaaagaaagacctgttcctggacttg
atagcagatgtgatgtttggtgtcccatctgtgattgtggcccggaaccacagagatgct
ggagcacccacctacatgtatgagtttcagtaccgtccaagcttctcatcagacatgaaa
cccaagacggtgataggagaccacggggatgagctcttctccgtctttggggccccattt
ttaaaagagggtgcctcagaagaggagatcagacttagcaagatggtgatgaaattctgg
gccaactttgctcgcaatggaaaccccaatggggaagggctgccccactggccagagtac
aaccagaaggaagggtatctgcagattggtgccaacacccaggcggcccagaagctgaag
gacaaagaagtagctttctggaccaacctctttgccaagaaggcagtggagaagccaccc
cagacagaacacatagagctgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Chemical substance (18)   
   KEGG COMPOUND (18)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (46)   
   RefSeq(nuc) (6)   
   GenBank (20)   
   EMBL (20)   
3D Structure (19)   
   PDB (19)   
Protein domain (7)   
   Pfam (7)   
All databases (121)   

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