KEGG   Homo sapiens (human): 10667
Entry
10667             CDS       T01001                                 
Symbol
FARS2, COXPD14, FARS1, HSPC320, PheRS, SPG77, mtPheRS
Name
(RefSeq) phenylalanyl-tRNA synthetase 2, mitochondrial
  KO
K01889  phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00266  Hereditary spastic paraplegia
H00891  Combined oxidative phosphorylation deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    10667 (FARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    10667 (FARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    10667 (FARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.20  phenylalanine---tRNA ligase
     10667 (FARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (U)
   10667 (FARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    10667 (FARS2)
 Prokaryotic type
    10667 (FARS2)
SSDB
Motif
Pfam: tRNA-synt_2d FDX-ACB tRNA-synt_2
Other DBs
NCBI-GeneID: 10667
NCBI-ProteinID: NP_001305801
OMIM: 611592
HGNC: 21062
Ensembl: ENSG00000145982
UniProt: O95363
Structure
Position
6:5249934..5771583
AA seq 451 aa
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF
NT seq 1356 nt   +upstreamnt  +downstreamnt
atggtgggctcagctctcaggagaggtgcccatgcatatgtctacctggtgagtaaggcc
agtcacatctccagaggccatcagcaccaggcctggggatcgaggcctcctgcagcagag
tgtgccacccaaagagctccaggcagtgtggtggagctgctgggcaaatcctaccctcag
gacgaccacagcaacctcacccggaaggtcctcaccagagttggcaggaacctgcacaac
cagcagcatcaccctctgtggctgatcaaggagagggtgaaggagcacttctacaagcag
tatgtgggccgctttgggaccccgttgttctcggtctacgacaacctttctccagtggtc
acgacctggcagaactttgacagcctgctcatcccagctgatcaccccagcaggaagaag
ggggacaactattacctgaatcggactcacatgctgagagcgcacacgtctgcacaccag
tgggacttgctgcacgcgggactggatgccttcctggtggtgggtgatgtctacaggcgt
gaccagatcgactcccagcactaccctattttccaccagctggaggccgtgcggctcttc
tccaagcatgagttatttgctggtataaaggatggagaaagcctgcagctctttgaacaa
agttctcgctctgcgcataaacaagagacacacaccatggaggccgtgaagcttgtagag
tttgatcttaagcaaacgcttaccaggctcatggcacatctttttggagatgagctggag
ataagatgggtagactgctacttcccttttacacatccttcctttgagatggagatcaac
tttcatggagaatggctggaagttcttggctgcggggtgatggaacaacaactggtcaat
tcagctggtgctcaagaccgaatcggctgggcttttggcctaggattagaaaggctagcc
atgatcctctacgacatccctgatatccgtctcttctggtgtgaggacgagcgcttcctg
aagcagttctgtgtatccaacattaatcagaaggtgaagtttcagcctcttagcaaatat
ccggctgtgatcaatgatatttcattctggttgccctctgagaattacgcagaaaatgat
ttctatgacttagtccgaacaattggaggagacctggtggaaaaggttgatctcatagac
aagtttgtacatccaaagacgcacaagaccagccactgctaccgcatcacgtaccgccac
atggaacggactctgtcccagagagaggtcaggcacatccaccaggccttgcaggaggct
gcagtccagctgttgggtgtggagggcaggttctga

  All links  
Disease (3)   
   OMIM (3)   
Gene (13)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (27)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (25)   
DNA sequence (70)   
   RefSeq(nuc) (36)   
   GenBank (17)   
   EMBL (17)   
3D Structure (9)   
   PDB (9)   
Protein domain (3)   
   Pfam (3)   
All databases (125)   

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