KEGG   Homo sapiens (human): 10788
Entry
10788             CDS       T01001                                 

Gene name
IQGAP2
Definition
(RefSeq) IQ motif containing GTPase activating protein 2
  KO
K05767  Ras GTPase-activating-like protein IQGAP2/3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10788 (IQGAP2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10788 (IQGAP2)
   04147 Exosome [BR:hsa04147]
    10788 (IQGAP2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     10788 (IQGAP2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10788 (IQGAP2)
  Exosomal proteins of colorectal cancer cells
   10788 (IQGAP2)
SSDB
Motif
Pfam: RasGAP RasGAP_C CH IQ
Other DBs
NCBI-GeneID: 10788
NCBI-ProteinID: NP_006624
OMIM: 605401
HGNC: 6111
Ensembl: ENSG00000145703
Vega: OTTHUMG00000162432
Pharos: Q13576(Tbio)
UniProt: Q13576 B7Z7U6 Q59HA3
Structure
PDB: 
4EZA 3IEZ 5CJP

Position
5q13.3
AA seq 1575 aa
MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP
PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM
ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS
NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP
NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK
VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL
AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK
LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT
ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVT
LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW
LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS
EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN
TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP
LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI
TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA
KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG
NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG
EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL
KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS
VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL
VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD
PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT
EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT
LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN
YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT
NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN
VNLLIYLLNKKFYGK
NT seq 4728 nt   +upstreamnt  +downstreamnt
atgccacacgaagagctgccgtcgctgcagagaccccgctatggctctattgtggacgat
gaaaggctctctgcagaggagatggatgagaggaggcggcagaacattgcttatgaatat
ctgtgccacttagaggaagccaaaaggtggatggaagtttgcttagttgaagaattgcca
ccaaccactgaattggaagaagggctccggaatggagtttaccttgcaaagttagccaag
ttctttgccccgaaaatggtatcagagaaaaagatctatgatgtggaacaaacacgttat
aagaagtctggccttcattttcgacacacagataataccgtccagtggttaagagcgatg
gagtctattggtctacccaagatattttatccagaaacaacagatgtctatgatcggaaa
aacataccaagaatgatatattgcattcacgcactgagtttgtatctgttcaaactagga
atagcaccccagatccaggatttgttgggcaaagtagacttcacagaggaggaaatcagt
aatatgagaaaagaacttgagaaatatggaatacagatgccatctttcagcaaaataggt
ggtattctggccaatgaactgtccgtggatgaagctgcattacatgctgcagttatagcc
attaatgaagcagttgaaaaaggaatagcagagcaaaccgttgtaacactaagaaaccca
aatgcggttttaactttagtggatgacaaccttgcaccagaatatcagaaagaactctgg
gatgccaaaaagaaaaaagaggaaaatgcaagactgaagaatagctgtatttcagaagaa
gaaagagatgcttatgaagaactgctgacacaagcagaaatccaaggcaatattaataaa
gtcaacaggcaggctgcagtggaccatatcaatgctgtcattccggaaggtgaccccgag
aatacgctgcttgcactgaagaaaccagaggcccagctgcctgctgtttatccctttgct
gctgccatgtatcagaacgaacttttcaacctccagaaacagaacaccatgaactacttg
gcccacgaggagcttttgattgctgtggaaatgttgtctgctgttgctttactaaaccag
gccttggaaagcaacgatcttgtgtctgtgcagaatcaactcagaagccccgcaataggc
ttaaacaatctggacaaggcatatgtggaacgttatgcaaacacactactctctgttaaa
ctagaagttttatcccaagggcaagataacttaagctggaatgaaattcagaattgtatt
gatatggttaatgctcaaattcaagaagaaaatgaccgagttgtagctgtagggtacatc
aatgaagctattgatgaagggaatcctttgaggactttagaaactttgctcctacctact
gcgaatattagtgatgtggacccagcccatgcccagcactaccaggatgttttataccat
gctaaatcacagaaactcggagactctgagagtgtttccaaagtgctttggctggatgag
atacagcaagccgtcgatgatgccaacgtggacaaggacagagcaaaacaatgggttact
ctggtggttgatgttaatcagtgtttggaaggaaaaaaatcaagtgatattttgtctgta
ttgaagtcttccacttctaatgcaaatgacataatcccggagtgtgctgacaaatactat
gatgcccttgtgaaggcaaaagagctcaaatctgaaagagtgtctagtgacggttcatgg
ctcaaactcaacctgcacaaaaaatatgactactattacaacactgattcaaaagagagt
tcctgggtcacacctgaatcatgcttgtataaagaatcatggctcacaggaaaagaaatc
gaggacattattgaggaagtcacagtaggttacattcgtgagaatatatggtctgcttca
gaagagttgcttcttcgctttcaagccacaagctcaggacccatccttagggaagagttt
gaagctagaaaatcatttttgcatgaacaagaagagaatgtggtcaaaatacaggctttt
tggaaaggatataaacaacggaaggagtatatgcacaggcggcaaacgttcattgataat
actgattctattgtgaagattcagtcctggttccgaatggcaactgcaagaaagagctat
ctttcaagactacagtatttcagagatcataataatgaaattgtgaaaatacagtcactg
ttgagagcgaacaaagctagagatgactacaaaacattggttggctctgaaaacccacca
ttaacagtaattcgcaaatttgtatacctgctggaccaaagtgatttggatttccaggag
gaactagaggttgcacgattaagggaagaagtagtgaccaagatcagggccaatcaacag
ctggaaaaagacctgaacctgatggacatcaagattggactgctggtgaagaacaggatc
acactagaggatgtaatttcacatagtaaaaagctgaacaagaaaaaaggaggagaaatg
gaaatactgaataacaccgacaaccaaggaataaaaagtttgagtaaggagaggagaaaa
acactagaaacatatcagcagctgttttaccttttacagaccaaccctttatacttggct
aagctgattttccagatgccacagaacaagtccactaaatttatggatactgttattttc
acactatataattatgcctctaatcagcgagaagaatatctacttctcaagctttttaaa
actgctctggaggaagaaataaaatcaaaagtggaccaggtacaggacatagttactggt
aaccctacagtcatcaagatggtcgtcagcttcaatagaggtgcccggggacagaacacc
ctgcgccaactcctggctccagtggtaaaagagatcatcgacgacaagtcgctgattatc
aacacaaaccctgtagaggtgtacaaggcttgggtgaaccaactagaaacacagactgga
gaggccagcaagttgccttatgatgtgaccacagaacaagctctaacatacccagaagtg
aaaaataaactggaggcttccattgagaacctgagaagggtcaccgacaaagtcctgaat
tctatcatttcttcccttgatctactgccttatggattgaggtatatagccaaagtactg
aagaattcgatccatgagaaattccccgatgcaacagaagatgagctattaaagattgtt
ggaaacctcctgtactatcggtacatgaatccagccattgtagctccagatggctttgat
atcatcgacatgacagctggaggtcagataaattctgaccaaaggagaaacttaggatca
gtggccaaggttcttcagcacgcagcctccaacaagctgtttgaaggagaaaatgagcat
ctctcatctatgaacaattatttatcagagacgtatcaggaattcaggaaatatttcaaa
gaagcatgtaatgtccctgagccagaagagaagtttaatatggacaaatacacagacctg
gtgacagtcagcaaaccagtcatttatatttcaattgaagaaatcatcagcacacactca
ctcctgttggaacaccaggatgcaattgcccctgagaaaaatgacttactgagtgaattg
ctggggtcgctgggagaggtgccaaccgtggaatcttttcttggggaaggagcagttgac
cccaatgaccctaacaaggcaaatacactaagtcagctttcaaagaccgagatttctctt
gtcttgacaagcaaatatgacatagaggacggtgaagctatagatagccgaagcctcatg
ataaagaccaagaagctgataattgatgtgatccggaaccagccagggaacacattgaca
gaaatcttagagacaccagcaactgcgcaacaggaggtagaccatgccacggacatggtg
agccgtgcaatgatagattccaggactccagaagaaatgaagcatagccaatctatgatt
gaagatgcacagctgcctcttgagcagaagaagaggaaaatccagaggaatcttcggacg
ttggaacagactggacacgtgtcatccgaaaataaataccaagacattctcaatgagatt
gccaaggatattcgaaatcaaagaatctatcgtaagcttcgaaaagctgaattggcaaaa
cttcagcagaccctgaatgcacttaacaagaaggcagcattttatgaagagcaaatcaat
tattatgacacctacataaagacttgtttagacaacttaaaaagaaaaaatactcggaga
tcaattaaactagatggaaaaggagaacccaaaggggcgaagagagcgaagccagtgaag
tacactgcagcaaagctgcatgagaaaggtgtcctgctagatatagatgatcttcaaaca
aaccagtttaagaatgttacatttgatatcatagctactgaagatgtaggcattttcgat
gtaagatcaaaattccttggtgttgagatggaaaaggtgcaactcaatattcaggattta
cttcagatgcaatatgaaggagtagctgtaatgaaaatgtttgataaggttaaagtgaat
gtaaaccttctcatatacctgctgaacaagaagttctatggaaagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (14)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (40)   
   RefSeq(nuc) (10)   
   GenBank (15)   
   EMBL (15)   
Protein domain (4)   
   Pfam (4)   
All databases (91)   

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