KEGG   Homo sapiens (human): 10800Help
Entry
10800             CDS       T01001                                 

Gene name
CYSLTR1, CYSLT1, CYSLT1R, CYSLTR, HMTMF81
Definition
(RefSeq) cysteinyl leukotriene receptor 1
  KO
K04322  cysteinyl leukotriene receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Ablukast (DG01244): D02739 D02741
Cinalukast: D02846
Ibudilast: D01385
Montelukast (DG01066): D00529 D08229
Pobilukast edamine: D02848
Pranlukast (DG01065): D02732 D08408
Ritolukast: D02849
Sulukast: D02850
Tipelukast: D06659
Tomelukast: D02851
Verlukast: D02384
Zafirlukast: D00411
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    10800 (CYSLTR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    10800 (CYSLTR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    10800 (CYSLTR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Cysteinyl leukotriene
    10800 (CYSLTR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srw 7TM_GPCR_Srv DUF420 SieB Shisa COX7C MscS_TM TMEM234
Motif
Other DBs
NCBI-GeneID: 10800
NCBI-ProteinID: NP_001269115
OMIM: 300201
HGNC: 17451
Ensembl: ENSG00000173198
Vega: OTTHUMG00000021889
Pharos: Q9Y271(Tclin)
UniProt: Q9Y271 Q38Q91 Q38Q88
Position
Xq21.1
AA seq 337 aa AA seqDB search
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
NT seq 1014 nt NT seq  +upstreamnt  +downstreamnt
atggatgaaacaggaaatctgacagtatcttctgccacatgccatgacactattgatgac
ttccgcaatcaagtgtattccaccttgtactctatgatctctgttgtaggcttctttggc
aatggctttgtgctctatgtcctcataaaaacctatcacaagaagtcagccttccaagta
tacatgattaatttagcagtagcagatctactttgtgtgtgcacactgcctctccgtgtg
gtctattatgttcacaaaggcatttggctctttggtgacttcttgtgccgcctcagcacc
tatgctttgtatgtcaacctctattgtagcatcttctttatgacagccatgagctttttc
cggtgcattgcaattgtttttccagtccagaacattaatttggttacacagaaaaaagcc
aggtttgtgtgtgtaggtatttggatttttgtgattttgaccagttctccatttctaatg
gccaaaccacaaaaagatgagaaaaataataccaagtgctttgagcccccacaagacaat
caaactaaaaatcatgttttggtcttgcattatgtgtcattgtttgttggctttatcatc
ccttttgttattataattgtctgttacacaatgatcattttgaccttactaaaaaaatca
atgaaaaaaaatctgtcaagtcataaaaaggctataggaatgatcatggtcgtgaccgct
gcctttttagtcagtttcatgccatatcatattcaacgtaccattcaccttcatttttta
cacaatgaaactaaaccctgtgattctgtccttagaatgcagaagtccgtggtcataacc
ttgtctctggctgcatccaattgttgctttgaccctctcctatatttcttttctgggggt
aactttaggaaaaggctgtctacattcagaaagcattctttgtccagcgtgacttatgta
cccagaaagaaggcctctttgccagaaaaaggagaagaaatatgtaaagtatag

KEGG   Homo sapiens (human): 1128Help
Entry
1128              CDS       T01001                                 

Gene name
CHRM1, HM1, M1, M1R
Definition
(RefSeq) cholinergic receptor muscarinic 1
  KO
K04129  muscarinic acetylcholine receptor M1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04725  Cholinergic synapse
hsa04810  Regulation of actin cytoskeleton
Drug target
Aceclidine: D02750
Acetylcholine (DG01133): D00999
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837
Alvameline maleate: D02876
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113 D02069
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778 D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000
Bevonium: D01532
Biperiden (DG00852): D00779 D02246 D02247
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451
Carbachol: D00524
Carpronium (DG01289): D01175 D09752
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002 D07759
Darotropium bromide: D09402
Dexetimide (DG00856): D03711 D07804
Dicycloverine (DG00032): D00717 D07820
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Diphenidol (DG02880): D01318 D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Esoxybutynin chloride: D04057
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Flutropium bromide: D02417
Glycopyrronium (DG02467): D10939
Heteronium bromide: D04434
Homatropine (DG01142): D01004 D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Imidafenacin: D06273
Ipratropium bromide: D02212
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720
Methacholine (DG01290): D04970
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465 D00722
Oxyphencyclimine (DG00029): D01006 D08325
Oxyphenonium: D06877
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pipenzolate: D07084
Piperidolate (DG00034): D01165 D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276 D08389
Piroheptine (DG01272): D01231 D08395
Poldine: D05535
Pridinol (DG00774): D02064 D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007 D08441
Rapacuronium bromide: D05703
Revefenacin: D10978
Rocuronium bromide: D00765
Sabcomeline hydrochloride: D05779
Scopolamine (DG00065): D00138 D02071
Sofpironium bromide: D10989
Talsaclidine fumarate: D06000
Tazomeline citrate: D06015
Telenzepine hydrochloride hydrate: D11098
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535
Tofenacin hydrochloride: D06175
Toquizine: D06192
Triampyzine sulfate: D06217
Tridihexethyl (DG00037): D00723
Trihexyphenidyl (DG00851): D00787 D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181
Valethamate: D01538
Xanomeline (DG01300): D06330 D06331
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1128 (CHRM1)
   04024 cAMP signaling pathway
    1128 (CHRM1)
   04151 PI3K-Akt signaling pathway
    1128 (CHRM1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1128 (CHRM1)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1128 (CHRM1)
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1128 (CHRM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1128 (CHRM1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1128 (CHRM1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srbc
Motif
Other DBs
NCBI-GeneID: 1128
NCBI-ProteinID: NP_000729
OMIM: 118510
HGNC: 1950
Ensembl: ENSG00000168539
Vega: OTTHUMG00000167765
Pharos: P11229(Tclin)
UniProt: P11229 Q53XZ3
Structure
PDB: 

Position
11q12.3
AA seq 460 aa AA seqDB search
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
NT seq 1383 nt NT seq  +upstreamnt  +downstreamnt
atgaacacttcagccccacctgctgtcagccccaacatcaccgtcctggcaccaggaaag
ggtccctggcaagtggccttcattgggatcaccacgggcctcctgtcgctagccacagtg
acaggcaacctgctggtactcatctctttcaaggtcaacacggagctcaagacagtcaat
aactacttcctgctgagcctggcctgtgctgacctcatcatcggtaccttctccatgaac
ctctataccacgtacctgctcatgggccactgggctctgggcacgctggcttgtgacctc
tggctggccctggactatgtggccagcaatgcctccgtcatgaatctgctgctcatcagc
tttgaccgctacttctccgtgactcggcccctgagctaccgtgccaagcgcacaccccgc
cgggcagctctgatgatcggcctggcctggctggtttcctttgtgctctgggccccagcc
atcctcttctggcagtacctggtaggggagcggacagtgctagctgggcagtgctacatc
cagttcctctcccagcccatcatcacctttggcacagccatggctgccttctacctccct
gtcacagtcatgtgcacgctctactggcgcatctaccgggagacagagaaccgagcacgg
gagctggcagcccttcagggctccgagacgccaggcaaagggggtggcagcagcagcagc
tcagagaggtctcagccaggggctgagggctcaccagagactcctccaggccgctgctgt
cgctgctgccgggcccccaggctgctgcaggcctacagctggaaggaagaagaggaagag
gacgaaggctccatggagtccctcacatcctcagagggagaggagcctggctccgaagtg
gtgatcaagatgccaatggtggaccccgaggcacaggcccccaccaagcagcccccacgg
agctccccaaatacagtcaagaggccgactaagaaagggcgtgatcgagctggcaagggc
cagaagccccgtggaaaggagcagctggccaagcggaagaccttctcgctggtcaaggag
aagaaggcggctcggaccctgagtgccatcctcctggccttcatcctcacctggacaccg
tacaacatcatggtgctggtgtccaccttctgcaaggactgtgttcccgagaccctgtgg
gagctgggctactggctgtgctacgtcaacagcaccatcaaccccatgtgctacgcactc
tgcaacaaagccttccgggacacctttcgcctgctgctgctttgccgctgggacaagaga
cgctggcgcaagatccccaagcgccctggctccgtgcaccgcactccctcccgccaatgc
tga

KEGG   Homo sapiens (human): 1129Help
Entry
1129              CDS       T01001                                 

Gene name
CHRM2, HM2
Definition
(RefSeq) cholinergic receptor muscarinic 2
  KO
K04130  muscarinic acetylcholine receptor M2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04725  Cholinergic synapse
hsa04810  Regulation of actin cytoskeleton
Drug target
Acetylcholine (DG01133): D00999
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837
Alvameline maleate: D02876
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113 D02069
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778 D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000
Bevonium: D01532
Biperiden (DG00852): D00779 D02246 D02247
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451
Carbachol: D00524
Carpronium (DG01289): D01175 D09752
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002 D07759
Darotropium bromide: D09402
Dexetimide (DG00856): D03711 D07804
Dicycloverine (DG00032): D00717 D07820
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Dimetindene (DG00386): D07853
Diphenidol (DG02880): D01318 D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Esoxybutynin chloride: D04057
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Fesoterodine (DG00483): D07226 D08923
Flutropium bromide: D02417
Gallamine: D02292
Glycopyrronium (DG02467): D10939
Heteronium bromide: D04434
Homatropine (DG01142): D01004 D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Ipratropium bromide: D02212
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720
Methacholine (DG01290): D04970
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465 D00722
Oxyphencyclimine (DG00029): D01006 D08325
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pilocarpine (DG00992): D00525 D02200 D05478 D08376
Pipenzolate: D07084
Piperidolate (DG00034): D01165 D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276 D08389
Piroheptine (DG01272): D01231 D08395
Poldine: D05535
Pridinol (DG00774): D02064 D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007 D08441
Rapacuronium bromide: D05703
Revefenacin: D10978
Rocuronium bromide: D00765
Scopolamine (DG00065): D00138 D02071
Sofpironium bromide: D10989
Tazomeline citrate: D06015
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535
Tofenacin hydrochloride: D06175
Toquizine: D06192
Triampyzine sulfate: D06217
Tridihexethyl (DG00037): D00723
Trihexyphenidyl (DG00851): D00787 D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397
Trospium: D01103
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181
Valethamate: D01538
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1129 (CHRM2)
   04024 cAMP signaling pathway
    1129 (CHRM2)
   04151 PI3K-Akt signaling pathway
    1129 (CHRM2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1129 (CHRM2)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1129 (CHRM2)
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1129 (CHRM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1129 (CHRM2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1129 (CHRM2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 1129
NCBI-ProteinID: NP_000730
OMIM: 118493
HGNC: 1951
Ensembl: ENSG00000181072
Vega: OTTHUMG00000155658
Pharos: P08172(Tclin)
UniProt: P08172 Q86SJ1 Q6SL56 A4D1Q0
Structure
PDB: 

Position
7q33
AA seq 466 aa AA seqDB search
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
NT seq 1401 nt NT seq  +upstreamnt  +downstreamnt
atgaataactcaacaaactcctctaacaatagcctggctcttacaagtccttataagaca
tttgaagtggtgtttattgtcctggtggctggatccctcagtttggtgaccattatcggg
aacatcctagtcatggtttccattaaagtcaaccgccacctccagaccgtcaacaattac
tttttattcagcttggcctgtgctgaccttatcataggtgttttctccatgaacttgtac
accctctacactgtgattggttactggcctttgggacctgtggtgtgtgacctttggcta
gccctggactatgtggtcagcaatgcctcagttatgaatctgctcatcatcagctttgac
aggtacttctgtgtcacaaaacctctgacctacccagtcaagcggaccacaaaaatggca
ggtatgatgattgcagctgcctgggtcctctctttcatcctctgggctccagccattctc
ttctggcagttcattgtaggggtgagaactgtggaggatggggagtgctacattcagttt
ttttccaatgctgctgtcacctttggtacggctattgcagccttctatttgccagtgatc
atcatgactgtgctatattggcacatatcccgagccagcaagagcaggataaagaaggac
aagaaggagcctgttgccaaccaagaccccgtttctccaagtctggtacaaggaaggata
gtgaagccaaacaataacaacatgcccagcagtgacgatggcctggagcacaacaaaatc
cagaatggcaaagcccccagggatcctgtgactgaaaactgtgttcagggagaggagaag
gagagctccaatgactccacctcagtcagtgctgttgcctctaatatgagagatgatgaa
ataacccaggatgaaaacacagtttccacttccctgggccattccaaagatgagaactct
aagcaaacatgcatcagaattggcaccaagaccccaaaaagtgactcatgtaccccaact
aataccaccgtggaggtagtggggtcttcaggtcagaatggagatgaaaagcagaatatt
gtagcccgcaagattgtgaagatgactaagcagcctgcaaaaaagaagcctcctccttcc
cgggaaaagaaagtcaccaggacaatcttggctattctgttggctttcatcatcacttgg
gccccatacaatgtcatggtgctcattaacaccttttgtgcaccttgcatccccaacact
gtgtggacaattggttactggctttgttacatcaacagcactatcaaccctgcctgctat
gcactttgcaatgccaccttcaagaagacctttaaacaccttctcatgtgtcattataag
aacataggcgctacaaggtaa

KEGG   Homo sapiens (human): 1131Help
Entry
1131              CDS       T01001                                 

Gene name
CHRM3, EGBRS, HM3, PBS
Definition
(RefSeq) cholinergic receptor muscarinic 3
  KO
K04131  muscarinic acetylcholine receptor M3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04742  Taste transduction
hsa04810  Regulation of actin cytoskeleton
hsa04911  Insulin secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
Disease
H02129  Prune belly syndrome
Drug target
Acetylcholine (DG01133): D00999
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837
Alvameline maleate: D02876
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113 D02069
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778 D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000
Bevonium: D01532
Biperiden (DG00852): D00779 D02246 D02247
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451
Carbachol: D00524
Carpronium (DG01289): D01175 D09752
Cevimeline (DG00993): D00661 D07667
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002 D07759
Darifenacin (DG00482): D01699 D03654
Darotropium bromide: D09402
Desfesoterodine: D10853
Dexetimide (DG00856): D03711 D07804
Dexpanthenol: D00193
Dicycloverine (DG00032): D00717 D07820
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Diphemanil: D06878
Diphenidol (DG02880): D01318 D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Esoxybutynin chloride: D04057
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Fesoterodine (DG00483): D07226 D08923
Flutropium bromide: D02417
Glycopyrronium: D00540
Glycopyrronium (DG02467): D10938 D10939
Heteronium bromide: D04434
Hexocyclium (DG00039): D01003
Homatropine (DG01142): D01004 D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Imidafenacin: D06273
Ipratropium bromide: D02212
Isopropamide (DG00038): D01005
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720
Methacholine (DG01290): D04970
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465 D00722
Oxyphencyclimine (DG00029): D01006 D08325
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pilocarpine (DG00992): D00525 D02200 D05478 D08376
Pipenzolate: D07084
Piperidolate (DG00034): D01165 D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276 D08389
Piroheptine (DG01272): D01231 D08395
Poldine: D05535
Pridinol (DG00774): D02064 D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007 D08441
Rapacuronium bromide: D05703
Revefenacin: D10978
Rociverine: D07078
Rocuronium bromide: D00765
Scopolamine (DG00065): D00138 D02071
Sofpironium bromide: D10989
Solifenacin (DG00481): D01269 D08522
Tazomeline citrate: D06015
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535
Tiotropium bromide: D01929
Tiquizium bromide: D01875
Tofenacin hydrochloride: D06175
Tolterodine (DG00480): D00646 D01148
Toquizine: D06192
Triampyzine sulfate: D06217
Tridihexethyl (DG00037): D00723
Trihexyphenidyl (DG00851): D00787 D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397
Trospium: D01103
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181
Valethamate: D01538
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1131 (CHRM3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1131 (CHRM3)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1131 (CHRM3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1131 (CHRM3)
  09154 Digestive system
   04970 Salivary secretion
    1131 (CHRM3)
   04971 Gastric acid secretion
    1131 (CHRM3)
   04972 Pancreatic secretion
    1131 (CHRM3)
  09156 Nervous system
   04725 Cholinergic synapse
    1131 (CHRM3)
  09157 Sensory system
   04742 Taste transduction
    1131 (CHRM3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1131 (CHRM3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1131 (CHRM3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srbc
Motif
Other DBs
NCBI-GeneID: 1131
NCBI-ProteinID: NP_000731
OMIM: 118494
HGNC: 1952
Ensembl: ENSG00000133019
Vega: OTTHUMG00000039649
Pharos: P20309(Tclin)
UniProt: P20309 A0A024R3S2
Position
1q43
AA seq 590 aa AA seqDB search
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
NT seq 1773 nt NT seq  +upstreamnt  +downstreamnt
atgaccttgcacaataacagtacaacctcgcctttgtttccaaacatcagctcctcctgg
atacacagcccctccgatgcagggctgcccccgggaaccgtcactcatttcggcagctac
aatgtttctcgagcagctggcaatttctcctctccagacggtaccaccgatgaccctctg
ggaggtcataccgtctggcaagtggtcttcatcgctttcttaacgggcatcctggccttg
gtgaccatcatcggcaacatcctggtaattgtgtcatttaaggtcaacaagcagctgaag
acggtcaacaactacttcctcttaagcctggcctgtgccgatctgattatcggggtcatt
tcaatgaatctgtttacgacctacatcatcatgaatcgatgggccttagggaacttggcc
tgtgacctctggcttgccattgactacgtagccagcaatgcctctgttatgaatcttctg
gtcatcagctttgacagatacttttccatcacgaggccgctcacgtaccgagccaaacga
acaacaaagagagccggtgtgatgatcggtctggcttgggtcatctcctttgtcctttgg
gctcctgccatcttgttctggcaatactttgttggaaagagaactgtgcctccgggagag
tgcttcattcagttcctcagtgagcccaccattacttttggcacagccatcgctgctttt
tatatgcctgtcaccattatgactattttatactggaggatctataaggaaactgaaaag
cgtaccaaagagcttgctggcctgcaagcctctgggacagaggcagagacagaaaacttt
gtccaccccacgggcagttctcgaagctgcagcagttacgaacttcaacagcaaagcatg
aaacgctccaacaggaggaagtatggccgctgccacttctggttcacaaccaagagctgg
aaacccagctccgagcagatggaccaagaccacagcagcagtgacagttggaacaacaat
gatgctgctgcctccctggagaactccgcctcctccgacgaggaggacattggctccgag
acgagagccatctactccatcgtgctcaagcttccgggtcacagcaccatcctcaactcc
accaagttaccctcatcggacaacctgcaggtgcctgaggaggagctggggatggtggac
ttggagaggaaagccgacaagctgcaggcccagaagagcgtggacgatggaggcagtttt
ccaaaaagcttctccaagcttcccatccagctagagtcagccgtggacacagctaagact
tctgacgtcaactcctcagtgggtaagagcacggccactctacctctgtccttcaaggaa
gccactctggccaagaggtttgctctgaagaccagaagtcagatcactaagcggaaaagg
atgtccctggtcaaggagaagaaagcggcccagaccctcagtgcgatcttgcttgccttc
atcatcacttggaccccatacaacatcatggttctggtgaacaccttttgtgacagctgc
atacccaaaaccttttggaatctgggctactggctgtgctacatcaacagcaccgtgaac
cccgtgtgctatgctctgtgcaacaaaacattcagaaccactttcaagatgctgctgctg
tgccagtgtgacaaaaaaaagaggcgcaagcagcagtaccagcagagacagtcggtcatt
tttcacaagcgcgcacccgagcaggccttgtag

KEGG   Homo sapiens (human): 146Help
Entry
146               CDS       T01001                                 

Gene name
ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
Definition
(RefSeq) adrenoceptor alpha 1D
  KO
K04137  adrenergic receptor alpha-1D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636 D02910
Amosulalol (DG01302): D01469 D07451
Arotinolol (DG01303): D01830 D07465
Bevantolol: D01369
Bunazosin (DG01316): D01887 D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255 D03415
Dapiprazole (DG01140): D03648 D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017 D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608 D07874
Dronedarone (DG00207): D02537 D03914
Droperidol: D00308
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163 D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679
Etilefrine (DG00210): D01573 D07931
Flesinoxan: D02568
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445 D08064
Indoramin (DG00254): D04531 D04532
Labetalol (DG00320): D00600 D08106
Levobunolol (DG01136): D01025 D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Methylergometrine (DG00445): D00680 D08207
Midodrine (DG00224): D01307 D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674
Naphazoline (DG01032): D00743 D01021 D08253
Nefazodone (DG00953): D00819 D08257
Nicergoline (DG00283): D01290 D08271
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454 D06623
Pelanserin hydrochloride: D05395
Periciazine: D01485
Phenoxybenzamine (DG00285): D00507 D08358
Phentolamine (DG00280): D00509 D08362
Phenylephrine (DG00215): D00511 D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609 D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Tamsulosin (DG00490): D01024 D08560
Terazosin (DG00491): D00610 D08569
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347 D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333 D08662
Xylometazoline (DG01031): D00757 D08684
Zolertine hydrochloride: D06380
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    146 (ADRA1D)
   04022 cGMP-PKG signaling pathway
    146 (ADRA1D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    146 (ADRA1D)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    146 (ADRA1D)
   04270 Vascular smooth muscle contraction
    146 (ADRA1D)
  09154 Digestive system
   04970 Salivary secretion
    146 (ADRA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    146 (ADRA1D)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    146 (ADRA1D)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srv
Motif
Other DBs
NCBI-GeneID: 146
NCBI-ProteinID: NP_000669
OMIM: 104219
HGNC: 280
Ensembl: ENSG00000171873
Vega: OTTHUMG00000031779
Pharos: P25100(Tclin)
UniProt: P25100 B0ZBE0
Position
20p13
AA seq 572 aa AA seqDB search
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
NT seq 1719 nt NT seq  +upstreamnt  +downstreamnt
atgactttccgcgatctcctgagcgtcagtttcgagggaccccgcccggacagcagcgca
gggggctccagcgcgggcggcggcgggggcagcgcgggcggcgcggccccctcggagggc
ccggcggtgggcggcgtgccggggggcgcgggcggcggcggcggcgtggtgggcgcaggc
agcggcgaggacaaccggagctccgcgggggagccggggagcgcgggcgcgggcggcgac
gtgaatggcacggcggccgtcgggggactggtggtgagcgcgcagggcgtgggcgtgggc
gtcttcctggcagccttcatccttatggccgtggcaggtaacctgcttgtcatcctctca
gtggcctgcaaccgccacctgcagaccgtcaccaactatttcatcgtgaacctggccgtg
gccgacctgctgctgagcgccaccgtactgcccttctcggccaccatggaggttctgggc
ttctgggcctttggccgcgccttctgcgacgtatgggccgccgtggacgtgctgtgctgc
acggcctccatcctcagcctctgcaccatctccgtggaccggtacgtgggcgtgcgccac
tcactcaagtacccagccatcatgaccgagcgcaaggcggccgccatcctggccctgctc
tgggtcgtagccctggtggtgtccgtagggcccctgctgggctggaaggagcccgtgccc
cctgacgagcgcttctgcggtatcaccgaggaggcgggctacgctgtcttctcctccgtg
tgctccttctacctgcccatggcggtcatcgtggtcatgtactgccgcgtgtacgtggtc
gcgcgcagcaccacgcgcagcctcgaggcgggcgtcaagcgcgagcgaggcaaggcctcc
gaggtggtgctgcgcatccactgtcgcggcgcggccacgggcgccgacggggcgcacggc
atgcgcagcgccaagggccacaccttccgcagctcgctctccgtgcgcctgctcaagttc
tcccgtgagaagaaagcggccaagactctggccatcgtcgtgggtgtcttcgtgctctgc
tggttccctttcttctttgtcctgccgctcggctccttgttcccgcagctgaagccatcg
gagggcgtcttcaaggtcatcttctggctcggctacttcaacagctgcgtgaacccgctc
atctacccctgttccagccgcgagttcaagcgcgccttcctccgtctcctgcgctgccag
tgccgtcgtcgccggcgccgccgccctctctggcgtgtctacggccaccactggcgggcc
tccaccagcggcctgcgccaggactgcgccccgagttcgggcgacgcgccccccggagcg
ccgctggccctcaccgcgctccccgaccccgaccccgaacccccaggcacgcccgagatg
caggctccggtcgccagccgtcgaaagccacccagcgccttccgcgagtggaggctgctg
gggccgttccggagacccacgacccagctgcgcgccaaagtctccagcctgtcgcacaag
atccgcgccgggggcgcgcagcgcgcagaggcagcgtgcgcccagcgctcagaggtggag
gctgtgtccctaggcgtcccacacgaggtggccgagggcgccacctgccaggcctacgaa
ttggccgactacagcaacctacgggagaccgatatttaa

KEGG   Homo sapiens (human): 147Help
Entry
147               CDS       T01001                                 

Gene name
ADRA1B, ADRA1, ALPHA1BAR
Definition
(RefSeq) adrenoceptor alpha 1B
  KO
K04136  adrenergic receptor alpha-1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636 D02910
Amosulalol (DG01302): D01469 D07451
Arotinolol (DG01303): D01830 D07465
Bevantolol: D01369
Bunazosin (DG01316): D01887 D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255 D03415
Dapiprazole (DG01140): D03648 D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017 D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608 D07874
Dronedarone (DG00207): D02537 D03914
Droperidol: D00308
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163 D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679
Etilefrine (DG00210): D01573 D07931
Flesinoxan: D02568
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445 D08064
Indoramin (DG00254): D04531 D04532
Labetalol (DG00320): D00600 D08106
Levobunolol (DG01136): D01025 D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Methylergometrine (DG00445): D00680 D08207
Midodrine (DG00224): D01307 D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674
Naphazoline (DG01032): D00743 D01021 D08253
Nefazodone (DG00953): D00819 D08257
Nicergoline (DG00283): D01290 D08271
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454 D06623
Pelanserin hydrochloride: D05395
Periciazine: D01485
Phenoxybenzamine (DG00285): D00507 D08358
Phentolamine (DG00280): D00509 D08362
Phenylephrine (DG00215): D00511 D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609 D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Tamsulosin (DG00490): D01024 D08560
Terazosin (DG00491): D00610 D08569
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347 D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333 D08662
Xylometazoline (DG01031): D00757 D08684
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    147 (ADRA1B)
   04022 cGMP-PKG signaling pathway
    147 (ADRA1B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    147 (ADRA1B)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    147 (ADRA1B)
   04270 Vascular smooth muscle contraction
    147 (ADRA1B)
  09154 Digestive system
   04970 Salivary secretion
    147 (ADRA1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    147 (ADRA1B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    147 (ADRA1B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srv Shisa
Motif
Other DBs
NCBI-GeneID: 147
NCBI-ProteinID: NP_000670
OMIM: 104220
HGNC: 278
Ensembl: ENSG00000170214
Vega: OTTHUMG00000130327
Pharos: P35368(Tclin)
UniProt: P35368
Position
5q33.3
AA seq 520 aa AA seqDB search
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
NT seq 1563 nt NT seq  +upstreamnt  +downstreamnt
atgaatcccgacctggacaccggccacaacacatcagcacctgcccactggggagagttg
aaaaatgccaacttcactggccccaaccagacctcgagcaactccacactgccccagctg
gacatcaccagggccatctctgtgggcctggtgctgggcgccttcatcctctttgccatc
gtgggcaacatcctagtcatcttgtctgtggcctgcaaccggcacctgcggacgcccacc
aactacttcattgtcaacctggccatggccgacctgctgttgagcttcaccgtcctgccc
ttctcagcggccctagaggtgctcggctactgggtgctggggcggatcttctgtgacatc
tgggcagccgtggatgtcctgtgctgcacagcgtccattctgagcctgtgcgccatctcc
atcgatcgctacatcggggtgcgctactctctgcagtatcccacgctggtcacccggagg
aaggccatcttggcgctgctcagtgtctgggtcttgtccaccgtcatctccatcgggcct
ctccttgggtggaaggagccggcacccaacgatgacaaggagtgcggggtcaccgaagaa
cccttctatgccctcttctcctctctgggctccttctacatccctctggcggtcattcta
gtcatgtactgccgtgtctatatagtggccaagagaaccaccaagaacctagaggcagga
gtcatgaaggagatgtccaactccaaggagctgaccctgaggatccattccaagaacttt
cacgaggacacccttagcagtaccaaggccaagggccacaaccccaggagttccatagct
gtcaaactttttaagttctccagggaaaagaaagcagctaagacgttgggcattgtggtc
ggtatgttcatcttgtgctggctacccttcttcatcgctctaccgcttggctccttgttc
tccaccctgaagccccccgacgccgtgttcaaggtggtgttctggctgggctacttcaac
agctgcctcaaccccatcatctacccatgctccagcaaggagttcaagcgcgctttcgtg
cgcatcctcgggtgccagtgccgcggccgcggccgccgccgacgccgccgccgccgtcgc
ctgggcggctgcgcctacacctaccggccgtggacgcgcggcggctcgctggagcgctcg
cagtcgcgcaaggactcgctggacgacagcggcagctgcctgagcggcagccagcggacc
ctgccctcggcctcgccgagcccgggctacctgggccgcggcgcgccaccgccagtcgag
ctgtgcgccttccccgagtggaaggcgcccggcgccctcctgagcctgcccgcgcctgag
ccccccggccgccgcggccgccacgactcgggcccgctcttcaccttcaagctcctgacc
gagcccgagagccccgggaccgacggcggcgccagcaacggaggctgcgaggccgcggcc
gacgtggccaacgggcagccgggcttcaaaagcaacatgcccctggcgcccgggcagttt
tag

KEGG   Homo sapiens (human): 148Help
Entry
148               CDS       T01001                                 

Gene name
ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR
Definition
(RefSeq) adrenoceptor alpha 1A
  KO
K04135  adrenergic receptor alpha-1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04152  AMPK signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Alfuzosin (DG00489): D01692 D07124
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636 D02910
Amosulalol (DG01302): D01469 D07451
Arotinolol (DG01303): D01830 D07465
Bevantolol: D01369
Bunazosin (DG01316): D01887 D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255 D03415
Dabuzalgron hydrochloride: D06394
Dapiprazole (DG01140): D03648 D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017 D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608 D07874
Dronedarone (DG00207): D02537 D03914
Droperidol: D00308
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163 D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679
Etilefrine (DG00210): D01573 D07931
Fiduxosin hydrochloride: D04184
Flesinoxan: D02568
Garomefrine hydrochloride: D09784
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445 D08064
Indoramin (DG00254): D04531 D04532
Isometheptene: D07097
Labetalol (DG00320): D00600 D08106
Levobunolol (DG01136): D01025 D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Methylergometrine (DG00445): D00680 D08207
Midodrine (DG00224): D01307 D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674
Naphazoline (DG01032): D00743 D01021 D08253
Nefazodone (DG00953): D00819 D08257
Nicergoline (DG00283): D01290 D08271
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454 D06623
Oxymetazoline (DG01029): D01022 D08322
Pelanserin hydrochloride: D05395
Periciazine: D01485
Phenoxybenzamine (DG00285): D00507 D08358
Phentolamine (DG00280): D00509 D08362
Phenylephrine (DG00215): D00511 D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609 D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Silodosin: D01965
Tamsulosin (DG00490): D01024 D08560
Terazosin (DG00491): D00610 D08569
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347 D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333 D08662
Xylometazoline (DG01031): D00757 D08684
Zolertine hydrochloride: D06380
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    148 (ADRA1A)
   04022 cGMP-PKG signaling pathway
    148 (ADRA1A)
   04152 AMPK signaling pathway
    148 (ADRA1A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    148 (ADRA1A)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    148 (ADRA1A)
   04270 Vascular smooth muscle contraction
    148 (ADRA1A)
  09154 Digestive system
   04970 Salivary secretion
    148 (ADRA1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    148 (ADRA1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    148 (ADRA1A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 148
NCBI-ProteinID: NP_000671
OMIM: 104221
HGNC: 277
Ensembl: ENSG00000120907
Vega: OTTHUMG00000099459
Pharos: P35348(Tclin)
UniProt: P35348
Position
8p21.2
AA seq 466 aa AA seqDB search
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
NT seq 1401 nt NT seq  +upstreamnt  +downstreamnt
atggtgtttctctcgggaaatgcttccgacagctccaactgcacccaaccgccggcaccg
gtgaacatttccaaggccattctgctcggggtgatcttggggggcctcattcttttcggg
gtgctgggtaacatcctagtgatcctctccgtagcctgtcaccgacacctgcactcagtc
acgcactactacatcgtcaacctggcggtggccgacctcctgctcacctccacggtgctg
cccttctccgccatcttcgaggtcctaggctactgggccttcggcagggtcttctgcaac
atctgggcggcagtggatgtgctgtgctgcaccgcgtccatcatgggcctctgcatcatc
tccatcgaccgctacatcggcgtgagctacccgctgcgctacccaaccatcgtcacccag
aggaggggtctcatggctctgctctgcgtctgggcactctccctggtcatatccattgga
cccctgttcggctggaggcagccggcccccgaggacgagaccatctgccagatcaacgag
gagccgggctacgtgctcttctcagcgctgggctccttctacctgcctctggccatcatc
ctggtcatgtactgccgcgtctacgtggtggccaagagggagagccggggcctcaagtct
ggcctcaagaccgacaagtcggactcggagcaagtgacgctccgcatccatcggaaaaac
gccccggcaggaggcagcgggatggccagcgccaagaccaagacgcacttctcagtgagg
ctcctcaagttctcccgggagaagaaagcggccaaaacgctgggcatcgtggtcggctgc
ttcgtcctctgctggctgccttttttcttagtcatgcccattgggtctttcttccctgat
ttcaagccctctgaaacagtttttaaaatagtattttggctcggatatctaaacagctgc
atcaaccccatcatatacccatgctccagccaagagttcaaaaaggcctttcagaatgtc
ttgagaatccagtgtctctgcagaaagcagtcttccaaacatgccctgggctacaccctg
cacccgcccagccaggccgtggaagggcaacacaaggacatggtgcgcatccccgtggga
tcaagagagaccttctacaggatctccaagacggatggcgtttgtgaatggaaatttttc
tcttccatgccccgtggatctgccaggattacagtgtccaaagaccaatcctcctgtacc
acagcccgggtgagaagtaaaagctttttgcaggtctgctgctgtgtagggccctcaacc
cccagccttgacaagaaccatcaagttccaaccattaaggtccacaccatctccctcagt
gagaacggggaggaagtctag

KEGG   Homo sapiens (human): 185Help
Entry
185               CDS       T01001                                 

Gene name
AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
Definition
(RefSeq) angiotensin II receptor type 1
  KO
K04166  angiotensin II receptor type 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04614  Renin-angiotensin system
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04934  Cushing syndrome
hsa05200  Pathways in cancer
Network
nt06316  Angiotensin-aldosterone signaling
  Element
N00301  Angiotensin-aldosterone signaling pathway
Disease
H00575  Renal tubular dysgenesis
Drug target
Angiotensin II: D00150 D02014 D11142
Angiotensinamide: D02939
Azilsartan (DG00351): D08864
Azilsartan medoxomil (DG00351): D08067 D08865
Candesartan (DG00350): D00522 D00626
Eprosartan (DG00349): D02082 D04040
Fimasartan: D10556
Forasartan: D04243
Irbesartan: D00523
Losartan (DG00348): D00357 D08146
Olmesartan (DG01544): D05246
Olmesartan medoxomil: D01204
Pratosartan: D01922
Saprisartan potassium: D05801
Saralasin acetate: D04126
Tasosartan: D06010
Telmisartan: D00627
Valsartan: D00400
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    185 (AGTR1)
   04020 Calcium signaling pathway
    185 (AGTR1)
   04072 Phospholipase D signaling pathway
    185 (AGTR1)
   04022 cGMP-PKG signaling pathway
    185 (AGTR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    185 (AGTR1)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    185 (AGTR1)
   04614 Renin-angiotensin system
    185 (AGTR1)
   04925 Aldosterone synthesis and secretion
    185 (AGTR1)
   04927 Cortisol synthesis and secretion
    185 (AGTR1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    185 (AGTR1)
   04270 Vascular smooth muscle contraction
    185 (AGTR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    185 (AGTR1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    185 (AGTR1)
   04934 Cushing syndrome
    185 (AGTR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    185 (AGTR1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    185 (AGTR1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    185 (AGTR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Angiotensin
    185 (AGTR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 185
NCBI-ProteinID: NP_000676
OMIM: 106165
HGNC: 336
Ensembl: ENSG00000144891
Vega: OTTHUMG00000159503
Pharos: P30556(Tclin)
UniProt: P30556 Q53YY0
Position
3q24
AA seq 359 aa AA seqDB search
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
NT seq 1080 nt NT seq  +upstreamnt  +downstreamnt
atgattctcaactcttctactgaagatggtattaaaagaatccaagatgattgtcccaaa
gctggaaggcataattacatatttgtcatgattcctactttatacagtatcatctttgtg
gtgggaatatttggaaacagcttggtggtgatagtcatttacttttatatgaagctgaag
actgtggccagtgtttttcttttgaatttagcactggctgacttatgctttttactgact
ttgccactatgggctgtctacacagctatggaataccgctggccctttggcaattaccta
tgtaagattgcttcagccagcgtcagtttcaacctgtacgctagtgtgtttctactcacg
tgtctcagcattgatcgatacctggctattgttcacccaatgaagtcccgccttcgacgc
acaatgcttgtagccaaagtcacctgcatcatcatttggctgctggcaggcttggccagt
ttgccagctataatccatcgaaatgtatttttcattgagaacaccaatattacagtttgt
gctttccattatgagtcccaaaattcaaccctcccgatagggctgggcctgaccaaaaat
atactgggtttcctgtttccttttctgatcattcttacaagttatactcttatttggaag
gccctaaagaaggcttatgaaattcagaagaacaaaccaagaaatgatgatatttttaag
ataattatggcaattgtgcttttctttttcttttcctggattccccaccaaatattcact
tttctggatgtattgattcaactaggcatcatacgtgactgtagaattgcagatattgtg
gacacggccatgcctatcaccatttgtatagcttattttaacaattgcctgaatcctctt
ttttatggctttctggggaaaaaatttaaaagatattttctccagcttctaaaatatatt
cccccaaaagccaaatcccactcaaacctttcaacaaaaatgagcacgctttcctaccgc
ccctcagataatgtaagctcatccaccaagaagcctgcaccatgttttgaggttgagtga

KEGG   Homo sapiens (human): 1909Help
Entry
1909              CDS       T01001                                 

Gene name
EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR
Definition
(RefSeq) endothelin receptor type A
  KO
K04197  endothelin receptor type A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04924  Renin secretion
hsa05200  Pathways in cancer
Disease
H02126  Mandibulofacial dysostosis with alopecia
Drug target
Ambrisentan: D07077
Aprocitentan: D11441
Atrasentan hydrochloride: D03009
Bosentan (DG00266): D01227 D07538
Clazosentan sodium: D07682
Edonentan: D03953
Fandosentan potassium: D04128
Macitentan: D10135
Sitaxentan (DG00267): D07171 D08517
Zibotentan: D07741
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1909 (EDNRA)
   04024 cAMP signaling pathway
    1909 (EDNRA)
   04022 cGMP-PKG signaling pathway
    1909 (EDNRA)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1909 (EDNRA)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    1909 (EDNRA)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    1909 (EDNRA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1909 (EDNRA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1909 (EDNRA)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Endothelin
    1909 (EDNRA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx
Motif
Other DBs
NCBI-GeneID: 1909
NCBI-ProteinID: NP_001948
OMIM: 131243
HGNC: 3179
Ensembl: ENSG00000151617
Vega: OTTHUMG00000161354
Pharos: P25101(Tclin)
UniProt: P25101
Position
4q31.22-q31.23
AA seq 427 aa AA seqDB search
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
NT seq 1284 nt NT seq  +upstreamnt  +downstreamnt
atggaaaccctttgcctcagggcatccttttggctggcactggttggatgtgtaatcagt
gataatcctgagagatacagcacaaatctaagcaatcatgtggatgatttcaccactttt
cgtggcacagagctcagcttcctggttaccactcatcaacccactaatttggtcctaccc
agcaatggctcaatgcacaactattgcccacagcagactaaaattacttcagctttcaaa
tacattaacactgtgatatcttgtactattttcatcgtgggaatggtggggaatgcaact
ctgctcaggatcatttaccagaacaaatgtatgaggaatggccccaacgcgctgatagcc
agtcttgcccttggagaccttatctatgtggtcattgatctccctatcaatgtatttaag
ctgctggctgggcgctggccttttgatcacaatgactttggcgtatttctttgcaagctg
ttcccctttttgcagaagtcctcggtggggatcaccgtcctcaacctctgcgctcttagt
gttgacaggtacagagcagttgcctcctggagtcgtgttcagggaattgggattcctttg
gtaactgccattgaaattgtctccatctggatcctgtcctttatcctggccattcctgaa
gcgattggcttcgtcatggtaccctttgaatataggggtgaacagcataaaacctgtatg
ctcaatgccacatcaaaattcatggagttctaccaagatgtaaaggactggtggctcttc
gggttctatttctgtatgcccttggtgtgcactgcgatcttctacaccctcatgacttgt
gagatgttgaacagaaggaatggcagcttgagaattgccctcagtgaacatcttaagcag
cgtcgagaagtggcaaaaacagttttctgcttggttgtaatttttgctctttgctggttc
cctcttcatttaagccgtatattgaagaaaactgtgtataacgagatggacaagaaccga
tgtgaattacttagtttcttactgctcatggattacatcggtattaacttggcaaccatg
aattcatgtataaaccccatagctctgtattttgtgagcaagaaatttaaaaattgtttc
cagtcatgcctctgctgctgctgttaccagtccaaaagtctgatgacctcggtccccatg
aacggaacaagcatccagtggaagaaccacgatcaaaacaaccacaacacagaccggagc
agccataaggacagcatgaactga

KEGG   Homo sapiens (human): 1910Help
Entry
1910              CDS       T01001                                 

Gene name
EDNRB, ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
Definition
(RefSeq) endothelin receptor type B
  KO
K04198  endothelin receptor type B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04916  Melanogenesis
hsa04926  Relaxin signaling pathway
hsa05200  Pathways in cancer
Disease
H00054  Nasopharyngeal cancer
H00759  Waardenburg syndrome
H00823  ABCD syndrome
H00910  Hirschsprung disease
Drug target
Aprocitentan: D11441
Bosentan (DG00266): D01227 D07538
Macitentan: D10135
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1910 (EDNRB)
   04022 cGMP-PKG signaling pathway
    1910 (EDNRB)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1910 (EDNRB)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    1910 (EDNRB)
   04916 Melanogenesis
    1910 (EDNRB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1910 (EDNRB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1910 (EDNRB)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Endothelin
    1910 (EDNRB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srw
Motif
Other DBs
NCBI-GeneID: 1910
NCBI-ProteinID: NP_000106
OMIM: 131244
HGNC: 3180
Ensembl: ENSG00000136160
Vega: OTTHUMG00000017111
Pharos: P24530(Tclin)
UniProt: P24530
Structure
PDB: 

Position
13q22.3
AA seq 442 aa AA seqDB search
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
NT seq 1329 nt NT seq  +upstreamnt  +downstreamnt
atgcagccgcctccaagtctgtgcggacgcgccctggttgcgctggttcttgcctgcggc
ctgtcgcggatctggggagaggagagaggcttcccgcctgacagggccactccgcttttg
caaaccgcagagataatgacgccacccactaagaccttatggcccaagggttccaacgcc
agtctggcgcggtcgttggcacctgcggaggtgcctaaaggagacaggacggcaggatct
ccgccacgcaccatctcccctcccccgtgccaaggacccatcgagatcaaggagactttc
aaatacatcaacacggttgtgtcctgccttgtgttcgtgctggggatcatcgggaactcc
acacttctgagaattatctacaagaacaagtgcatgcgaaacggtcccaatatcttgatc
gccagcttggctctgggagacctgctgcacatcgtcattgacatccctatcaatgtctac
aagctgctggcagaggactggccatttggagctgagatgtgtaagctggtgcctttcata
cagaaagcctccgtgggaatcactgtgctgagtctatgtgctctgagtattgacagatat
cgagctgttgcttcttggagtagaattaaaggaattggggttccaaaatggacagcagta
gaaattgttttgatttgggtggtctctgtggttctggctgtccctgaagccataggtttt
gatataattacgatggactacaaaggaagttatctgcgaatctgcttgcttcatcccgtt
cagaagacagctttcatgcagttttacaagacagcaaaagattggtggctattcagtttc
tatttctgcttgccattggccatcactgcatttttttatacactaatgacctgtgaaatg
ttgagaaagaaaagtggcatgcagattgctttaaatgatcacctaaagcagagacgggaa
gtggccaaaaccgtcttttgcctggtccttgtctttgccctctgctggcttccccttcac
ctcagcaggattctgaagctcactctttataatcagaatgatcccaatagatgtgaactt
ttgagctttctgttggtattggactatattggtatcaacatggcttcactgaattcctgc
attaacccaattgctctgtatttggtgagcaaaagattcaaaaactgctttaagtcatgc
ttatgctgctggtgccagtcatttgaagaaaaacagtccttggaggaaaagcagtcgtgc
ttaaagttcaaagctaatgatcacggatatgacaacttccgttccagtaataaatacagc
tcatcttga

KEGG   Homo sapiens (human): 2149Help
Entry
2149              CDS       T01001                                 

Gene name
F2R, CF2R, HTR, PAR-1, PAR1, TR
Definition
(RefSeq) coagulation factor II thrombin receptor
  KO
K03914  coagulation factor II (thrombin) receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04610  Complement and coagulation cascades
hsa04611  Platelet activation
hsa04810  Regulation of actin cytoskeleton
hsa05200  Pathways in cancer
Drug target
Atopaxar (DG01348): D09866 D09867
Vorapaxar (DG01349): D09765 D09766
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    2149 (F2R)
   04020 Calcium signaling pathway
    2149 (F2R)
   04072 Phospholipase D signaling pathway
    2149 (F2R)
   04024 cAMP signaling pathway
    2149 (F2R)
   04151 PI3K-Akt signaling pathway
    2149 (F2R)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2149 (F2R)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    2149 (F2R)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2149 (F2R)
   04611 Platelet activation
    2149 (F2R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2149 (F2R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2149 (F2R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Thrombin
    2149 (F2R)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 DUF4064
Motif
Other DBs
NCBI-GeneID: 2149
NCBI-ProteinID: NP_001983
OMIM: 187930
HGNC: 3537
Ensembl: ENSG00000181104
Vega: OTTHUMG00000131299
Pharos: P25116(Tclin)
UniProt: P25116 A0A024RAP7
Structure
PDB: 

Position
5q13.3
AA seq 425 aa AA seqDB search
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
NT seq 1278 nt NT seq  +upstreamnt  +downstreamnt
atggggccgcggcggctgctgctggtggccgcctgcttcagtctgtgcggcccgctgttg
tctgcccgcacccgggcccgcaggccagaatcaaaagcaacaaatgccaccttagatccc
cggtcatttcttctcaggaaccccaatgataaatatgaaccattttgggaggatgaggag
aaaaatgaaagtgggttaactgaatacagattagtctccatcaataaaagcagtcctctt
caaaaacaacttcctgcattcatctcagaagatgcctccggatatttgaccagctcctgg
ctgacactctttgtcccatctgtgtacaccggagtgtttgtagtcagcctcccactaaac
atcatggccatcgttgtgttcatcctgaaaatgaaggtcaagaagccggcggtggtgtac
atgctgcacctggccacggcagatgtgctgtttgtgtctgtgctcccctttaagatcagc
tattacttttccggcagtgattggcagtttgggtctgaattgtgtcgcttcgtcactgca
gcattttactgtaacatgtacgcctctatcttgctcatgacagtcataagcattgaccgg
tttctggctgtggtgtatcccatgcagtccctctcctggcgtactctgggaagggcttcc
ttcacttgtctggccatctgggctttggccatcgcaggggtagtgcctctgctcctcaag
gagcaaaccatccaggtgcccgggctcaacatcactacctgtcatgatgtgctcaatgaa
accctgctcgaaggctactatgcctactacttctcagccttctctgctgtcttctttttt
gtgccgctgatcatttccacggtctgttatgtgtctatcattcgatgtcttagctcttcc
gcagttgccaaccgcagcaagaagtcccgggctttgttcctgtcagctgctgttttctgc
atcttcatcatttgcttcggacccacaaacgtcctcctgattgcgcattactcattcctt
tctcacacttccaccacagaggctgcctactttgcctacctcctctgtgtctgtgtcagc
agcataagctgctgcatcgaccccctaatttactattacgcttcctctgagtgccagagg
tacgtctacagtatcttatgctgcaaagaaagttccgatcccagcagttataacagcagt
gggcagttgatggcaagtaaaatggatacctgctctagtaacctgaataacagcatatac
aaaaagctgttaacttag

KEGG   Homo sapiens (human): 2911Help
Entry
2911              CDS       T01001                                 

Gene name
GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13
Definition
(RefSeq) glutamate metabotropic receptor 1
  KO
K04603  metabotropic glutamate receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04068  FoxO signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04730  Long-term depression
hsa04742  Taste transduction
hsa04915  Estrogen signaling pathway
Disease
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    2911 (GRM1)
   04020 Calcium signaling pathway
    2911 (GRM1)
   04072 Phospholipase D signaling pathway
    2911 (GRM1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2911 (GRM1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2911 (GRM1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    2911 (GRM1)
  09156 Nervous system
   04724 Glutamatergic synapse
    2911 (GRM1)
   04720 Long-term potentiation
    2911 (GRM1)
   04730 Long-term depression
    2911 (GRM1)
   04723 Retrograde endocannabinoid signaling
    2911 (GRM1)
  09157 Sensory system
   04742 Taste transduction
    2911 (GRM1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2911 (GRM1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2911 (GRM1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     2911 (GRM1)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2911 (GRM1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ANF_receptor 7tm_3 GluR_Homer-bdg NCD3G DUF5438 DUF2318 AAA_34
Motif
Other DBs
NCBI-GeneID: 2911
NCBI-ProteinID: NP_001264993
OMIM: 604473
HGNC: 4593
Ensembl: ENSG00000152822
Vega: OTTHUMG00000015752
Pharos: Q13255(Tchem)
UniProt: Q13255 Q59HC2
Structure
PDB: 

Position
6q24.3
AA seq 1194 aa AA seqDB search
MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM
AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE
VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGG
GQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEE
EDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQ
QQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPL
QLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPD
DSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
NT seq 3585 nt NT seq  +upstreamnt  +downstreamnt
atggtcgggctccttttgttttttttcccagcgatctttttggaggtgtcccttctcccc
agaagccccggcaggaaagtgttgctggcaggagcgtcgtctcagcgctcggtggccaga
atggacggagatgtcatcattggagccctcttctcagtccatcaccagcctccggccgag
aaagtgcccgagaggaagtgtggggagatcagggagcagtatggcatccagagggtggag
gccatgttccacacgttggataagatcaacgcggacccggtcctcctgcccaacatcacc
ctgggcagtgagatccgggactcctgctggcactcttccgtggctctggaacagagcatt
gagttcattagggactctctgatttccattcgagatgagaaggatgggatcaaccggtgt
ctgcctgacggccagtccctccccccaggcaggactaagaagcccattgcgggagtgatc
ggtcccggctccagctctgtagccattcaagtgcagaacctgctccagctcttcgacatc
ccccagatcgcttattcagccacaagcatcgacctgagtgacaaaactttgtacaaatac
ttcctgagggttgtcccttctgacactttgcaggcaagggccatgcttgacatagtcaaa
cgttacaattggacctatgtctctgcagtccacacggaagggaattatggggagagcgga
atggacgctttcaaagagctggctgcccaggaaggcctctgtatcgcccattctgacaaa
atctacagcaacgctggggagaagagctttgaccgactcttgcgcaaactccgagagagg
cttcccaaggctagagtggtggtctgcttctgtgaaggcatgacagtgcgaggactcctg
agcgccatgcggcgccttggcgtcgtgggcgagttctcactcattggaagtgatggatgg
gcagacagagatgaagtcattgaaggttatgaggtggaagccaacgggggaatcacgata
aagctgcagtctccagaggtcaggtcatttgatgattatttcctgaaactgaggctggac
actaacacgaggaatccctggttccctgagttctggcaacatcggttccagtgccgcctt
ccaggacaccttctggaaaatcccaactttaaacgaatctgcacaggcaatgaaagctta
gaagaaaactatgtccaggacagtaagatggggtttgtcatcaatgccatctatgccatg
gcacatgggctgcagaacatgcaccatgccctctgccctggccacgtgggcctctgcgat
gccatgaagcccatcgacggcagcaagctgctggacttcctcatcaagtcctcattcatt
ggagtatctggagaggaggtgtggtttgatgagaaaggagacgctcctggaaggtatgat
atcatgaatctgcagtacactgaagctaatcgctatgactatgtgcacgttggaacctgg
catgaaggagtgctgaacattgatgattacaaaatccagatgaacaagagtggagtggtg
cggtctgtgtgcagtgagccttgcttaaagggccagattaaggttatacggaaaggagaa
gtgagctgctgctggatttgcacggcctgcaaagagaatgaatatgtgcaagatgagttc
acctgcaaagcttgtgacttgggatggtggcccaatgcagatctaacaggctgtgagccc
attcctgtgcgctatcttgagtggagcaacatcgaatccattatagccatcgccttttca
tgcctgggaatccttgttaccttgtttgtcaccctaatctttgtactgtaccgggacaca
ccagtggtcaaatcctccagtcgggagctctgctacatcatcctagctggcatcttcctt
ggttatgtgtgcccattcactctcattgccaaacctactaccacctcctgctacctccag
cgcctcttggttggcctctcctctgcgatgtgctactctgctttagtgactaaaaccaat
cgtattgcacgcatcctggctggcagcaagaagaagatctgcacccggaagcccaggttc
atgagtgcctgggctcaggtgatcattgcctcaattctgattagtgtgcaactaaccctg
gtggtaaccctgatcatcatggaaccccctatgcccattctgtcctacccaagtatcaag
gaagtctaccttatctgcaataccagcaacctgggtgtggtggcccctttgggctacaat
ggactcctcatcatgagctgtacctactatgccttcaagacccgcaacgtgcccgccaac
ttcaacgaggccaaatatatcgcgttcaccatgtacaccacctgtatcatctggctagct
tttgtgcccatttactttgggagcaactacaagatcatcacaacttgctttgcagtgagt
ctcagtgtaacagtggctctggggtgcatgttcactcccaagatgtacatcattattgcc
aagcctgagaggaatgtccgcagtgccttcaccacctctgatgttgtccgcatgcatgtt
ggcgatggcaagctgccctgccgctccaacactttcctcaacatcttccgaagaaagaag
gcaggggcagggaatgccaattctaatggcaagtctgtgtcatggtctgaaccaggtgga
ggacaggtgcccaagggacagcatatgtggcaccgcctctctgtgcacgtgaagaccaat
gagacggcctgcaaccaaacagccgtcatcaagcccctcactaaaagttaccaaggctct
ggcaagagcctgaccttttcagataccagcaccaagaccctttacaacgtagaggaggag
gaggatgcccagccgattcgctttagcccgcctggtagcccttccatggtggtgcacagg
cgcgtgccaagcgcggcgaccactccgcctctgccgtcccacctgaccgcagaggagacc
cccctcttcctggccgaaccagccctccccaagggcttgccccctcctctccagcagcag
cagcaaccccctccacagcagaaatcgctgatggaccagctccagggagtggtcagcaac
ttcagtaccgcgatcccggattttcacgcggtgctggcaggccccggtggtcccgggaac
gggctgcggtccctgtacccgcccccgccacctccgcagcacctgcagatgctgccgctg
cagctgagcacctttggggaggagctggtctccccgcccgcggacgacgacgacgacagc
gagaggtttaagctcctccaggagtacgtgtatgagcacgagcgggaagggaacacggaa
gaagacgaactggaagaggaggaggaggacctgcaggcggccagcaaactgaccccggat
gattcgcctgcgctgacgcctccgtcgcctttccgcgactcggtggcctcgggcagctcg
gtgcccagctcccccgtgtccgagtcggtgctctgcacccctcccaacgtatcctacgcc
tctgtcattctgcgggactacaagcaaagctcttccaccctgtaa

KEGG   Homo sapiens (human): 2915Help
Entry
2915              CDS       T01001                                 

Gene name
GRM5, GPRC1E, MGLUR5, PPP1R86, mGlu5
Definition
(RefSeq) glutamate metabotropic receptor 5
  KO
K04604  metabotropic glutamate receptor 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa05016  Huntington disease
Drug target
Fenobam: D04155
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2915 (GRM5)
   04072 Phospholipase D signaling pathway
    2915 (GRM5)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2915 (GRM5)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2915 (GRM5)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2915 (GRM5)
   04720 Long-term potentiation
    2915 (GRM5)
   04723 Retrograde endocannabinoid signaling
    2915 (GRM5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    2915 (GRM5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2915 (GRM5)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2915 (GRM5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ANF_receptor 7tm_3 GluR_Homer-bdg NCD3G DUF5438
Motif
Other DBs
NCBI-GeneID: 2915
NCBI-ProteinID: NP_001137303
OMIM: 604102
HGNC: 4597
Ensembl: ENSG00000168959
Vega: OTTHUMG00000134306
Pharos: P41594(Tchem)
UniProt: P41594
Structure
PDB: 

Position
11q14.2-q14.3
AA seq 1212 aa AA seqDB search
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG
NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG
LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS
PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML
STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA
RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL
IIRDYTQSSSSL
NT seq 3639 nt NT seq  +upstreamnt  +downstreamnt
atggtccttctgttgatcctgtcagtcttacttttgaaagaagatgtccgtgggagtgca
cagtccagtgagaggagggtggtggctcacatgccgggtgacatcattattggagctctc
ttttctgttcatcaccagcctactgtggacaaagttcatgagaggaagtgtggggcggtc
cgtgaacagtatggcattcagagagtggaggccatgctgcataccctggaaaggatcaat
tcagaccccacactcttgcccaacatcacactgggctgtgagataagggactcctgctgg
cattcggctgtggccctagagcagagcattgagttcataagagattccctcatttcttca
gaagaggaagaaggcttggtacgctgtgtggatggctcctcctcttccttccgctccaag
aagcccatagtaggggtcattgggcctggctccagttctgtagccattcaggtccagaat
ttgctccagcttttcaacatacctcagattgcttactcagcaaccagcatggatctgagt
gacaagactctgttcaaatatttcatgagggttgtgccttcagatgctcagcaggcaagg
gccatggtggacatagtgaagaggtacaactggacctatgtatcagccgtgcacacagaa
ggcaactatggagaaagtgggatggaagccttcaaagatatgtcagcgaaggaagggatt
tgcatcgcccactcttacaaaatctacagtaatgcaggggagcagagctttgataagctg
ctgaagaagctcacaagtcacttgcccaaggcccgggtggtggcctgcttctgtgagggc
atgacggtgagaggtctgctgatggccatgaggcgcctgggtctagcgggagaatttctg
cttctgggcagtgatggctgggctgacaggtatgatgtgacagatggatatcagcgagaa
gctgttggtggcatcacaatcaagctccaatctcccgatgtcaagtggtttgatgattat
tatctgaagctccggccagaaacaaaccaccgaaacccttggtttcaagaattttggcag
catcgttttcagtgccgactggaagggtttccacaggagaacagcaaatacaacaagact
tgcaatagttctctgactctgaaaacacatcatgttcaggattccaaaatgggatttgtg
atcaacgccatctattcgatggcctatgggctccacaacatgcagatgtccctctgccca
ggctatgcaggactctgtgatgccatgaagccaattgatggacggaaacttttggagtcc
ctgatgaaaaccaattttactggggtttctggagatacgatcctattcgatgagaatgga
gactctccaggaaggtatgaaataatgaatttcaaggaaatgggaaaagattactttgat
tatatcaacgttggaagttgggacaatggagaattaaaaatggatgatgatgaagtatgg
tccaagaaaagcaacatcatcagatctgtgtgcagtgaaccatgtgagaaaggccagatc
aaggtgatccgaaagggagaagtcagctgttgttggacctgtacaccttgtaaggagaat
gagtatgtctttgatgagtacacatgcaaggcatgccaactggggtcttggcccactgat
gatctcacaggttgtgacttgatcccagtacagtatcttcgatggggtgaccctgaaccc
attgcagctgtggtgtttgcctgccttggcctcctggccaccctgtttgttactgtagtc
ttcatcatttaccgtgatacaccagtagtcaagtcctcaagcagggaactctgctacatt
atccttgctggcatctgcctgggctacttatgtaccttctgcctcattgcgaagcccaaa
cagatttactgctaccttcagagaattggcattggtctctccccagccatgagctactca
gcccttgtaacaaagaccaaccgtattgcaaggatcctggctggcagcaagaagaagatc
tgtaccaaaaagcccagattcatgagtgcctgtgcccagctagtgattgctttcattctc
atatgcatccagttgggcatcatcgttgccctctttataatggagcctcctgacataatg
catgactacccaagcattcgagaagtctacctgatctgtaacaccaccaacctaggagtt
gtcactccacttggatacaatggattgttgattttgagctgcaccttctatgcgttcaag
accagaaatgttccagctaacttcaacgaggccaagtatatcgccttcacaatgtacacg
acctgcattatatggctagcttttgtgccaatctactttggcagcaactacaaaatcatc
accatgtgtttctcggtcagcctcagtgccacagtggccctaggctgcatgtttgtgccg
aaggtgtacatcatcctggccaaaccagagagaaacgtgcgcagcgccttcaccacatct
accgtggtgcgcatgcatgtaggggatggcaagtcatcctccgcagccagcagatccagc
agcctagtcaacctgtggaagagaaggggctcctctggggaaaccttaaggtacaaagac
aggagactggcccagcacaagtcggaaatagagtgtttcacccccaaagggagtatgggg
aatggtgggagagcaacaatgagcagttccaatggaaaatccgtcacgtgggcccagaat
gagaagagcagccgggggcagcacctgtggcagcgcctgtccatccacatcaacaagaaa
gaaaaccccaaccaaacggccgtcatcaagcccttccccaagagcacggagagccgtggc
ctgggcgctggcgctggcgcaggcgggagcgctgggggcgtgggggccacgggcggtgcg
ggctgcgcaggcgccggcccaggcgggcccgagtccccagacgccggccccaaggcgctg
tatgatgtggccgaggctgaggagcacttcccggcgcccgcgcggccgcgctcaccgtcg
cccatcagcacgctgagccaccgcgcgggctcggccagccgcacggacgacgatgtgccg
tcgctgcactcggagcctgtggcgcgcagcagctcctcgcagggctccctcatggagcag
atcagcagtgtggtcacccgcttcacggccaacatcagcgagctcaactccatgatgctg
tccaccgcggcccccagccccggcgtcggcgccccgctctgctcgtcctacctgatcccc
aaagagatccagttgcccacgaccatgacgacctttgccgaaatccagcctctgccggcc
atcgaagtcacgggaggcgcgcagcccgcggcaggggcgcaggcggctggggacgcggcc
cgggagagccccgcggccggtcccgaggctgcggccgccaagccagacctggaggagctg
gtggctctcaccccgccgtcccccttcagagactcggtggactcggggagcacaaccccc
aactcgccagtgtccgagtcggccctctgtatcccgtcgtctcccaaatatgacactctt
atcataagagattacactcagagctcctcgtcgttgtga

KEGG   Homo sapiens (human): 2925Help
Entry
2925              CDS       T01001                                 

Gene name
GRPR, BB2, BB2R
Definition
(RefSeq) gastrin releasing peptide receptor
  KO
K04169  gastrin-releasing peptide receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2925 (GRPR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2925 (GRPR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2925 (GRPR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Bombesin
    2925 (GRPR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srv 7TM_GPCR_Srsx 7tm_4
Motif
Other DBs
NCBI-GeneID: 2925
NCBI-ProteinID: NP_005305
OMIM: 305670
HGNC: 4609
Ensembl: ENSG00000126010
Vega: OTTHUMG00000021189
Pharos: P30550(Tchem)
UniProt: P30550 X5D7H2
Position
Xp22.2
AA seq 384 aa AA seqDB search
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
NT seq 1155 nt NT seq  +upstreamnt  +downstreamnt
atggctctaaatgactgtttccttctgaacttggaggtggaccatttcatgcactgcaac
atctccagtcacagtgcggatctccccgtgaacgatgactggtcccacccggggatcctc
tatgtcatccctgcagtttatggggttatcattctgataggcctcattggcaacatcact
ttgatcaagatcttctgtacagtcaagtccatgcgaaacgttccaaacctgttcatttcc
agtctggctttgggagacctgctcctcctaataacgtgtgctccagtggatgccagcagg
tacctggctgacagatggctatttggcaggattggctgcaaactgatcccctttatacag
cttacctctgttggggtgtctgtcttcacactcacggcgctctcggcagacagatacaaa
gccattgtccggccaatggatatccaggcctctcatgccctgatgaagatctgcctcaaa
gccgcctttatctggatcatctccatgctgctggccattccagaggccgtgttttctgac
ctccatcccttccatgaggaaagcaccaaccagaccttcattagctgtgccccataccca
cactctaatgagcttcaccccaaaatccattctatggcttcctttctggtcttctacgtc
attccactgtcgatcatctctgtttactactacttcattgctaaaaatctgatccagagt
gcttacaatcttcccgtggaagggaatatacatgtcaagaagcagattgaatcccggaag
cgacttgccaagacagtgctggtgtttgtgggcctgttcgccttctgctggctccccaat
catgtcatctacctgtaccgctcctaccactactctgaggtggacacctccatgctccac
tttgtcaccagcatctgtgcccgcctcctggccttcaccaactcctgcgtgaaccccttt
gccctctacctgctgagcaagagtttcaggaaacagttcaacactcagctgctctgttgc
cagcctggcctgatcatccggtctcacagcactggaaggagtacaacctgcatgacctcc
ctcaagagtaccaacccctccgtggccacctttagcctcatcaatggaaacatctgtcac
gagcggtatgtctag

KEGG   Homo sapiens (human): 3269Help
Entry
3269              CDS       T01001                                 

Gene name
HRH1, H1-R, H1R, HH1R, hisH1
Definition
(RefSeq) histamine receptor H1
  KO
K04149  histamine receptor H1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Drug target
Acrivastine: D02760
Alcaftadine: D06552
Alimemazine (DG01101): D02245 D07125
Antazoline (DG01037): D02950 D07458 D07459
Astemizole: D00234
Azatadine (DG01112): D00662 D07482
Azelastine (DG01036): D00659 D07483
Bamipine (DG00388): D07197 D07492 D07493
Barmastine: D03056
Bepotastine (DG01327): D01654 D09705
Betahistine (DG01004): D01592 D03102 D07522
Bilastine: D09570
Bisulepin: D07532
Bisulepin hydrochloride: D07533
Broizine: D09838
Bromazine: D03166
Brompheniramine (DG01097): D00663 D07543
Buclizine (DG01104): D02089 D07547
Carbinoxamine (DG01095): D01336 D07617 D09808
Cetirizine (DG01107): D00664 D07662
Chloropyramine (DG00384): D07195 D07679
Chlorphenamine (DG01099): D00665 D03475 D07398
Chlorphenoxamine (DG00391): D07198 D07684
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Cidoxepin hydrochloride: D03491
Cinnarizine (DG01005): D01295 D07734
Clemastine (DG00387): D00666 D03535
Closiramine aceturate: D03568
Cycliramine maleate: D03620
Cyclizine (DG01105): D02090 D03621 D03622
Cyproheptadine (DG01109): D02234 D07765
Deptropine (DG01114): D07404 D07790
Desloratadine: D03693
Dexbrompheniramine: D03704
Dexchlorpheniramine (DG01098): D00668 D07803
Difeterol (DG02077): D01701 D09747 D09748
Dimenhydrinate: D00520
Dimetindene (DG00386): D01343 D07853
Dimetotiazine (DG00843): D01902 D07854
Dioxopromethazine hydrochloride: D07860
Diphenhydramine (DG00390): D00300 D00669 D02419 D03285 D03360 D03854
Diphenylimidazole: D02067
Diphenylpyraline (DG01094): D01172 D01627 D07862
Dorastine hydrochloride: D03893
Doxepin (DG00937): D00814 D07875
Doxylamine (DG01096): D02327 D07878
Ebastine: D01478
Efletirizine dihydrochloride: D03963
Embramine: D07889
Emedastine (DG01144): D02249 D07890
Epinastine (DG01116): D01713 D07900
Esmirtazapine maleate: D04055
Fexofenadine (DG01117): D00671 D07958
Histamine: D08040
Histamine phosphate: D04445
Histapyrrodine: D07400
Homochlorcyclizine (DG01328): D01460 D08041
Hydroxyzine (DG00912): D00672 D01096 D08054
Icotidine: D04494
Isothipendyl (DG00389): D01143 D08091
Ketotifen (DG01115): D01332 D08105
Levocabastine (DG01035): D01717 D08117
Levocetirizine (DG01108): D07402 D08118
Loratadine: D00364
Mebhydrolin (DG01113): D01786 D08161
Meclozine (DG01106): D01317 D08163
Mepyramine (DG00382): D05660 D08183
Mequitazine: D01324
Methdilazine (DG01103): D04979 D04980
Mizolastine: D01117
Noberastine: D05196
Olanzapine (DG00898): D00454 D06623
Olopatadine (DG01039): D01192 D08293
Opipramol (DG00930): D01477 D08297
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774
Oxomemazine: D07401
Phenindamine (DG01110): D02148 D08353
Pheniramine (DG01100): D01174 D08355
Phenyltoloxamine citrate: D08967
Pimethixene: D07406
Promethazine (DG00385): D00480 D00494 D01242 D03290 D08432 D08768
Pyroxamine maleate: D05664
Pyrrobutamine: D07403
Quifenadine: D10230
Rocastine hydrochloride: D05742
Rotoxamine: D05769
Rupatadine (DG01118): D07407 D08497
Sequifenadine: D10510
Tazifylline hydrochloride: D06012
Tecastemizole: D06021
Temelastine: D06063
Terfenadine: D00521
Tesmilifene hydrochloride: D06084
Thenalidine: D07194
Thonzylamine (DG00381): D01801 D08587
Tolpropamine: D07196
Tripelennamine (DG00383): D02091 D06246 D08645
Triprolidine (DG01111): D01782 D08648
Zolamine hydrochloride: D06376
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3269 (HRH1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3269 (HRH1)
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3269 (HRH1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3269 (HRH1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Histamine
    3269 (HRH1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx DUF1601
Motif
Other DBs
NCBI-GeneID: 3269
NCBI-ProteinID: NP_000852
OMIM: 600167
HGNC: 5182
Ensembl: ENSG00000196639
Vega: OTTHUMG00000129719
Pharos: P35367(Tclin)
UniProt: P35367
Position
3p25.3
AA seq 487 aa AA seqDB search
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
NT seq 1464 nt NT seq  +upstreamnt  +downstreamnt
atgagcctccccaattcctcctgcctcttagaagacaagatgtgtgagggcaacaagacc
actatggccagcccccagctgatgcccctggtggtggtcctgagcactatctgcttggtc
acagtagggctcaacctgctggtgctgtatgccgtacggagtgagcggaagctccacact
gtggggaacctgtacatcgtcagcctctcggtggcggacttgatcgtgggtgccgtcgtc
atgcctatgaacatcctctacctgctcatgtccaagtggtcactgggccgtcctctctgc
ctcttttggctttccatggactatgtggccagcacagcgtccattttcagtgtcttcatc
ctgtgcattgatcgctaccgctctgtccagcagcccctcaggtaccttaagtatcgtacc
aagacccgagcctcggccaccattctgggggcctggtttctctcttttctgtgggttatt
cccattctaggctggaatcacttcatgcagcagacctcggtgcgccgagaggacaagtgt
gagacagacttctatgatgtcacctggttcaaggtcatgactgccatcatcaacttctac
ctgcccaccttgctcatgctctggttctatgccaagatctacaaggccgtacgacaacac
tgccagcaccgggagctcatcaataggtccctcccttccttctcagaaattaagctgagg
ccagagaaccccaagggggatgccaagaaaccagggaaggagtctccctgggaggttctg
aaaaggaagccaaaagatgctggtggtggatctgtcttgaagtcaccatcccaaaccccc
aaggagatgaaatccccagttgtcttcagccaagaggatgatagagaagtagacaaactc
tactgctttccacttgatattgtgcacatgcaggctgcggcagaggggagtagcagggac
tatgtagccgtcaaccggagccatggccagctcaagacagatgagcagggcctgaacaca
catggggccagcgagatatcagaggatcagatgttaggtgatagccaatccttctctcga
acggactcagataccaccacagagacagcaccaggcaaaggcaaattgaggagtgggtct
aacacaggcctggattacatcaagtttacttggaagaggctccgctcgcattcaagacag
tatgtatctgggttgcacatgaaccgcgaaaggaaggccgccaaacagttgggttttatc
atggcagccttcatcctctgctggatcccttatttcatcttcttcatggtcattgccttc
tgcaagaactgttgcaatgaacatttgcacatgttcaccatctggctgggctacatcaac
tccacactgaaccccctcatctaccccttgtgcaatgagaacttcaagaagacattcaag
agaattctgcatattcgctcctaa

KEGG   Homo sapiens (human): 3356Help
Entry
3356              CDS       T01001                                 

Gene name
HTR2A, 5-HT2A, HTR2
Definition
(RefSeq) 5-hydroxytryptamine receptor 2A
  KO
K04157  5-hydroxytryptamine receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04726  Serotonergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
Disease
H01450  Obsessive-compulsive disorder
H01611  Alcohol dependence
H01646  Major depressive disorder
H01649  Schizophrenia
Drug target
Adatanserin hydrochloride: D02767
Altanserin tartrate: D02836
Amesergide: D02893
Aripiprazole (DG00906): D01164 D10355 D10364 D10516
Asenapine: D02995
Atiprosin maleate: D03005
Blonanserin: D01176
Brexpiprazole: D10309
Cariprazine (DG01305): D09876 D09997
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Cinanserin hydrochloride: D03506
Cinitapride (DG01520): D07700 D07701
Cisapride (DG00056): D00274 D02092
Clozapine: D00283
Cyamemazine (DG00872): D07307 D07756
Dimetotiazine (DG00843): D01902 D07854
Eplivanserin: D10006
Esmirtazapine maleate: D04055
Fananserin: D02656
Fenfluramine (DG00103): D04148 D07945
Flibanserin: D02577
Glemanserin: D04320
Iloperidone: D02666
Ketanserin (DG00265): D02363 D08099
Loxapine (DG00897): D00794 D02340 D08148
Lubazodone hydrochloride: D04788
Lumateperone (DG02937): D11169 D11170
Lurasidone: D04820
Mesoridazine (DG00883): D00795 D02671
Methysergide (DG00835): D00681 D02357
Metrenperone: D05015
Mirtazapine (DG02838): D00563 D11056
Naftidrofuryl (DG00290): D05107 D08244
Nefazodone (DG00953): D00819 D08257
Nelotanserin: D09645
Ocaperidone: D02675
Olanzapine (DG00898): D00454 D06623
Opipramol (DG00930): D01477 D08297
Paliperidone (DG00907): D05339 D05340
Pelanserin hydrochloride: D05395
Periciazine: D01485
Perospirone hydrochloride hydrate: D02372
Pimavanserin: D08969
Pipotiazine (DG00884): D02680 D08385
Pizotifen (DG00842): D05523 D08397
Pruvanserin (DG01278): D06632 D06633
Quetiapine (DG00899): D00458 D08456
Risperidone: D00426
Ritanserin: D05738
Sarpogrelate (DG01333): D01624 D08508
Sergolexole maleate: D05829
Sertindole: D00561
Setoperone: D02686
Temanogrel (DG01334): D09976 D09977
Tiospirone hydrochloride: D02688
Trazodone (DG00952): D00820 D08626
Tropanserin hydrochloride: D06253
Xylamidine tosylate: D06343
Zicronapine (DG01539): D10329 D10495
Ziprasidone (DG00892): D01939 D02100 D08687
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3356 (HTR2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3356 (HTR2A)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3356 (HTR2A)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3356 (HTR2A)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3356 (HTR2A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3356 (HTR2A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3356 (HTR2A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 3356
NCBI-ProteinID: NP_000612
OMIM: 182135
HGNC: 5293
Ensembl: ENSG00000102468
Vega: OTTHUMG00000016881
Pharos: P28223(Tclin)
UniProt: P28223
Position
13q14.2
AA seq 471 aa AA seqDB search
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
NT seq 1416 nt NT seq  +upstreamnt  +downstreamnt
atggatattctttgtgaagaaaatacttctttgagctcaactacgaactccctaatgcaa
ttaaatgatgacaccaggctctacagtaatgactttaactccggagaagctaacacttct
gatgcatttaactggacagtcgactctgaaaatcgaaccaacctttcctgtgaagggtgc
ctctcaccgtcgtgtctctccttacttcatctccaggaaaaaaactggtctgctttactg
acagccgtagtgattattctaactattgctggaaacatactcgtcatcatggcagtgtcc
ctagagaaaaagctgcagaatgccaccaactatttcctgatgtcacttgccatagctgat
atgctgctgggtttccttgtcatgcccgtgtccatgttaaccatcctgtatgggtaccgg
tggcctctgccgagcaagctttgtgcagtctggatttacctggacgtgctcttctccacg
gcctccatcatgcacctctgcgccatctcgctggaccgctacgtcgccatccagaatccc
atccaccacagccgcttcaactccagaactaaggcatttctgaaaatcattgctgtttgg
accatatcagtaggtatatccatgccaataccagtctttgggctacaggacgattcgaag
gtctttaaggaggggagttgcttactcgccgatgataactttgtcctgatcggctctttt
gtgtcatttttcattcccttaaccatcatggtgatcacctactttctaactatcaagtca
ctccagaaagaagctactttgtgtgtaagtgatcttggcacacgggccaaattagcttct
ttcagcttcctccctcagagttctttgtcttcagaaaagctcttccagcggtcgatccat
agggagccagggtcctacacaggcaggaggactatgcagtccatcagcaatgagcaaaag
gcatgcaaggtgctgggcatcgtcttcttcctgtttgtggtgatgtggtgccctttcttc
atcacaaacatcatggccgtcatctgcaaagagtcctgcaatgaggatgtcattggggcc
ctgctcaatgtgtttgtttggatcggttatctctcttcagcagtcaacccactagtctac
acactgttcaacaagacctataggtcagccttttcacggtatattcagtgtcagtacaag
gaaaacaaaaaaccattgcagttaattttagtgaacacaataccggctttggcctacaag
tctagccaacttcaaatgggacaaaaaaagaattcaaagcaagatgccaagacaacagat
aatgactgctcaatggttgctctaggaaagcagcattctgaagaggcttctaaagacaat
agcgacggagtgaatgaaaaggtgagctgtgtgtga

KEGG   Homo sapiens (human): 3357Help
Entry
3357              CDS       T01001                                 

Gene name
HTR2B, 5-HT(2B), 5-HT-2B, 5-HT2B
Definition
(RefSeq) 5-hydroxytryptamine receptor 2B
  KO
K04157  5-hydroxytryptamine receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04726  Serotonergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
Drug target
Adatanserin hydrochloride: D02767
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Cinitapride (DG01520): D07700 D07701
Dimetotiazine (DG00843): D01902 D07854
Fenfluramine (DG00103): D04148 D07945
Flibanserin: D02577
Glemanserin: D04320
Iloperidone: D02666
Methysergide (DG00835): D00681 D02357
Metrenperone: D05015
Mirtazapine (DG02838): D00563 D11056
Ocaperidone: D02675
Olanzapine (DG00898): D00454 D06623
Opipramol (DG00930): D01477 D08297
Pelanserin hydrochloride: D05395
Periciazine: D01485
Pizotifen (DG00842): D05523 D08397
Sergolexole maleate: D05829
Setoperone: D02686
Tiospirone hydrochloride: D02688
Trazodone (DG00952): D00820 D08626
Tropanserin hydrochloride: D06253
Xylamidine tosylate: D06343
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3357 (HTR2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3357 (HTR2B)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3357 (HTR2B)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3357 (HTR2B)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3357 (HTR2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3357 (HTR2B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3357 (HTR2B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7tm_4 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 3357
NCBI-ProteinID: NP_000858
OMIM: 601122
HGNC: 5294
Ensembl: ENSG00000135914
Vega: OTTHUMG00000133222
Pharos: P41595(Tclin)
UniProt: P41595
Position
2q37.1
AA seq 481 aa AA seqDB search
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
NT seq 1446 nt NT seq  +upstreamnt  +downstreamnt
atggctctctcttacagagtgtctgaacttcaaagcacaattcctgagcacattttgcag
agcacctttgttcacgttatctcttctaactggtctggattacagacagaatcaatacca
gaggaaatgaaacagattgttgaggaacagggaaataaactgcactgggcagctcttctg
atactcatggtgataatacccacaattggtggaaatacccttgttattctggctgtttca
ctggagaagaagctgcagtatgctactaattactttctaatgtccttggcggtggctgat
ttgctggttggattgtttgtgatgccaattgccctcttgacaataatgtttgaggctatg
tggcccctcccacttgttctatgtcctgcctggttatttcttgacgttctcttttcaacc
gcatccatcatgcatctctgtgccatttcagtggatcgttacatagccatcaaaaagcca
atccaggccaatcaatataactcacgggctacagcattcatcaagattacagtggtgtgg
ttaatttcaataggcattgccattccagtccctattaaagggatagagactgatgtggac
aacccaaacaatatcacttgtgtgctgacaaaggaacgttttggcgatttcatgctcttt
ggctcactggctgccttcttcacacctcttgcaattatgattgtcacctactttctcact
atccatgctttacagaagaaggcttacttagtcaaaaacaagccacctcaacgcctaaca
tggttgactgtgtctacagttttccaaagggatgaaacaccttgctcgtcaccggaaaag
gtggcaatgctggatggttctcgaaaggacaaggctctgcccaactcaggtgatgaaaca
cttatgcgaagaacatccacaattgggaaaaagtcagtgcagaccatttccaacgaacag
agagcctcaaaggtcctagggattgtgtttttcctctttttgcttatgtggtgtcccttc
tttattacaaatataactttagttttatgtgattcctgtaaccaaactactctccaaatg
ctcctggagatatttgtgtggataggctatgtttcctcaggagtgaatcctttggtctac
accctcttcaataagacatttcgggatgcatttggccgatatatcacctgcaattaccgg
gccacaaagtcagtaaaaactctcagaaaacgctccagtaagatctacttccggaatcca
atggcagagaactctaagtttttcaagaaacatggaattcgaaatgggattaaccctgcc
atgtaccagagtccaatgaggctccgaagttcaaccattcagtcttcatcaatcattcta
ctagatacgcttctcctcactgaaaatgaaggtgacaaaactgaagagcaagttagttat
gtatag

KEGG   Homo sapiens (human): 3358Help
Entry
3358              CDS       T01001                                 

Gene name
HTR2C, 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
Definition
(RefSeq) 5-hydroxytryptamine receptor 2C
  KO
K04157  5-hydroxytryptamine receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04726  Serotonergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
Drug target
Adatanserin hydrochloride: D02767
Agomelatine: D02578
Amesergide: D02893
Asenapine: D02995
Captodiame: D07316
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Cinanserin hydrochloride: D03506
Cinitapride (DG01520): D07700 D07701
Clozapine: D00283
Cyamemazine (DG00872): D07307 D07756
Dimetotiazine (DG00843): D01902 D07854
Fenfluramine (DG00103): D04148 D07945
Flibanserin: D02577
Glemanserin: D04320
Idalopirdine (DG01878): D10710
Iloperidone: D02666
Lorcaserin: D06613
Methysergide (DG00835): D00681 D02357
Metrenperone: D05015
Mirtazapine (DG02838): D00563 D11056
Nefazodone (DG00953): D00819 D08257
Ocaperidone: D02675
Olanzapine (DG00898): D00454 D06623
Opipramol (DG00930): D01477 D08297
Pelanserin hydrochloride: D05395
Periciazine: D01485
Pizotifen (DG00842): D05523 D08397
Ritanserin: D05738
Sergolexole maleate: D05829
Setoperone: D02686
Tedatioxetine (DG01311): D10170 D10171
Tiospirone hydrochloride: D02688
Trazodone (DG00952): D00820 D08626
Tropanserin hydrochloride: D06253
Vabicaserin hydrochloride: D06660
Xylamidine tosylate: D06343
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3358 (HTR2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3358 (HTR2C)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3358 (HTR2C)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3358 (HTR2C)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3358 (HTR2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3358 (HTR2C)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3358 (HTR2C)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 DUF1385 UPF0182 Pox_P21
Motif
Other DBs
NCBI-GeneID: 3358
NCBI-ProteinID: NP_000859
OMIM: 312861
HGNC: 5295
Ensembl: ENSG00000147246
Vega: OTTHUMG00000022226
Pharos: P28335(Tclin)
UniProt: P28335
Position
Xq23
AA seq 458 aa AA seqDB search
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
NT seq 1377 nt NT seq  +upstreamnt  +downstreamnt
atggtgaacctgaggaatgcggtgcattcattccttgtgcacctaattggcctattggtt
tggcaatgtgatatttctgtgagcccagtagcagctatagtaactgacattttcaatacc
tccgatggtggacgcttcaaattcccagacggggtacaaaactggccagcactttcaatc
gtcatcataataatcatgacaataggtggcaacatccttgtgatcatggcagtaagcatg
gaaaagaaactgcacaatgccaccaattacttcttaatgtccctagccattgctgatatg
ctagtgggactacttgtcatgcccctgtctctcctggcaatcctttatgattatgtctgg
ccactacctagatatttgtgccccgtctggatttctttagatgttttattttcaacagcg
tccatcatgcacctctgcgctatatcgctggatcggtatgtagcaatacgtaatcctatt
gagcatagccgtttcaattcgcggactaaggccatcatgaagattgctattgtttgggca
atttctataggtgtatcagttcctatccctgtgattggactgagggacgaagaaaaggtg
ttcgtgaacaacacgacgtgcgtgctcaacgacccaaatttcgttcttattgggtccttc
gtagctttcttcataccgctgacgattatggtgattacgtattgcctgaccatctacgtt
ctgcgccgacaagctttgatgttactgcacggccacaccgaggaaccgcctggactaagt
ctggatttcctgaagtgctgcaagaggaatacggccgaggaagagaactctgcaaaccct
aaccaagaccagaacgcacgccgaagaaagaagaaggagagacgtcctaggggcaccatg
caggctatcaacaatgaaagaaaagcttcgaaagtccttgggattgttttctttgtgttt
ctgatcatgtggtgcccatttttcattaccaatattctgtctgttctttgtgagaagtcc
tgtaaccaaaagctcatggaaaagcttctgaatgtgtttgtttggattggctatgtttgt
tcaggaatcaatcctctggtgtatactctgttcaacaaaatttaccgaagggcattctcc
aactatttgcgttgcaattataaggtagagaaaaagcctcctgtcaggcagattccaaga
gttgccgccactgctttgtctgggagggagcttaatgttaacatttatcggcataccaat
gaaccggtgatcgagaaagccagtgacaatgagcccggtatagagatgcaagttgagaat
ttagagttaccagtaaatccctccagtgtggttagcgaaaggattagcagtgtgtga

KEGG   Homo sapiens (human): 3973Help
Entry
3973              CDS       T01001                                 

Gene name
LHCGR, HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5
Definition
(RefSeq) luteinizing hormone/choriogonadotropin receptor
  KO
K04248  lutropin-choriogonadotropic hormone receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04913  Ovarian steroidogenesis
hsa04917  Prolactin signaling pathway
Disease
H00608  46,XY disorder of sex development due to testosterone secretion defect
H00627  Premature ovarian failure
H00937  Precocious puberty
H02019  Familial male-limited precocious puberty
Drug target
Choriogonadotropin alfa: D03478
Chorionic gonadotrophin: D06457
Human menopausal gonadotrophin (DG00472): D02692 D06459
Lutropin alfa: D04824
Serum gonadotrophin: D05258
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3973 (LHCGR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3973 (LHCGR)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    3973 (LHCGR)
   04917 Prolactin signaling pathway
    3973 (LHCGR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3973 (LHCGR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Lutropin-choriogonadotropic hormone
    3973 (LHCGR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 LRR_8 LRR_5 Comm
Motif
Other DBs
NCBI-GeneID: 3973
NCBI-ProteinID: NP_000224
OMIM: 152790
HGNC: 6585
Ensembl: ENSG00000138039
Vega: OTTHUMG00000129257
Pharos: P22888(Tclin)
UniProt: P22888
Position
2p16.3
AA seq 699 aa AA seqDB search
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLP
VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI
NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK
LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY
GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF
SKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYD
FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS
QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRL
RHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFF
IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT
VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYT
SNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
NT seq 2100 nt NT seq  +upstreamnt  +downstreamnt
atgaagcagcggttctcggcgctgcagctgctgaagctgctgctgctgctgcagccgccg
ctgccacgagcgctgcgcgaggcgctctgccctgagccctgcaactgcgtgcccgacggc
gccctgcgctgccccggccccacggccggtctcactcgactatcacttgcctacctccct
gtcaaagtgatcccatctcaagctttcagaggacttaatgaggtcataaaaattgaaatc
tctcagattgattccctggaaaggatagaagctaatgcctttgacaacctcctcaatttg
tctgaaatactgatccagaacaccaaaaatctgagatacattgagcccggagcatttata
aatcttccccgattaaaatacttgagcatctgtaacacaggcatcagaaagtttccagat
gttacgaaggtcttctcctctgaatcaaatttcattctggaaatttgtgataacttacac
ataaccaccataccaggaaatgcttttcaagggatgaataatgaatctgtaacactcaaa
ctatatggaaatggatttgaagaagtacaaagtcatgcattcaatgggacgacactgact
tcactggagctaaaggaaaacgtacatctggagaagatgcacaatggagccttccgtggg
gccacagggccgaaaaccttggatatttcttccaccaaattgcaggccctgccgagctat
ggcctagagtccattcagaggctaattgccacgtcatcctattctctaaaaaaattgcca
tcaagagaaacatttgtcaatctcctggaggccacgttgacttaccccagccactgctgt
gcttttagaaacttgccaacaaaagaacagaatttttcacattccatttctgaaaacttt
tccaaacaatgtgaaagcacagtaaggaaagtgaataacaaaacactttattcttccatg
cttgctgagagtgaactgagtggctgggactatgaatatggtttctgcttacccaagaca
ccccgatgtgctcctgaaccagatgcttttaatccctgtgaagatattatgggctatgac
ttccttagggtcctgatttggctgattaatattctagccatcatgggaaacatgactgtt
ctttttgttctcctgacaagtcgttacaaacttacagtgcctcgttttctcatgtgcaat
ctctcctttgcagacttttgcatggggctctatctgctgctcatagcctcagttgattcc
caaaccaagggccagtactataaccatgccatagactggcagacagggagtgggtgcagc
actgctggctttttcactgtattcgcaagtgaactttctgtctacaccctcaccgtcatc
actctagaaagatggcacaccatcacctatgctattcacctggaccaaaagctgcgatta
agacatgccattctgattatgcttggaggatggctcttttcttctctaattgctatgttg
ccccttgtcggtgtcagcaattacatgaaggtcagtatttgcttccccatggatgtggaa
accactctctcacaagtctatatattaaccatcctgattctcaatgtggtggccttcttc
ataatttgtgcttgctacattaaaatttattttgcagttcgaaacccagaattaatggct
accaataaagatacaaagattgctaagaaaatggcaatcctcatcttcaccgatttcacc
tgcatggcacctatctctttttttgccatctcagctgccttcaaagtacctcttatcaca
gtaaccaactctaaagttttactggttcttttttatcccatcaattcttgtgccaatcca
tttctgtatgcaatattcactaagacattccaaagagatttctttcttttgctgagcaaa
tttggctgctgtaaacgtcgggctgaactttatagaaggaaagatttttcagcttacacc
tccaactgcaaaaatggcttcactggatcaaataagccttctcaatccaccttgaagttg
tccacattgcactgtcaaggtacagctctcctagacaagactcgctacacagagtgttaa

KEGG   Homo sapiens (human): 4923Help
Entry
4923              CDS       T01001                                 

Gene name
NTSR1, NTR
Definition
(RefSeq) neurotensin receptor 1
  KO
K04211  neurotensin receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    4923 (NTSR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4923 (NTSR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4923 (NTSR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Neurotensin
    4923 (NTSR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srv 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srsx
Motif
Other DBs
NCBI-GeneID: 4923
NCBI-ProteinID: NP_002522
OMIM: 162651
HGNC: 8039
Ensembl: ENSG00000101188
Vega: OTTHUMG00000032932
Pharos: P30989(Tchem)
UniProt: P30989
Structure
PDB: 

Position
20q13.33
AA seq 418 aa AA seqDB search
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
NT seq 1257 nt NT seq  +upstreamnt  +downstreamnt
atgcgcctcaacagctccgcgccgggaaccccgggcacgccggccgccgaccccttccag
cgggcgcaggccggactggaggaggcgctgctggccccgggcttcggcaacgcttcgggc
aacgcgtcggagcgcgtcctggcggcacccagcagcgagctggacgtgaacaccgacatc
tactccaaggtgctggtgaccgccgtgtacctggcgctcttcgtggtgggcacggtgggc
aacacggtgacggcgttcacgctggcgcggaagaagtcgctgcagagcctgcagagcacg
gtgcattaccacctgggcagcctggcgctgtccgacctgctcaccctgctgctggccatg
cccgtggagctgtacaacttcatctgggtgcaccacccctgggccttcggcgacgccggc
tgccgcggctactacttcctgcgcgacgcctgcacctacgccacggccctcaacgtggcc
agcctgagtgtggagcgctacctggccatctgccaccccttcaaggccaagaccctcatg
tcccgaagccgcaccaagaagttcatcagcgccatctggctcgcctcggccctgctggcg
gtgcctatgctgttcaccatgggcgagcagaaccgcagcgccgacggccagcacgccggc
ggcctggtgtgcacccccaccatccacactgccaccgtcaaggtcgtcatacaggtcaac
accttcatgtccttcatattccccatggtggtcatctcggtcctgaacaccatcatcgcc
aacaagctgaccgtcatggtacgccaggcggccgagcagggccaagtgtgcacggtcggg
ggcgagcacagcacattcagcatggccatcgagcctggcagggtccaggccctgcggcac
ggcgtgcgcgtcctacgtgcagtggtcatcgcctttgtggtctgctggctgccctaccac
gtgcggcgcctcatgttctgctacatctcggatgagcagtggactccgttcctctatgac
ttctaccactacttctacatggtgaccaacgcactcttctacgtcagctccaccatcaac
cccatcctgtacaacctcgtctctgccaacttccgccacatcttcctggccacactggcc
tgcctctgcccggtgtggcggcgcaggaggaagaggccagccttctcgaggaaggccgac
agcgtgtccagcaaccacaccctctccagcaatgccacccgcgagacgctgtactag

KEGG   Homo sapiens (human): 5021Help
Entry
5021              CDS       T01001                                 

Gene name
OXTR, OT-R
Definition
(RefSeq) oxytocin receptor
  KO
K04229  oxytocin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04921  Oxytocin signaling pathway
Drug target
Atosiban (DG02835): D03008 D07475
Carbetocin: D07229
Cargutocin: D09797
Demoxytocin: D07228
Epelsiban (DG01543): D10117 D10118
Oxytocin: D00089
Retosiban: D08986
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5021 (OXTR)
   04024 cAMP signaling pathway
    5021 (OXTR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5021 (OXTR)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    5021 (OXTR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5021 (OXTR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Oxytocin
    5021 (OXTR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srv 7tm_4 7TM_GPCR_Srsx
Motif
Other DBs
NCBI-GeneID: 5021
NCBI-ProteinID: NP_000907
OMIM: 167055
HGNC: 8529
Ensembl: ENSG00000180914
Vega: OTTHUMG00000090537
Pharos: P30559(Tclin)
UniProt: P30559 B2R9L7
Position
3p25.3
AA seq 389 aa AA seqDB search
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACV
LLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVW
DANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGET
SASKKSNSSSFVLSHRSSSQRSCSQPSTA
NT seq 1170 nt NT seq  +upstreamnt  +downstreamnt
atggagggcgcgctcgcagccaactggagcgccgaggcagccaacgccagcgccgcgccg
ccgggggccgagggcaaccgcaccgccggacccccgcggcgcaacgaggccctggcgcgc
gtggaggtggcggtgctgtgtctcatcctgctcctggcgctgagcgggaacgcgtgtgtg
ctgctggcgctgcgcaccacacgccagaagcactcgcgcctcttcttcttcatgaagcac
ctaagcatcgccgacctggtggtggcagtgtttcaggtgctgccgcagttgctgtgggac
atcaccttccgcttctacgggcccgacctgctgtgccgcctggtcaagtacttgcaggtg
gtgggcatgttcgcctccacctacctgctgctgctcatgtccctggaccgctgcctggcc
atctgccagccgctgcgctcgctgcgccgccgcaccgaccgcctggcagtgctcgccacg
tggctcggctgcctggtggccagcgcgccgcaggtgcacatcttctctctgcgcgaggtg
gctgacggcgtcttcgactgctgggccgtcttcatccagccctggggacccaaggcctac
atcacatggatcacgctagctgtctacatcgtgccggtcatcgtgctcgctgcctgctac
ggccttatcagcttcaagatctggcagaacttgcggctcaagaccgctgcagcggcggcg
gccgaggcgccagagggcgcggcggctggcgatggggggcgcgtggccctggcgcgtgtc
agcagcgtcaagctcatctccaaggccaagatccgcacggtcaagatgactttcatcatc
gtgctggccttcatcgtgtgctggacgcctttcttcttcgtgcagatgtggagcgtctgg
gatgccaacgcgcccaaggaagcctcggccttcatcatcgtcatgctcctggccagcctc
aacagctgctgcaacccctggatctacatgctgttcacgggccacctcttccacgaactc
gtgcagcgcttcctgtgctgctccgccagctacctgaagggcagacgcctgggagagacg
agtgccagcaaaaagagcaactcgtcctcctttgtcctgagccatcgcagctccagccag
aggagctgctcccagccatccacggcgtga

KEGG   Homo sapiens (human): 552Help
Entry
552               CDS       T01001                                 

Gene name
AVPR1A, AVPR_V1a, AVPR1, V1aR
Definition
(RefSeq) arginine vasopressin receptor 1A
  KO
K04226  arginine vasopressin receptor 1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Drug target
Balovaptan: D11476
Conivaptan (DG00276): D01236 D07748
Felypressin: D04137
Lypressin: D00366
Ornipressin: D07227
Terlipressin (DG00498): D06672 D08571
Vasopressin (Argipressin) (DG00496): D00101 D02983 D09820
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    552 (AVPR1A)
   04072 Phospholipase D signaling pathway
    552 (AVPR1A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    552 (AVPR1A)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    552 (AVPR1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    552 (AVPR1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Vasopressin
    552 (AVPR1A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 DUF1856 7TM_GPCR_Srsx 7TM_GPCR_Srv 7tm_4
Motif
Other DBs
NCBI-GeneID: 552
NCBI-ProteinID: NP_000697
OMIM: 600821
HGNC: 895
Ensembl: ENSG00000166148
Vega: OTTHUMG00000169980
Pharos: P37288(Tclin)
UniProt: P37288 X5D2B0
Structure
PDB: 

Position
12q14.2
AA seq 418 aa AA seqDB search
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAV
TFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGP
DWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV
LSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFIC
YNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAY
IVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCV
QSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
NT seq 1257 nt NT seq  +upstreamnt  +downstreamnt
atgcgtctctccgccggtcccgacgcggggccctcgggcaactccagcccatggtggcct
ctggccaccggcgctggcaacacaagccgggaggccgaagccctcggggagggcaacggc
ccaccgagggacgtgcgcaacgaggagctggccaaactggagatcgccgtgctggcggtg
actttcgcggtggccgtgctgggcaacagcagcgtactgctggctctgcaccggacgccg
cgcaagacgtcccgcatgcacctcttcatccgacacctcagcctggccgacctggccgtg
gcattcttccaggtgctgccgcaaatgtgctgggacatcacctaccgcttccgcggcccc
gactggctgtgccgcgtggtgaagcacctgcaggtgttcggcatgtttgcgtcggcctac
atgctggtagtcatgacagccgaccgctacatcgcggtgtgccacccgctcaagactctg
caacagcccgcgcgccgctcgcgcctcatgatcgcggccgcctgggtgctgagcttcgtg
ctgagcacgccgcagtacttcgtcttctccatgatcgaggtgaacaatgtcaccaaggcc
cgcgactgctgggccaccttcatccagccctggggttctcgtgcctacgtgacctggatg
acgggcggcatctttgtggcgcccgtggtcatcttgggtacctgctacggcttcatctgc
tacaacatctggtgcaacgtccgcgggaagacggcgtcgcgccagagcaagggtgcagag
caagcgggtgtggccttccaaaaggggttcctgctcgcaccctgtgtcagcagcgtgaag
tccatttcccgggccaagatccgcacggtgaagatgacttttgtgatcgtgacggcttac
atcgtctgctgggcgcctttcttcatcatccagatgtggtctgtctgggatcccatgtcc
gtctggaccgaatcggaaaaccctaccatcaccatcactgcattactgggttccttgaat
agctgctgtaatccctggatatacatgttttttagtggccatctccttcaagactgtgtt
caaagcttcccatgctgccaaaacatgaaggaaaaattcaacaaagaagatactgacagt
atgagcagaagacagactttttattctaacaatcgaagcccaacaaacagtacgggtatg
tggaaggactcgcctaaatcttccaagtccatcaaattcattcctgtttcaacttga

KEGG   Homo sapiens (human): 553Help
Entry
553               CDS       T01001                                 

Gene name
AVPR1B, AVPR3, V1bR
Definition
(RefSeq) arginine vasopressin receptor 1B
  KO
K04227  arginine vasopressin receptor 1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Drug target
Lypressin: D00366
Ornipressin: D07227
Terlipressin (DG00498): D06672 D08571
Vasopressin (Argipressin) (DG00496): D00101 D02983 D09820
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    553 (AVPR1B)
   04072 Phospholipase D signaling pathway
    553 (AVPR1B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    553 (AVPR1B)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    553 (AVPR1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    553 (AVPR1B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Vasopressin
    553 (AVPR1B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srv DUF1856 7TM_GPCR_Srx Srg
Motif
Other DBs
NCBI-GeneID: 553
NCBI-ProteinID: NP_000698
OMIM: 600264
HGNC: 896
Ensembl: ENSG00000198049
Vega: OTTHUMG00000184377
Pharos: P47901(Tclin)
UniProt: P47901
Position
1q32.1
AA seq 424 aa AA seqDB search
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
NT seq 1275 nt NT seq  +upstreamnt  +downstreamnt
atggattctgggcctctgtgggatgccaaccccacccctcggggcaccctctctgccccc
aatgccacaacaccctggctgggccgggatgaggagctggccaaggtggagatcggagtc
ctggccactgtcctggtgctggcgaccgggggcaacctggctgtgctgctgaccctgggc
cagctgggccgcaagcgctcccgcatgcacctgttcgtgctgcacttagccctgacagac
ctggccgtggcgctcttccaggtgctgccacagctgctgtgggacatcacctaccgcttc
cagggccccgacctcctgtgcagggccgtcaagtacctgcaggtgctcagcatgtttgcc
tccacctacatgctgctggccatgacgctggaccgctacctggctgtctgtcaccccctg
cgcagcctccagcagccaggccagtccacctacctgctcatcgctgctccctggctgctg
gccgccatcttcagcctccctcaagtcttcattttttccctgcgggaggtgatccagggc
tcaggggtgctggactgctgggcagacttcggcttcccttgggggccacgggcctacctc
acctggaccaccctggctatcttcgttctgccggtgaccatgctcacggcctgctacagc
ctcatctgccatgagatctgtaaaaacctaaaagtcaagacacaggcctggcgggtggga
ggagggggctggaggacttgggacaggccctcaccttccaccttagctgccaccactcgg
gggctgccatctcgggtcagcagcatcaacaccatctcacgggccaagatccgaacagtg
aagatgacctttgtcatcgtgctggcctacatcgcttgctgggctcccttcttcagtgtc
cagatgtggtccgtgtgggacaagaatgcccctgatgaagattccaccaatgtggctttc
accatctctatgcttttgggcaacctcaacagctgctgcaacccctggatctacatgggc
ttcaacagccacctgttaccgcggcccctgcgtcaccttgcctgctgtgggggtccccag
cccaggatgcgccggcggctctccgacggcagcctctcgagccgccacaccacgctgctg
acccgctccagctgcccggccaccctcagcctcagcctcagcctaaccctcagtgggagg
cccaggcctgaagagtcaccaagggacttggagctggcagatggggaaggcaccgctgag
accatcatcttttag

KEGG   Homo sapiens (human): 56413Help
Entry
56413             CDS       T01001                                 

Gene name
LTB4R2, BLT2, BLTR2, JULF2, KPG_004, LTB4-R_2, LTB4-R2, NOP9
Definition
(RefSeq) leukotriene B4 receptor 2
  KO
K04297  leukotriene B4 receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Etalocib: D04074
Moxilubant maleate: D05085
Ticolubant: D06140
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    56413 (LTB4R2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    56413 (LTB4R2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    56413 (LTB4R2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Leukotriene
    56413 (LTB4R2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 56413
NCBI-ProteinID: NP_001158164
OMIM: 605773
HGNC: 19260
Ensembl: ENSG00000213906
Vega: OTTHUMG00000186500
Pharos: Q9NPC1(Tchem)
UniProt: Q9NPC1 B4E292
Position
14q12
AA seq 358 aa AA seqDB search
MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATL
VLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRC
LAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAA
HLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPY
HAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAG
PRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
NT seq 1077 nt NT seq  +upstreamnt  +downstreamnt
atgtcggtctgctaccgtcccccagggaacgagacactgctgagctggaagacttcgcgg
gccacaggcacagccttcctgctgctggcggcgctgctggggctgcctggcaacggcttc
gtggtgtggagcttggcgggctggcggcctgcacgggggcgaccgctggcggccacgctt
gtgctgcacctggcgctggccgacggcgcggtgctgctgctcacgccgctctttgtggcc
ttcctgacccggcaggcctggccgctgggccaggcgggctgcaaggcggtgtactacgtg
tgcgcgctcagcatgtacgccagcgtgctgctcaccggcctgctcagcctgcagcgctgc
ctcgcagtcacccgccccttcctggcgcctcggctgcgcagcccggccctggcccgccgc
ctgctgctggcggtctggctggccgccctgttgctcgccgtcccggccgccgtctaccgc
cacctgtggagggaccgcgtatgccagctgtgccacccgtcgccggtccacgccgccgcc
cacctgagcctggagactctgaccgctttcgtgcttcctttcgggctgatgctcggctgc
tacagcgtgacgctggcacggctgcggggcgcccgctggggctccgggcggcacggggcg
cgggtgggccggctggtgagcgccatcgtgcttgccttcggcttgctctgggccccctac
cacgcagtcaaccttctgcaggcggtcgcagcgctggctccaccggaaggggccttggcg
aagctgggcggagccggccaggcggcgcgagcgggaactacggccttggccttcttcagt
tctagcgtcaacccggtgctctacgtcttcaccgctggagatctgctgccccgggcaggt
ccccgtttcctcacgcggctcttcgaaggctctggggaggcccgagggggcggccgctct
agggaagggaccatggagctccgaactacccctcagctgaaagtggtggggcagggccgc
ggcaatggagacccggggggtgggatggagaaggacggtccggaatgggacctttga

KEGG   Homo sapiens (human): 57105Help
Entry
57105             CDS       T01001                                 

Gene name
CYSLTR2, CYSLT2, CYSLT2R, GPCR21, HG57, HPN321, KPG_011, PSEC0146, hGPCR21
Definition
(RefSeq) cysteinyl leukotriene receptor 2
  KO
K04323  cysteinyl leukotriene receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    57105 (CYSLTR2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    57105 (CYSLTR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    57105 (CYSLTR2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Cysteinyl leukotriene
    57105 (CYSLTR2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 TAS2R 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 57105
NCBI-ProteinID: NP_001295394
OMIM: 605666
HGNC: 18274
Ensembl: ENSG00000152207
Vega: OTTHUMG00000016906
Pharos: Q9NS75(Tchem)
UniProt: Q9NS75 A4ZKH2 Q5KU17
Position
13q14.2
AA seq 346 aa AA seqDB search
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
NT seq 1041 nt NT seq  +upstreamnt  +downstreamnt
atggagagaaaatttatgtccttgcaaccatccatctccgtatcagaaatggaaccaaat
ggcaccttcagcaataacaacagcaggaactgcacaattgaaaacttcaagagagaattt
ttcccaattgtatatctgataatatttttctggggagtcttgggaaatgggttgtccata
tatgttttcctgcagccttataagaagtccacatctgtgaacgttttcatgctaaatctg
gccatttcagatctcctgttcataagcacgcttcccttcagggctgactattatcttaga
ggctccaattggatatttggagacctggcctgcaggattatgtcttattccttgtatgtc
aacatgtacagcagtatttatttcctgaccgtgctgagtgttgtgcgtttcctggcaatg
gttcacccctttcggcttctgcatgtcaccagcatcaggagtgcctggatcctctgtggg
atcatatggatccttatcatggcttcctcaataatgctcctggacagtggctctgagcag
aacggcagtgtcacatcatgcttagagctgaatctctataaaattgctaagctgcagacc
atgaactatattgccttggtggtgggctgcctgctgccatttttcacactcagcatctgt
tatctgctgatcattcgggttctgttaaaagtggaggtcccagaatcggggctgcgggtt
tctcacaggaaggcactgaccaccatcatcatcaccttgatcatcttcttcttgtgtttc
ctgccctatcacacactgaggaccgtccacttgacgacatggaaagtgggtttatgcaaa
gacagactgcataaagctttggttatcacactggccttggcagcagccaatgcctgcttc
aatcctctgctctattactttgctggggagaattttaaggacagactaaagtctgcactc
agaaaaggccatccacagaaggcaaagacaaagtgtgttttccctgttagtgtgtggttg
agaaaggaaacaagagtataa

KEGG   Homo sapiens (human): 5724Help
Entry
5724              CDS       T01001                                 

Gene name
PTAFR, PAFR
Definition
(RefSeq) platelet activating factor receptor
  KO
K04279  platelet-activating factor receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05150  Staphylococcus aureus infection
Drug target
Apafant: D01652
Israpafant: D02590
Lexipafant: D04724
Rupatadine (DG01118): D07407 D08497
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5724 (PTAFR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5724 (PTAFR)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    5724 (PTAFR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5724 (PTAFR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Platelet activating factor
    5724 (PTAFR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 SHNi-TPR
Motif
Other DBs
NCBI-GeneID: 5724
NCBI-ProteinID: NP_000943
OMIM: 173393
HGNC: 9582
Ensembl: ENSG00000169403
Vega: OTTHUMG00000003953
Pharos: P25105(Tchem)
UniProt: P25105
Position
1p35.3
AA seq 342 aa AA seqDB search
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
NT seq 1029 nt NT seq  +upstreamnt  +downstreamnt
atggagccacatgactcctcccacatggactctgagttccgatacactctcttcccgatt
gtttacagcatcatctttgtgctcggggtcattgctaatggctacgtgctgtgggtcttt
gcccgcctgtacccttgcaagaaattcaatgagataaagatcttcatggtgaacctcacc
atggcggacatgctcttcttgatcaccctgccactttggattgtctactaccaaaaccag
ggcaactggatactccccaaattcctgtgcaacgtggctggctgccttttcttcatcaac
acctactgctctgtggccttcctgggcgtcatcacttataaccgcttccaggcagtaact
cggcccatcaagactgctcaggccaacacccgcaagcgtggcatctctttgtccttggtc
atctgggtggccattgtgggagctgcatcctacttcctcatcctggactccaccaacaca
gtgcccgacagtgctggctcaggcaacgtcactcgctgctttgagcattacgagaagggc
agcgtgccagtcctcatcatccacatcttcatcgtgttcagcttcttcctggtcttcctc
atcatcctcttctgcaacctggtcatcatccgtaccttgctcatgcagccggtgcagcag
cagcgcaacgctgaagtcaagcgccgggcgctgtggatggtgtgcacggtcttggcggtg
ttcatcatctgcttcgtgccccaccacgtggtgcagctgccctggacccttgctgagctg
ggcttccaggacagcaaattccaccaggccattaatgatgcacatcaggtcaccctctgc
ctccttagcaccaactgtgtcttagaccctgttatctactgtttcctcaccaagaagttc
cgcaagcacctcaccgaaaagttctacagcatgcgcagtagccggaaatgctcccgggcc
accacggatacggtcactgaagtggttgtgccattcaaccagatccctggcaattccctc
aaaaattag

KEGG   Homo sapiens (human): 5731Help
Entry
5731              CDS       T01001                                 

Gene name
PTGER1, EP1
Definition
(RefSeq) prostaglandin E receptor 1
  KO
K04258  prostaglandin E receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05163  Human cytomegalovirus infection
hsa05200  Pathways in cancer
Drug target
Alprostadil (DG00239): D00180 D02705
Ecraprost: D02723
Enisoprost: D03999
Gemeprost: D02073
Limaprost (DG01271): D02722 D02860
Ornoprostil: D01869
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5731 (PTGER1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5731 (PTGER1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5731 (PTGER1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    5731 (PTGER1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5731 (PTGER1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Prostaglandin
    5731 (PTGER1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1
Motif
Other DBs
NCBI-GeneID: 5731
NCBI-ProteinID: NP_000946
OMIM: 176802
HGNC: 9593
Ensembl: ENSG00000160951
Vega: OTTHUMG00000039610
Pharos: P34995(Tclin)
UniProt: P34995
Position
19p13.12
AA seq 402 aa AA seqDB search
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA
AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF
GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE
LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR
PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV
GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR
QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
NT seq 1209 nt NT seq  +upstreamnt  +downstreamnt
atgagcccttgcgggcccctcaacctgagcctggcgggcgaggcgaccacatgcgcggcg
ccctgggtccccaacacgtcggccgtgccgccgtcgggcgcttcgcccgcgctgcccatc
ttctccatgacgctgggcgccgtgtccaacctgctggcgctggcgctgctggcgcaggcc
gcgggccgcctgcgacgccgccgctcggccgccaccttcctgctgttcgtggccagcctg
ctggccaccgacctggcgggccacgtgatcccgggcgcgctggtgctgcgtctgtacact
gcggggcgcgctccggccggcggggcctgccacttcctgggcggctgcatggtcttcttc
ggcctgtgcccgctgctgctgggctgtggcatggccgtggagcgctgcgtgggcgtcacg
cggccgctgctccacgccgcgcgggtctcggtcgcccgcgcgcgcctggcgctggccgcg
gtggccgcggtggccttggccgtggcgctgctgccgctggcgcgcgtgggccgctatgag
ctgcagtacccgggcacgtggtgcttcatcggcctgggtcccccgggcggctggcgccag
gcactgcttgctggcctcttcgccagcctcggcctggtcgcgctcctcgccgcgctggtg
tgcaacacgctcagcggcctggccctgctacgcgcccgctggcgacgccgctcccgacgg
cctcccccggcctcaggccccgacagccggcgtcgctggggggcgcacggaccccgctcg
gcctccgcctcgtccgcctcgtccatcgcttcggcctccaccttctttggcggctctcgg
agcagcggctcggcacgcagagctcgcgcccacgacgtggagatggtgggccagcttgtc
ggtatcatggtggtgtcgtgcatctgctggagcccaatgctggtgttggtggcgctggcc
gtcggcggctggagctctacctccctgcagcggccactgttcctggccgtgcgccttgcc
tcctggaaccagatcctggacccttgggtgtacatcctactgcgccaggccgtgctgcgc
caactgcttcgcctcttgcccccgagggccggagccaagggcggccccgcggggctgggc
ctaacaccgagcgcctgggaggccagctcgctgcgcagctcccggcacagcggcctcagc
cacttctaa

KEGG   Homo sapiens (human): 5733Help
Entry
5733              CDS       T01001                                 

Gene name
PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, EP3e, PGE2-R
Definition
(RefSeq) prostaglandin E receptor 3
  KO
K04260  prostaglandin E receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04923  Regulation of lipolysis in adipocytes
hsa05163  Human cytomegalovirus infection
hsa05200  Pathways in cancer
Drug target
Enprostil: D01891
Misoprostol: D00419
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5733 (PTGER3)
   04024 cAMP signaling pathway
    5733 (PTGER3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5733 (PTGER3)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    5733 (PTGER3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5733 (PTGER3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    5733 (PTGER3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5733 (PTGER3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Prostaglandin
    5733 (PTGER3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srbc
Motif
Other DBs
NCBI-GeneID: 5733
NCBI-ProteinID: NP_001119516
OMIM: 176806
HGNC: 9595
Ensembl: ENSG00000050628
Vega: OTTHUMG00000009399
Pharos: P43115(Tclin)
UniProt: P43115
Position
1p31.1
AA seq 390 aa AA seqDB search
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
NT seq 1173 nt NT seq  +upstreamnt  +downstreamnt
atgaaggagacccggggctacggaggggatgcccccttctgcacccgcctcaaccactcc
tacacaggcatgtgggcgcccgagcgttccgccgaggcgcggggcaacctcacgcgccct
ccagggtctggcgaggattgcggatcggtgtccgtggccttcccgatcaccatgctgctc
actggtttcgtgggcaacgcactggccatgctgctcgtgtcgcgcagctaccggcgccgg
gagagcaagcgcaagaagtccttcctgctgtgcatcggctggctggcgctcaccgacctg
gtcgggcagcttctcaccaccccggtcgtcatcgtcgtgtacctgtccaagcagcgttgg
gagcacatcgacccgtcggggcggctctgcacctttttcgggctgaccatgactgttttc
gggctctcctcgttgttcatcgccagcgccatggccgtcgagcgggcgctggccatcagg
gcgccgcactggtatgcgagccacatgaagacgcgtgccacccgcgctgtgctgctcggc
gtgtggctggccgtgctcgccttcgccctgctgccggtgctgggcgtgggccagtacacc
gtccagtggcccgggacgtggtgcttcatcagcaccgggcgagggggcaacgggactagc
tcttcgcataactggggcaaccttttcttcgcctctgcctttgccttcctggggctcttg
gcgctgacagtcaccttttcctgcaacctggccaccattaaggccctggtgtcccgctgc
cgggccaaggccacggcatctcagtccagtgcccagtggggccgcatcacgaccgagacg
gccattcagcttatggggatcatgtgcgtgctgtcggtctgctggtctccgctcctgata
atgatgttgaaaatgatcttcaatcagacatcagttgagcactgcaagacacacacggag
aagcagaaagaatgcaacttcttcttaatagctgttcgcctggcttcactgaaccagatc
ttggatccttgggtttacctgctgttaagaaagatccttcttcgaaagttttgccagatc
aggtaccacacaaacaactatgcatccagctccacctccttaccctgccagtgttcctca
accttgatgtggagcgaccatttggaaagatga

KEGG   Homo sapiens (human): 5737Help
Entry
5737              CDS       T01001                                 

Gene name
PTGFR, FP
Definition
(RefSeq) prostaglandin F receptor
  KO
K04262  prostaglandin F receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Bimatoprost: D02724
Carboprost (DG00449): D00682 D02343 D03399
Cloprostenol (DG02874): D02727 D07730
Dinoprost (DG00447): D00081 D01352
Etiproston: D07932
Latanoprost: D00356
Latanoprostene bunod: D10441
Prostalene: D05642
Rosaprostol: D02719
Tafluprost: D06274
Tiaprost: D08591
Travoprost: D01964
Unoprostone (DG01139): D01452 D08661
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5737 (PTGFR)
   04072 Phospholipase D signaling pathway
    5737 (PTGFR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5737 (PTGFR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5737 (PTGFR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Prostaglandin
    5737 (PTGFR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srv Serpentine_r_xa C_GCAxxG_C_C Saf_2TM
Motif
Other DBs
NCBI-GeneID: 5737
NCBI-ProteinID: NP_000950
OMIM: 600563
HGNC: 9600
Ensembl: ENSG00000122420
Vega: OTTHUMG00000009644
Pharos: P43088(Tclin)
UniProt: P43088
Position
1p31.1
AA seq 359 aa AA seqDB search
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQ
KSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGL
CPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQ
ASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQG
RSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILD
PWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
NT seq 1080 nt NT seq  +upstreamnt  +downstreamnt
atgtccatgaacaattccaaacagctagtgtctcctgcagctgcgcttctttcaaacaca
acctgccagacggaaaaccggctttccgtatttttttcagtaatcttcatgacagtggga
atcttgtcaaacagccttgccatcgccattctcatgaaggcatatcagagatttagacag
aagtccaaggcatcgtttctgcttttggccagtggcctggtaatcactgatttctttggc
catctcatcaatggagccatagcagtatttgtatatgcttctgataaagaatggatccgc
tttgaccaatcaaatgtcctttgcagtatttttggtatctgcatggtgttttctggtctg
tgcccacttcttctaggcagtgtgatggccattgagcggtgtattggagtcacaaaacca
atatttcattctacgaaaattacatccaaacatgtgaaaatgatgttaagtggtgtgtgc
ttgtttgctgttttcatagctttgctgcccatccttggacatcgagactataaaattcag
gcgtcgaggacctggtgtttctacaacacagaagacatcaaagactgggaagatagattt
tatcttctacttttttcttttctggggctcttagcccttggtgtttcattgttgtgcaat
gcaatcacaggaattacacttttaagagttaaatttaaaagtcagcagcacagacaaggc
agatctcatcatttggaaatggtaatccagctcctggcgataatgtgtgtctcctgtatt
tgttggagcccatttctggttacaatggccaacattggaataaatggaaatcattctctg
gaaacctgtgaaacaacactttttgctctccgaatggcaacatggaatcaaatcttagat
ccttgggtatatattcttctacgaaaggctgtccttaagaatctctataagcttgccagt
caatgctgtggagtgcatgtcatcagcttacatatttgggagcttagttccattaaaaat
tccttaaaggttgctgctatttctgagtcaccagttgcagagaaatcagcaagcacctag

KEGG   Homo sapiens (human): 623Help
Entry
623               CDS       T01001                                 

Gene name
BDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1
Definition
(RefSeq) bradykinin receptor B1
  KO
K03915  bradykinin receptor B1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    623 (BDKRB1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    623 (BDKRB1)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    623 (BDKRB1)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    623 (BDKRB1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    623 (BDKRB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    623 (BDKRB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    623 (BDKRB1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Bradykinin
    623 (BDKRB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srw 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 623
NCBI-ProteinID: NP_000701
OMIM: 600337
HGNC: 1029
Ensembl: ENSG00000100739
Vega: OTTHUMG00000171412
Pharos: P46663(Tchem)
UniProt: P46663
Position
14q32.2
AA seq 353 aa AA seqDB search
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
NT seq 1062 nt NT seq  +upstreamnt  +downstreamnt
atggcatcatcctggccccctctagagctccaatcctccaaccagagccagctcttccct
caaaatgctacggcctgtgacaatgctccagaagcctgggacctgctgcacagagtgctg
ccaacatttatcatctccatctgtttcttcggcctcctagggaacctttttgtcctgttg
gtcttcctcctgccccggcggcaactgaacgtggcagaaatctacctggccaacctggca
gcctctgatctggtgtttgtcttgggcttgcccttctgggcagagaatatctggaaccag
tttaactggcctttcggagccctcctctgccgtgtcatcaacggggtcatcaaggccaat
ttgttcatcagcatcttcctggtggtggccatcagccaggaccgctaccgcgtgctggtg
caccctatggccagccggaggcagcagcggcggaggcaggcccgggtcacctgcgtgctc
atctgggttgtggggggcctcttgagcatccccacattcctgctgcgatccatccaagcc
gtcccagatctgaacatcaccgcctgcatcctgctcctcccccatgaggcctggcacttt
gcaaggattgtggagttaaatattctgggtttcctcctaccactggctgcgatcgtcttc
ttcaactaccacatcctggcctccctgcgaacgcgggaggaggtcagcaggacaaggtgc
gggggccgcaaggatagcaagaccacagcgctgatcctcacgctcgtggttgccttcctg
gtctgctgggccccttaccacttctttgccttcctggaattcttattccaggtgcaagca
gtccgaggctgcttttgggaggacttcattgacctgggcctgcaattggccaacttcttt
gccttcactaacagctccctgaatccagtaatttatgtctttgtgggccggctcttcagg
accaaggtctgggaactttataaacaatgcacccctaaaagtcttgctccaatatcttca
tcccataggaaagaaatcttccaacttttctggcggaattaa

KEGG   Homo sapiens (human): 624Help
Entry
624               CDS       T01001                                 

Gene name
BDKRB2, B2R, BK-2, BK2, BKR2, BRB2
Definition
(RefSeq) bradykinin receptor B2
  KO
K03916  bradykinin receptor B2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa05142  Chagas disease (American trypanosomiasis)
hsa05200  Pathways in cancer
Drug target
Deltibant: D03677
Icatibant: D04492
Labradimil: D08937
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    624 (BDKRB2)
   04071 Sphingolipid signaling pathway
    624 (BDKRB2)
   04022 cGMP-PKG signaling pathway
    624 (BDKRB2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    624 (BDKRB2)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    624 (BDKRB2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    624 (BDKRB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    624 (BDKRB2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    624 (BDKRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    624 (BDKRB2)
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    624 (BDKRB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    624 (BDKRB2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Bradykinin
    624 (BDKRB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1
Motif
Other DBs
NCBI-GeneID: 624
NCBI-ProteinID: NP_000614
OMIM: 113503
HGNC: 1030
Ensembl: ENSG00000168398
Vega: OTTHUMG00000171408
Pharos: P30411(Tclin)
UniProt: P30411
Position
14q32.2
AA seq 391 aa AA seqDB search
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
NT seq 1176 nt NT seq  +upstreamnt  +downstreamnt
atgttctctccctggaagatatcaatgtttctgtctgttcgtgaggactccgtgcccacc
acggcctctttcagcgccgacatgctcaatgtcaccttgcaagggcccactcttaacggg
acctttgcccagagcaaatgcccccaagtggagtggctgggctggctcaacaccatccag
ccccccttcctctgggtgctgttcgtgctggccaccctagagaacatctttgtcctcagc
gtcttctgcctgcacaagagcagctgcacggtggcagagatctacctggggaacctggcc
gcagcagacctgatcctggcctgcgggctgcccttctgggccatcaccatctccaacaac
ttcgactggctctttggggagacgctctgccgcgtggtgaatgccattatctccatgaac
ctgtacagcagcatctgtttcctgatgctggtgagcatcgaccgctacctggccctggtg
aaaaccatgtccatgggccggatgcgcggcgtgcgctgggccaagctctacagcttggtg
atctgggggtgtacgctgctcctgagctcacccatgctggtgttccggaccatgaaggag
tacagcgatgagggccacaacgtcaccgcttgtgtcatcagctacccatccctcatctgg
gaagtgttcaccaacatgctcctgaatgtcgtgggcttcctgctgcccctgagtgtcatc
accttctgcacgatgcagatcatgcaggtgctgcggaacaacgagatgcagaagttcaag
gagatccagacagagaggagggccacggtgctagtcctggttgtgctgctgctattcatc
atctgctggctgcccttccagatcagcaccttcctggatacgctgcatcgcctcggcatc
ctctccagctgccaggacgagcgcatcatcgatgtaatcacacagatcgcctccttcatg
gcctacagcaacagctgcctcaacccactggtgtacgtgatcgtgggcaagcgcttccga
aagaagtcttgggaggtgtaccagggagtgtgccagaaagggggctgcaggtcagaaccc
attcagatggagaactccatgggcacactgcggacctccatctccgtggaacgccagatt
cacaaactgcaggactgggcagggagcagacagtga

KEGG   Homo sapiens (human): 6865Help
Entry
6865              CDS       T01001                                 

Gene name
TACR2, NK2R, NKNAR, SKR, TAC2R
Definition
(RefSeq) tachykinin receptor 2
  KO
K04223  tachykinin receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    6865 (TACR2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    6865 (TACR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    6865 (TACR2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Tachykinin
    6865 (TACR2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4
Motif
Other DBs
NCBI-GeneID: 6865
NCBI-ProteinID: NP_001048
OMIM: 162321
HGNC: 11527
Ensembl: ENSG00000075073
Vega: OTTHUMG00000018377
Pharos: P21452(Tchem)
UniProt: P21452
Position
10q22.1
AA seq 398 aa AA seqDB search
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
NT seq 1197 nt NT seq  +upstreamnt  +downstreamnt
atggggacctgtgacattgtgactgaagccaatatctcatctggccctgagagcaacacc
acgggcatcacagccttctccatgcccagctggcaactggcactgtgggccacagcctac
ctggccctggtgctggtggccgtgacgggtaatgccatcgtcatctggatcatcctggcc
catcggaggatgcgcacagtcaccaactacttcatcgtcaatctggcgctggctgacctc
tgcatggctgccttcaatgccgccttcaactttgtctatgccagccacaacatctggtac
tttggccgtgccttctgctacttccagaacctcttccccatcacagccatgtttgtcagc
atctactccatgaccgccattgctgccgacaggtacatggccatcgtccaccccttccag
cctcggctttcagctcccagcaccaaggcggttattgctggcatctggctggtggctctc
gccctggcctcccctcagtgcttctactccaccgtcaccatggaccagggtgccaccaag
tgcgtggtggcctggcccgaagacagcgggggcaagacgctcctcctgtaccacctcgtg
gtgatcgccctcatctacttcctgccgctcgcggtgatgtttgtagcctacagcgtcatc
ggcctcacgctctggaggcgcgcagtgcccggacatcaggcgcacggtgccaacctgcgc
cacctgcaggccatgaagaagtttgtgaagaccatggtgctggtggtgctgacgtttgcc
atctgctggctgccctaccacctctacttcatcctgggcagcttccaggaggacatctac
tgccacaagttcatccagcaagtctacctggcactcttctggttggccatgagctctacc
atgtacaatcccatcatctactgctgtctcaaccacaggtttcgctctggattccggctt
gccttccgctgctgcccatgggtcacacccaccaaggaagataagctcgagctgactccc
acgacctccctctccacgagagtcaacaggtgtcacactaaggagactttgttcatggct
ggggacacagccccctccgaggctaccagtggggaggcggggcgtccccaggatggatca
gggctatggtttgggtatggtttgcttgcccccaccaaaactcatgttgaaatttga

KEGG   Homo sapiens (human): 6869Help
Entry
6869              CDS       T01001                                 

Gene name
TACR1, NK1R, NKIR, SPR, TAC1R
Definition
(RefSeq) tachykinin receptor 1
  KO
K04222  tachykinin receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Aprepitant (DG00066): D02968 D06597 D10895
Befetupitant: D03221
Casopitant: D06574
Ezlopitant: D04122
Fosnetupitant (DG02999): D11370
Maropitant citrate: D04860
Netupitant (DG02843): D05152 D11065
Orvepitant (DG01315): D09650 D09651
Rolapitant (DG01868): D08988 D10742
Serlopitant: D09378
Telmapitant: D10391
Vestipitant mesylate: D06293
Vofopitant dihydrochloride: D06317
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    6869 (TACR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    6869 (TACR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    6869 (TACR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Tachykinin
    6869 (TACR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7tm_4 TctB
Motif
Other DBs
NCBI-GeneID: 6869
NCBI-ProteinID: NP_001049
OMIM: 162323
HGNC: 11526
Ensembl: ENSG00000115353
Vega: OTTHUMG00000129973
Pharos: P25103(Tclin)
UniProt: P25103
Structure
PDB: 

Position
2p12
AA seq 407 aa AA seqDB search
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
NT seq 1224 nt NT seq  +upstreamnt  +downstreamnt
atggataacgtcctcccggtggactcagacctctccccaaacatctccactaacacctcg
gaacccaatcagttcgtgcaaccagcctggcaaattgtcctttgggcagctgcctacacg
gtcattgtggtgacctctgtggtgggcaacgtggtagtgatgtggatcatcttagcccac
aaaagaatgaggacagtgacgaactattttctggtgaacctggccttcgcggaggcctcc
atggctgcattcaatacagtggtgaacttcacctatgctgtccacaacgaatggtactac
ggcctgttctactgcaagttccacaacttctttcccatcgccgctgtcttcgccagtatc
tactccatgacggctgtggcctttgataggtacatggccatcatacatcccctccagccc
cggctgtcagccacagccaccaaagtggtcatctgtgtcatctgggtcctggctctcctg
ctggccttcccccagggctactactcaaccacagagaccatgcccagcagagtcgtgtgc
atgatcgaatggccagagcatccgaacaagatttatgagaaagtgtaccacatctgtgtg
actgtgctgatctacttcctccccctgctggtgattggctatgcatacaccgtagtggga
atcacactatgggccagtgagatccccggggactcctctgaccgctaccacgagcaagtc
tctgccaagcgcaaggtggtcaaaatgatgattgtcgtggtgtgcaccttcgccatctgc
tggctgcccttccacatcttcttcctcctgccctacatcaacccagatctctacctgaag
aagtttatccagcaggtctacctggccatcatgtggctggccatgagctccaccatgtac
aaccccatcatctactgctgcctcaatgacaggttccgtctgggcttcaagcatgccttc
cggtgctgccccttcatcagcgccggcgactatgaggggctggaaatgaaatccacccgg
tatctccagacccagggcagtgtgtacaaagtcagccgcctggagaccaccatctccaca
gtggtgggggcccacgaggaggagccagaggacggccccaaggccacaccctcgtccctg
gacctgacctccaactgctcttcacgaagtgactccaagaccatgacagagagcttcagc
ttctcctccaatgtgctctcctag

KEGG   Homo sapiens (human): 6870Help
Entry
6870              CDS       T01001                                 

Gene name
TACR3, HH11, NK-3R, NK3, NK3R, NKR, TAC3R, TAC3RL
Definition
(RefSeq) tachykinin receptor 3
  KO
K04224  tachykinin receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00255  Hypogonadotropic hypogonadism
Drug target
Pavinetant: D11345
Talnetant hydrochloride: D05996
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    6870 (TACR3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    6870 (TACR3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    6870 (TACR3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Tachykinin
    6870 (TACR3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 zf_C2H2_ZHX SUa-2TM
Motif
Other DBs
NCBI-GeneID: 6870
NCBI-ProteinID: NP_001050
OMIM: 162332
HGNC: 11528
Ensembl: ENSG00000169836
Vega: OTTHUMG00000131124
Pharos: P29371(Tchem)
UniProt: P29371
Position
4q24
AA seq 465 aa AA seqDB search
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
NT seq 1398 nt NT seq  +upstreamnt  +downstreamnt
atggccactctcccagcagcagaaacctggatagacgggggtggaggcgtgggtgcagac
gccgtgaacctgaccgcctcgctagctgccggggcggccacgggggcagttgagactggg
tggctgcaactgctggaccaagctggcaacctctcctcctccccttccgcgctgggactg
cctgtggcttcccccgcgccctcccagccctgggccaacctcaccaaccagttcgtgcag
ccgtcctggcgcatcgcgctctggtccctggcgtatggtgtggtggtggcagtggcagtt
ttgggaaatctcatcgtcatctggatcatcctggcccacaagcgcatgaggactgtcacc
aactacttccttgtgaacctggctttctccgacgcctccatggccgccttcaacacgttg
gtcaatttcatctacgcgcttcatagcgagtggtactttggcgccaactactgccgcttc
cagaacttctttcctatcacagctgtgttcgccagcatctactccatgacggccattgcg
gtggacaggtatatggctattattgatcccttgaaacccagactgtctgctacagcaacc
aagattgtcattggaagtatttggattctagcatttctacttgccttccctcagtgtctt
tattccaaaaccaaagtcatgccaggccgtactctctgctttgtgcaatggccagaaggt
cccaaacaacatttcacttaccatattatcgtcattatactggtgtactgtttcccattg
ctcatcatgggtattacatacaccattgttggaattactctctggggaggagaaatccca
ggagatacctgtgacaagtatcatgagcagctaaaggccaaaagaaaggttgtcaaaatg
atgattattgttgtcatgacatttgctatctgctggctgccctatcatatttacttcatt
ctcactgcaatctatcaacaactaaatagatggaaatacatccagcaggtctacctggct
agcttttggctggcaatgagctcaaccatgtacaatcccatcatctactgctgtctgaat
aaaagatttcgagctggcttcaagagagcatttcgctggtgtcctttcatcaaagtttcc
agctatgatgagctagagctcaagaccaccaggtttcatccaaaccggcaaagcagtatg
tacaccgtgaccagaatggagtccatgacagtcgtgtttgaccccaacgatgcagacacc
accaggtccagtcggaagaaaagagcaacgccaagagacccaagtttcaatggctgctct
cgcaggaattccaaatctgcctccgccacttcaagtttcataagctcaccctatacctct
gtggatgaatattcttaa

KEGG   Homo sapiens (human): 6915Help
Entry
6915              CDS       T01001                                 

Gene name
TBXA2R, BDPLT13, TXA2-R
Definition
(RefSeq) thromboxane A2 receptor
  KO
K04264  thromboxane A2 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04611  Platelet activation
Disease
H01235  Bleeding disorder platelet-type
Drug target
Cilostazol: D01896
Daltroban: D03642
Domitroban calcium hydrate: D09824
Ifetroban (DG01350): D04500 D04501
Imitrodast sodium: D09774
Picotamide: D07140
Ramatroban: D01128
Ridogrel: D05727
Seratrodast: D01123
Sulotroban: D05970
Terbogrel: D06077
Vapiprost hydrochloride: D06280
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    6915 (TBXA2R)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    6915 (TBXA2R)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    6915 (TBXA2R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    6915 (TBXA2R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Thromboxane
    6915 (TBXA2R)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx DUF3784 7TM_GPCR_Srv
Motif
Other DBs
NCBI-GeneID: 6915
NCBI-ProteinID: NP_001051
OMIM: 188070
HGNC: 11608
Ensembl: ENSG00000006638
Vega: OTTHUMG00000180806
Pharos: P21731(Tclin)
UniProt: P21731 Q05C92 Q0VAB0
Position
19p13.3
AA seq 343 aa AA seqDB search
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
NT seq 1032 nt NT seq  +upstreamnt  +downstreamnt
atgtggcccaacggcagttccctggggccctgtttccggcccacaaacattaccctggag
gagagacggctgatcgcctcgccctggttcgccgcctccttctgcgtggtgggcctggcc
tccaacctgctggccctgagcgtgctggcgggcgcgcggcaggggggttcgcacacgcgc
tcctccttcctcaccttcctctgcggcctcgtcctcaccgacttcctggggctgctggtg
accggtaccatcgtggtgtcccagcacgccgcgctcttcgagtggcacgccgtggaccct
ggctgccgtctctgtcgcttcatgggcgtcgtcatgatcttcttcggcctgtccccgctg
ctgctgggggccgccatggcctcagagcgctacctgggtatcacccggcccttctcgcgc
ccggcggtcgcctcgcagcgccgcgcctgggccaccgtggggctggtgtgggcggccgcg
ctggcgctgggcctgctgcccctgctgggcgtgggtcgctacaccgtgcaatacccgggg
tcctggtgcttcctgacgctgggcgccgagtccggggacgtggccttcgggctgctcttc
tccatgctgggcggcctctcggtcgggctgtccttcctgctgaacacggtcagcgtggcc
accctgtgccacgtctaccacgggcaggaggcggcccagcagcgtccccgggactccgag
gtggagatgatggctcagctcctggggatcatggtggtggccagcgtgtgttggctgccc
cttctggtcttcatcgcccagacagtgctgcgaaacccgcctgccatgagccccgccggg
cagctgtcccgcaccacggagaaggagctgctcatctacttgcgcgtggccacctggaac
cagatcctggacccctgggtgtatatcctgttccgccgcgccgtgctccggcgtctccag
cctcgcctcagcacccggcccaggtcgctgtccctccagccccagctcacgcagcgctcc
gggctgcagtag

KEGG   Homo sapiens (human): 7201Help
Entry
7201              CDS       T01001                                 

Gene name
TRHR, TRH-R
Definition
(RefSeq) thyrotropin releasing hormone receptor
  KO
K04282  thyrotropin-releasing hormone receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H01700  Hypopituitarism
Drug target
Montirelin (DG01347): D02588 D09845
Protirelin (DG01171): D00176 D02007
Rovatirelin hydrate: D10594
Taltirelin hydrate: D01925
Thyrotropin alfa: D06120
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    7201 (TRHR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    7201 (TRHR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    7201 (TRHR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Thyrotropin-releasing hormone (TRH)
    7201 (TRHR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 7201
NCBI-ProteinID: NP_003292
OMIM: 188545
HGNC: 12299
Ensembl: ENSG00000174417
Vega: OTTHUMG00000164910
Pharos: P34981(Tclin)
UniProt: P34981
Position
8q23.1
AA seq 398 aa AA seqDB search
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
NT seq 1197 nt NT seq  +upstreamnt  +downstreamnt
atggaaaacgagacagtcagtgaactgaaccaaacacagcttcagccacgagcagtggtg
gccttagaataccaggtggtcaccatcttacttgtactcattatttgtggcctgggcatt
gtaggcaacatcatggtagtcctggttgtcatgagaaccaagcacatgaggacccccaca
aactgctacctggtgagcctggcagtagctgatctcatggtcttggtggccgcaggcctc
cccaacataacagacagtatctacggttcctgggtctatggctatgttggatgcctctgc
attacttacctccagtatttgggaattaatgcatcctcttgttcaataacagcctttacc
attgagaggtacatagcaatctgtcaccccatcaaagcccagtttctctgcacattttcc
agagccaaaaagattatcatctttgtctgggctttcacatctctttactgtatgctctgg
ttcttcttgctggatctcaatattagcacctacaaagatgctattgtgatatcctgtggc
tacaagatctccaggaattactactcacctatttacctaatggactttggtgtcttttat
gttgtgccaatgatcctggctaccgtcctctatggattcatagctagaatccttttctta
aatcccattccttcagatcctaaagaaaactctaagacatggaaaaatgattcaacccat
cagaacacaaatctgaatgtaaatacctctaatagatgtttcaacagcacagtatcttca
aggaagcaggtcaccaagatgctggcagtggttgtaattctgtttgcccttttatggatg
ccctacaggactctagtggttgtcaactcatttctctccagtcctttccaagaaaattgg
tttttgctcttttgcagaatttgcatttatctcaacagtgccatcaacccggtgatttac
aatctcatgtcccagaaattccgtgcagccttcagaaagctctgcaactgcaagcagaag
ccaacagagaaacctgctaactacagtgtggccctaaattacagcgtcatcaaggagtca
gaccatttcagcacagagcttgatgatatcactgtcactgacacttacctgtctgccaca
aaagtgtcttttgatgacacctgcttggcttctgaggtatcctttagccaaagttga

KEGG   Homo sapiens (human): 886Help
Entry
886               CDS       T01001                                 

Gene name
CCKAR, CCK-A, CCK1-R, CCK1R, CCKRA
Definition
(RefSeq) cholecystokinin A receptor
  KO
K04194  cholecystokinin A receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04911  Insulin secretion
hsa04972  Pancreatic secretion
Drug target
Ceruletide (DG01165): D03442 D03443
Devazepide: D02693
Loxiglumide: D01113
Panazepide: D01858
Tarazepide: D02710
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    886 (CCKAR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    886 (CCKAR)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    886 (CCKAR)
  09154 Digestive system
   04972 Pancreatic secretion
    886 (CCKAR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    886 (CCKAR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Cholecystokinin
    886 (CCKAR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 CholecysA-Rec_N 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 886
NCBI-ProteinID: NP_000721
OMIM: 118444
HGNC: 1570
Ensembl: ENSG00000163394
Vega: OTTHUMG00000128567
Pharos: P32238(Tclin)
UniProt: P32238
Position
4p15.2
AA seq 428 aa AA seqDB search
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
NT seq 1287 nt NT seq  +upstreamnt  +downstreamnt
atggatgtggttgacagccttcttgtgaatggaagcaacatcactcctccctgtgaactc
gggctcgaaaatgagacgcttttctgcttggatcagccccgtccttccaaagagtggcag
ccagcggtgcagattctcttgtactccttgatattcctgctcagcgtgctgggaaacacg
ctggtcatcaccgtgctgattcggaacaagcggatgcggacggtcaccaacatcttcctc
ctctccctggctgtcagcgacctcatgctctgtctcttctgcatgccgttcaacctcatc
cccaatctgctcaaggatttcatcttcgggagcgccgtttgcaagaccaccacctacttc
atgggcacctctgtgagtgtatctacctttaatctggtagccatatctctagagagatat
ggtgcgatttgcaaacccttacagtcccgggtctggcagacaaaatcccatgctttgaag
gtgattgctgctacctggtgcctttcctttaccatcatgactccgtaccccatttatagc
aacttggtgccttttaccaaaaataacaaccagaccgcgaatatgtgccgctttctactg
ccaaatgatgttatgcagcagtcctggcacacattcctgttactcatcctctttcttatt
cctggaattgtgatgatggtggcatatggattaatctctttggaactctaccagggaata
aaatttgaggctagccagaagaagtctgctaaagaaaggaaacctagcaccaccagcagc
ggcaaatatgaggacagcgatgggtgttacctgcaaaagaccaggcccccgaggaagctg
gagctccggcagctgtccaccggcagcagcagcagggccaaccgcatccggagtaacagc
tccgcagccaacctgatggccaagaaaagggtgatccgcatgctcatcgtcatcgtggtc
ctcttcttcctgtgctggatgcccatcttcagcgccaacgcctggcgggcctacgacacc
gcctccgcagagcgccgcctctcaggaacccccatttccttcatcctcctcctgtcctac
acctcctcctgcgtcaaccccatcatctactgcttcatgaacaaacgcttccgcctcggc
ttcatggccaccttcccctgctgccccaatcctggtcccccaggggcgaggggagaggtg
ggggaggaggaggaaggcgggaccacaggagcctctctgtccaggttctcgtacagccat
atgagtgcctcggtgccaccccagtga

KEGG   Homo sapiens (human): 887Help
Entry
887               CDS       T01001                                 

Gene name
CCKBR, CCK-B, CCK2R, GASR
Definition
(RefSeq) cholecystokinin B receptor
  KO
K04195  cholecystokinin B receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Drug target
Panazepide: D01858
Pentagastrin: D01631
Proglumide: D01818
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    887 (CCKBR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    887 (CCKBR)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    887 (CCKBR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    887 (CCKBR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Cholecystokinin
    887 (CCKBR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 887
NCBI-ProteinID: NP_795344
OMIM: 118445
HGNC: 1571
Ensembl: ENSG00000110148
Vega: OTTHUMG00000133380
Pharos: P32239(Tclin)
UniProt: P32239
Position
11p15.4
AA seq 447 aa AA seqDB search
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
NT seq 1344 nt NT seq  +upstreamnt  +downstreamnt
atggagctgctaaagctgaaccggagcgtgcagggaaccggacccgggccgggggcttcc
ctgtgccgcccgggggcgcctctcctcaacagcagcagtgtgggcaacctcagctgcgag
ccccctcgcattcgcggagccgggacacgagaattggagctggccattagaatcactctt
tacgcagtgatcttcctgatgagcgttggaggaaatatgctcatcatcgtggtcctggga
ctgagccgccgcctgaggactgtcaccaatgccttcctcctctcactggcagtcagcgac
ctcctgctggctgtggcttgcatgcccttcaccctcctgcccaatctcatgggcacattc
atctttggcaccgtcatctgcaaggcggtttcctacctcatgggggtgtctgtgagtgtg
tccacgctaagcctcgtggccatcgcactggagcggtacagcgccatctgccgaccactg
caggcacgagtgtggcagacgcgctcccacgcggctcgcgtgattgtagccacgtggctg
ctgtccggactactcatggtgccctaccccgtgtacactgtcgtgcaaccagtggggcct
cgtgtgctgcagtgcgtgcatcgctggcccagtgcgcgggtccgccagacctggtccgta
ctgctgcttctgctcttgttcttcatcccgggtgtggttatggccgtggcctacgggctt
atctctcgcgagctctacttagggcttcgctttgacggcgacagtgacagcgacagccaa
agcagggtccgaaaccaaggcgggctgccaggggctgttcaccagaacgggcgttgccgg
cctgagactggcgcggttggcgaagacagcgatggctgctacgtgcaacttccacgttcc
cggcctgccctggagctgacggcgctgacggctcctgggccgggatccggctcccggccc
acccaggccaagctgctggctaagaagcgcgtggtgcgaatgttgctggtgatcgttgtg
cttttttttctgtgttggttgccagtttatagtgccaacacgtggcgcgcctttgatggc
ccgggtgcacaccgagcactctcgggtgctcctatctccttcattcacttgctgagctac
gcctcggcctgtgtcaaccccctggtctactgcttcatgcaccgtcgctttcgccaggcc
tgcctggaaacttgcgctcgctgctgcccccggcctccacgagctcgccccagggctctt
cccgatgaggaccctcccactccctccattgcttcgctgtccaggcttagctacaccacc
atcagcacactgggccctggctga

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