KEGG   Homo sapiens (human): 10905
Entry
10905             CDS       T01001                                 

Gene name
MAN1A2, MAN1B
Definition
(RefSeq) mannosidase alpha class 1A member 2
  KO
K01230  mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa01100  Metabolic pathways
hsa04141  Protein processing in endoplasmic reticulum
Module
hsa_M00073  N-glycan precursor trimming
Network
nt06015  N-Glycan biosynthesis
  Element
N00820  N-Glycan biosynthesis
N00821  B4GALT1 deficiency in N-glycan biosynthesis
N00822  MGAT2 deficiency in N-glycan biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    10905 (MAN1A2)
   00513 Various types of N-glycan biosynthesis
    10905 (MAN1A2)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    10905 (MAN1A2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10905 (MAN1A2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.113  mannosyl-oligosaccharide 1,2-alpha-mannosidase
     10905 (MAN1A2)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    10905 (MAN1A2)
SSDB
Motif
Pfam: Glyco_hydro_47 iSTAND
Other DBs
NCBI-GeneID: 10905
NCBI-ProteinID: NP_006690
OMIM: 604345
HGNC: 6822
Ensembl: ENSG00000198162
Vega: OTTHUMG00000012149
Pharos: O60476(Tdark)
UniProt: O60476
Position
1p12
AA seq 641 aa
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDS
SKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALE
EAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLH
DEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLP
AFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVM
HIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEAR
KMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKA
GHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWY
LWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYL
YLLFSGDDLLPLDHWVFNTEAHPLPVLHLANTTLSGNPAVR
NT seq 1926 nt   +upstreamnt  +downstreamnt
atgactaccccagccctgctgcccctctctggacgtaggataccacctctgaacctgggg
ccgccttccttcccacatcacagggctaccttgagactttctgagaagtttattcttctc
cttattcttagtgccttcatcactctgtgttttggggcattctttttccttccagactct
tcaaaacacaaacgctttgatttgggtttagaagatgtgttaattccacatgtagatgcc
ggtaaaggggctaaaaaccccggagtcttcctgatccatggacccgatgaacatagacac
agggaagaggaagaacgtctgagaaataaaattcgagctgatcatgagaaggccttggaa
gaagcaaaagaaaaattaagaaagtcaagagaggaaattcgagcagaaattcagacagag
aaaaataaggtagtccaagaaatgaagataaaagagaacaagccactgccaccagtccct
attcccaaccttgtaggaatacgtggtggagacccagaagataatgacataagagagaaa
agggaaaaaattaaagagatgatgaaacatgcttgggataactataggacatatgggtgg
ggacataatgaactcagacctattgcaaggaaaggacactcccctaacatatttggaagt
tcacaaatgggtgctaccatagtagatgctttggataccctttatatcatgggacttcat
gatgaattcctagatgggcaaagatggattgaagacaaccttgatttcagtgtgaattca
gaggtgtctgtgtttgaagtcaacattcgatttattggaggcctacttgcagcatattac
ctatcaggagaggagatattcaagattaaagcagtgcaattggctgagaaactccttcct
gcctttaacacacctactgggattccttgggcaatggtgaatttgaaaagtggagtaggg
cgaaactggggctgggcatctgcaggtagcagcattctggctgaatttggtacactacat
atggagttcatccacctcagctacttgacaggggacctgacttactacaaaaaggttatg
cacattcggaaactacttcagaaaatggatcgtccaaatggtctttatccaaattatttg
aaccccagaacagggcgctggggtcagtatcatacatctgtcggtggcctgggagacagt
ttttatgaatacttactgaaagcatggttgatgtcagataaaacagaccatgaggcaaga
aagatgtatgatgatgctattgaggctatagaaaaacatcttattaagaagtctcgtgga
ggtcttacctttattggagaatggaagaatgggcacttggaaaaaaagatggggcatttg
gcctgctttgctgggggaatgtttgcactaggagcagatggttccagagcagataaagct
ggtcattatttagagctaggggcagaaattgcacgtacttgtcatgagtcatatgacaga
actgcattaaagctaggtcctgaatcattcaagtttgatggtgcagtggaggctgtggct
gtccggcaggctgaaaagtattatatcctccgtccagaagtaattgaaacctattggtac
ctatggcgattcactcacgatccaagatacaggcagtggggctgggaagcagcactggcc
attgaaaagtattgccgagttaatggtgggttttctggagtcaaagatgtatattcctct
actcctacacatgatgatgtacagcagagcttttttcttgctgaaacattaaaatatttg
tatctgctgttctccggtgatgaccttttacctttagaccactgggtgtttaatacagag
gctcaccctctgcctgtgttacatttagccaacaccacactttcaggtaatcctgctgtt
cgatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (25)   
   RefSeq(nuc) (5)   
   GenBank (10)   
   EMBL (10)   
Protein domain (2)   
   Pfam (2)   
All databases (69)   

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