KEGG   Homo sapiens (human): 11073Help
Entry
11073             CDS       T01001                                 

Gene name
TOPBP1, Dpb11, TOP2BP1
Definition
(RefSeq) DNA topoisomerase II binding protein 1
  KO
K10728  topoisomerase (DNA) II binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    11073 (TOPBP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    11073 (TOPBP1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    11073 (TOPBP1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    11073 (TOPBP1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-B complex
     11073 (TOPBP1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: BRCT PTCB-BRCT BRCT_2 LIG3_BRCT RTT107_BRCT_5
Motif
Other DBs
NCBI-GeneID: 11073
NCBI-ProteinID: NP_008958
OMIM: 607760
HGNC: 17008
Ensembl: ENSG00000163781
Vega: OTTHUMG00000159773
Pharos: Q92547(Tbio)
UniProt: Q92547 Q05BV8 A0AV47 A7E2X7
Structure
PDB: 

Position
3q22.1
AA seq 1522 aa AA seqDB search
MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
TGLSQKRKAPTEKNKIKRPRVH
NT seq 4569 nt NT seq  +upstreamnt  +downstreamnt
atgtccagaaatgacaaagaaccgttttttgtgaagtttttaaagtcttcagacaattcc
aaatgtttttttaaagctctcgagtccataaaagaattccaatcagaagaatatcttcag
attattacagaagaagaggcattgaagataaaggagaatgatagatcactttatatctgt
gacccttttagtggcgttgtctttgatcacctcaaaaagcttggctgcagaattgttggt
cctcaagtagtcatattttgtatgcaccaccagcgatgtgtcccaagagccgaacatcca
gtttataatatggttatgtctgatgtaaccatatcttgtacaagtctggaaaaagaaaaa
agggaagaagttcataaatatgtacaaatgatgggcggacgagtatacagagaccttaat
gtatcagtaactcaccttattgcaggagaagttggtagcaaaaaatatttagttgctgca
aacctgaagaaacctattttgcttccctcttggataaaaacactttgggagaagtcacaa
gagaaaaaaataactagatatactgatataaacatggaagatttcaagtgtcctattttt
cttggttgcataatctgtgtgactggcttatgtggcttagacaggaaagaagttcagcaa
ctcacagttaagcatggaggtcaatacatgggacaattgaaaatgaatgaatgtacacac
ctcattgtgcaagaaccaaaaggtcagaagtatgagtgtgccaagagatggaatgtacac
tgtgtgaccacacagtggttttttgacagtattgagaaaggtttttgtcaggatgaatcc
atatacaagacagaacctagaccagaagcaaagactatgcccaattcttcaactcctacc
agccagatcaacacaattgatagtcgtactctttcagatgtcagcaatatttccaacata
aatgcaagttgcgtaagtgaatcaatatgtaattcacttaacagcaaactggagcctaca
cttgaaaatctagaaaatctggatgtcagtgcatttcaagcacctgaagatttattagat
ggttgtcggatatatctttgcggttttagtggcagaaagctagataaactgagaagactt
attaacagtggaggtggagttcgttttaaccagctaaatgaagatgtaactcatgttatt
gtgggagattatgatgatgaattgaagcagttttggaataaatcagcccacaggcctcat
gtagtgggagcaaagtggttgctagagtgtttcagtaaaggttatatgctttctgaagaa
ccatatatccatgctaattaccagccagtggaaattccagtttcacataagcctgaaagt
aaagcagctcttttaaaaaagaagaacagcagcttctctaagaaagactttgctcctagt
gaaaagcatgagcaagctgatgaagatctgctctctcaatatgaaaatggtagctccaca
gtagttgaggctaagacgtctgaagccaggccctttaatgattctactcatgctgagccc
ttgaatgattctactcacatttctttgcaagaagaaaaccagtcttctgtcagtcattgt
gtccctgatgtttctacaattactgaagaaggcttatttagccaaaagagtttccttgtt
ttgggttttagtaatgaaaatgaatctaacatcgcaaacatcataaaagaaaatgctggg
aaaatcatgtcccttctgagcagaactgttgcggattatgctgtggttcctctgctgggg
tgtgaagtggaagccactgtgggagaagttgttacaaatacatggctggttacttgcata
gactatcagactttgtttgatccaaagtcgaatcctctcttcacaccagttccagtaatg
acaggaatgactcctttagaggattgtgttatttcatttagccagtgtgctggagcagaa
aaagagtctttaacattcctagcaaacctccttggagcaagtgttcaagaatactttgtt
cgcaaatccaatgcaaagaaaggcatgtttgccagtactcatcttatactgaaagaacgt
ggtggctctaaatatgaagctgcaaagaagtggaatttacctgccgttactatagcttgg
ctgttggagactgctagaacgggaaagagagcagacgaaagccattttctgattgaaaat
tcaactaaagaagaacgaagtttggaaacagaaataacaaatggaatcaatctaaattca
gatactgcagagcatcctggcacacgcctgcaaactcacagaaaaaccgtcgttacacct
ttagatatgaaccgctttcagagtaaagctttccgtgctgtggtctcacaacatgccaga
caggtcgcagcctccccagcagtaggacaaccacttcagaaggagccctcgttacacctg
gatacaccatcaaaattcctgtccaaggacaaactcttcaagccttcctttgatgtgaag
gatgcacttgcagccttggaaactccaggacgtcccagccaacagaaaaggaaaccgagt
acgccactctcagaagttattgtcaaaaacttgcaacttgctttggcaaatagctctcga
aatgctgtcgctctttctgccagccctcaactgaaagaggcccagtcagagaaggaagaa
gccccaaagccacttcacaaagtagtggtatgtgttagtaaaaaactcagtaagaagcag
agtgaactaaatgggatcgcagcctctctaggagcagattacaggtggagttttgatgaa
acagtgactcatttcatctatcaagggcggccaaatgacactaatcgggagtataaatct
gtaaaagaaagaggagtacacattgtttccgagcactggcttttagattgtgcccaagag
tgtaaacatcttcctgaatctctttatccacatacttataatcccaaaatgagcttggat
atcagcgcagtgcaagatggccggctctgtaatagtcgactactctcagctgtgtcttca
acaaaggatgatgagccagatcctttgattttagaagaaaatgatgtagacaatatggcc
accaataataaagagtcagcaccatcaaatggaagtggaaagaatgactctaaaggagtt
ctgacacagaccttagagatgagagagaactttcagaagcagttacaggagataatgtct
gcaacatcaatagtgaaaccccaagggcagaggacttccctttcaagaagtggttgtaac
agcgcatcttcaacccctgacagcactcgctctgctcgcagtggacgaagtagagtccta
gaggcactgaggcagtctcgtcagacagtacctgatgtcaacacagagccttcccaaaat
gaacagatcatttgggatgaccctacagcaagggaggagagagcaaggcttgccagcaat
ttgcagtggcctagttgtcccacacaatactctgagcttcaggttgacattcaaaacttg
gaggattctccttttcaaaagcctttacatgattcagaaattgctaaacaggctgtctgt
gatcctggaaacatacgtgtgactgaagctcccaaacacccaatctctgaagaactggaa
actcccataaaagacagccacctgatccctacgcctcaagcccccagtattgcctttcca
ctcgccaacccccctgtggctccgcaccctagagaaaagattataacgatagaggagact
catgaagaattaaaaaaacagtacatatttcagttatcatctctgaatcctcaagaacgt
attgactattgtcatctgattgagaaactaggtggattggtgatagaaaagcagtgcttt
gatcccacctgtacacacattgttgtgggacatccacttcgaaacgagaagtatttagcc
tcagtggcagctgggaagtgggtgcttcatcgctcctaccttgaagcctgcaggactgct
ggacacttcgtgcaggaagaagactatgaatggggaagtagttccatacttgatgttctg
actggaatcaatgtacagcaacgaagactagcacttgcagcaatgagatggagaaaaaaa
atccagcaaagacaagaatctggcattgttgagggagcatttagtgggtggaaggttatt
ttacatgtggatcagtctcgagaagcaggcttcaaacgccttcttcagtcaggaggagca
aaggtgctacctggtcattctgtacctttatttaaagaggccacacatcttttttctgac
ttgaataaactgaaaccagatgactcaggagttaatatagcagaagctgctgcccagaac
gtgtactgcttgagaacagaatacattgctgattatctcatgcaggaatcacctcctcat
gtagaaaattactgtctaccagaagctatttcatttattcagaataataaggaacttggg
actggattatcacaaaagaggaaagctcctacagaaaaaaataaaatcaaacgacctaga
gtacactaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (4)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (24)   
   RefSeq(nuc) (6)   
   GenBank (9)   
   EMBL (9)   
Protein domain (5)   
   Pfam (5)   
All databases (63)   

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