KEGG   Homo sapiens (human): 11096
Entry
11096             CDS       T01001                                 
Symbol
ADAMTS5, ADAM-TS_11, ADAM-TS_5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2
Name
(RefSeq) ADAM metallopeptidase with thrombospondin type 1 motif 5
  KO
K08620  a disintegrin and metalloproteinase with thrombospondin motifs 5 [EC:3.4.24.-]
Organism
hsa  Homo sapiens (human)
Drug target
Aldumastat: D11995
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    11096 (ADAMTS5)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   11096 (ADAMTS5)
SSDB
Motif
Pfam: ADAMTS_spacer1 Reprolysin ADAMTS_CR_2 Reprolysin_5 Reprolysin_3 TSP1_ADAMTS ADAMTS_CR_3 TSP_1 Reprolysin_2 Reprolysin_4 TSP1_spondin Peptidase_M10 Pep_M12B_propep TSP1_CCN DUF4953 CxC6
Other DBs
NCBI-GeneID: 11096
NCBI-ProteinID: NP_008969
OMIM: 605007
HGNC: 221
Ensembl: ENSG00000154736
UniProt: Q9UNA0
Structure
Position
21:complement(26917922..26967088)
AA seq 930 aa
MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
NT seq 2793 nt   +upstreamnt  +downstreamnt
atgctgctcgggtgggcgtccctgctgctgtgcgcgttccgcctgcccctggccgcggtc
ggccccgccgcgacacctgcccaggataaagccgggcagcctccgactgctgcagcagcc
gcccagccccgccggcggcagggggaggaggtgcaggagcgagccgagcctcccggccac
ccgcaccccctggcgcagcggcgcaggagcaaggggctggtgcagaacatcgaccaactc
tactccggcggcggcaaggtgggctacctcgtctacgcgggcggccggaggttcctcttg
gacctggagcgagatggttcggtgggcattgctggcttcgtgcccgcaggaggcgggacg
agtgcgccctggcgccaccggagccactgcttctatcggggcacagtggacggtagtccc
cgctctctggctgtctttgacctctgtgggggtctcgacggcttcttcgcggtcaagcac
gcgcgctacaccctaaagccactgctgcgcggaccctgggcggaggaagaaaaggggcgc
gtgtacggggatgggtccgcacggatcctgcacgtctacacccgcgagggcttcagcttc
gaggccctgccgccgcgcgccagctgcgaaacccccgcgtccacaccggaggcccacgag
catgctccggcgcacagcaacccgagcggacgcgcagcactggcctcgcagctcttggac
cagtccgctctctcgcccgctgggggctcaggaccgcagacgtggtggcggcggcggcgc
cgctccatctcccgggcccgccaggtggagctgcttctggtggctgacgcgtccatggcg
cggttgtatggccggggcctgcagcattacctgctgaccctggcctccatcgccaatagg
ctgtacagccatgctagcatcgagaaccacatccgcctggccgtggtgaaggtggtggtg
ctaggcgacaaggacaagagcctggaagtgagcaagaacgctgccaccacactcaagaac
ttttgcaagtggcagcaccaacacaaccagctgggagatgaccatgaggagcactacgat
gcagctatcctgtttactcgggaggatttatgtgggcatcattcatgtgacaccctggga
atggcagacgttgggaccatatgttctccagagcgcagctgtgctgtgattgaagacgat
ggcctccacgcagccttcactgtggctcacgaaatcggacatttacttggcctctcccat
gacgattccaaattctgtgaagagacctttggttccacagaagataagcgcttaatgtct
tccatccttaccagcattgatgcatctaagccctggtccaaatgcacttcagccaccatc
acagaattcctggatgatggccatggtaactgtttgctggacctaccacgaaagcagatc
ctgggccccgaagaactcccaggacagacctacgatgccacccagcagtgcaacctgaca
ttcgggcctgagtactccgtgtgtcccggcatggatgtctgtgctcgcctgtggtgtgct
gtggtacgccagggccagatggtctgtctgaccaagaagctgcctgcggtggaagggacg
ccttgtggaaaggggagaatctgcctgcagggcaaatgtgtggacaaaaccaagaaaaaa
tattattcaacgtcaagccatggcaactggggatcttggggatcctggggccagtgttct
cgctcatgtggaggaggagtgcagtttgcctatcgtcactgtaataaccctgctcccaga
aacaacggacgctactgcacagggaagagggccatctaccgctcctgcagtctcatgccc
tgcccacccaatggtaaatcatttcgtcatgaacagtgtgaggccaaaaatggctatcag
tctgatgcaaaaggagtcaaaacttttgtggaatgggttcccaaatatgcaggtgtcctg
ccagcggatgtgtgcaagctgacctgcagagccaagggcactggctactatgtggtattt
tctccaaaggtgaccgatggcactgaatgtaggctgtacagtaattccgtctgcgtccgg
gggaagtgtgtgagaactggctgtgacggcatcattggctcaaagctgcagtatgacaag
tgcggagtatgtggaggagacaactccagctgtacaaagattgttggaacctttaataag
aaaagtaagggttacactgacgtggtgaggattcctgaaggggcaacccacataaaagtt
cgacagttcaaagccaaagaccagactagattcactgcctatttagccctgaaaaagaaa
aacggtgagtaccttatcaatggaaagtacatgatctccacttcagagactatcattgac
atcaatggaacagtcatgaactatagcggttggagccacagggatgacttcctgcatggc
atgggctactctgccacgaaggaaattctaatagtgcagattcttgcaacagaccccact
aaaccattagatgtccgttatagcttttttgttcccaagaagtccactccaaaagtaaac
tctgtcactagtcatggcagcaataaagtgggatcacacacttcgcagccgcagtgggtc
acgggcccatggctcgcctgctctaggacctgtgacacaggttggcacaccagaacggtg
cagtgccaggatggaaaccggaagttagcaaaaggatgtcctctctcccaaaggccttct
gcgtttaagcaatgcttgttgaagaaatgttag

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Ontology (2)   
   KEGG BRITE (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (23)   
   RefSeq(nuc) (5)   
   GenBank (9)   
   EMBL (9)   
3D Structure (7)   
   PDB (7)   
Protein domain (16)   
   Pfam (16)   
All databases (82)   

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