KEGG   Homo sapiens (human): 11277
Entry
11277             CDS       T01001                                 
Symbol
TREX1, AGS1, CRV, DRN3, HERNS, RVCLS
Name
(RefSeq) three prime repair exonuclease 1
  KO
K10790  three prime repair exonuclease 1 [EC:3.1.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04623  Cytosolic DNA-sensing pathway
Network
nt06520  CGAS-STING signaling
  Element
N01571  DNA degradation by extracellular/endolysosomal DNAse
Disease
H00080  Systemic lupus erythematosus
H00290  Aicardi-Goutieres syndrome
H00291  Familial chilblain lupus (FCL)
H01000  Retinal vasculopathy with cerebral leukodystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    11277 (TREX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    11277 (TREX1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.11.2  exodeoxyribonuclease III
     11277 (TREX1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Nucleases
    11277 (TREX1)
SSDB
Motif
Pfam: RNase_T Herpesvir_UL11
Other DBs
NCBI-GeneID: 11277
NCBI-ProteinID: NP_338599
OMIM: 606609
HGNC: 12269
Ensembl: ENSG00000213689
UniProt: Q9NSU2
Structure
Position
3:48465830..48467645
AA seq 314 aa
MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLG
SIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASAR
TKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLA
VATLYGLSLATPGE
NT seq 945 nt   +upstreamnt  +downstreamnt
atgggctcgcaggccctgcccccggggcccatgcagaccctcatctttttcgacatggag
gccactggcttgcccttctcccagcccaaggtcacggagctgtgcctgctggctgtccac
agatgtgccctggagagcccccccacctctcaggggccacctcccacagttcctccacca
ccgcgtgtggtagacaagctctccctgtgtgtggctccggggaaggcctgcagccctgca
gccagcgagatcacaggtctgagcacagctgtgctggcagcgcatgggcgtcaatgtttt
gatgacaacctggccaacctgctcctagccttcctgcggcgccagccacagccctggtgc
ctggtggcacacaatggtgaccgctacgacttccccctgctccaagcagagctggctatg
ctgggcctcaccagtgctctggatggtgccttctgtgtggatagcatcactgcgctgaag
gccctggagcgagcaagcagcccctcagaacacggcccaaggaagagctatagcctaggc
agcatctacactcgcctgtatgggcagtcccctccagactcgcacacggctgagggtgat
gtcctggccctgctcagcatctgtcagtggagaccacaggccctgctgcggtgggtggat
gctcacgccaggcctttcggcaccatcaggcccatgtatggggtcacagcctctgctagg
accaagccaagaccatctgctgtcacaaccactgcacacctggccacaaccaggaacact
agtcccagccttggagagagcaggggtaccaaggatcttcctccagtgaaggaccctgga
gccctatccagggaggggctgctggccccactgggtctgctggccatcctgaccttggca
gtagccacactgtatggactatccctggccacacctggggagtag

  All links  
Disease (5)   
   OMIM (5)   
Gene (17)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (31)   
   RefSeq(nuc) (5)   
   GenBank (13)   
   EMBL (13)   
3D Structure (6)   
   PDB (6)   
Protein domain (2)   
   Pfam (2)   
All databases (65)   

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