KEGG   Homo sapiens (human): 1128Help
Entry
1128              CDS       T01001                                 

Gene name
CHRM1, HM1, M1, M1R
Definition
(RefSeq) cholinergic receptor muscarinic 1
  KO
K04129  muscarinic acetylcholine receptor M1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04725  Cholinergic synapse
hsa04810  Regulation of actin cytoskeleton
Drug target
Aceclidine: D02750
Acetylcholine (DG01133): D00999
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837
Alvameline maleate: D02876
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113 D02069
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778 D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000
Bevonium: D01532
Biperiden (DG00852): D00779 D02246 D02247
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451
Carbachol: D00524
Carpronium (DG01289): D01175 D09752
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002 D07759
Darotropium bromide: D09402
Dexetimide (DG00856): D03711 D07804
Dicycloverine (DG00032): D00717 D07820
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Diphenidol (DG02880): D01318 D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Esoxybutynin chloride: D04057
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Flutropium bromide: D02417
Glycopyrronium (DG02467): D10939
Heteronium bromide: D04434
Homatropine (DG01142): D01004 D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Imidafenacin: D06273
Ipratropium bromide: D02212
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720
Methacholine (DG01290): D04970
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465 D00722
Oxyphencyclimine (DG00029): D01006 D08325
Oxyphenonium: D06877
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pipenzolate: D07084
Piperidolate (DG00034): D01165 D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276 D08389
Piroheptine (DG01272): D01231 D08395
Poldine: D05535
Pridinol (DG00774): D02064 D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007 D08441
Rapacuronium bromide: D05703
Revefenacin: D10978
Rocuronium bromide: D00765
Sabcomeline hydrochloride: D05779
Scopolamine (DG00065): D00138 D02071
Sofpironium bromide: D10989
Talsaclidine fumarate: D06000
Tazomeline citrate: D06015
Telenzepine hydrochloride hydrate: D11098
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535
Tofenacin hydrochloride: D06175
Toquizine: D06192
Triampyzine sulfate: D06217
Tridihexethyl (DG00037): D00723
Trihexyphenidyl (DG00851): D00787 D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181
Valethamate: D01538
Xanomeline (DG01300): D06330 D06331
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1128 (CHRM1)
   04024 cAMP signaling pathway
    1128 (CHRM1)
   04151 PI3K-Akt signaling pathway
    1128 (CHRM1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1128 (CHRM1)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1128 (CHRM1)
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1128 (CHRM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1128 (CHRM1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1128 (CHRM1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srbc
Motif
Other DBs
NCBI-GeneID: 1128
NCBI-ProteinID: NP_000729
OMIM: 118510
HGNC: 1950
Ensembl: ENSG00000168539
Vega: OTTHUMG00000167765
Pharos: P11229(Tclin)
UniProt: P11229 Q53XZ3
Structure
PDB: 

Position
11q12.3
AA seq 460 aa AA seqDB search
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
NT seq 1383 nt NT seq  +upstreamnt  +downstreamnt
atgaacacttcagccccacctgctgtcagccccaacatcaccgtcctggcaccaggaaag
ggtccctggcaagtggccttcattgggatcaccacgggcctcctgtcgctagccacagtg
acaggcaacctgctggtactcatctctttcaaggtcaacacggagctcaagacagtcaat
aactacttcctgctgagcctggcctgtgctgacctcatcatcggtaccttctccatgaac
ctctataccacgtacctgctcatgggccactgggctctgggcacgctggcttgtgacctc
tggctggccctggactatgtggccagcaatgcctccgtcatgaatctgctgctcatcagc
tttgaccgctacttctccgtgactcggcccctgagctaccgtgccaagcgcacaccccgc
cgggcagctctgatgatcggcctggcctggctggtttcctttgtgctctgggccccagcc
atcctcttctggcagtacctggtaggggagcggacagtgctagctgggcagtgctacatc
cagttcctctcccagcccatcatcacctttggcacagccatggctgccttctacctccct
gtcacagtcatgtgcacgctctactggcgcatctaccgggagacagagaaccgagcacgg
gagctggcagcccttcagggctccgagacgccaggcaaagggggtggcagcagcagcagc
tcagagaggtctcagccaggggctgagggctcaccagagactcctccaggccgctgctgt
cgctgctgccgggcccccaggctgctgcaggcctacagctggaaggaagaagaggaagag
gacgaaggctccatggagtccctcacatcctcagagggagaggagcctggctccgaagtg
gtgatcaagatgccaatggtggaccccgaggcacaggcccccaccaagcagcccccacgg
agctccccaaatacagtcaagaggccgactaagaaagggcgtgatcgagctggcaagggc
cagaagccccgtggaaaggagcagctggccaagcggaagaccttctcgctggtcaaggag
aagaaggcggctcggaccctgagtgccatcctcctggccttcatcctcacctggacaccg
tacaacatcatggtgctggtgtccaccttctgcaaggactgtgttcccgagaccctgtgg
gagctgggctactggctgtgctacgtcaacagcaccatcaaccccatgtgctacgcactc
tgcaacaaagccttccgggacacctttcgcctgctgctgctttgccgctgggacaagaga
cgctggcgcaagatccccaagcgccctggctccgtgcaccgcactccctcccgccaatgc
tga

KEGG   Homo sapiens (human): 1131Help
Entry
1131              CDS       T01001                                 

Gene name
CHRM3, EGBRS, HM3, PBS
Definition
(RefSeq) cholinergic receptor muscarinic 3
  KO
K04131  muscarinic acetylcholine receptor M3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04742  Taste transduction
hsa04810  Regulation of actin cytoskeleton
hsa04911  Insulin secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
Disease
H02129  Prune belly syndrome
Drug target
Acetylcholine (DG01133): D00999
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837
Alvameline maleate: D02876
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113 D02069
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778 D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000
Bevonium: D01532
Biperiden (DG00852): D00779 D02246 D02247
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451
Carbachol: D00524
Carpronium (DG01289): D01175 D09752
Cevimeline (DG00993): D00661 D07667
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002 D07759
Darifenacin (DG00482): D01699 D03654
Darotropium bromide: D09402
Desfesoterodine: D10853
Dexetimide (DG00856): D03711 D07804
Dexpanthenol: D00193
Dicycloverine (DG00032): D00717 D07820
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Diphemanil: D06878
Diphenidol (DG02880): D01318 D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Esoxybutynin chloride: D04057
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Fesoterodine (DG00483): D07226 D08923
Flutropium bromide: D02417
Glycopyrronium: D00540
Glycopyrronium (DG02467): D10938 D10939
Heteronium bromide: D04434
Hexocyclium (DG00039): D01003
Homatropine (DG01142): D01004 D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Imidafenacin: D06273
Ipratropium bromide: D02212
Isopropamide (DG00038): D01005
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720
Methacholine (DG01290): D04970
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465 D00722
Oxyphencyclimine (DG00029): D01006 D08325
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pilocarpine (DG00992): D00525 D02200 D05478 D08376
Pipenzolate: D07084
Piperidolate (DG00034): D01165 D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276 D08389
Piroheptine (DG01272): D01231 D08395
Poldine: D05535
Pridinol (DG00774): D02064 D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007 D08441
Rapacuronium bromide: D05703
Revefenacin: D10978
Rociverine: D07078
Rocuronium bromide: D00765
Scopolamine (DG00065): D00138 D02071
Sofpironium bromide: D10989
Solifenacin (DG00481): D01269 D08522
Tazomeline citrate: D06015
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535
Tiotropium bromide: D01929
Tiquizium bromide: D01875
Tofenacin hydrochloride: D06175
Tolterodine (DG00480): D00646 D01148
Toquizine: D06192
Triampyzine sulfate: D06217
Tridihexethyl (DG00037): D00723
Trihexyphenidyl (DG00851): D00787 D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397
Trospium: D01103
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181
Valethamate: D01538
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1131 (CHRM3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1131 (CHRM3)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1131 (CHRM3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1131 (CHRM3)
  09154 Digestive system
   04970 Salivary secretion
    1131 (CHRM3)
   04971 Gastric acid secretion
    1131 (CHRM3)
   04972 Pancreatic secretion
    1131 (CHRM3)
  09156 Nervous system
   04725 Cholinergic synapse
    1131 (CHRM3)
  09157 Sensory system
   04742 Taste transduction
    1131 (CHRM3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1131 (CHRM3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1131 (CHRM3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srbc
Motif
Other DBs
NCBI-GeneID: 1131
NCBI-ProteinID: NP_000731
OMIM: 118494
HGNC: 1952
Ensembl: ENSG00000133019
Vega: OTTHUMG00000039649
Pharos: P20309(Tclin)
UniProt: P20309 A0A024R3S2
Position
1q43
AA seq 590 aa AA seqDB search
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
NT seq 1773 nt NT seq  +upstreamnt  +downstreamnt
atgaccttgcacaataacagtacaacctcgcctttgtttccaaacatcagctcctcctgg
atacacagcccctccgatgcagggctgcccccgggaaccgtcactcatttcggcagctac
aatgtttctcgagcagctggcaatttctcctctccagacggtaccaccgatgaccctctg
ggaggtcataccgtctggcaagtggtcttcatcgctttcttaacgggcatcctggccttg
gtgaccatcatcggcaacatcctggtaattgtgtcatttaaggtcaacaagcagctgaag
acggtcaacaactacttcctcttaagcctggcctgtgccgatctgattatcggggtcatt
tcaatgaatctgtttacgacctacatcatcatgaatcgatgggccttagggaacttggcc
tgtgacctctggcttgccattgactacgtagccagcaatgcctctgttatgaatcttctg
gtcatcagctttgacagatacttttccatcacgaggccgctcacgtaccgagccaaacga
acaacaaagagagccggtgtgatgatcggtctggcttgggtcatctcctttgtcctttgg
gctcctgccatcttgttctggcaatactttgttggaaagagaactgtgcctccgggagag
tgcttcattcagttcctcagtgagcccaccattacttttggcacagccatcgctgctttt
tatatgcctgtcaccattatgactattttatactggaggatctataaggaaactgaaaag
cgtaccaaagagcttgctggcctgcaagcctctgggacagaggcagagacagaaaacttt
gtccaccccacgggcagttctcgaagctgcagcagttacgaacttcaacagcaaagcatg
aaacgctccaacaggaggaagtatggccgctgccacttctggttcacaaccaagagctgg
aaacccagctccgagcagatggaccaagaccacagcagcagtgacagttggaacaacaat
gatgctgctgcctccctggagaactccgcctcctccgacgaggaggacattggctccgag
acgagagccatctactccatcgtgctcaagcttccgggtcacagcaccatcctcaactcc
accaagttaccctcatcggacaacctgcaggtgcctgaggaggagctggggatggtggac
ttggagaggaaagccgacaagctgcaggcccagaagagcgtggacgatggaggcagtttt
ccaaaaagcttctccaagcttcccatccagctagagtcagccgtggacacagctaagact
tctgacgtcaactcctcagtgggtaagagcacggccactctacctctgtccttcaaggaa
gccactctggccaagaggtttgctctgaagaccagaagtcagatcactaagcggaaaagg
atgtccctggtcaaggagaagaaagcggcccagaccctcagtgcgatcttgcttgccttc
atcatcacttggaccccatacaacatcatggttctggtgaacaccttttgtgacagctgc
atacccaaaaccttttggaatctgggctactggctgtgctacatcaacagcaccgtgaac
cccgtgtgctatgctctgtgcaacaaaacattcagaaccactttcaagatgctgctgctg
tgccagtgtgacaaaaaaaagaggcgcaagcagcagtaccagcagagacagtcggtcatt
tttcacaagcgcgcacccgagcaggccttgtag

KEGG   Homo sapiens (human): 1133Help
Entry
1133              CDS       T01001                                 

Gene name
CHRM5, HM5
Definition
(RefSeq) cholinergic receptor muscarinic 5
  KO
K04133  muscarinic acetylcholine receptor M5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04810  Regulation of actin cytoskeleton
Drug target
Acetylcholine (DG01133): D00999
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113 D02069
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778 D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000
Bevonium: D01532
Biperiden (DG00852): D00779 D02246 D02247
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451
Carbachol: D00524
Carpronium (DG01289): D01175 D09752
Chlorpromazine (DG00867): D00270 D00789 D03274 D04034 D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002 D07759
Darotropium bromide: D09402
Dexetimide (DG00856): D03711 D07804
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Diphenidol (DG02880): D01318 D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Flutropium bromide: D02417
Glycopyrronium (DG02467): D10939
Heteronium bromide: D04434
Homatropine (DG01142): D01004 D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Ipratropium bromide: D02212
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720
Methacholine (DG01290): D04970
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465 D00722
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pipenzolate: D07084
Piperidolate (DG00034): D01165 D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276 D08389
Piroheptine (DG01272): D01231 D08395
Poldine: D05535
Pridinol (DG00774): D02064 D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007 D08441
Rapacuronium bromide: D05703
Revefenacin: D10978
Rocuronium bromide: D00765
Scopolamine (DG00065): D00138 D02071
Sofpironium bromide: D10989
Tazomeline citrate: D06015
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535
Tofenacin hydrochloride: D06175
Toquizine: D06192
Triampyzine sulfate: D06217
Trihexyphenidyl (DG00851): D00787 D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181
Valethamate: D01538
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1133 (CHRM5)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1133 (CHRM5)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1133 (CHRM5)
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1133 (CHRM5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1133 (CHRM5)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1133 (CHRM5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc
Motif
Other DBs
NCBI-GeneID: 1133
NCBI-ProteinID: NP_001307846
OMIM: 118496
HGNC: 1954
Ensembl: ENSG00000184984
Vega: OTTHUMG00000129369
Pharos: P08912(Tclin)
UniProt: P08912 A0A024R9I2
Position
15q14
AA seq 532 aa AA seqDB search
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
NT seq 1599 nt NT seq  +upstreamnt  +downstreamnt
atggaaggggattcttaccacaatgcaaccaccgtcaatggcaccccagtaaatcaccag
cctttggaacgccacaggttgtgggaagtcatcaccattgcagctgtgactgctgtggta
agcctgatcaccattgtgggcaatgtcttggtcatgatctccttcaaagtcaacagccag
ctcaagacagttaacaactattacctgctcagcttagcctgtgcagatctcatcattgga
atcttctccatgaacctctacaccacctacatcctcatgggacgctgggctctcgggagt
ctggcttgtgacctttggcttgcactggactacgtggccagcaacgcttctgtcatgaac
cttctggtgatcagttttgaccgttacttttccatcacaagacccttgacatatcgggcc
aagcgtactccgaaaagggctggcatcatgattggcttggcctggctgatctccttcatc
ctctgggccccagcaatcctctgctggcagtacttggttgggaagcggacagttccactg
gatgagtgccagatccagtttctctctgagcccaccatcacttttggcactgccattgct
gccttctacatccctgtttctgtcatgaccatcctctactgtcgaatctaccgggaaaca
gagaagcgaaccaaggacctggctgacctccagggttctgactctgtgaccaaagctgag
aagagaaagccagctcatagggctctgttcagatcctgcttgcgctgtcctcgacccacc
ctggcccagcgggaaaggaaccaggcctcctggtcatcctcccgcaggagcacctccacc
actgggaagccatcccaagccactggcccaagcgccaattgggccaaagctgagcagctc
accacctgtagcagctacccttcctcagaggatgaggacaagcccgccactgaccctgtc
ctccaagtggtctacaagagtcagggtaaggaaagcccaggggaagaattcagtgctgaa
gagactgaggaaacttttgtgaaagctgaaactgaaaaaagtgactatgacaccccaaac
taccttctgtctccagcagctgctcatagacccaagagtcagaaatgtgtggcctataag
ttccgattggtggtaaaagctgacgggaaccaggagaccaacaatggctgtcacaaggtg
aaaatcatgccctgccccttcccagtggccaaggaaccttcaacgaaaggcctcaatccc
aaccccagccatcaaatgaccaaacgaaagagagtggtcctagtcaaagagaggaaagca
gcccagacactgagtgccattctcctggccttcatcatcacatggaccccgtataacatc
atggtcctggtttctaccttctgtgacaagtgtgtcccagtcaccctgtggcacttgggc
tattggttgtgctatgtcaatagcactgtcaaccccatctgctatgccctctgcaacaga
accttcaggaagacctttaagatgctgcttctctgccgatggaaaaagaaaaaagtggaa
gagaagttgtactggcaggggaacagcaagctaccctga

KEGG   Homo sapiens (human): 135Help
Entry
135               CDS       T01001                                 

Gene name
ADORA2A, A2aR, ADORA2, RDC8
Definition
(RefSeq) adenosine A2a receptor
  KO
K04266  adenosine receptor A2a
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa05012  Parkinson disease
hsa05034  Alcoholism
Drug target
Adenosine (DG00243): D00045 D02300 D02769 D08646 D08647
Apadenoson: D03212
Binodenoson: D03120
Caffeine (DG00974): D00528 D01453 D07603
Choline theophyllinate: D02017
Ciforadenant: D11547
Doxofylline: D03898
Enprofylline: D04006
Evodenoson: D10362
Istradefylline: D04641
Preladenant: D09717
Proxyphylline: D01771
Regadenoson: D05711
Sonedenoson: D09003
Tozadenant: D10174
Vipadenant: D09991
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    135 (ADORA2A)
   04020 Calcium signaling pathway
    135 (ADORA2A)
   04024 cAMP signaling pathway
    135 (ADORA2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    135 (ADORA2A)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    135 (ADORA2A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    135 (ADORA2A)
  09165 Substance dependence
   05034 Alcoholism
    135 (ADORA2A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    135 (ADORA2A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Base and nucleoside
   Adenosine
    135 (ADORA2A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx GPR_Gpa2_C Ni_hydr_CYTB
Motif
Other DBs
NCBI-GeneID: 135
NCBI-ProteinID: NP_000666
OMIM: 102776
HGNC: 263
Ensembl: ENSG00000128271
Vega: OTTHUMG00000150761
Pharos: P29274(Tclin)
UniProt: P29274 B3KVQ4 X5DNB4
Structure
PDB: 

Position
22q11.23
AA seq 412 aa AA seqDB search
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
NT seq 1239 nt NT seq  +upstreamnt  +downstreamnt
atgcccatcatgggctcctcggtgtacatcacggtggagctggccattgctgtgctggcc
atcctgggcaatgtgctggtgtgctgggccgtgtggctcaacagcaacctgcagaacgtc
accaactactttgtggtgtcactggcggcggccgacatcgcagtgggtgtgctcgccatc
ccctttgccatcaccatcagcaccgggttctgcgctgcctgccacggctgcctcttcatt
gcctgcttcgtcctggtcctcacgcagagctccatcttcagtctcctggccatcgccatt
gaccgctacattgccatccgcatcccgctccggtacaatggcttggtgaccggcacgagg
gctaagggcatcattgccatctgctgggtgctgtcgtttgccatcggcctgactcccatg
ctaggttggaacaactgcggtcagccaaaggagggcaagaaccactcccagggctgcggg
gagggccaagtggcctgtctctttgaggatgtggtccccatgaactacatggtgtacttc
aacttctttgcctgtgtgctggtgcccctgctgctcatgctgggtgtctatttgcggatc
ttcctggcggcgcgacgacagctgaagcagatggagagccagcctctgccgggggagcgg
gcacggtccacactgcagaaggaggtccatgctgccaagtcactggccatcattgtgggg
ctctttgccctctgctggctgcccctacacatcatcaactgcttcactttcttctgcccc
gactgcagccacgcccctctctggctcatgtacctggccatcgtcctctcccacaccaat
tcggttgtgaatcccttcatctacgcctaccgtatccgcgagttccgccagaccttccgc
aagatcattcgcagccacgtcctgaggcagcaagaacctttcaaggcagctggcaccagt
gcccgggtcttggcagctcatggcagtgacggagagcaggtcagcctccgtctcaacggc
cacccgccaggagtgtgggccaacggcagtgctccccaccctgagcggaggcccaatggc
tatgccctggggctggtgagtggagggagtgcccaagagtcccaggggaacacgggcctc
ccagacgtggagctccttagccatgagctcaagggagtgtgcccagagccccctggccta
gatgaccccctggcccaggatggagcaggagtgtcctga

KEGG   Homo sapiens (human): 136Help
Entry
136               CDS       T01001                                 

Gene name
ADORA2B, ADORA2
Definition
(RefSeq) adenosine A2b receptor
  KO
K04267  adenosine receptor A2b
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa05034  Alcoholism
Drug target
Adenosine (DG00243): D00045 D02300 D02769 D08646 D08647
Aminophylline (DG01062): D00227 D05429 D11630
Diprophylline: D00691
Enprofylline: D04006
Proxyphylline: D01771
Theophylline (DG01061): D00371 D01712 D06103 D06104
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    136 (ADORA2B)
   04020 Calcium signaling pathway
    136 (ADORA2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    136 (ADORA2B)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    136 (ADORA2B)
 09160 Human Diseases
  09165 Substance dependence
   05034 Alcoholism
    136 (ADORA2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    136 (ADORA2B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Base and nucleoside
   Adenosine
    136 (ADORA2B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx GPR_Gpa2_C 7TM_GPCR_Sri
Motif
Other DBs
NCBI-GeneID: 136
NCBI-ProteinID: NP_000667
OMIM: 600446
HGNC: 264
Ensembl: ENSG00000170425
Vega: OTTHUMG00000059140
Pharos: P29275(Tclin)
UniProt: P29275
Position
17p12
AA seq 332 aa AA seqDB search
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
NT seq 999 nt NT seq  +upstreamnt  +downstreamnt
atgctgctggagacacaggacgcgctgtacgtggcgctggagctggtcatcgccgcgctt
tcggtggcgggcaacgtgctggtgtgcgccgcggtgggcacggcgaacactctgcagacg
cccaccaactacttcctggtgtccctggctgcggccgacgtggccgtggggctcttcgcc
atcccctttgccatcaccatcagcctgggcttctgcactgacttctacggctgcctcttc
ctcgcctgcttcgtgctggtgctcacgcagagctccatcttcagccttctggccgtggca
gtcgacagatacctggccatctgtgtcccgctcaggtataaaagtttggtcacggggacc
cgagcaagaggggtcattgctgtcctctgggtccttgcctttggcatcggattgactcca
ttcctggggtggaacagtaaagacagtgccaccaacaactgcacagaaccctgggatgga
accacgaatgaaagctgctgccttgtgaagtgtctctttgagaatgtggtccccatgagc
tacatggtatatttcaatttctttgggtgtgttctgcccccactgcttataatgctggtg
atctacattaagatcttcctggtggcctgcaggcagcttcagcgcactgagctgatggac
cactcgaggaccaccctccagcgggagatccatgcagccaagtcactggccatgattgtg
gggatttttgccctgtgctggttacctgtgcatgctgttaactgtgtcactcttttccag
ccagctcagggtaaaaataagcccaagtgggcaatgaatatggccattcttctgtcacat
gccaattcagttgtcaatcccattgtctatgcttaccggaaccgagacttccgctacact
tttcacaaaattatctccaggtatcttctctgccaagcagatgtcaagagtgggaatggt
caggctggggtacagcctgctctcggtgtgggcctatga

KEGG   Homo sapiens (human): 153Help
Entry
153               CDS       T01001                                 

Gene name
ADRB1, ADRB1R, B1AR, BETA1AR, RHR
Definition
(RefSeq) adrenoceptor beta 1
  KO
K04141  adrenergic receptor beta-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
hsa04923  Regulation of lipolysis in adipocytes
hsa04924  Renin secretion
hsa04970  Salivary secretion
hsa05414  Dilated cardiomyopathy (DCM)
Drug target
Acebutolol (DG00314): D00597 D02338
Adaprolol maleate: D02765
Alprenolol (DG00303): D01182 D07156
Alprenoxime hydrochloride: D02834
Amiodarone (DG00204): D00636 D02910
Amosulalol (DG01302): D01469 D07451
Arbutamine: D02976
Arotinolol (DG01303): D01830 D07465
Atenolol: D00235
Befunolol (DG01138): D01512 D07496
Beradilol monoethyl maleate: D09843
Betaxolol (DG00315): D00598 D07526
Bevantolol: D01369
Bisoprolol (DG00316): D00634 D02342
Bopindolol (DG00310): D01794 D07537
Bucumolol hydrochloride: D01492
Bufetolol hydrochloride: D01504
Bunitrolol hydrochloride: D01444
Bunolol hydrochloride: D03177
Bupranolol (DG00311): D01454 D07590
Butopamine: D03195
Carteolol (DG00308): D00599 D07624
Carvedilol (DG00321): D00255 D03415
Celiprolol (DG00317): D01741 D07660
Cetamolol hydrochloride: D03449
Cicloprolol hydrochloride: D03490
Cimaterol: D03502
Cloranolol: D07183
Denopamine: D02614
Dexpropranolol hydrochloride: D03729
Diacetolol hydrochloride: D03759
Dilevalol hydrochloride: D01906
Dipivefrine (DG01129): D01017 D02349
Dobutamine (DG00216): D00632 D03879 D03880 D03881
Docarpamine: D01903
Dronedarone (DG00207): D02537 D03914
Droxidopa: D01277
Epanolol: D06646
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Esmolol (DG00318): D00644 D07916
Etilefrine (DG00210): D01573 D07931
Exaprolol hydrochloride: D04120
Flestolol sulfate: D04190
Indenolol (DG01323): D01958 D08078
Isoprenaline (DG00211): D01390 D02066 D02150 D08090
Labetalol (DG00320): D00600 D08106
Landiolol: D01847
Levdobutamine lactobionate: D04708
Levobetaxolol hydrochloride: D04710
Levobunolol (DG01136): D01025 D08115
Medroxalol (DG01317): D04888 D04889
Mepindolol: D07181
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Metipranolol (DG01137): D02081 D02374
Metoprolol (DG00313): D00601 D00635 D02358 D05011
Nadolol: D00432
Nebivolol (DG00319): D05127 D06622
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Oxprenolol (DG00304): D01806 D08318
Pamatolol sulfate: D05345
Penbutolol (DG00312): D00602 D08074
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Pindolol: D00513
Practolol: D05587
Primidolol: D02389
Propranolol (DG00305): D00483 D08443
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
S-atenolol: D01471
Sotalol (DG00307): D01026 D08525
Talinolol: D07184
Tazolol hydrochloride: D06014
Tertatolol (DG00309): D07182 D08572
Tilisolol (DG01322): D01795 D08598
Timolol (DG00306): D00378 D00603 D08600
Tiprenolol hydrochloride: D06162
Tolamolol: D06176
Xamoterol (DG00231): D06328 D06329
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    153 (ADRB1)
   04024 cAMP signaling pathway
    153 (ADRB1)
   04022 cGMP-PKG signaling pathway
    153 (ADRB1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    153 (ADRB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    153 (ADRB1)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    153 (ADRB1)
   04924 Renin secretion
    153 (ADRB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    153 (ADRB1)
  09154 Digestive system
   04970 Salivary secretion
    153 (ADRB1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    153 (ADRB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    153 (ADRB1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    153 (ADRB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4
Motif
Other DBs
NCBI-GeneID: 153
NCBI-ProteinID: NP_000675
OMIM: 109630
HGNC: 285
Ensembl: ENSG00000043591
Vega: OTTHUMG00000019079
Pharos: P08588(Tclin)
UniProt: P08588
Position
10q25.3
AA seq 477 aa AA seqDB search
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
NT seq 1434 nt NT seq  +upstreamnt  +downstreamnt
atgggcgcgggggtgctcgtcctgggcgcctccgagcccggtaacctgtcgtcggccgca
ccgctccccgacggcgcggccaccgcggcgcggctgctggtgcccgcgtcgccgcccgcc
tcgttgctgcctcccgccagcgaaagccccgagccgctgtctcagcagtggacagcgggc
atgggtctgctgatggcgctcatcgtgctgctcatcgtggcgggcaatgtgctggtgatc
gtggccatcgccaagacgccgcggctgcagacgctcaccaacctcttcatcatgtccctg
gccagcgccgacctggtcatggggctgctggtggtgccgttcggggccaccatcgtggtg
tggggccgctgggagtacggctccttcttctgcgagctgtggacctcagtggacgtgctg
tgcgtgacggccagcatcgagaccctgtgtgtcattgccctggaccgctacctcgccatc
acctcgcccttccgctaccagagcctgctgacgcgcgcgcgggcgcggggcctcgtgtgc
accgtgtgggccatctcggccctggtgtccttcctgcccatcctcatgcactggtggcgg
gcggagagcgacgaggcgcgccgctgctacaacgaccccaagtgctgcgacttcgtcacc
aaccgggcctacgccatcgcctcgtccgtagtctccttctacgtgcccctgtgcatcatg
gccttcgtgtacctgcgggtgttccgcgaggcccagaagcaggtgaagaagatcgacagc
tgcgagcgccgtttcctcggcggcccagcgcggccgccctcgccctcgccctcgcccgtc
cccgcgcccgcgccgccgcccggacccccgcgccccgccgccgccgccgccaccgccccg
ctggccaacgggcgtgcgggtaagcggcggccctcgcgcctcgtggccctgcgcgagcag
aaggcgctcaagacgctgggcatcatcatgggcgtcttcacgctctgctggctgcccttc
ttcctggccaacgtggtgaaggccttccaccgcgagctggtgcccgaccgcctcttcgtc
ttcttcaactggctgggctacgccaactcggccttcaaccccatcatctactgccgcagc
cccgacttccgcaaggccttccagggactgctctgctgcgcgcgcagggctgcccgccgg
cgccacgcgacccacggagaccggccgcgcgcctcgggctgtctggcccggcccggaccc
ccgccatcgcccggggccgcctcggacgacgacgacgacgatgtcgtcggggccacgccg
cccgcgcgcctgctggagccctgggccggctgcaacggcggggcggcggcggacagcgac
tcgagcctggacgagccgtgccgccccggcttcgcctcggaatccaaggtgtag

KEGG   Homo sapiens (human): 154Help
Entry
154               CDS       T01001                                 

Gene name
ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Definition
(RefSeq) adrenoceptor beta 2
  KO
K04142  adrenergic receptor beta-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04923  Regulation of lipolysis in adipocytes
hsa04924  Renin secretion
hsa04970  Salivary secretion
Disease
H00079  Asthma
H02106  Genetic obesity
Drug target
Abediterol (DG01232): D10219 D10220
Adaprolol maleate: D02765
Alprenolol (DG00303): D01182 D07156
Alprenoxime hydrochloride: D02834
Amosulalol (DG01302): D01469 D07451
Arformoterol (DG01233): D02981 D07463
Arotinolol (DG01303): D01830 D07465
Bambuterol (DG01060): D07377 D07489
Batefenterol (DG01627): D10545 D10546
Bedoradrine sulfate: D06562
Befunolol (DG01138): D01512 D07496
Beradilol monoethyl maleate: D09843
Bitolterol (DG01056): D00684 D07534
Bopindolol (DG00310): D01794 D07537
Bucindolol hydrochloride: D03170
Bucumolol hydrochloride: D01492
Bufetolol hydrochloride: D01504
Bunitrolol hydrochloride: D01444
Bunolol hydrochloride: D03177
Bupranolol (DG00311): D01454 D07590
Butoxamine hydrochloride: D03198
Carazolol: D07608
Carbuterol: D03402
Carteolol (DG00308): D00599 D07624
Carvedilol (DG00321): D00255 D03415
Cimaterol: D03502
Clenbuterol (DG01053): D01360 D07713
Cloranolol: D07183
Clorprenaline hydrochloride: D01835
Colterol mesylate: D03587
Dexpropranolol hydrochloride: D03729
Diacetolol hydrochloride: D03759
Dilevalol hydrochloride: D01906
Dipivefrine (DG01129): D01017 D02349
Dopexamine (DG00222): D03891 D03892
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Etafedrine hydrochloride: D04072
Etilefrine (DG00210): D01573 D07931
Exaprolol hydrochloride: D04120
Fenoterol (DG00451): D01428 D04157
Flestolol sulfate: D04190
Formoterol (DG01052): D01373 D05277 D07990
Hexoprenaline (DG01047): D02396 D08039
Indacaterol (DG01057): D09318 D09319 D11009
Indenolol (DG01323): D01958 D08078
Isoetarine (DG01234): D02093 D04625 D04626
Isoprenaline (DG00211): D01390 D02066 D02150 D08090
Isoxsuprine (DG00277): D01748 D08092 D08093
Labetalol (DG00320): D00600 D08106
Levalbuterol  
Levosalbutamol (DG01235): D02281 D04701 D04703 D08124
Levobunolol (DG01136): D01025 D08115
Mabuterol hydrochloride: D01589
Medroxalol (DG01317): D04888 D04889
Mepindolol: D07181
Metalol hydrochloride: D04953
Methoxyphenamine: D01635
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Metipranolol (DG01137): D02081 D02374
Milveterol hydrochloride: D08945
Nadolol: D00432
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Olodaterol (DG01058): D10020 D10145
Orciprenaline (DG01044): D00685 D04954 D08300
Oxprenolol (DG00304): D01806 D08318
Pamatolol sulfate: D05345
Penbutolol (DG00312): D00602 D08074
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Picumeterol fumarate: D05476
Pindolol: D00513
Pirbuterol (DG01048): D00686 D01349 D08387
Primidolol: D02389
Procaterol (DG01055): D02404 D05366 D08424
Propranolol (DG00305): D00483 D08443
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Ractopamine hydrochloride: D05691
Reproterol (DG01054): D05718 D08474
Rimiterol: D05730
Ritodrine (DG00450): D01263 D02359
Salbutamol (DG01045): D00683 D02147
Salmeterol (DG01051): D00687 D05792
Sibenadet hydrochloride: D05832
Sotalol (DG00307): D01026 D08525
Soterenol hydrochloride: D05902
Talinolol: D07184
Tazolol hydrochloride: D06014
Terbutaline (DG01046): D00688 D08570
Tertatolol (DG00309): D07182 D08572
Tilisolol (DG01322): D01795 D08598
Timolol (DG00306): D00378 D00603 D08600
Tiprenolol hydrochloride: D06162
Tolamolol: D06176
Tretoquinol (DG01049): D01978 D05037 D08629
Tulobuterol (DG01050): D01362 D02151
Vilanterol (DG01236): D09696 D09697
Zinterol hydrochloride: D06374
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    154 (ADRB2)
   04024 cAMP signaling pathway
    154 (ADRB2)
   04022 cGMP-PKG signaling pathway
    154 (ADRB2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    154 (ADRB2)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    154 (ADRB2)
   04924 Renin secretion
    154 (ADRB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    154 (ADRB2)
  09154 Digestive system
   04970 Salivary secretion
    154 (ADRB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    154 (ADRB2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    154 (ADRB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srv
Motif
Other DBs
NCBI-GeneID: 154
NCBI-ProteinID: NP_000015
OMIM: 109690
HGNC: 286
Ensembl: ENSG00000169252
Vega: OTTHUMG00000129933
Pharos: P07550(Tclin)
UniProt: P07550
Structure
PDB: 

Position
5q32
AA seq 413 aa AA seqDB search
MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
NT seq 1242 nt NT seq  +upstreamnt  +downstreamnt
atggggcaacccgggaacggcagcgccttcttgctggcacccaatagaagccatgcgccg
gaccacgacgtcacgcagcaaagggacgaggtgtgggtggtgggcatgggcatcgtcatg
tctctcatcgtcctggccatcgtgtttggcaatgtgctggtcatcacagccattgccaag
ttcgagcgtctgcagacggtcaccaactacttcatcacttcactggcctgtgctgatctg
gtcatgggcctggcagtggtgccctttggggccgcccatattcttatgaaaatgtggact
tttggcaacttctggtgcgagttttggacttccattgatgtgctgtgcgtcacggccagc
attgagaccctgtgcgtgatcgcagtggatcgctactttgccattacttcacctttcaag
taccagagcctgctgaccaagaataaggcccgggtgatcattctgatggtgtggattgtg
tcaggccttacctccttcttgcccattcagatgcactggtaccgggccacccaccaggaa
gccatcaactgctatgccaatgagacctgctgtgacttcttcacgaaccaagcctatgcc
attgcctcttccatcgtgtccttctacgttcccctggtgatcatggtcttcgtctactcc
agggtctttcaggaggccaaaaggcagctccagaagattgacaaatctgagggccgcttc
catgtccagaaccttagccaggtggagcaggatgggcggacggggcatggactccgcaga
tcttccaagttctgcttgaaggagcacaaagccctcaagacgttaggcatcatcatgggc
actttcaccctctgctggctgcccttcttcatcgttaacattgtgcatgtgatccaggat
aacctcatccgtaaggaagtttacatcctcctaaattggataggctatgtcaattctggt
ttcaatccccttatctactgccggagcccagatttcaggattgccttccaggagcttctg
tgcctgcgcaggtcttctttgaaggcctatgggaatggctactccagcaacggcaacaca
ggggagcagagtggatatcacgtggaacaggagaaagaaaataaactgctgtgtgaagac
ctcccaggcacggaagactttgtgggccatcaaggtactgtgcctagcgataacattgat
tcacaagggaggaattgtagtacaaatgactcactgctgtaa

KEGG   Homo sapiens (human): 155Help
Entry
155               CDS       T01001                                 

Gene name
ADRB3, BETA3AR
Definition
(RefSeq) adrenoceptor beta 3
  KO
K04143  adrenergic receptor beta-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04714  Thermogenesis
hsa04923  Regulation of lipolysis in adipocytes
hsa04924  Renin secretion
hsa04970  Salivary secretion
Disease
H02106  Genetic obesity
Drug target
Adaprolol maleate: D02765
Alprenolol (DG00303): D01182 D07156
Alprenoxime hydrochloride: D02834
Amibegron (DG01237): D08850 D08851
Befunolol (DG01138): D01512 D07496
Beradilol monoethyl maleate: D09843
Bopindolol (DG00310): D01794 D07537
Bufetolol hydrochloride: D01504
Bunitrolol hydrochloride: D01444
Bunolol hydrochloride: D03177
Bupranolol (DG00311): D01454 D07590
Carteolol (DG00308): D00599 D07624
Cimaterol: D03502
Cloranolol: D07183
Dexpropranolol hydrochloride: D03729
Diacetolol hydrochloride: D03759
Dilevalol hydrochloride: D01906
Dipivefrine (DG01129): D01017 D02349
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Etilefrine (DG00210): D01573 D07931
Exaprolol hydrochloride: D04120
Fasobegron: D09344
Flestolol sulfate: D04190
Isoprenaline (DG00211): D01390 D02066 D02150 D08090
Levobunolol (DG01136): D01025 D08115
Medroxalol (DG01317): D04888 D04889
Mepindolol: D07181
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Metipranolol (DG01137): D02081 D02374
Mirabegron: D09535
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Oxprenolol (DG00304): D01806 D08318
Pamatolol sulfate: D05345
Penbutolol (DG00312): D00602 D08074
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Pindolol: D00513
Primidolol: D02389
Propranolol (DG00305): D00483 D08443
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Ritobegron ethyl hydrochloride: D09732
Solabegron hydrochloride: D05879
Talibegron hydrochloride: D02702
Talinolol: D07184
Tazolol hydrochloride: D06014
Tertatolol (DG00309): D07182 D08572
Tilisolol (DG01322): D01795 D08598
Tiprenolol hydrochloride: D06162
Tolamolol: D06176
Vibegron: D10433
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    155 (ADRB3)
   04022 cGMP-PKG signaling pathway
    155 (ADRB3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    155 (ADRB3)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    155 (ADRB3)
   04924 Renin secretion
    155 (ADRB3)
  09154 Digestive system
   04970 Salivary secretion
    155 (ADRB3)
  09159 Environmental adaptation
   04714 Thermogenesis
    155 (ADRB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    155 (ADRB3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    155 (ADRB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srv
Motif
Other DBs
NCBI-GeneID: 155
NCBI-ProteinID: NP_000016
OMIM: 109691
HGNC: 288
Ensembl: ENSG00000188778
Vega: OTTHUMG00000164028
Pharos: P13945(Tclin)
UniProt: P13945 A8KAG8
Position
8p11.23
AA seq 408 aa AA seqDB search
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
NT seq 1227 nt NT seq  +upstreamnt  +downstreamnt
atggctccgtggcctcacgagaacagctctcttgccccatggccggacctccccaccctg
gcgcccaataccgccaacaccagtgggctgccaggggttccgtgggaggcggccctagcc
ggggccctgctggcgctggcggtgctggccaccgtgggaggcaacctgctggtcatcgtg
gccatcgcctggactccgagactccagaccatgaccaacgtgttcgtgacttcgctggcc
gcagccgacctggtgatgggactcctggtggtgccgccggcggccaccttggcgctgact
ggccactggccgttgggcgccactggctgcgagctgtggacctcggtggacgtgctgtgt
gtgaccgccagcatcgaaaccctgtgcgccctggccgtggaccgctacctggctgtgacc
aacccgctgcgttacggcgcactggtcaccaagcgctgcgcccggacagctgtggtcctg
gtgtgggtcgtgtcggccgcggtgtcgtttgcgcccatcatgagccagtggtggcgcgta
ggggccgacgccgaggcgcagcgctgccactccaacccgcgctgctgtgccttcgcctcc
aacatgccctacgtgctgctgtcctcctccgtctccttctaccttcctcttctcgtgatg
ctcttcgtctacgcgcgggttttcgtggtggctacgcgccagctgcgcttgctgcgcggg
gagctgggccgctttccgcccgaggagtctccgccggcgccgtcgcgctctctggccccg
gccccggtggggacgtgcgctccgcccgaaggggtgcccgcctgcggccggcggcccgcg
cgcctcctgcctctccgggaacaccgggccctgtgcaccttgggtctcatcatgggcacc
ttcactctctgctggttgcccttctttctggccaacgtgctgcgcgccctggggggcccc
tctctagtcccgggcccggctttccttgccctgaactggctaggttatgccaattctgcc
ttcaacccgctcatctactgccgcagcccggactttcgcagcgccttccgccgtcttctg
tgccgctgcggccgtcgcctgcctccggagccctgcgccgccgcccgcccggccctcttc
ccctcgggcgttcctgcggcccggagcagcccagcgcagcccaggctttgccaacggctc
gacggggcttcttggggagtttcttag

KEGG   Homo sapiens (human): 1812Help
Entry
1812              CDS       T01001                                 

Gene name
DRD1, DADR, DRD1A
Definition
(RefSeq) dopamine receptor D1
  KO
K04144  dopamine receptor D1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05032  Morphine addiction
hsa05034  Alcoholism
Network
nt06124  Chemokine signaling (viruses)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00410  DRD1-GNAS-AC-PKA signaling pathway
Drug target
Acepromazine (DG00870): D02604 D07065
Acetophenazine (DG00878): D00788
Adrogolide hydrochloride: D02775
Apomorphine (DG00486): D02004 D07460
Butaclamol hydrochloride: D02641
Carphenazine maleate: D02644
Chlorprothixene (DG00894): D00790 D02162 D07686 D07687
Ciladopa hydrochloride: D03494
Clopenthixol: D02613
Dexpramipexole (DG01331): D09886 D09887
Docarpamine: D01903
Dopamine (DG00213): D00633 D07870
Dopexamine (DG00222): D03891 D03892
Ecopipam hydrochloride: D03937
Etilevodopa: D04097
Fenoldopam (DG00226): D00613 D07946
Flupentixol (DG00893): D01044 D02236 D07976
Ibopamine (DG00223): D04488 D08057
Levodopa: D00059
Oxiperomide: D02676
Pergolide (DG00861): D00502 D08339
Pipotiazine (DG00884): D02680 D08385
Tavapadon: D11431
Tiotixene (DG00895): D00374 D02612
Zicronapine (DG01539): D10329 D10495
Zuclopenthixol (DG00896): D03556 D08691 D08692 D08693
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1812 (DRD1)
   04024 cAMP signaling pathway
    1812 (DRD1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1812 (DRD1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    1812 (DRD1)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    1812 (DRD1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    1812 (DRD1)
  09165 Substance dependence
   05030 Cocaine addiction
    1812 (DRD1)
   05031 Amphetamine addiction
    1812 (DRD1)
   05032 Morphine addiction
    1812 (DRD1)
   05034 Alcoholism
    1812 (DRD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1812 (DRD1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Dopamine
    1812 (DRD1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 1812
NCBI-ProteinID: NP_000785
OMIM: 126449
HGNC: 3020
Ensembl: ENSG00000184845
Vega: OTTHUMG00000130557
Pharos: P21728(Tclin)
UniProt: P21728
Position
5q35.2
AA seq 446 aa AA seqDB search
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
NT seq 1341 nt NT seq  +upstreamnt  +downstreamnt
atgaggactctgaacacctctgccatggacgggactgggctggtggtggagagggacttc
tctgttcgtatcctcactgcctgtttcctgtcgctgctcatcctgtccacgctcctgggg
aacacgctggtctgtgctgccgttatcaggttccgacacctgcggtccaaggtgaccaac
ttctttgtcatctccttggctgtgtcagatctcttggtggccgtcctggtcatgccctgg
aaggcagtggctgagattgctggcttctggccctttgggtccttctgtaacatctgggtg
gcctttgacatcatgtgctccactgcatccatcctcaacctctgtgtgatcagcgtggac
aggtattgggctatctccagccctttccggtatgagagaaagatgacccccaaggcagcc
ttcatcctgatcagtgtggcatggaccttgtctgtactcatctccttcatcccagtgcag
ctcagctggcacaaggcaaaacccacaagcccctctgatggaaatgccacttccctggct
gagaccatagacaactgtgactccagcctcagcaggacatatgccatctcatcctctgta
ataagcttttacatccctgtggccatcatgattgtcacctacaccaggatctacaggatt
gctcagaaacaaatacggcgcattgcggccttggagagggcagcagtccacgccaagaat
tgccagaccaccacaggtaatggaaagcctgtcgaatgttctcaaccggaaagttctttt
aagatgtccttcaaaagagaaactaaagtcctgaagactctgtcggtgatcatgggtgtg
tttgtgtgctgttggctacctttcttcatcttgaactgcattttgcccttctgtgggtct
ggggagacgcagcccttctgcattgattccaacacctttgacgtgtttgtgtggtttggg
tgggctaattcatccttgaaccccatcatttatgcctttaatgctgattttcggaaggca
ttttcaaccctcttaggatgctacagactttgccctgcgacgaataatgccatagagacg
gtgagtatcaataacaatggggccgcgatgttttccagccatcatgagccacgaggctcc
atctccaaggagtgcaatctggtttacctgatcccacatgctgtgggctcctctgaggac
ctgaaaaaggaggaggcagctggcatcgccagacccttggagaagctgtccccagcccta
tcagtcatattggactatgacactgacgtctctctggagaagatccaacccatcacacaa
aacggtcagcacccaacctga

KEGG   Homo sapiens (human): 1816Help
Entry
1816              CDS       T01001                                 

Gene name
DRD5, DBDR, DRD1B, DRD1L2
Definition
(RefSeq) dopamine receptor D5
  KO
K05840  dopamine receptor D5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Disease
H01895  Attention deficit hyperactivity disorder (ADHD)
Drug target
Dexpramipexole (DG01331): D09886 D09887
Dopamine (DG00213): D00633 D07870
Dopexamine (DG00222): D03891 D03892
Ecopipam hydrochloride: D03937
Etilevodopa: D04097
Levodopa: D00059
Oxiperomide: D02676
Tavapadon: D11431
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1816 (DRD5)
   04024 cAMP signaling pathway
    1816 (DRD5)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1816 (DRD5)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    1816 (DRD5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1816 (DRD5)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Dopamine
    1816 (DRD5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 1816
NCBI-ProteinID: NP_000789
OMIM: 126453
HGNC: 3026
Ensembl: ENSG00000169676
Vega: OTTHUMG00000128489
Pharos: P21918(Tchem)
UniProt: P21918
Position
4p16.1
AA seq 477 aa AA seqDB search
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
NT seq 1434 nt NT seq  +upstreamnt  +downstreamnt
atgctgccgccaggcagcaacggcaccgcgtacccggggcagttcgctctataccagcag
ctggcgcaggggaacgccgtggggggctcggcgggggcaccgccactggggccctcacag
gtggtcaccgcctgcctgctgaccctactcatcatctggaccctgctgggcaacgtgctg
gtgtgcgcagccatcgtgcggagccgccacctgcgcgccaacatgaccaacgtcttcatc
gtgtctctggccgtgtcagaccttttcgtggcgctgctggtcatgccctggaaggcagtc
gccgaggtggccggttactggccctttggagcgttctgcgacgtctgggtggccttcgac
atcatgtgctccactgcctccatcctgaacctgtgcgtcatcagcgtggaccgctactgg
gccatctccaggcccttccgctacaagcgcaagatgactcagcgcatggccttggtcatg
gtcggcctggcatggaccttgtccatcctcatctccttcattccggtccagctcaactgg
cacagggaccaggcggcctcttggggcgggctggacctgccaaacaacctggccaactgg
acgccctgggaggaggacttttgggagcccgacgtgaatgcagagaactgtgactccagc
ctgaatcgaacctacgccatctcttcctcgctcatcagcttctacatccccgttgccatc
atgatcgtgacctacacgcgcatctaccgcatcgcccaggtgcagatccgcaggatttcc
tccctggagagggccgcagagcacgcgcagagctgccggagcagcgcagcctgcgcgccc
gacaccagcctgcgcgcttccatcaagaaggagaccaaggttctcaagaccctgtcggtg
atcatgggggtcttcgtgtgttgctggctgcccttcttcatccttaactgcatggtccct
ttctgcagtggacaccccgaaggccctccggccggcttcccctgcgtcagtgagaccacc
ttcgacgtcttcgtctggttcggctgggctaactcctcactcaaccccgtcatctatgcc
ttcaacgccgactttcagaaggtgtttgcccagctgctggggtgcagccacttctgctcc
cgcacgccggtggagacggtgaacatcagcaatgagctcatctcctacaaccaagacatc
gtcttccacaaggaaatcgcagctgcctacatccacatgatgcccaacgccgttaccccc
ggcaaccgggaggtggacaacgacgaggaggagggtcctttcgatcgcatgttccagatc
tatcagacgtccccagatggtgaccctgttgctgagtctgtctgggagctggactgcgag
ggggagatttctttagacaaaataacacctttcaccccgaatggattccattaa

KEGG   Homo sapiens (human): 3274Help
Entry
3274              CDS       T01001                                 

Gene name
HRH2, H2R, HH2R
Definition
(RefSeq) histamine receptor H2
  KO
K04150  histamine receptor H2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Drug target
Betazole: D01187
Cimetidine (DG00017): D00295 D03503
Dalcotidine: D01698
Donetidine: D03889
Etintidine hydrochloride: D04098
Famotidine: D00318
Histamine: D08040
Histamine phosphate: D04445
Icotidine: D04494
Impromidine hydrochloride: D04517
Lafutidine: D01131
Lavoltidine succinate: D04680
Lupitidine hydrochloride: D04794
Methantheline (DG00036): D00721
Metiamide: D05004
Niperotidine: D07072
Nizatidine: D00440
Osutidine: D01193
Oxmetidine (DG01225): D05306 D05307
Pibutidine hydrochloride: D01861
Ranitidine (DG00018): D00422 D00673
Ranitidine bismuth citrate: D05699
Roxatidine (DG00019): D01467 D08494 D08495
Sufotidine: D05939
Tiotidine: D06157
Zaltidine hydrochloride: D06355
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3274 (HRH2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3274 (HRH2)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    3274 (HRH2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3274 (HRH2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Histamine
    3274 (HRH2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4
Motif
Other DBs
NCBI-GeneID: 3274
NCBI-ProteinID: NP_001124527
OMIM: 142703
HGNC: 5183
Ensembl: ENSG00000113749
Vega: OTTHUMG00000130660
Pharos: P25021(Tclin)
UniProt: P25021
Position
5q35.2
AA seq 397 aa AA seqDB search
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
NT seq 1194 nt NT seq  +upstreamnt  +downstreamnt
atggcacccaatggcacagcctcttccttttgcctggactctaccgcatgcaagatcacc
atcaccgtggtccttgcggtcctcatcctcatcaccgttgctggcaatgtggtcgtctgt
ctggccgtgggcttgaaccgccggctccgcaacctgaccaattgtttcatcgtgtccttg
gctatcactgacctgctcctcggcctcctggtgctgcccttctctgccatctaccagctg
tcctgcaagtggagctttggcaaggtcttctgcaatatctacaccagcctggatgtgatg
ctctgcacagcctccattcttaacctcttcatgatcagcctcgaccggtactgcgctgtc
atggacccactgcggtaccctgtgctggtcaccccagttcgggtcgccatctctctggtc
ttaatttgggtcatctccattaccctgtcctttctgtctatccacctggggtggaacagc
aggaacgagaccagcaagggcaatcataccacctctaagtgcaaagtccaggtcaatgaa
gtgtacgggctggtggatgggctggtcaccttctacctcccgctactgatcatgtgcatc
acctactaccgcatcttcaaggtcgcccgggatcaggccaagaggatcaatcacattagc
tcctggaaggcagccaccatcagggagcacaaagccacagtgacactggccgccgtcatg
ggggccttcatcatctgctggtttccctacttcaccgcgtttgtgtaccgtgggctgaga
ggggatgatgccatcaatgaggtgttagaagccatcgttctgtggctgggctatgccaac
tcagccctgaaccccatcctgtatgctgcgctgaacagagacttccgcaccgggtaccaa
cagctcttctgctgcaggctggccaaccgcaactcccacaaaacttctctgaggtccaac
gcctctcagctgtccaggacccaaagccgagaacccaggcaacaggaagagaaacccctg
aagctccaggtgtggagtgggacagaagtcacggccccccagggagccacagacagacca
tggctttgccttccagaatgctggtctgtggaactgacccattcattcattcatttgttc
attcattcatttgcaaacattcatccaattcccaccacatgccaggaattatga

KEGG   Homo sapiens (human): 3360Help
Entry
3360              CDS       T01001                                 

Gene name
HTR4, 5-HT4, 5-HT4R
Definition
(RefSeq) 5-hydroxytryptamine receptor 4
  KO
K04160  5-hydroxytryptamine receptor 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Drug target
Cinitapride (DG01520): D07700 D07701
Cisapride (DG00056): D00274 D02092
Fabesetron hydrochloride: D01838
Mosapride (DG01285): D01994 D08236
Naronapride (DG01335): D09933 D09934
Piboserod hydrochloride: D05471
Prucalopride (DG00080): D09205 D10152
Relenopride (DG02948): D11220 D11221
Renzapride: D06396
Sulamserod hydrochloride: D05941
Tegaserod (DG00081): D02730 D06056
Velusetrag (DG01336): D09693 D09694
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3360 (HTR4)
   04024 cAMP signaling pathway
    3360 (HTR4)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3360 (HTR4)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3360 (HTR4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3360 (HTR4)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3360 (HTR4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1
Motif
Other DBs
NCBI-GeneID: 3360
NCBI-ProteinID: NP_000861
OMIM: 602164
HGNC: 5299
Ensembl: ENSG00000164270
Vega: OTTHUMG00000129931
Pharos: Q13639(Tclin)
UniProt: Q13639 A0A2D3FAF9
Position
5q32
AA seq 388 aa AA seqDB search
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT
NT seq 1167 nt NT seq  +upstreamnt  +downstreamnt
atggacaaacttgatgctaatgtgagttctgaggagggtttcgggtcagtggagaaggtg
gtgctgctcacgtttctctcgacggttatcctgatggccatcttggggaacctgctggtg
atggtggctgtgtgctgggacaggcagctcaggaaaataaaaacaaattatttcattgta
tctcttgcttttgcggatctgctggtttcggtgctggtgatgccctttggtgccattgag
ctggttcaagacatctggatttatggggaggtgttttgtcttgttcggacatctctggac
gtcctgctcacaacggcatcgatttttcacctgtgctgcatttctctggataggtattac
gccatctgctgccagcctttggtctataggaacaagatgacccctctgcgcatcgcatta
atgctgggaggctgctgggtcatccccacgtttatttcttttctccctataatgcaaggc
tggaataacattggcataattgatttgatagaaaagaggaagttcaaccagaactctaac
tctacgtactgtgtcttcatggtcaacaagccctacgccatcacctgctctgtggtggcc
ttctacatcccatttctcctcatggtgctggcctattaccgcatctatgtcacagctaag
gagcatgcccatcagatccagatgttacaacgggcaggagcctcctccgagagcaggcct
cagtcggcagaccagcatagcactcatcgcatgaggacagagaccaaagcagccaagacc
ctgtgcatcatcatgggttgcttctgcctctgctgggcaccattctttgtcaccaatatt
gtggatcctttcatagactacactgtccctgggcaggtgtggactgctttcctctggctc
ggctatatcaattccgggttgaacccttttctctacgccttcttgaataagtcttttaga
cgtgccttcctcatcatcctctgctgtgatgatgagcgctaccgaagaccttccattctg
ggccagactgtcccttgttcaaccacaaccattaatggatccacacatgtactaagggat
gcagtggagtgtggtggccagtgggagagtcagtgtcacccgccagcaacttctcctttg
gtggctgctcagcccagtgacacttag

KEGG   Homo sapiens (human): 3361Help
Entry
3361              CDS       T01001                                 

Gene name
HTR5A, 5-HT5A
Definition
(RefSeq) 5-hydroxytryptamine receptor 5A
  KO
K04161  5-hydroxytryptamine receptor 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3361 (HTR5A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3361 (HTR5A)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3361 (HTR5A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3361 (HTR5A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3361 (HTR5A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srv
Motif
Other DBs
NCBI-GeneID: 3361
NCBI-ProteinID: NP_076917
OMIM: 601305
HGNC: 5300
Ensembl: ENSG00000157219
Vega: OTTHUMG00000151327
Pharos: P47898(Tchem)
UniProt: P47898 A4D2N2
Position
7q36.2
AA seq 357 aa AA seqDB search
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG
WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS
PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP
FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
NT seq 1074 nt NT seq  +upstreamnt  +downstreamnt
atggatttacctgtgaacctaacctccttttccctctccaccccctcccctttggagacc
aaccacagcctcggcaaagacgacctgcgccccagctcgcccctgctctcggtcttcgga
gtgcttattctcaccttgctgggctttctggtggcggcgacgttcgcctggaacctgctg
gtgctggcgaccatcctccgtgtacgcaccttccaccgcgtgccccacaacctggtggca
tccatggccgtctcggatgtcctggtggccgcgctggtcatgccgctgagcctggtgcac
gagctgtccgggcgccgctggcagctaggtcggaggctgtgccagctttggatcgcgtgc
gacgtgctttgctgcacggccagcatctggaacgtgacggccatagccctggaccgctac
tggtccatcacgcgccacatggaatacacgctccgcacccgcaagtgcgtctccaacgtc
atgatcgcgctcacctgggcactctccgctgtcatctctctggccccgctgctttttggc
tggggagagacgtactctgagggcagcgaggagtgccaggtaagccgcgagccttcctac
gccgtgttctccaccgtaggcgccttctacctgccgctctgtgtggtgctcttcgtgtac
tggaagatctacaaggctgccaagttccgcgtgggctccaggaagaccaatagcgtctca
cccatatccgaagctgtggaggtgaaggactctgccaaacagccccagatggtgttcacg
gtccgccacgccaccgtcaccttccagccagaaggggacacgtggcgggagcagaaggag
cagcgggccgccctcatggtgggcatcctcattggcgtgttcgtgctctgctggatcccc
ttctttctcaccgagctcatcagtcccctctgctcctgtgacatccccgccatctggaaa
agcatcttcctgtggcttggctactccaactccttctttaaccccctgatctatacggct
ttcaacaagaactacaacagcgccttcaagaacttcttttctaggcaacactga

KEGG   Homo sapiens (human): 3362Help
Entry
3362              CDS       T01001                                 

Gene name
HTR6, 5-HT6, 5-HT6R
Definition
(RefSeq) 5-hydroxytryptamine receptor 6
  KO
K04162  5-hydroxytryptamine receptor 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Drug target
Asenapine: D02995
Cerlapirdine (DG01337): D10099 D10100
Idalopirdine (DG01878): D10710 D10747
Olanzapine (DG00898): D00454 D06623
Tiospirone hydrochloride: D02688
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3362 (HTR6)
   04024 cAMP signaling pathway
    3362 (HTR6)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3362 (HTR6)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3362 (HTR6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3362 (HTR6)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3362 (HTR6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx DUF1385
Motif
Other DBs
NCBI-GeneID: 3362
NCBI-ProteinID: NP_000862
OMIM: 601109
HGNC: 5301
Ensembl: ENSG00000158748
Vega: OTTHUMG00000002713
Pharos: P50406(Tchem)
UniProt: P50406
Position
1p36.13
AA seq 440 aa AA seqDB search
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
NT seq 1323 nt NT seq  +upstreamnt  +downstreamnt
atggtcccagagccgggcccaaccgccaatagcaccccggcctggggggcagggccgccg
tcggccccggggggcagcggctgggtggcggccgcgctgtgcgtggtcatcgcgctgacg
gcggcggccaactcgctgctgatcgcgctcatctgcactcagcccgcgctgcgcaacacg
tccaacttcttcctggtgtcgctcttcacgtctgacctgatggtggggctggtggtgatg
ccgccggccatgctgaacgcgctgtacgggcgctgggtgctggcgcgcggcctctgcctg
ctctggaccgccttcgacgtgatgtgctgcagcgcctccatcctcaacctctgcctcatc
agcctggaccgctacctgctcatcctctcgccgctgcgctacaagctgcgcatgacgccc
ctgcgtgccctggccctagtcctgggcgcctggagcctcgccgctctcgcctccttcctg
cccctgctgctgggctggcacgagctgggccacgcacggccacccgtccctggccagtgc
cgcctgctggccagcctgccttttgtccttgtggcgtcgggcctcaccttcttcctgccc
tcgggtgccatatgcttcacctactgcaggatcctgctagctgcccgcaagcaggccgtg
caggtggcctccctcaccaccggcatggccagtcaggcctcggagacgctgcaggtgccc
aggaccccacgcccaggggtggagtctgctgacagcaggcgtctagccacgaagcacagc
aggaaggccctgaaggccagcctgacgctgggcatcctgctgggcatgttctttgtgacc
tggttgcccttctttgtggccaacatagtccaggccgtgtgcgactgcatctccccaggc
ctcttcgatgtcctcacatggctgggttactgtaacagcaccatgaaccccatcatctac
ccactcttcatgcgggacttcaagcgggcgctgggcaggttcctgccatgtccacgctgt
ccccgggagcgccaggccagcctggcctcgccatcactgcgcacctctcacagcggcccc
cggcccggccttagcctacagcaggtgctgccgctgcccctgccgccggactcagattcg
gactcagacgcaggctcaggcggctcctcgggcctgcggctcacggcccagctgctgctt
cctggcgaggccacccaggaccccccgctgcccaccagggccgctgccgccgtcaatttc
ttcaacatcgaccccgcggagcccgagctgcggccgcatccacttggcatccccacgaac
tga

KEGG   Homo sapiens (human): 3363Help
Entry
3363              CDS       T01001                                 

Gene name
HTR7, 5-HT7
Definition
(RefSeq) 5-hydroxytryptamine receptor 7
  KO
K04163  5-hydroxytryptamine receptor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Drug target
Asenapine: D02995
Methysergide (DG00835): D00681 D02357
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    3363 (HTR7)
   04020 Calcium signaling pathway
    3363 (HTR7)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3363 (HTR7)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3363 (HTR7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3363 (HTR7)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Serotonin
    3363 (HTR7)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 3363
NCBI-ProteinID: NP_062873
OMIM: 182137
HGNC: 5302
Ensembl: ENSG00000148680
Vega: OTTHUMG00000018732
Pharos: P34969(Tclin)
UniProt: P34969
Position
10q23.31
AA seq 479 aa AA seqDB search
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt
atgatggacgttaacagcagcggccgcccggacctctacgggcacctccgctctttcctt
ctgccagaagtggggcgcgggctgcccgacttgagccccgacggtggcgccgacccggtc
gcgggctcctgggcgccgcacctgctgagcgaggtgacagccagcccggcgcccacctgg
gacgcgcccccggacaatgcctccggctgtggggaacagatcaactacggcagagtcgag
aaagttgtgatcggctccatcctgacgctcatcacgctgctgacgatcgcgggcaactgc
ctggtggtgatctccgtgtgcttcgtcaagaagctccgccagccctccaactacctgatc
gtgtccctggcgctggccgacctctcggtggctgtggcggtcatgcccttcgtcagcgtc
accgacctcatcgggggcaagtggatctttggacactttttctgtaatgtcttcatcgcc
atggacgtcatgtgctgcacggcctcgatcatgaccctgtgcgtgatcagcattgacagg
taccttgggatcacaaggcccctcacataccctgtgaggcagaatgggaaatgcatggcg
aagatgattctctccgtctggcttctctccgcctccatcaccttacctccactctttgga
tgggctcagaatgtaaatgatgataaggtgtgcttgatcagccaggactttggctatacg
atttactctaccgcagtggcattttatatccccatgtccgtcatgcttttcatgtactac
cagatttacaaggctgccaggaagagtgctgccaaacacaagtttcctggcttccctcga
gtggagccagacagcgtcatcgccctgaatggcatagtgaagctccagaaggaggtggaa
gagtgtgcaaacctttcgagactcctcaagcatgaaaggaaaaacatctccatctttaag
cgagaacagaaagcagccaccaccctggggatcatcgtcggggcctttaccgtgtgctgg
ctgccatttttcctcctctcgacagccagacccttcatctgtggcacttcctgcagctgc
atcccactgtgggtggagaggacatttctgtggctaggctatgcaaactctctcattaac
ccttttatatatgccttcttcaaccgggacctgaggaccacctatcgcagcctgctccag
tgccagtaccggaatatcaaccggaagctctcagctgcaggcatgcatgaagccctgaag
cttgctgagaggccagagagacctgagtttgtgctgagggcctgcacaaggagggtgctg
ttgagaccagaaaagaggccaccggtatctgtgtgggtgctacaatctccagaccatcac
aattggttagcagacaaaatgctgactactgtagaaaaaaaggtcatgattcatgattga

DBGET integrated database retrieval system